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Select item 116286291.

JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia

Karoline Strobl, Jörg Klufa, Regina Jin, Lena Artner-Gent, Dana Krauß, Philipp Novoszel, Johanna Strobl, Georg Stary, Igor Vujic, Johannes Griss, Martin Holcmann, Matthias Farlik, Bernhard Homey, Maria Sibilia, Thomas Bauer

EMBO Mol Med. 2024 Dec; 16(12): 3142–3168. Published online 2024 Nov 9. doi: 10.1038/s44321-024-00166-3

PMCID:: PMC11628629

Abstract Article PDF–26M

Select item 111940142.

The Janus kinase 1 is critical for pancreatic cancer initiation and progression

Hridaya Shrestha, Patrick D. Rädler, Rayane Dennaoui, Madison N. Wicker, Nirakar Rajbhandari, Yunguang Sun, Amy R. Peck, Kerry Vistisen, Aleata A. Triplett, Rafic Beydoun, Esta Sterneck, Dieter Saur, Hallgeir Rui, Kay-Uwe Wagner

Cell Rep. Author manuscript; available in PMC 2024 Jun 23.

Published in final edited form as: Cell Rep. 2024 May 28; 43(5): 114202. Published online 2024 May 10. doi: 10.1016/j.celrep.2024.114202

PMCID:: PMC11194014

Abstract Article PDF–3.3M

Select item 111469603.

The Janus kinase family of protein tyrosine kinases and their role in signaling

T. C. Yeh, S. Pellegrini

Cell Mol Life Sci. 1999 Sep; 55(12): 1523–1534. doi: 10.1007/s000180050392

PMCID:: PMC11146960

Abstract PDF–790K

Select item 111085194.

Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases

Lorraine Springuel, Elisabeth Losdyck, Pascale Saussoy, Béatrice Turcq, François-Xavier Mahon, Laurent Knoops, Jean-Christophe Renauld

Cell Mol Life Sci. 2016 Dec; 73(24): 4739–4748. Published online 2016 Jul 19. doi: 10.1007/s00018-016-2310-2

PMCID:: PMC11108519

Abstract Article PDF–1.2M

Select item 110722375.

Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling

Jishou Zhang, Yao Xu, Cheng Wei, Zheng Yin, Wei Pan, Mengmeng Zhao, Wen Ding, Shuwan Xu, Jianfang Liu, Junping Yu, Jing Ye, Di Ye, Juan-Juan Qin, Jun Wan, Menglong Wang

Cell Mol Life Sci. 2023 Nov; 80(11): 324. Published online 2023 Oct 12. doi: 10.1007/s00018-023-04974-7

PMCID:: PMC11072237

Abstract Article PDF–17M

Select item 99324616.

Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1

Yudai Iino, Tatsuro Naganuma, Makoto Arita

J Lipid Res. 2023 Feb; 64(2): 100329. Published online 2023 Jan 11. doi: 10.1016/j.jlr.2023.100329

PMCID:: PMC9932461

Abstract Article PDF–2.1M

Select item 94819337.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 90973878.

IL-32 promotes the occurrence of atopic dermatitis by activating the JAK1/microRNA-155 axis

Jing Chang, Bin Zhou, Zhu Wei, Yongqi Luo

J Transl Med. 2022; 20: 207. Published online 2022 May 11. doi: 10.1186/s12967-022-03375-x

PMCID:: PMC9097387

Abstract Article PDF–1.9M

Select item 90439589.

EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice

Zili Lei, Wanwan Liu, Ya Nie, Yanhong Yang, Guibin Chen, Li Huang, Huijuan Wu, Yuting Lei, Lei Chen, Qing Hu, Hedong Rong, Siping Yu, Qi Song, Fengxue Tong, Jiao Guo

Front Immunol. 2022; 13: 843378. Published online 2022 Apr 13. doi: 10.3389/fimmu.2022.843378

PMCID:: PMC9043958

Abstract Article PDF–8.1M

Select item 898194110.

Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2

Zhenghui Song, Xinhui Liu, Wan Zhang, Yue Luo, Hua Xiao, Yun Liu, Guanqi Dai, Jian Hong, Aimin Li

J Transl Med. 2022; 20: 157. Published online 2022 Apr 5. doi: 10.1186/s12967-022-03366-y

PMCID:: PMC8981941

Abstract Article PDF–16M

Select item 876185811.

Autoinflammatory Keratinization Disease With Hepatitis and Autism Reveals Roles for JAK1 Kinase Hyperactivity in Autoinflammation

Takuya Takeichi, John Y. W. Lee, Yusuke Okuno, Yuki Miyasaka, Yuya Murase, Takenori Yoshikawa, Kana Tanahashi, Emi Nishida, Tatsuya Okamoto, Komei Ito, Yoshinao Muro, Kazumitsu Sugiura, Tamio Ohno, John A. McGrath, Masashi Akiyama

Front Immunol. 2021; 12: 737747. Published online 2022 Jan 3. doi: 10.3389/fimmu.2021.737747

PMCID:: PMC8761858

Abstract Article PDF–4.0M

Select item 858880012.

Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes

John D. Nowery, Rylee N. Cisney, Jacob W. Feldmann, Gordon P. Meares

ASN Neuro. 2021 Jan-Dec; 13: 17590914211033650. Published online 2021 Sep 9. doi: 10.1177/17590914211033650

PMCID:: PMC8588800

Abstract Article PDF–2.7M

Select item 853132913.

Dual recombinase action in the normal and neoplastic mammary gland epithelium

Patrick D. Rädler, Kerry Vistisen, Aleata A. Triplett, Rayane Dennaoui, Yong Li, Hridaya Shrestha, Rosa-Maria Ferraiuolo, Amalraj Thangasamy, Dieter Saur, Kay-Uwe Wagner

Sci Rep. 2021; 11: 20775. Published online 2021 Oct 21. doi: 10.1038/s41598-021-00231-8

PMCID:: PMC8531329

Abstract Article PDF–3.7M

Select item 798315614.

IL-7-induced phosphorylation of the adaptor Crk-like and other targets

Francesca B. Aiello, Tad Guszczynski, Wenqing Li, Julie A. Hixon, Qiong Jiang, Deborah L. Hodge, Tania Massignan, Chiara Di Lisio, Anand Merchant, Antonio D. Procopio, Valentina Bonetto, Scott K. Durum

Cell Signal. Author manuscript; available in PMC 2021 Mar 22.

Published in final edited form as: Cell Signal. 2018 Jul; 47: 131–141. Published online 2018 Mar 24. doi: 10.1016/j.cellsig.2018.03.008

PMCID:: PMC7983156

Abstract Article PDF–1.7M

Select item 793877015.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 786267016.

RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense

Xiaomin Guo, Pengcheng Ma, Yuwei Li, Yanan Yang, Chaoming Wang, Tao Xu, Huishan Wang, Chaocui Li, Bingyu Mao, Xiaopeng Qi

Cell Death Differ. 2021 Feb; 28(2): 640–656. Published online 2020 Aug 19. doi: 10.1038/s41418-020-00609-7

PMCID:: PMC7862670

Abstract Article PDF–6.2M

Select item 751902917.

STAT1 Isoforms Differentially Regulate NK Cell Maturation and Anti-tumor Activity

Katrin Meissl, Natalija Simonović, Lena Amenitsch, Agnieszka Witalisz-Siepracka, Klara Klein, Caroline Lassnig, Ana Puga, Claus Vogl, Andrea Poelzl, Markus Bosmann, Alexander Dohnal, Veronika Sexl, Mathias Müller, Birgit Strobl

Front Immunol. 2020; 11: 2189. Published online 2020 Sep 11. doi: 10.3389/fimmu.2020.02189

PMCID:: PMC7519029

Abstract Article PDF–2.6M

Select item 724897218.

Banhahubak-Tang Tablet, a Standardized Medicine Attenuates Allergic Asthma via Inhibition of Janus Kinase 1 (JAK1)/ Signal Transducer and Activator of Transcription 6 (STAT6) Signal Pathway

Yeon Kyung Nam, Seong Chul Jin, Mi Hye Kim, La Yoon Choi, Yong-Bok Lee, Woong Mo Yang

Molecules. 2020 May; 25(9): 2206. Published online 2020 May 8. doi: 10.3390/molecules25092206

PMCID:: PMC7248972

Abstract Article PDF–6.6M

Select item 707975319.

Dipyrithione inhibits IFN-γ-induced JAK/STAT1 signaling pathway activation and IP-10/CXCL10 expression in RAW264.7 cells

Cui Han, Jin Fu, Ziwen Liu, Huang Huang, Lan Luo, Zhimin Yin

Inflamm Res. 2010; 59(10): 809–816. Published online 2010 Apr 7. doi: 10.1007/s00011-010-0192-6

PMCID:: PMC7079753

Abstract Article PDF–377K

Select item 698813120.

Generation of Janus kinase 1 (JAK1) conditional knockout mice

Kazuhito Sakamoto, Barbara L. Wehde, Patrick D. Rädler, Aleata A. Triplett, Kay-Uwe Wagner

Genesis. Author manuscript; available in PMC 2020 Jan 29.

Published in final edited form as: Genesis. 2016 Nov; 54(11): 582–588. Published online 2016 Oct 19. doi: 10.1002/dvg.22982

PMCID:: PMC6988131

Abstract Article PDF–722K

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