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Select item 100848391.

Differential contribution of C5aR and C5b-9 pathways to renal thrombic microangiopathy and macrovascular thrombosis in mice carrying an atypical hemolytic syndrome-related factor H mutation.

Yoshiyasu Ueda, Takashi Miwa, Daisuke Ito, Hangsoo Kim, Sayaka Sato, Damodar Gullipalli, Lin Zhou, Madhu Golla, Delu Song, Joshua L. Dunaief, Matthew Palmer, Wen-Chao Song

Kidney Int. Author manuscript; available in PMC 2023 Apr 10.

Published in final edited form as: Kidney Int. 2019 Jul; 96(1): 67–79. Published online 2019 Feb 27. doi: 10.1016/j.kint.2019.01.009

PMCID:: PMC10084839

Abstract Article PDF–2.9M

Select item 99684102.

Neutrophil-activating therapy for the treatment of cancer

Ian L. Linde, Tyler R. Prestwood, Jingtao Qiu, Genay Pilarowski, Miles H. Linde, Xiangyue Zhang, Lei Shen, Nathan E. Reticker-Flynn, David Kung-Chun Chiu, Lauren Y. Sheu, Simon Van Deursen, Lorna L. Tolentino, Wen-Chao Song, Edgar G. Engleman

Cancer Cell. Author manuscript; available in PMC 2024 Feb 13.

Published in final edited form as: Cancer Cell. 2023 Feb 13; 41(2): 356–372.e10. Published online 2023 Jan 26. doi: 10.1016/j.ccell.2023.01.002

PMCID:: PMC9968410

Abstract Article PDF–4.0M

Select item 93880873.

Neutrophils activated by membrane attack complexes increase the permeability of melanoma blood vessels

Xiaobo Liu, Yuanyuan Wang, Alexander T. Bauer, Michael Kirschfink, Peipei Ding, Christoffer Gebhardt, Lubor Borsig, Thomas Tüting, Thomas Renné, Karsten Häffner, Weiguo Hu, Stefan W. Schneider, Christian Gorzelanny

Proc Natl Acad Sci U S A. 2022 Aug 16; 119(33): e2122716119. Published online 2022 Aug 12. doi: 10.1073/pnas.2122716119

PMCID:: PMC9388087

Abstract Article PDF–3.3M

Select item 81503274.

C3 Drives Inflammatory Skin Carcinogenesis Independently of C5

William D. Jackson, Alessandro Gulino, Liliane Fossati-Jimack, Rocio Castro Seoane, Kunyuan Tian, Katie Best, Jörg Köhl, Beatrice Belmonte, Jessica Strid, Marina Botto

J Invest Dermatol. 2021 Feb; 141(2): 404–414.e6. doi: 10.1016/j.jid.2020.06.025

PMCID:: PMC8150327

Abstract Article PDF–4.5M

Select item 66201855.

Development and characterization of novel anti‐C5 monoclonal antibodies capable of inhibiting complement in multiple species

Wioleta M. Zelek, Philip R. Taylor, B. Paul Morgan

Immunology. 2019 Aug; 157(4): 283–295. Published online 2019 Jun 17. doi: 10.1111/imm.13083

PMCID:: PMC6620185

Abstract Article PDF–1.5M

Select item 64585216.

Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice

Delu Song, Yoshiyasu Ueda, Rupak Bhuyan, Imran Mohammed, Takashi Miwa, Damodar Gullipali, Hangsoo Kim, Lin Zhou, Ying Song, Hannah Schultz, Albert Bargoud, Joshua L. Dunaief, Wen-Chao Song

Am J Pathol. 2019 Apr; 189(4): 826–838. doi: 10.1016/j.ajpath.2019.01.009

PMCID:: PMC6458521

Abstract Article PDF–6.2M

Select item 62942497.

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

Anaïs Menny, Marina Serna, Courtney M. Boyd, Scott Gardner, Agnel Praveen Joseph, B. Paul Morgan, Maya Topf, Nicholas J. Brooks, Doryen Bubeck

Nat Commun. 2018; 9: 5316. Published online 2018 Dec 14. doi: 10.1038/s41467-018-07653-5

PMCID:: PMC6294249

Abstract Article PDF–3.4M

Select item 62871018.

Complement Inhibitor CRIg/FH Ameliorates Renal Ischemia Reperfusion Injury via Activation of PI3K/AKT Signaling

Chao Hu, Long Li, Peipei Ding, Ling Li, Xiaowen Ge, Long Zheng, Xuanchuan Wang, Jina Wang, Weitao Zhang, Na Wang, Hongyu Gu, Fan Zhong, Ming Xu, Ruiming Rong, Tongyu Zhu, Weiguo Hu

J Immunol. 2018 Dec 15; 201(12): 3717–3730. Published online 2018 Nov 14. doi: 10.4049/jimmunol.1800987

PMCID:: PMC6287101

Abstract Article PDF–3.6M

Select item 47319909.

Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain

Fengjiao Wu, Qiang Zou, Xiaodan Ding, Dongyan Shi, Xingxing Zhu, Weiguo Hu, Lixin Liu, Hong Zhou

J Neuroinflammation. 2016; 13: 23. Published online 2016 Jan 28. doi: 10.1186/s12974-016-0485-y

PMCID:: PMC4731990

Abstract Article PDF–3.6M

Select item 392332210.

C6 knock-out Mice Are Protected from Thrombophilia Mediated by Antiphospholipid Antibodies

Carrera-Marín Ana Laura, Romay-Penabad Zurina, Papalardo Elizabeth, Reyes-Maldonado Elba, Garcia-Latorre Ethel, Vargas Gracie, Shilagard Tuya, Pierangeli Silvia

Lupus. Author manuscript; available in PMC 2014 Feb 13.

Published in final edited form as: Lupus. 2012 Dec; 21(14): 1497–1505. Published online 2012 Aug 29. doi: 10.1177/0961203312458839

PMCID:: PMC3923322

Abstract Article PDF–647K

Select item 390456011.

C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN

Hong Xiao, Daniel J. Dairaghi, Jay P. Powers, Linda S. Ertl, Trageen Baumgart, Yu Wang, Lisa C. Seitz, Mark E.T. Penfold, Lin Gan, Peiqi Hu, Bao Lu, Norma P. Gerard, Craig Gerard, Thomas J. Schall, Juan C. Jaen, Ronald J. Falk, J. Charles Jennette

J Am Soc Nephrol. 2014 Feb; 25(2): 225–231. Published online 2013 Oct 31. doi: 10.1681/ASN.2013020143

PMCID:: PMC3904560

Abstract Article

Select item 357241012.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 347848513.

The alternative complement pathway propagates inflammation and injury in murine ischemic stroke

Andrew Elvington, Carl Atkinson, Hong Zhu, Jin Yu, Kazue Takahashi, Gregory L. Stahl, Mark S Kindy, Stephen Tomlinson

J Immunol. Author manuscript; available in PMC 2013 Nov 1.

Published in final edited form as: J Immunol. 2012 Nov 1; 189(9): 4640–4647. Published online 2012 Oct 1. doi: 10.4049/jimmunol.1201904

PMCID:: PMC3478485

Abstract Article PDF–3.6M

Select item 326294914.

Role of C3a Receptors, C5a Receptors, and Complement Protein C6 Deficiency in Collagen Antibody-Induced Arthritis in Mice

Nirmal K. Banda, Stephanie Hyatt, Alexandra H. Antonioli, Jason T. White, Magdalena Glogowska, Kazue Takahashi, Tod J. Merkel, Gregory L. Stahl, Stacey Mueller-Ortiz, Rick Wetsel, William P. Arend, V. Michael Holers

J Immunol. Author manuscript; available in PMC 2013 Feb 1.

Published in final edited form as: J Immunol. 2012 Feb 1; 188(3): 1469–1478. Published online 2011 Dec 28. doi: 10.4049/jimmunol.1102310

PMCID:: PMC3262949

Abstract Article PDF–1.6M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 293710116.

O-Fucosylation of Thrombospondin Type 1 Repeats Restricts Epithelial to Mesenchymal Transition (EMT) and Maintains Epiblast Pluripotency During Mouse Gastrulation

Jianguang Du, Hideyuki Takeuchi, Christina Leonhard-Melief, Kenneth R. Shroyer, Malgosia Dlugosz, Robert S. Haltiwanger, Bernadette C. Holdener

Dev Biol. Author manuscript; available in PMC 2011 Oct 1.

Published in final edited form as: Dev Biol. 2010 Oct 1; 346(1): 25–38. Published online 2010 Jul 14. doi: 10.1016/j.ydbio.2010.07.008

PMCID:: PMC2937101

Abstract Article PDF–3.9M

Select item 286229117.

The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice

Ruth D. Lewis, Christopher L. Jackson, B. Paul Morgan, Timothy R. Hughes

Mol Immunol. 2010 Feb; 47(5): 1098–1105. doi: 10.1016/j.molimm.2009.10.035

PMCID:: PMC2862291

Abstract Article

Select item 198894518.

Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody–induced fetal injury

Patricia Redecha, Rachel Tilley, Michael Tencati, Jane E. Salmon, Daniel Kirchhofer, Nigel Mackman, Guillermina Girardi

Blood. 2007 Oct 1; 110(7): 2423–2431. Prepublished online 2007 May 29. doi: 10.1182/blood-2007-01-070631

PMCID:: PMC1988945

Abstract Article

Select item 31546319.

Predominant role for C5b-9 in renal ischemia/reperfusion injury

Wuding Zhou, Conrad A. Farrar, Katsushige Abe, Julian R. Pratt, James E. Marsh, Yi Wang, Gregory L. Stahl, Steven H. Sacks

J Clin Invest. 2000 May 15; 105(10): 1363–1371. doi: 10.1172/JCI8621

PMCID:: PMC315463

Abstract Article PDF–3.2M

Select item 31099220.

RIKEN Integrated Sequence Analysis (RISA) System—384-Format Sequencing Pipeline with 384 Multicapillary Sequencer

Kazuhiro Shibata, Masayoshi Itoh, Katsunori Aizawa, Sumiharu Nagaoka, Nobuya Sasaki, Piero Carninci, Hideaki Konno, Junichi Akiyama, Katsuo Nishi, Tokuji Kitsunai, Hideo Tashiro, Mari Itoh, Noriko Sumi, Yoshiyuki Ishii, Shin Nakamura, Makoto Hazama, Tsutomu Nishine, Akira Harada, Rintaro Yamamoto, Hiroyuki Matsumoto, Sumito Sakaguchi, Takashi Ikegami, Katsuya Kashiwagi, Syuji Fujiwake, Kouji Inoue, Yoshiyuki Togawa, Masaki Izawa, Eiji Ohara, Masanori Watahiki, Yuko Yoneda, Tomokazu Ishikawa, Kaori Ozawa, Takumi Tanaka, Shuji Matsuura, Jun Kawai, Yasushi Okazaki, Masami Muramatsu, Yorinao Inoue, Akira Kira, Yoshihide Hayashizaki

Genome Res. 2000 Nov; 10(11): 1757–1771. doi: 10.1101/gr.152600

PMCID:: PMC310992

Abstract Article PDF–3.4M

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