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Select item 113544431.

Activation of the TRPML1 Ion Channel Induces Proton Secretion in the Human Gastric Parietal Cell Line HGT-1

Alina Ulrike Mueller, Gaby Andersen, Phil Richter, Veronika Somoza

Int J Mol Sci. 2024 Aug; 25(16): 8829. Published online 2024 Aug 13. doi: 10.3390/ijms25168829

PMCID:: PMC11354443

Abstract Article PDF–4.1M

Select item 112894532.

TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells

D. Wünkhaus, R. Tang, K. Nyame, N. N. Laqtom, M. Schweizer, A. Scotto Rosato, E. K. Krogsæter, C. Wollnik, M. Abu-Remaileh, C. Grimm, G. Hermey, R. Kuhn, D. Gruber-Schoffnegger, S. Markmann

Sci Rep. 2024; 14: 17469. Published online 2024 Jul 29. doi: 10.1038/s41598-024-67479-8

PMCID:: PMC11289453

Abstract Article PDF–3.9M

Select item 111878103.

Transient receptor potential mucolipin 1 circumvents oxidative stress in primary human melanocytes

Yi Chen, Bo Xie, Yebei Hu, Jiayi Sun, Jinhui Xu, Yuqing Shen, Yuqi Zhu, Xiuzu Song

Skin Res Technol. 2024 Jun; 30(6): e13772. Published online 2024 Jun 20. doi: 10.1111/srt.13772

PMCID:: PMC11187810

Abstract Article PDF–5.7M

Select item 109323384.

UBA6 Inhibition Accelerates Lysosomal TRPML1 Depletion and Exosomal Secretion in Lung Cancer Cells

Dongun Lee, Peter Chang-Whan Lee, Jeong Hee Hong

Int J Mol Sci. 2024 Mar; 25(5): 2843. Published online 2024 Feb 29. doi: 10.3390/ijms25052843

PMCID:: PMC10932338

Abstract Article PDF–3.1M

Select item 108256945.

Endolysosomal TRPML1 channel regulates cancer cell migration by altering intracellular trafficking of E-cadherin and β₁-integrin

Nadine Frey, Lina Ouologuem, Julia Blenninger, Wei-Xiong Siow, Julia Thorn-Seshold, Jan Stöckl, Carla Abrahamian, Thomas Fröhlich, Angelika M. Vollmar, Christian Grimm, Karin Bartel

J Biol Chem. 2024 Jan; 300(1): 105581. Published online 2023 Dec 21. doi: 10.1016/j.jbc.2023.105581

PMCID:: PMC10825694

Abstract Article PDF–6.0M

Select item 108146986.

Modulation of Cisplatin Sensitivity through TRPML1-Mediated Lysosomal Exocytosis in Ovarian Cancer Cells: A Comprehensive Metabolomic Approach

Boyun Kim, Gaeun Kim, Heeyeon Kim, Yong Sang Song, Jewon Jung

Cells. 2024 Jan; 13(2): 115. Published online 2024 Jan 8. doi: 10.3390/cells13020115

PMCID:: PMC10814698

Abstract Article PDF–3.4M

Select item 105791497.

The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk

Dennis Clement, Edina K. Szabo, Silje Zandstra Krokeide, Merete Thune Wiiger, Marianna Vincenti, Daniel Palacios, Young-Tae Chang, Christian Grimm, Sandip Patel, Harald Stenmark, Andreas Brech, Rakesh Kumar Majhi, Karl-Johan Malmberg

J Immunol. 2023 Nov 1; 211(9): 1348–1358. Published online 2023 Sep 22. doi: 10.4049/jimmunol.2300406

PMCID:: PMC10579149

Abstract Article PDF–2.5M

Select item 104920248.

Increased expression or activation of TRPML1 reduces hepatic storage of toxic Z alpha-1 antitrypsin

Nunzia Pastore, Francesco Annunziata, Rita Colonna, Veronica Maffia, Teresa Giuliano, Bruno Maria Custode, Bernadette Lombardi, Elena Polishchuk, Vincenzo Cacace, Lucia De Stefano, Edoardo Nusco, Nicolina Cristina Sorrentino, Pasquale Piccolo, Nicola Brunetti-Pierri

Mol Ther. 2023 Sep 6; 31(9): 2651–2661. Published online 2023 Jul 1. doi: 10.1016/j.ymthe.2023.06.018

PMCID:: PMC10492024

Abstract Article PDF–4.0M

Select item 103786949.

Modulation of Lysosomal Cl⁻ Mediates Migration and Apoptosis through the TRPML1 as a Lysosomal Cl⁻ Sensor

Dongun Lee, Jeong Hee Hong

Cells. 2023 Jul; 12(14): 1835. Published online 2023 Jul 12. doi: 10.3390/cells12141835

PMCID:: PMC10378694

Abstract Article PDF–9.6M

Select item 945098310.

Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway

Yanhong Xing, Xiangqing Wei, Yucheng Liu, Meng-Meng Wang, Zhongheng Sui, Xinyan Wang, Wucheng Zhu, Mengmei Wu, Chen Lu, Yuan-Hui Fei, Yi Jiang, Yang Zhang, Yuqing Wang, Feng Guo, Jun-Li Cao, Jiansong Qi, Wuyang Wang

Autophagy. 2022; 18(8): 1932–1954. Published online 2021 Dec 8. doi: 10.1080/15548627.2021.2008752

PMCID:: PMC9450983

Abstract Article PDF–7.7M

Select item 911973611.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 895155612.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 887250813.

Mucolipidosis Type IV in Omani Families with a Novel MCOLN1 Mutation: Search for Evidence of Founder Effect

Badriya Al-Alawi, Beena Harikrishna, Khalid Al-Thihli, Sana Al Zuhabi, Anuradha Ganesh, Zainab Al Hashami, Zeyana Al Dhamhmani, Razan Zadjali, Nafila B. Al Riyami, Fahad Zadjali

Genes (Basel) 2022 Feb; 13(2): 248. Published online 2022 Jan 28. doi: 10.3390/genes13020248

PMCID:: PMC8872508

Abstract Article PDF–1.8M

Select item 880703514.

Interaction between TRPML1 and p62 in Regulating Autophagosome-Lysosome Fusion and Impeding Neuroaxonal Dystrophy in Alzheimer's Disease

Lu Zhang, Yu Fang, Xuan Cheng, Yajun Lian, Hongliang Xu

Oxid Med Cell Longev. 2022; 2022: 8096009. Published online 2022 Jan 25. doi: 10.1155/2022/8096009

PMCID:: PMC8807035

Abstract Article PDF–2.6M

Select item 850268015.

ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress

Di Chen, Qiaoxia Zheng, Long Sun, Mingming Ji, Yan Li, Hongyu Deng, Hong Zhang

Dev Cell. 2021 Dec 6; 56(23): 3250–3263.e5. Published online 2021 Oct 11. doi: 10.1016/j.devcel.2021.10.006

PMCID:: PMC8502680

Abstract Article PDF–5.0M

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 805027617.

Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors

Philipp Rühl, Anna Scotto Rosato, Nicole Urban, Susanne Gerndt, Rachel Tang, Carla Abrahamian, Charlotte Leser, Jiansong Sheng, Archana Jha, Günter Vollmer, Michael Schaefer, Franz Bracher, Christian Grimm

Sci Rep. 2021; 11: 8313. Published online 2021 Apr 15. doi: 10.1038/s41598-021-87817-4

PMCID:: PMC8050276

Abstract Article PDF–7.4M

Select item 773761018.

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy

Amelia E Ohnstad, Jose M Delgado, Brian J North, Isha Nasa, Arminja N Kettenbach, Sebastian W Schultz, Christopher J Shoemaker

EMBO J. 2020 Dec 15; 39(24): e104948. Published online 2020 Nov 23. doi: 10.15252/embj.2020104948

PMCID:: PMC7737610

Abstract Article PDF–3.7M

Select item 748553919.

Genome-wide Scan Identifies Opioid Overdose Risk Locus Close to MCOLN1

Zhongshan Cheng, Bao-Zhu Yang, Hang Zhou, Yaira Nunez, Henry R. Kranzler, Joel Gelernter

Addict Biol. Author manuscript; available in PMC 2020 Sep 11.

Published in final edited form as: Addict Biol. 2020 Mar; 25(2): e12811. Published online 2019 Jul 30. doi: 10.1111/adb.12811

PMCID:: PMC7485539

Abstract Article PDF–2.0M

Select item 743099320.

Mitochondria-lysosome contacts regulate mitochondrial Ca²⁺ dynamics via lysosomal TRPML1

Wesley Peng, Yvette C. Wong, Dimitri Krainc

Proc Natl Acad Sci U S A. 2020 Aug 11; 117(32): 19266–19275. Published online 2020 Jul 23. doi: 10.1073/pnas.2003236117

PMCID:: PMC7430993

Abstract Article PDF–1.6M

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