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Items: 1 to 20 of 37

1.
Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation-driven colorectal cancers
Hector A. Cuello, Saptarshi Sinha, Andrea L. Verhagen, Nissi Varki, Ajit Varki, Pradipta Ghosh
JCI Insight. 2024 Aug 22; 9(16): e181539. Published online 2024 Jul 11. doi: 10.1172/jci.insight.181539
PMCID:
PMC11343606
AbstractArticlePDF–17M
2.
The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell activation in sepsis
Roberto Lozano-Rodríguez, José Avendaño-Ortíz, Karla Montalbán-Hernández, Juan Carlos Ruiz-Rodríguez, Ricardo Ferrer, Alejandro Martín-Quirós, Charbel Maroun-Eid, Juan José González-López, Anna Fàbrega, Verónica Terrón-Arcos, María Gutiérrez-Fernández, Elisa Alonso-López, Carolina Cubillos-Zapata, María Fernández-Velasco, Rebeca Pérez de Diego, Pablo Pelegrin, Carlos García-Palenciano, Francisco J. Cueto, Carlos del Fresno, Eduardo López-Collazo
eBioMedicine. 2023 Nov; 97: 104841. Published online 2023 Oct 25. doi: 10.1016/j.ebiom.2023.104841
PMCID:
PMC10630607
AbstractArticlePDF–1.8M
3.
Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization
Lara-Jasmin Schröder, Hauke Thiesler, Lina Gretenkort, Thiemo Malte Möllenkamp, Martin Stangel, Viktoria Gudi, Herbert Hildebrandt
Front Cell Neurosci. 2023; 17: 1207540. Published online 2023 Jul 10. doi: 10.3389/fncel.2023.1207540
Correction in:
Front Cell Neurosci. 2023; 17: 1275048.
PMCID:
PMC10365911
AbstractArticlePDF–6.8M
4.
CD24-Siglec Axis Is an Innate Immune Checkpoint against Metaflammation and Metabolic Disorder
Xu Wang, Mingyue Liu, Jifeng Zhang, Nicholas K. Brown, Peng Zhang, Yan Zhang, Heng Liu, Xuexiang Du, Wei Wu, Martin Devenport, Weng Tao, Yang Mao-Draayer, Guo-Yun Chen, Y. Eugene Chen, Pan Zheng, Yang Liu
Cell Metab. Author manuscript; available in PMC 2023 Aug 2.
Published in final edited form as: Cell Metab. 2022 Aug 2; 34(8): 1088–1103.e6. doi: 10.1016/j.cmet.2022.07.005
PMCID:
PMC9393047
AbstractArticlePDF–3.9M
5.
Ablation of Siglec-E augments brain inflammation and ischemic injury
Lexiao Li, Yu Chen, Madison N. Sluter, Ruida Hou, Jiukuan Hao, Yin Wu, Guo-Yun Chen, Ying Yu, Jianxiong Jiang
J Neuroinflammation. 2022; 19: 191. Published online 2022 Jul 20. doi: 10.1186/s12974-022-02556-1
PMCID:
PMC9301848
AbstractArticlePDF–7.6M
6.
O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells
Jinghua Yang, Wei Ma, Yuanyuan Wu, Hui Zhou, Siyu Song, Yuqi Cao, Chengxu Wang, Xiangyuan Liu, Jinwei Ren, Jinyou Duan, Zhichao Pei, Cheng Jin
Microbiol Spectr. 2021 Nov-Dec; 9(3): e00399-21. Published online 2021 Dec 8. doi: 10.1128/spectrum.00399-21
PMCID:
PMC8653822
AbstractArticlePDF–3.3M
7.
ST8Sia6 Promotes Tumor Growth in Mice by Inhibiting Immune Responses
David J. Friedman, Sydney B. Crotts, Michael J. Shapiro, Matthew Rajcula, Shaylene McCue, Xin Liu, Khashayarsha Khazaie, Haidong Dong, Virginia Smith Shapiro
Cancer Immunol Res. Author manuscript; available in PMC 2022 Feb 1.
Published in final edited form as: Cancer Immunol Res. 2021 Aug; 9(8): 952–966. Published online 2021 Jun 1. doi: 10.1158/2326-6066.CIR-20-0834
PMCID:
PMC8338779
AbstractArticlePDF–2.8M
8.
Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity
Itziar Ibarlucea-Benitez, Polina Weitzenfeld, Patrick Smith, Jeffrey V. Ravetch
Proc Natl Acad Sci U S A. 2021 Jun 29; 118(26): e2107424118. Published online 2021 Jun 21. doi: 10.1073/pnas.2107424118
PMCID:
PMC8256000
AbstractArticlePDF–2.0M
9.
Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation
Hauke Thiesler, Julia Beimdiek, Herbert Hildebrandt
Cell Mol Life Sci. 2021 Feb; 78(4): 1637–1653. Published online 2020 Jul 28. doi: 10.1007/s00018-020-03601-z
PMCID:
PMC7904730
AbstractArticlePDF–9.3M
10.
Selective Response to Bacterial Infection by Regulating Siglec-E Expression
Yin Wu, Darong Yang, Runhua Liu, Lizhong Wang, Guo-Yun Chen
iScience. 2020 Sep 25; 23(9): 101473. Published online 2020 Aug 20. doi: 10.1016/j.isci.2020.101473
PMCID:
PMC7479279
AbstractArticlePDF–5.4M
11.
Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing
Satoshi Uchiyama, Josh Sun, Kyoko Fukahori, Nao Ando, Mengyou Wu, Flavio Schwarz, Shoib S. Siddiqui, Ajit Varki, Jamey D. Marth, Victor Nizet
Proc Natl Acad Sci U S A. 2019 Apr 9; 116(15): 7465–7470. Published online 2019 Mar 25. doi: 10.1073/pnas.1815572116
PMCID:
PMC6462088
AbstractArticlePDF–1.2M
12.
Siglec genes confer resistance to systemic lupus erythematosus in humans and mice
Rhonda Flores, Peng Zhang, Wei Wu, Xu Wang, Peiying Ye, Pan Zheng, Yang Liu
Cell Mol Immunol. 2019 Feb; 16(2): 154–164. Published online 2018 Mar 5. doi: 10.1038/cmi.2017.160
PMCID:
PMC6355849
AbstractArticlePDF–5.3M
13.
Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells
Michal A. Stanczak, Shoib S. Siddiqui, Marcel P. Trefny, Daniela S. Thommen, Kayluz Frias Boligan, Stephan von Gunten, Alexandar Tzankov, Lothar Tietze, Didier Lardinois, Viola Heinzelmann-Schwarz, Michael von Bergwelt-Baildon, Wu Zhang, Heinz-Josef Lenz, Younghun Han, Christopher I. Amos, Mohammedyaseen Syedbasha, Adrian Egli, Frank Stenner, Daniel E. Speiser, Ajit Varki, Alfred Zippelius, Heinz Läubli
J Clin Invest. 2018 Nov 1; 128(11): 4912–4923. Published online 2018 Sep 24. doi: 10.1172/JCI120612
PMCID:
PMC6205408
AbstractArticlePDF–4.8M
14.
Siglec-E Is Up-Regulated and Phosphorylated Following Lipopolysaccharide Stimulation in Order to Limit TLR-Driven Cytokine Production
Caroline R. Boyd, Selinda J. Orr, Shaun Spence, James F. Burrows, Joanne Elliott, Helen P. Carroll, Kiva Brennan, Joan Ní Gabhann, Wilson A. Coulter, James A. Johnston, Caroline A. Jefferies
J Immunol. Author manuscript; available in PMC 2017 Sep 1.
Published in final edited form as: J Immunol. 2009 Dec 15; 183(12): 7703–7709. doi: 10.4049/jimmunol.0902780
PMCID:
PMC5580793
AbstractArticlePDF–1.4M
15.
Paired Siglec receptors generate opposite inflammatory responses to a human‐specific pathogen
Flavio Schwarz, Corinna S Landig, Shoib Siddiqui, Ismael Secundino, Joshua Olson, Nissi Varki, Victor Nizet, Ajit Varki
EMBO J. 2017 Mar 15; 36(6): 751–760. Published online 2017 Jan 18. doi: 10.15252/embj.201695581
PMCID:
PMC5350563
AbstractArticlePDF–2.8M
16.
Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E
Shoib Siddiqui, Flavio Schwarz, Stevan Springer, Zahra Khedri, Hai Yu, Lingquan Deng, Andrea Verhagen, Yuko Naito-Matsui, Weiping Jiang, Daniel Kim, Jie Zhou, Beibei Ding, Xi Chen, Nissi Varki, Ajit Varki
J Biol Chem. 2017 Jan 20; 292(3): 1029–1037. Published online 2016 Dec 5. doi: 10.1074/jbc.M116.738351
PMCID:
PMC5247637
AbstractArticlePDF–2.5M
17.
Siglec-E negatively regulates the activation of Toll-like Receptor 4 by controlling its endocytosis
Yin Wu, Dongren Ren, Guo-Yun Chen
J Immunol. Author manuscript; available in PMC 2017 Oct 15.
Published in final edited form as: J Immunol. 2016 Oct 15; 197(8): 3336–3347. Published online 2016 Sep 12. doi: 10.4049/jimmunol.1600772
PMCID:
PMC5101162
AbstractArticlePDF–3.3M
18.
Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm
Saptarshi Roy, Chitra Mandal
PLoS Negl Trop Dis. 2016 Aug; 10(8): e0004904. Published online 2016 Aug 5. doi: 10.1371/journal.pntd.0004904
PMCID:
PMC4975436
AbstractArticlePDF–6.5M
19.
The transcription factor XBP1 is selectively required for eosinophil differentiation
Sarah E. Bettigole, Raphael Lis, Stanley Adoro, Ann-Hwee Lee, Lisa A. Spencer, Peter F. Weller, Laurie H. Glimcher
Nat Immunol. Author manuscript; available in PMC 2016 Feb 1.
Published in final edited form as: Nat Immunol. 2015 Aug; 16(8): 829–837. Published online 2015 Jul 6. doi: 10.1038/ni.3225
PMCID:
PMC4577297
AbstractArticlePDF–2.1M
20.
Siglec receptors impact mammalian lifespan by modulating oxidative stress
Flavio Schwarz, Oliver MT Pearce, Xiaoxia Wang, Annie N Samraj, Heinz Läubli, Javier O Garcia, Hongqiao Lin, Xiaoming Fu, Andrea Garcia-Bingman, Patrick Secrest, Casey E Romanoski, Charles Heyser, Christopher K Glass, Stanley L Hazen, Nissi Varki, Ajit Varki, Pascal Gagneux
eLife. 2015; 4: e06184. Published online 2015 Apr 7. doi: 10.7554/eLife.06184
PMCID:
PMC4384638
AbstractArticlePDF–1.6M

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