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Select item 101978881.

Decreased methylation of ZNF671 suppresses tumor progression by promoting MAPK6 transcription in laryngeal carcinoma

Wei Zhang, Ting Liu, Xinyi Li, Tianshu Li, Xiangchi Ma, Dongxu Zhao, Xudong Zhao

Int J Biol Sci. 2023; 19(8): 2443–2457. Published online 2023 May 8. doi: 10.7150/ijbs.82692

PMCID:: PMC10197888

Abstract Article PDF–11M

Select item 101916262.

ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization

Katarzyna Bogucka-Janczi, Gregory Harms, Marie-May Coissieux, Mohamed Bentires-Alj, Bernd Thiede, Krishnaraj Rajalingam

eLife. 2023; 12: e85167. Published online 2023 Apr 14. doi: 10.7554/eLife.85167

PMCID:: PMC10191626

Abstract Article PDF–30M

Select item 100729063.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 98811364.

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke

Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188

PMCID:: PMC9881136

Abstract Article PDF–4.4M

Select item 96223685.

miR-128-3p inhibits the inflammation by targeting MAPK6 in penicillin-induced astrocytes

Yuejiu Pang, Dingzhen Luo, Shuhua Wang

Neuroreport. 2022 Dec 14; 33(17): 742–749. Published online 2022 Oct 17. doi: 10.1097/WNR.0000000000001840

PMCID:: PMC9622368

Abstract Article PDF–1.3M

Select item 91197366.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 91052357.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 85645208.

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair

Maria Pilar Sanchez-Bailon, Soo-Youn Choi, Elizabeth R. Dufficy, Karan Sharma, Gavin S. McNee, Emma Gunnell, Kelly Chiang, Debashish Sahay, Sarah Maslen, Grant S. Stewart, J. Mark Skehel, Ingrid Dreveny, Clare C. Davies

Nat Commun. 2021; 12: 6313. Published online 2021 Nov 2. doi: 10.1038/s41467-021-26413-6

PMCID:: PMC8564520

Abstract Article PDF–2.3M

Select item 85115799.

F-box Protein βTrCP1 Is a Substrate of Extracellular Signal-regulated Kinase 2

Cheol-Jung Lee, Ga-Eun Lee, Hyun-Jung An, Eun Suh Cho, Weidong Chen, Joo Young Lee, Han Chang Kang, Hye Suk Lee, Yong-Yeon Cho

J Cancer Prev. 2021 Sep 30; 26(3): 174–182. Published online 2021 Sep 30. doi: 10.15430/JCP.2021.26.3.174

PMCID:: PMC8511579

Abstract Article PDF–2.6M

Select item 836418110.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 831454711.

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang

Cell Biosci. 2021; 11: 146. Published online 2021 Jul 27. doi: 10.1186/s13578-021-00659-5

PMCID:: PMC8314547

Abstract Article PDF–3.7M

Select item 822574112.

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network

Yu-Kun Xia, Yi-Rong Zeng, Meng-Li Zhang, Peng Liu, Fang Liu, Hao Zhang, Chen-Xi He, Yi-Ping Sun, Jin-Ye Zhang, Cheng Zhang, Lei Song, Chen Ding, Yu-Jie Tang, Zhen Yang, Chen Yang, Pu Wang, Kun-Liang Guan, Yue Xiong, Dan Ye

Protein Cell. 2021 Jul; 12(7): 557–577. Published online 2020 Jul 18. doi: 10.1007/s13238-020-00754-2

PMCID:: PMC8225741

Abstract Article PDF–3.1M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 788156214.

ERK3 is transcriptionally upregulated by ∆Np63α and mediates the role of ∆Np63α in suppressing cell migration in non-melanoma skin cancers

Eid S. Alshammari, Amjad A. Aljagthmi, Andrew J. Stacy, Mike Bottomley, H. Nicholas Shamma, Madhavi P. Kadakia, Weiwen Long

BMC Cancer. 2021; 21: 155. Published online 2021 Feb 12. doi: 10.1186/s12885-021-07866-w

PMCID:: PMC7881562

Abstract Article PDF–1.5M

Select item 782128215.

miR-653-5p suppresses the growth and migration of breast cancer cells by targeting MAPK6

Mei Zhang, Hongwei Wang, Xiaomei Zhang, Fengping Liu

Mol Med Rep. 2021 Mar; 23(3): 200. Published online 2021 Jan 12. doi: 10.3892/mmr.2021.11839

PMCID:: PMC7821282

Abstract Article PDF–5.0M

Select item 772317416.

let7f-5p attenuates inflammatory injury in in vitro pneumonia models by targeting MAPK6

Lin Xu, Qingying Song, Zhanghong Ouyang, Xiangyan Zhang, Cheng Zhang

Mol Med Rep. 2021 Feb; 23(2): 95. Published online 2020 Nov 25. doi: 10.3892/mmr.2020.11734

PMCID:: PMC7723174

Abstract Article PDF–1.9M

Select item 766305617.

Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3

Martin Schröder, Panagis Filippakopoulos, Martin P. Schwalm, Carla A. Ferrer, David H. Drewry, Stefan Knapp, Apirat Chaikuad

Int J Mol Sci. 2020 Nov; 21(21): 7953. Published online 2020 Oct 26. doi: 10.3390/ijms21217953

PMCID:: PMC7663056

Abstract Article PDF–2.9M

Select item 756688118.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 742732719.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 719258520.

ERK3/MAPK6 controls IL-8 production and chemotaxis

Katarzyna Bogucka, Malvika Pompaiah, Federico Marini, Harald Binder, Gregory Harms, Manuel Kaulich, Matthias Klein, Christian Michel, Markus P Radsak, Sebastian Rosigkeit, Peter Grimminger, Hansjörg Schild, Krishnaraj Rajalingam

eLife. 2020; 9: e52511. Published online 2020 Apr 21. doi: 10.7554/eLife.52511

PMCID:: PMC7192585

Abstract Article PDF–7.4M

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