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Select item 112161731.

Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development

James F. Clark, Philippe Soriano

Genes Dev. 2024 May 1; 38(9-10): 393–414. doi: 10.1101/gad.351593.124

PMCID:: PMC11216173

Abstract Article PDF–17M

Select item 109238832.

DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response

Huipeng Jiao, Sharmy J. James, Chin Wen Png, Chaoyu Cui, Heng Li, Liang Li, Wan Ni Chia, Nyo Min, Weiyun Li, Carla Claser, Laurent Rénia, Hongyan Wang, Mark I-Cheng Chen, Justin Jang Hann Chu, Kevin Shyong Wei Tan, Yinyue Deng, Yongliang Zhang

Cell Death Differ. 2024 Mar; 31(3): 280–291. Published online 2024 Feb 21. doi: 10.1038/s41418-024-01269-7

PMCID:: PMC10923883

Abstract Article PDF–2.8M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108130594.

Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in Alzheimer’s Disease

Erming Wang, Allen L. Pan, Pritha Bagchi, Srikant Rangaraju, Nicholas T. Seyfried, Michelle E. Ehrlich, Stephen R. Salton, Bin Zhang

Biomolecules. 2024 Jan; 14(1): 66. Published online 2024 Jan 3. doi: 10.3390/biom14010066

PMCID:: PMC10813059

Abstract Article PDF–3.9M

Select item 106368945.

Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis

Sophie Klemm, Katja Evert, Kirsten Utpatel, Alexandra Muggli, Maria M. Simile, Xin Chen, Matthias Evert, Diego F. Calvisi, Alexander Scheiter

BMC Cancer. 2023; 23: 1086. Published online 2023 Nov 9. doi: 10.1186/s12885-023-11577-9

PMCID:: PMC10636894

Abstract Article PDF–4.0M

Select item 104036406.

Feto-maternal cholesterol transport regulated by β-Klotho–FGF15 axis is essential for fetal growth

Kanako Kobayashi, Kazuko Iwasa, Rika Azuma-Suzuki, Takeshi Kawauchi, Yo-ichi Nabeshima

Life Sci Alliance. 2023 Oct; 6(10): e202301916. Published online 2023 Aug 4. doi: 10.26508/lsa.202301916

PMCID:: PMC10403640

Abstract Article PDF–2.1M

Select item 97373647.

Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females

Allen L. Pan, Mickael Audrain, Emmy Sakakibara, Rajeev Joshi, Xiaodong Zhu, Qian Wang, Minghui Wang, Noam D. Beckmann, Eric E. Schadt, Sam Gandy, Bin Zhang, Michelle E. Ehrlich, Stephen R. Salton

Cells. 2022 Dec; 11(23): 3880. Published online 2022 Dec 1. doi: 10.3390/cells11233880

PMCID:: PMC9737364

Abstract Article PDF–5.6M

Select item 92282718.

Metabolic Impact of MKP-2 Upregulation in Obesity Promotes Insulin Resistance and Fatty Liver Disease

Savanie Fernando, Jacob Sellers, Shauri Smith, Sarayu Bhogoju, Sadie Junkins, Morgan Welch, Orion Willoughby, Nabin Ghimire, Cassandra Secunda, Marina Barmanova, Sean C. Kumer, Kisuk Min, Ahmed Lawan

Nutrients. 2022 Jun; 14(12): 2475. Published online 2022 Jun 15. doi: 10.3390/nu14122475

PMCID:: PMC9228271

Abstract Article PDF–3.5M

Select item 92135529.

NANOG initiates epiblast fate through the coordination of pluripotency genes expression

Nicolas Allègre, Sabine Chauveau, Cynthia Dennis, Yoan Renaud, Dimitri Meistermann, Lorena Valverde Estrella, Pierre Pouchin, Michel Cohen-Tannoudji, Laurent David, Claire Chazaud

Nat Commun. 2022; 13: 3550. Published online 2022 Jun 21. doi: 10.1038/s41467-022-30858-8

PMCID:: PMC9213552

Abstract Article PDF–4.4M

Select item 861731110.

MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model

William E. Tidyman, Alice F. Goodwin, Yoshiko Maeda, Ophir D. Klein, Katherine A. Rauen

Dis Model Mech. 2022 Feb 1; 15(2): dmm049166. Published online 2021 Nov 19. doi: 10.1242/dmm.049166

PMCID:: PMC8617311

Abstract Article

Select item 831323911.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 739196212.

A β-catenin gradient links the clock and wavefront systems in mouse embryo segmentation

Alexander Aulehla, Winfried Wiegraebe, Valerie Baubet, Matthias B. Wahl, Chuxia Deng, Makoto Taketo, Mark Lewandoski, Olivier Pourquié

Nat Cell Biol. Author manuscript; available in PMC 2020 Jul 30.

Published in final edited form as: Nat Cell Biol. 2008 Feb; 10(2): 186–193. Published online 2007 Dec 23. doi: 10.1038/ncb1679

PMCID:: PMC7391962

Abstract Article PDF–1.6M

Select item 667902513.

Whole Genome Microarray Analysis of DUSP4-Deletion Reveals A Novel Role for MAP Kinase Phosphatase-2 (MKP-2) in Macrophage Gene Expression and Function

Thikryat Neamatallah, Shilan Jabbar, Rothwelle Tate, Juliane Schroeder, Muhannad Shweash, James Alexander, Robin Plevin

Int J Mol Sci. 2019 Jul; 20(14): 3434. Published online 2019 Jul 12. doi: 10.3390/ijms20143434

PMCID:: PMC6679025

Abstract Article PDF–2.2M

Select item 646478614.

Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

Adelaida M Celaya, Isabel Sánchez-Pérez, Jose M Bermúdez-Muñoz, Lourdes Rodríguez-de la Rosa, Laura Pintado-Berninches, Rosario Perona, Silvia Murillo-Cuesta, Isabel Varela-Nieto

eLife. 2019; 8: e39159. Published online 2019 Apr 2. doi: 10.7554/eLife.39159

PMCID:: PMC6464786

Abstract Article PDF–5.9M

Select item 645951015.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 635860316.

Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling

Ryan Hamnett, Priya Crosby, Johanna E. Chesham, Michael H. Hastings

Nat Commun. 2019; 10: 542. Published online 2019 Feb 1. doi: 10.1038/s41467-019-08427-3

PMCID:: PMC6358603

Abstract Article PDF–7.2M

Select item 634053217.

Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis

Juliane Schroeder, Kirsty Ross, Kathryn McIntosh, Shilan Jabber, Stuart Woods, Jenny Crowe, Janet Patterson Kane, James Alexander, Catherine Lawrence, Robin Plevin

RMD Open. 2019; 5(1): e000711. Published online 2019 Jan 11. doi: 10.1136/rmdopen-2018-000711

PMCID:: PMC6340532

Abstract Article PDF–4.4M

Select item 630795518.

Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis

Ming Chen, Jiangwen Zhang, Alice H. Berger, Moussa S. Diolombi, Christopher Ng, Jacqueline Fung, Roderick T. Bronson, Mireia Castillo-Martin, Tin Htwe Thin, Carlos Cordon-Cardo, Robin Plevin, Pier Paolo Pandolfi

J Clin Invest. 2019 Jan 2; 129(1): 215–222. Published online 2018 Nov 26. doi: 10.1172/JCI99699

PMCID:: PMC6307955

Abstract Article PDF–9.3M

Select item 600515119.

Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival

Jason C Choi, Wei Wu, Elizabeth Phillips, Robin Plevin, Fusako Sera, Shunichi Homma, Howard J Worman

Hum Mol Genet. 2018 Jul 1; 27(13): 2290–2305. Published online 2018 Apr 16. doi: 10.1093/hmg/ddy134

PMCID:: PMC6005151

Abstract Article PDF–1.2M

Select item 592916220.

Unrestrained p38 MAPK Activation in Dusp1/4 Double Null Mice Induces Cardiomyopathy

Mannix Auger-Messier, Federica Accornero, Sanjeewa A. Goonasekera, Orlando F. Bueno, John N. Lorenz, Jop H. van Berlo, Robert N. Willette, Jeffery D. Molkentin

Circ Res. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Circ Res. 2013 Jan 4; 112(1): 48–56. Published online 2012 Sep 19. doi: 10.1161/CIRCRESAHA.112.272963

PMCID:: PMC5929162

Abstract Article PDF–1.3M

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