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Items: 1 to 20 of 40

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Upregulation of the serine palmitoyltransferase subunit SPTLC2 by endoplasmic reticulum stress inhibits the hepatic insulin response
Goon-Tae Kim, Shivani Devi, Amitesh Sharma, Kyung-Hee Cho, Su-Jung Kim, Bo-Rahm Kim, Sang-Ho Kwon, Tae-Sik Park
Exp Mol Med. 2022 May; 54(5): 573–584. Published online 2022 May 5. doi: 10.1038/s12276-022-00766-4
PMCID:
PMC9166747
AbstractArticlePDF–1.6M
3.
1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
Ting Wang, Zheng Wang, Lauriane de Fabritus, Jinglian Tao, Essa M. Saied, Ho-Joon Lee, Bulat R. Ramazanov, Benjamin Jackson, Daniel Burkhardt, Mikhail Parker, Anne S. Gleinich, Zhirui Wang, Dong Eun Seo, Ting Zhou, Shihao Xu, Irina Alecu, Parastoo Azadi, Christoph Arenz, Thorsten Hornemann, Smita Krishnaswamy, Serge A. van de Pavert, Susan M. Kaech, Natalia B. Ivanova, Fabio R. Santori
Dev Cell. Author manuscript; available in PMC 2022 Nov 22.
Published in final edited form as: Dev Cell. 2021 Nov 22; 56(22): 3128–3145.e15. Published online 2021 Nov 10. doi: 10.1016/j.devcel.2021.10.018
PMCID:
PMC8628544
AbstractArticlePDF–2.9M
4.
Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance
Su-Yeon Lee, Hui-Young Lee, Jae-Hwi Song, Goon-Tae Kim, Suwon Jeon, Yoo-Jeong Song, Jae Sung Lee, Jang-Ho Hur, Hyun Hee Oh, Shi-Young Park, Soon-Mi Shim, Hyun Joo Yoo, Byung Cheon Lee, Xian-Cheng Jiang, Cheol Soo Choi, Tae-Sik Park
Diabetes. 2017 Oct; 66(10): 2596–2609. Published online 2017 Jul 11. doi: 10.2337/db16-1232
PMCID:
PMC7970771
AbstractArticlePDF–2.3M
5.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
6.
Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
Jingxia Wu, Sicong Ma, Roger Sandhoff, Yanan Ming, Agnes Hotz-Wagenblatt, Vincent Timmerman, Nathalie Bonello-Palot, Beate Schlotter-Weigel, Michaela Auer-Grumbach, Pavel Seeman, Wolfgang N. Löscher, Markus Reindl, Florian Weiss, Eric Mah, Nina Weisshaar, Alaa Madi, Kerstin Mohr, Tilo Schlimbach, Rubí M.-H. Velasco Cárdenas, Jonas Koeppel, Florian Grünschläger, Lisann Müller, Maren Baumeister, Britta Brügger, Michael Schmitt, Guido Wabnitz, Yvonne Samstag, Guoliang Cui
Immunity. Author manuscript; available in PMC 2020 May 21.
Published in final edited form as: Immunity. 2019 May 21; 50(5): 1218–1231.e5. Published online 2019 Apr 2. doi: 10.1016/j.immuni.2019.03.005
PMCID:
PMC6531359
AbstractArticlePDF–2.8M
7.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M
8.
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function
Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang
Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626
PMCID:
PMC5381226
AbstractArticlePDF–1.4M
9.
The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase
Beezly S Groh, Feng Yan, Matthew D Smith, Yanbao Yu, Xian Chen, Yue Xiong
EMBO Rep. 2016 May; 17(5): 638–647. Published online 2016 Apr 9. doi: 10.15252/embr.201540500
PMCID:
PMC5341520
AbstractArticlePDF–1.1M
10.
Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity
Christina D. Camell, Kim Y. Nguyen, Michael J. Jurczak, Brooke E. Christian, Gerald I. Shulman, Gerald S. Shadel, Vishwa Deep Dixit
J Biol Chem. 2015 Dec 4; 290(49): 29402–29413. Published online 2015 Oct 5. doi: 10.1074/jbc.M115.680199
PMCID:
PMC4705943
AbstractArticlePDF–1.2M
11.
Tissue- and sex-specific effects of β-carotene 15,15′ oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice
Youn-Kyung Kim, Michael V. Zuccaro, Brianna K. Costabile, Rebeka Rodas, Loredana Quadro
Arch Biochem Biophys. Author manuscript; available in PMC 2016 Apr 15.
Published in final edited form as: Arch Biochem Biophys. 2015 Apr 15; 572: 11–18. Published online 2015 Jan 17. doi: 10.1016/j.abb.2015.01.002
PMCID:
PMC4402122
AbstractArticlePDF–1.1M
12.
ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis
Deanna Siow, Manjula Sunkara, Teresa M. Dunn, Andrew J. Morris, Binks Wattenberg
J Lipid Res. 2015 Apr; 56(4): 898–908. doi: 10.1194/jlr.M057539
PMCID:
PMC4373746
AbstractArticlePDF–1.1M
13.
Why we scratch an itch: the molecules, cells and circuits of itch
Diana M Bautista, Sarah R Wilson, Mark A Hoon
Nat Neurosci. Author manuscript; available in PMC 2015 Mar 18.
Published in final edited form as: Nat Neurosci. 2014 Feb; 17(2): 175–182. Published online 2014 Jan 28. doi: 10.1038/nn.3619
PMCID:
PMC4364402
AbstractArticlePDF–577K
14.
Autophagy regulates sphingolipid levels in the liver
Aikaterini Alexaki, Sita D. Gupta, Saurav Majumder, Mari Kono, Galina Tuymetova, Jeffrey M. Harmon, Teresa M. Dunn, Richard L. Proia
J Lipid Res. 2014 Dec; 55(12): 2521–2531. doi: 10.1194/jlr.M051862
PMCID:
PMC4242445
AbstractArticlePDF–1.7M
15.
Ceramide-Activated Phosphatase Mediates Fatty Acid–Induced Endothelial VEGF Resistance and Impaired Angiogenesis
Vishal C. Mehra, Elias Jackson, Xian M. Zhang, Xian-Cheng Jiang, Lawrence W. Dobrucki, Jun Yu, Pascal Bernatchez, Albert J. Sinusas, Gerald I. Shulman, William C. Sessa, Timur O. Yarovinsky, Jeffrey R. Bender
Am J Pathol. 2014 May; 184(5): 1562–1576. doi: 10.1016/j.ajpath.2014.01.009
PMCID:
PMC4005977
AbstractArticlePDF–2.4M
16.
Myeloid cell–specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis
Mahua Chakraborty, Caixia Lou, Chongmin Huan, Ming-Shang Kuo, Tae-Sik Park, Guoqing Cao, Xian-Cheng Jiang
J Clin Invest. 2013 Apr 1; 123(4): 1784–1797. Published online 2013 Mar 15. doi: 10.1172/JCI60415
Correction in:
J Clin Invest. 2013 May 1; 123(5): 2332.
Correction in:
J Clin Invest. 2013 May 1; 123(5): 2333.
PMCID:
PMC3613902
AbstractArticlePDF–5.4M
17.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
18.
Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development
Zhixing Wang, Jay S. Kirkwood, Alan W. Taylor, Jan F. Stevens, Mark Leid, Gitali Ganguli-Indra, Arup K. Indra
J Invest Dermatol. Author manuscript; available in PMC 2013 Sep 1.
Published in final edited form as: J Invest Dermatol. 2013 Mar; 133(3): 668–676. Published online 2012 Oct 25. doi: 10.1038/jid.2012.358
PMCID:
PMC3556343
AbstractArticlePDF–608K
19.
Endotoxin activates de novo sphingolipid biosynthesis via nuclear factor kappa B-mediated upregulation of Sptlc2
Zhi-Qiang Chang, Su-Yeon Lee, Hye-Jin Kim, Jung Ran Kim, Su-Jung Kim, In-Kyung Hong, Byung-Chul Oh, Cheol-Soo Choi, Ira J. Goldberg, Tae-Sik Park
Prostaglandins Other Lipid Mediat. Author manuscript; available in PMC 2012 Jun 3.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2011 Feb; 94(0): 44–52. Published online 2010 Dec 15. doi: 10.1016/j.prostaglandins.2010.12.003
PMCID:
PMC3366150
AbstractArticlePDF–1.1M
20.
Cardiomyocyte Specific Deficiency of Serine Palmitoyltransferase Subunit 2 Reduces Ceramide but Leads to Cardiac Dysfunction
Su-Yeon Lee, Jung Ran Kim, Yunying Hu, Raffay Khan, Su-Jung Kim, Kalyani G. Bharadwaj, Mercy M. Davidson, Cheol-Soo Choi, Kyong-Oh Shin, Yong-Moon Lee, Woo-Jin Park, In-Sun Park, Xian-Cheng Jiang, Ira J. Goldberg, Tae-Sik Park
J Biol Chem. 2012 May 25; 287(22): 18429–18439. Published online 2012 Apr 9. doi: 10.1074/jbc.M111.296947
PMCID:
PMC3365730
AbstractArticlePDF–3.4M

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