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Items: 1 to 20 of 25

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
The structure-specific endonuclease complex SLX4/XPF regulates Tus/Ter-induced homologous recombination
Rajula Elango, Arvind Panday, Francis P. Lach, Nicholas A. Willis, Kaitlin Nicholson, Erin E. Duffey, Agata Smogorzewska, Ralph Scully
Nat Struct Mol Biol. Author manuscript; available in PMC 2023 Feb 21.
Published in final edited form as: Nat Struct Mol Biol. 2022 Aug; 29(8): 801–812. Published online 2022 Aug 8. doi: 10.1038/s41594-022-00812-9
PMCID:
PMC9941964
AbstractArticlePDF–5.3M
3.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
4.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
5.
Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications
Kris G. Alavattam, Yasuko Kato, Ho-Su Sin, So Maezawa, Ian J. Kowalski, Fan Zhang, Qishen Pang, Paul R. Andreassen, Satoshi H. Namekawa
Cell Rep. Author manuscript; available in PMC 2016 Nov 4.
Published in final edited form as: Cell Rep. 2016 Oct 18; 17(4): 1141–1157. doi: 10.1016/j.celrep.2016.09.073
PMCID:
PMC5095620
AbstractArticlePDF–3.6M
6.
Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction
Supawat Thongthip, Marina Bellani, Siobhan Q. Gregg, Sunandini Sridhar, Brooke A. Conti, Yanglu Chen, Michael M. Seidman, Agata Smogorzewska
Genes Dev. 2016 Mar 15; 30(6): 645–659. doi: 10.1101/gad.276261.115
PMCID:
PMC4803051
AbstractArticlePDF–1.3M
7.
Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice
Christophe Lachaud, Meghan Slean, Francesco Marchesi, Claire Lock, Edward Odell, Dennis Castor, Rachel Toth, John Rouse
Genes Dev. 2016 Mar 15; 30(6): 639–644. doi: 10.1101/gad.276287.115
PMCID:
PMC4803050
AbstractArticlePDF–446K
8.
SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites
Román González-Prieto, Sabine AG Cuijpers, Martijn S Luijsterburg, Haico van Attikum, Alfred CO Vertegaal
EMBO Rep. 2015 Apr; 16(4): 512–519. Published online 2015 Feb 26. doi: 10.15252/embr.201440017
PMCID:
PMC4388617
AbstractArticlePDF–1.1M
9.
USP45 deubiquitylase controls ERCC1–XPF endonuclease-mediated DNA damage responses
Ana B Perez-Oliva, Christophe Lachaud, Piotr Szyniarowski, Ivan Muñoz, Thomas Macartney, Ian Hickson, John Rouse, Dario R Alessi
EMBO J. 2015 Feb 3; 34(3): 326–343. Published online 2014 Dec 23. doi: 10.15252/embj.201489184
PMCID:
PMC4339120
AbstractArticlePDF–2.7M
10.
Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein
Nidhi Nair, Dennis Castor, Thomas Macartney, John Rouse
DNA Repair (Amst) 2014 Dec; 24: 131–137. doi: 10.1016/j.dnarep.2014.08.004
PMCID:
PMC4251979
AbstractArticlePDF–2.2M
11.
Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia
Christophe Lachaud, Dennis Castor, Karolina Hain, Ivan Muñoz, Jamie Wilson, Thomas J. MacArtney, Detlev Schindler, John Rouse
J Cell Sci. 2014 Jul 1; 127(13): 2811–2817. doi: 10.1242/jcs.146167
PMCID:
PMC4075355
AbstractArticle
12.
Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair
Michael R.G. Hodskinson, Jan Silhan, Gerry P. Crossan, Juan I. Garaycoechea, Shivam Mukherjee, Christopher M. Johnson, Orlando D. Schärer, Ketan J. Patel
Mol Cell. 2014 May 8; 54(3): 472–484. doi: 10.1016/j.molcel.2014.03.014
PMCID:
PMC4017094
AbstractArticle
13.
Localization-Dependent and -Independent Roles of SLX4 in Regulating Telomeres
Jamie S.J. Wilson, Agueda M. Tejera, Dennis Castor, Rachel Toth, Maria A. Blasco, John Rouse
Cell Rep. 2013 Sep 12; 4(5): 853–860. Published online 2013 Aug 29. doi: 10.1016/j.celrep.2013.07.033
PMCID:
PMC3969258
AbstractArticle
14.
Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases
Dennis Castor, Nidhi Nair, Anne-Cécile Déclais, Christophe Lachaud, Rachel Toth, Thomas J. Macartney, David M.J. Lilley, J.Simon C. Arthur, John Rouse
Mol Cell. 2013 Oct 24; 52(2): 221–233. doi: 10.1016/j.molcel.2013.08.036
PMCID:
PMC3808987
AbstractArticle
15.
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi Anemia
Gerry P. Crossan, Louise van der Weyden, Ivan V. Rosado, Frederic Langevin, Pierre-Henri L. Gaillard, Rebecca E McIntyre, Sanger Mouse Genetics Project, Ferdia Gallagher, Mikko I Kettunen, David Y Lewis, Kevin Brindle, Mark J Arends, David J Adams, Ketan J Patel
Nat Genet. Author manuscript; available in PMC 2013 Apr 12.
Published in final edited form as: Nat Genet. 2011 Feb; 43(2): 147–152. Published online 2011 Jan 16. doi: 10.1038/ng.752
PMCID:
PMC3624090
ArticlePDF–3.3M
16.
Conditional Inactivation of the DNA Damage Response Gene Hus1 in Mouse Testis Reveals Separable Roles for Components of the RAD9-RAD1-HUS1 Complex in Meiotic Chromosome Maintenance
Amy M. Lyndaker, Pei Xin Lim, Joanna M. Mleczko, Catherine E. Diggins, J. Kim Holloway, Rebecca J. Holmes, Rui Kan, Donald H. Schlafer, Raimundo Freire, Paula E. Cohen, Robert S. Weiss
PLoS Genet. 2013 Feb; 9(2): e1003320. Published online 2013 Feb 28. doi: 10.1371/journal.pgen.1003320
PMCID:
PMC3585019
AbstractArticlePDF–15M
17.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
18.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
19.
Mammalian BTBD12 (SLX4) Protects against Genomic Instability during Mammalian Spermatogenesis
J. Kim Holloway, Swapna Mohan, Gabriel Balmus, Xianfei Sun, Andrew Modzelewski, Peter L. Borst, Raimundo Freire, Robert S. Weiss, Paula E. Cohen
PLoS Genet. 2011 Jun; 7(6): e1002094. Published online 2011 Jun 2. doi: 10.1371/journal.pgen.1002094
PMCID:
PMC3107204
AbstractArticlePDF–12M
20.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M

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