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Select item 107502941.

MANF Promotes Unexplained Recurrent Miscarriages by Interacting with NPM1 and Downregulating Trophoblast Cell Migration and Invasion

Yuan Fang, Junhui Zhang, Damin Zhu, Qiong Mei, Ting Liao, Huiru Cheng, Ye He, Yunxia Cao, Zhaolian Wei

Int J Biol Sci. 2024; 20(1): 296–311. Published online 2024 Jan 1. doi: 10.7150/ijbs.85378

PMCID:: PMC10750294

Abstract Article PDF–9.1M

Select item 106208152.

S100a16 Deficiency Prevents Alcohol-induced Fatty Liver Injury via Inducing MANF Expression in Mice

Dan Wang, Rihua Zhang, Xiaoxuan Qin, Jizheng Wang, Yifang Hu, Shan Lu, Jingbao Kan, Yaoqi Ge, Ke Jin, Wen-Song Zhang, Yun Liu

Int J Biol Sci. 2023; 19(16): 5074–5088. Published online 2023 Oct 2. doi: 10.7150/ijbs.84472

PMCID:: PMC10620815

Abstract Article PDF–9.7M

Select item 105768023.

MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice

Yeawon Kim, Chuang Li, Chenjian Gu, Yili Fang, Eric Tycksen, Anuradhika Puri, Terri A. Pietka, Jothilingam Sivapackiam, Kendrah Kidd, Sun-Ji Park, Bryce G. Johnson, Stanislav Kmoch, Jeremy S. Duffield, Anthony J. Bleyer, Meredith E. Jackrel, Fumihiko Urano, Vijay Sharma, Maria Lindahl, Ying Maggie Chen

Nat Commun. 2023; 14: 6493. Published online 2023 Oct 14. doi: 10.1038/s41467-023-42154-0

PMCID:: PMC10576802

Abstract Article PDF–6.7M

Select item 100140184.

Deficiency of Mesencephalic Astrocyte-derived Neurotrophic Factor Affects Neurogenesis in Mouse Brain

Yongchao Wang, Wen Wen, Hui Li, Hong Xu, Mei Xu, Murong Ma, Jia Luo

Brain Res Bull. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Brain Res Bull. 2022 Jun 1; 183: 49–56. Published online 2022 Feb 25. doi: 10.1016/j.brainresbull.2022.02.019

PMCID:: PMC10014018

Abstract Article PDF–1.3M

Select item 96300865.

MANF in POMC Neurons Promotes Brown Adipose Tissue Thermogenesis and Protects Against Diet-Induced Obesity

Qin Tang, Qinhui Liu, Jiahui Li, Jiamin Yan, Xiandan Jing, Jinhang Zhang, Yan Xia, Ying Xu, Yanping Li, Jinhan He

Diabetes. 2022 Nov; 71(11): 2344–2359. Published online 2022 Aug 12. doi: 10.2337/db21-1128

PMCID:: PMC9630086

Abstract Article PDF–6.7M

Select item 88210676.

CDNF and MANF regulate ER stress in a tissue-specific manner

Emmi Pakarinen, Päivi Lindholm, Mart Saarma, Maria Lindahl

Cell Mol Life Sci. 2022 Feb; 79(2): 124. Published online 2022 Feb 7. doi: 10.1007/s00018-022-04157-w

PMCID:: PMC8821067

Abstract Article PDF–5.4M

Select item 88109507.

Mesencephalic astrocyte-derived neurotrophic factor reprograms macrophages to ameliorate acetaminophen-induced acute liver injury via p38 MAPK pathway

Xin Hou, Qi Liu, Yimin Gao, Liang Yong, Huiyuan Xie, Wenting Li, Yuping Zhou, Jun Liu, Lijie Feng, Long Xu, Yuxian Shen, Hua Wang

Cell Death Dis. 2022 Feb; 13(2): 100. Published online 2022 Feb 2. doi: 10.1038/s41419-022-04555-9

PMCID:: PMC8810950

Abstract Article PDF–7.0M

Select item 86165588.

MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea

Kuu Ikäheimo, Anni Herranen, Vilma Iivanainen, Tuuli Lankinen, Antti A Aarnisalo, Ville Sivonen, Kashyap A Patel, Korcan Demir, Mart Saarma, Maria Lindahl, Ulla Pirvola

Life Sci Alliance. 2022 Feb; 5(2): e202101068. Published online 2021 Nov 23. doi: 10.26508/lsa.202101068

PMCID:: PMC8616558

Abstract Article PDF–5.5M

Select item 80542009.

Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway

Tong Wu, Qinhui Liu, Yanping Li, Hong Li, Lei Chen, Xuping Yang, Qin Tang, Shiyun Pu, Jiangying Kuang, Rui Li, Ya Huang, Jinhang Zhang, Zijing Zhang, Jian Zhou, Cuiyuan Huang, Guorong Zhang, Yingnan Zhao, Min Zou, Wei Jiang, Li Mo, Jinhan He

J Exp Med. 2021 Jun 7; 218(6): e20201203. Published online 2021 Apr 15. doi: 10.1084/jem.20201203

PMCID:: PMC8054200

Abstract Article PDF–8.0M

Select item 794905710.

The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor

Ave Eesmaa, Li-Ying Yu, Helka Göös, Kristofer Nõges, Vera Kovaleva, Maarit Hellman, Richard Zimmermann, Martin Jung, Perttu Permi, Markku Varjosalo, Päivi Lindholm, Mart Saarma

J Biol Chem. 2021 Jan-Jun; 296: 100295. Published online 2021 Jan 15. doi: 10.1016/j.jbc.2021.100295

PMCID:: PMC7949057

Abstract Article PDF–3.4M

Select item 785604911.

MANF is Neuroprotective against Ethanol-induced Neurodegeneration through Ameliorating ER Stress

Yongchao Wang, Wen Wen, Hui Li, Marco Clementino, Hong Xu, Mei Xu, Murong Ma, Jacqueline Frank, Jia Luo

Neurobiol Dis. Author manuscript; available in PMC 2022 Jan 1.

Published in final edited form as: Neurobiol Dis. 2021 Jan; 148: 105216. Published online 2020 Dec 6. doi: 10.1016/j.nbd.2020.105216

PMCID:: PMC7856049

Abstract Article PDF–2.2M

Select item 748361712.

MANF delivery improves retinal homeostasis and cell replacement therapies in ageing mice

Joana Neves, Kathleen R. Chirco, Wendy Cedron-Craft, Shereen Chew, Jie Zhu, Heinrich Jasper, Deepak A. Lamba

Exp Gerontol. Author manuscript; available in PMC 2021 Aug 28.

Published before final editing as: Exp Gerontol. 2020 Feb 28; 134: 110893. doi: 10.1016/j.exger.2020.110893 [Epub ahead of print]

PMCID:: PMC7483617

Abstract Article PDF–1.0M

Select item 726178813.

Mesencephalic astrocyte–derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart

Adrian Arrieta, Erik A. Blackwood, Winston T. Stauffer, Michelle Santo Domingo, Alina S. Bilal, Donna J. Thuerauf, Amber N. Pentoney, Cathrine Aivati, Anup V. Sarakki, Shirin Doroudgar, Christopher C. Glembotski

J Biol Chem. 2020 May 29; 295(22): 7566–7583. Published online 2020 Apr 23. doi: 10.1074/jbc.RA120.013345

PMCID:: PMC7261788

Abstract Article PDF–3.7M

Select item 725495714.

MANF is indispensable for the proliferation and survival of pancreatic β-cells

Maria Lindahl, Tatiana Danilova, Erik Palm, Päivi Lindholm, Vootele Võikar, Elina Hakonen, Jarkko Ustinov, Jaan-Olle Andressoo, Brandon K. Harvey, Timo Otonkoski, Jari Rossi, Mart Saarma

Cell Rep. Author manuscript; available in PMC 2020 May 28.

Published in final edited form as: Cell Rep. 2014 Apr 24; 7(2): 366–375. Published online 2014 Apr 13. doi: 10.1016/j.celrep.2014.03.023

PMCID:: PMC7254957

Abstract Article PDF–930K

Select item 705317415.

MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System

Emmi Pakarinen, Tatiana Danilova, Vootele Võikar, Piotr Chmielarz, Petteri Piepponen, Mikko Airavaara, Mart Saarma, Maria Lindahl

eNeuro. 2020 Jan-Feb; 7(1): ENEURO.0477-19.2019. Prepublished online 2020 Jan 31. Published online 2020 Feb 14. doi: 10.1523/ENEURO.0477-19.2019

PMCID:: PMC7053174

Abstract Article PDF–3.1M

Select item 700502816.

Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss

Anni Herranen, Kuu Ikäheimo, Tuuli Lankinen, Emmi Pakarinen, Bernd Fritzsch, Mart Saarma, Maria Lindahl, Ulla Pirvola

Cell Death Dis. 2020 Feb; 11(2): 100. Published online 2020 Feb 6. doi: 10.1038/s41419-020-2286-6

PMCID:: PMC7005028

Abstract Article PDF–17M

Select item 685102417.

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function

Tatiana Danilova, Emilia Galli, Emmi Pakarinen, Erik Palm, Päivi Lindholm, Mart Saarma, Maria Lindahl

Front Endocrinol (Lausanne) 2019; 10: 765. Published online 2019 Nov 6. doi: 10.3389/fendo.2019.00765

PMCID:: PMC6851024

Abstract Article PDF–3.8M

Select item 677818518.

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Upregulated with Therapeutic Fasting in Humans and Diet Fat Withdrawal in Obese Mice

Emilia Galli, Jari Rossi, Thomas Neumann, Jaan-Olle Andressoo, Stefan Drinda, Päivi Lindholm

Sci Rep. 2019; 9: 14318. Published online 2019 Oct 4. doi: 10.1038/s41598-019-50841-6

PMCID:: PMC6778185

Abstract Article PDF–2.9M

Select item 676316219.

Ducky Mouse Phenotype of Epilepsy and Ataxia Is Associated with Mutations in the Cacna2d2 Gene and Decreased Calcium Channel Current in Cerebellar Purkinje Cells

Jane Barclay, Nuria Balaguero, Marina Mione, Susan L. Ackerman, Verity A. Letts, Jens Brodbeck, Carles Canti, Alon Meir, Karen M. Page, Kenro Kusumi, Edward Perez-Reyes, Eric S. Lander, Wayne N. Frankel, R. Mark Gardiner, Annette C. Dolphin, Michele Rees

J Neurosci. 2001 Aug 15; 21(16): 6095–6104. doi: 10.1523/JNEUROSCI.21-16-06095.2001

PMCID:: PMC6763162

Abstract Article PDF–518K

Select item 672765220.

MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage

Pedro Sousa-Victor, Joana Neves, Wendy Cedron-Craft, P. Britten Ventura, Chen-Yu Liao, Rebeccah R. Riley, Ilya Soifer, Nicholas van Bruggen, Ganesh A. Kolumam, Saul A. Villeda, Deepak A. Lamba, Heinrich Jasper

Nat Metab. Author manuscript; available in PMC 2019 Sep 5.

Published in final edited form as: Nat Metab. 2019 Feb; 1(2): 276–290. Published online 2019 Jan 14. doi: 10.1038/s42255-018-0023-6