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Select item 111662011.

TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal

Yangchan Li, Meilin Xue, Xiaolan Deng, Lei Dong, Le Xuan Truong Nguyen, Lili Ren, Li Han, Chenying Li, Jianhuang Xue, Zhicong Zhao, Wei Li, Ying Qing, Chao Shen, Brandon Tan, Zhenhua Chen, Keith Leung, Kitty Wang, Srividya Swaminathan, Ling Li, Mark Wunderlich, James C. Mulloy, Xiaobo Li, Hao Chen, Bin Zhang, David Horne, Steven T. Rosen, Guido Marcucci, Mingjiang Xu, Zejuan Li, Minjie Wei, Jingyan Tian, Baiyong Shen, Rui Su, Jianjun Chen

Cell Stem Cell. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: Cell Stem Cell. 2023 Aug 3; 30(8): 1072–1090.e10. doi: 10.1016/j.stem.2023.07.001

PMCID:: PMC11166201

Abstract Article PDF–4.0M

Select item 111427372.

Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function

Candice Quin, Erica N. DeJong, Elina K. Cook, Yi Zhen Luo, Caitlyn Vlasschaert, Sanathan Sadh, Amy J.M. McNaughton, Marco M. Buttigieg, Jessica A. Breznik, Allison E. Kennedy, Kevin Zhao, Jeffrey Mewburn, Kimberly J. Dunham-Snary, Charles C.T. Hindmarch, Alexander G. Bick, Stephen L. Archer, Michael J. Rauh, Dawn M.E. Bowdish

J Clin Invest. 2024 Jun 3; 134(11): e171002. Published online 2024 Apr 4. doi: 10.1172/JCI171002

PMCID:: PMC11142737

Abstract Article PDF–1.1M

Select item 110580183.

Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation

Amy Erica Lin, Aneesh C. Bapat, Ling Xiao, Abhishek Niroula, Jiangchuan Ye, Waihay J. Wong, Mridul Agrawal, Christopher J. Farady, Andreas Boettcher, Christopher B. Hergott, Marie McConkey, Patricio Flores-Bringas, Veronica Shkolnik, Alexander G. Bick, David Milan, Pradeep Natarajan, Peter Libby, Patrick T. Ellinor, Benjamin L. Ebert

Circulation. 2024 Apr 30; 149(18): 1419–1434. Published online 2024 Feb 15. doi: 10.1161/CIRCULATIONAHA.123.065597

PMCID:: PMC11058018

Abstract Article PDF–1.6M

Select item 110042974.

Loss of TET2 increases B-1 cell number and IgM production while limiting CDR3 diversity

Emily Dennis, Maria Murach, Cassidy M.R. Blackburn, Melissa Marshall, Katherine Root, Tanyaporn Pattarabanjird, Justine Deroissart, Loren D. Erickson, Christoph J. Binder, Stefan Bekiranov, Coleen A. McNamara

Front Immunol. 2024; 15: 1380641. Published online 2024 Mar 27. doi: 10.3389/fimmu.2024.1380641

PMCID:: PMC11004297

Abstract Article PDF–16M

Select item 109851125.

A negative feedback loop between TET2 and leptin in adipocyte regulates body weight

Qin Zeng, Jianfeng Song, Xiaoxiao Sun, Dandan Wang, Xiyan Liao, Yujin Ding, Wanyu Hu, Yayi Jiao, Wuqian Mai, Wufuer Aini, Fanqi Wang, Hui Zhou, Limin Xie, Ying Mei, Yuan Tang, Zhiguo Xie, Haijing Wu, Wei Liu, Tuo Deng

Nat Commun. 2024; 15: 2825. Published online 2024 Apr 1. doi: 10.1038/s41467-024-46783-x

PMCID:: PMC10985112

Abstract Article PDF–2.5M

Select item 109436916.

Leukemic mutation FLT3-ITD is retained in dendritic cells and disrupts their homeostasis leading to expanded Th17 frequency

Patrick A. Flynn, Mark D. Long, Yoko Kosaka, Nicola Long, Jessica S. Mulkey, Jesse L. Coy, Anupriya Agarwal, Evan F. Lind

Front Immunol. 2024; 15: 1297338. Published online 2024 Mar 1. doi: 10.3389/fimmu.2024.1297338

PMCID:: PMC10943691

Abstract Article PDF–6.1M

Select item 109334717.

TET2 regulation of alcoholic fatty liver via Srebp1 mRNA in paraspeckles

Qinjin Li, Yanyan Pan, Jing Zhang, Boxu Hu, Dan Qin, Shenghui Liu, Ning Chen, Lisheng Zhang

iScience. 2024 Mar 15; 27(3): 109278. Published online 2024 Feb 20. doi: 10.1016/j.isci.2024.109278

PMCID:: PMC10933471

Abstract Article PDF–5.4M

Select item 108782748.

Ten-eleven translocation (Tet) methylcytosine dioxygenase-dependent viral DNA demethylation mediates in vivo hepatitis B virus (HBV) biosynthesis

Rachel Matrenec, Claudia E. Oropeza, Eddie Dekoven, Grant Tarnow, Mark Maienschein-Cline, Cecilia S. Chau, Stefan J. Green, Alan McLachlan

J Virol. 2024 Feb; 98(2): e01721-23. Published online 2024 Jan 5. doi: 10.1128/jvi.01721-23

PMCID:: PMC10878274

Abstract Article PDF–2.2M

Select item 107972099.

Endothelial TET2 regulates the white adipose browning and metabolism via fatty acid oxidation in obesity

Yefei Shi, Xinru Huang, Yanxi Zeng, Ming Zhai, Hongyun Yao, Chang Liu, Bo Li, Shiyu Gong, Qing Yu, Jianhui Zhuang, Yifan Zhao, Liesheng Lu, Bo Zhou, Weixia Jian, Wenhui Peng

Redox Biol. 2024 Feb; 69: 103013. Published online 2023 Dec 28. doi: 10.1016/j.redox.2023.103013

PMCID:: PMC10797209

Abstract Article PDF–16M

Select item 1076695210.

TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer

Hongwei Lv, Qianni Zong, Cian Chen, Guishuai Lv, Wei Xiang, Fuxue Xing, Guoqing Jiang, Bing Yan, Xiaoyan Sun, Yue Ma, Liang Wang, Zixin Wu, Xiuliang Cui, Hongyang Wang, Wen Yang

Nat Commun. 2024; 15: 6. Published online 2024 Jan 4. doi: 10.1038/s41467-023-43743-9

PMCID:: PMC10766952

Abstract Article PDF–9.2M

Select item 1075026811.

Microenvironmental CXCL12 Deletion Enhances Flt3-ITD Acute Myeloid Leukemia Stem Cell Response to Therapy by Reducing p38 MAPK Signaling

Nicholas R. Anderson, Vipul Sheth, Hui Li, Mason W. Harris, Shaowei Qiu, David K. Crossman, Harish Kumar, Puneet Agarwal, Takashi Nagasawa, Andrew J. Paterson, Robert S. Welner, Ravi Bhatia

Leukemia. Author manuscript; available in PMC 2023 Dec 26.

Published in final edited form as: Leukemia. 2023 Mar; 37(3): 560–570. Published online 2022 Dec 22. doi: 10.1038/s41375-022-01798-5

PMCID:: PMC10750268

Abstract Article PDF–1.3M

Select item 1068027612.

TET2 deficiency promotes anxiety and depression-like behaviors by activating NLRP3/IL-1β pathway in microglia of allergic rhinitis mice

Ziang Gao, Hao Lv, Yunfei Wang, Yulie Xie, Mengting Guan, Yu Xu

Mol Med. 2023; 29: 160. Published online 2023 Nov 27. doi: 10.1186/s10020-023-00757-9

PMCID:: PMC10680276

Abstract Article PDF–9.5M

Select item 1065302113.

Clonal germinal center B cells function as a niche for T-cell lymphoma

Manabu Fujisawa, Tran B. Nguyen, Yoshiaki Abe, Yasuhito Suehara, Kota Fukumoto, Sakurako Suma, Kenichi Makishima, Chihiro Kaneko, Yen T.M. Nguyen, Kensuke Usuki, Kentaro Narita, Kosei Matsue, Naoya Nakamura, Shumpei Ishikawa, Fumihito Miura, Takashi Ito, Ayako Suzuki, Yutaka Suzuki, Seiya Mizuno, Satoru Takahashi, Shigeru Chiba, Mamiko Sakata-Yanagimoto

Blood. 2022 Nov 3; 140(18): 1937–1950. Published online 2022 Aug 5. doi: 10.1182/blood.2022015451

PMCID:: PMC10653021

Abstract Article

Select item 1057954114.

DNA dioxygenases TET2 deficiency promotes cigarette smoke induced chronic obstructive pulmonary disease by inducing ferroptosis of lung epithelial cell

Zihang Zeng, Tiao Li, Xiangming Liu, Yiming Ma, Lijuan Luo, ZuLi Wang, Zhiqi Zhao, Herui Li, Xue He, Huihui Zeng, Yongguang Tao, Yan Chen

Redox Biol. 2023 Nov; 67: 102916. Published online 2023 Oct 4. doi: 10.1016/j.redox.2023.102916

PMCID:: PMC10579541

Abstract Article PDF–28M

Select item 1052468715.

Comparative analysis of Tet2 catalytic deficient and knockout bone marrow over time

Julio C. Flores, Kyoko Ito, Cheng-Yen Huang, Qin Tang, Chie Yanase, Keisuke Ito, Meelad M. Dawlaty

Exp Hematol. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Exp Hematol. 2023 Aug; 124: 45–55.e2. Published online 2023 May 22. doi: 10.1016/j.exphem.2023.05.004

PMCID:: PMC10524687

Abstract Article PDF–1.5M

Select item 1048364016.

Tet2 deletion in CD4+ T cells disrupts Th1 lineage commitment in memory cells and enhances T follicular helper cell recall responses to viral rechallenge

Andrew Baessler, Bryce Fuchs, Bryant Perkins, Andrew W. Richens, Camille L. Novis, Malia Harrison-Chau, Linda M. Sircy, Kendall A. Thiede, J. Scott Hale

Proc Natl Acad Sci U S A. 2023 Sep 5; 120(36): e2218324120. Published online 2023 Aug 28. doi: 10.1073/pnas.2218324120

PMCID:: PMC10483640

Abstract Article PDF–3.8M

Select item 1036930017.

Epigenetic Regulation of Hepatic Lipid Metabolism by DNA Methylation

Shirong Wang, Lin Zha, Xin Cui, Yu‐Te Yeh, Ruochuan Liu, Jia Jing, Huidong Shi, Weiping Chen, John Hanover, Jun Yin, Liqing Yu, Bingzhong Xue, Hang Shi

Adv Sci (Weinh) 2023 Jul; 10(20): 2206068. Published online 2023 Jun 6. doi: 10.1002/advs.202206068

PMCID:: PMC10369300

Abstract Article PDF–8.3M

Select item 1032605418.

TET2 and TET3 loss disrupts small intestine differentiation and homeostasis

Ihab Ansari, Llorenç Solé-Boldo, Meshi Ridnik, Julian Gutekunst, Oliver Gilliam, Maria Korshko, Timur Liwinski, Birgit Jickeli, Noa Weinberg-Corem, Michal Shoshkes-Carmel, Eli Pikarsky, Eran Elinav, Frank Lyko, Yehudit Bergman

Nat Commun. 2023; 14: 4005. Published online 2023 Jul 6. doi: 10.1038/s41467-023-39512-3

PMCID:: PMC10326054

Abstract Article PDF–11M

Select item 1031562419.

RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice

Charles Bramlett, Jiya Eerdeng, Du Jiang, Yeachan Lee, Ivon Garcia, Mary Vergel-Rodriguez, Patrick Condie, Anna Nogalska, Rong Lu

Blood. 2023 Jun 15; 141(24): 2961–2972. Published online 2023 Mar 29. doi: 10.1182/blood.2023019620

PMCID:: PMC10315624

Abstract Article

Select item 1015737520.

DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation

Athmane Teghanemt, Kara Misel‐Wuchter, Jace Heath, Andrew Thurman, Priyanjali Pulipati, Garima Dixit, Ramasatya Geesala, David K Meyerholz, Thorsten Maretzky, Alejandro Pezzulo, Priya D Issuree

EMBO Rep. 2023 May; 24(5): e55543. Published online 2023 Mar 7. doi: 10.15252/embr.202255543

PMCID:: PMC10157375

Abstract Article PDF–9.7M

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