PMC Links for GEO Profiles (Select 120252329) - PMC

Cécily Lucas, Kay-Sara Sauter, Michael Steigert, Delphine Mallet, James Wilmouth, Julie Olabe, Ingrid Plotton, Yves Morel, Daniel Aeberli, Franca Wagner, Hans Clevers, Amit V. Pandey, Pierre Val, Florence Roucher-Boulez, Christa E. Flück

J Clin Invest. 2023 Feb 15; 133(4): e164915. Published online 2023 Feb 15. doi: 10.1172/JCI164915

PMCID:: PMC9927937

Abstract Article PDF–7.6M

Select item 94339384.

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB

Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan

EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698

PMCID:: PMC9433938

Abstract Article PDF–9.3M

Select item 94061875.

Bioinformatics Analysis of LGR4 in Colon Adenocarcinoma as Potential Diagnostic Biomarker, Therapeutic Target and Promoting Immune Cell Infiltration

Lijuan Wu, Xiaoxiao Tian, Hao Du, Xiaomin Liu, Haigang Wu

Biomolecules. 2022 Aug; 12(8): 1081. Published online 2022 Aug 6. doi: 10.3390/biom12081081

PMCID:: PMC9406187

Abstract Article PDF–10M

Select item 92316236.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 87597947.

RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis

Zhiying Yue, Xin Niu, Zengjin Yuan, Qin Qin, Wenhao Jiang, Liang He, Jingduo Gao, Yi Ding, Yanxi Liu, Ziwei Xu, Zhenxi Li, Zhengfeng Yang, Rong Li, Xiwen Xue, Yankun Gao, Fei Yue, Xiang H.-F. Zhang, Guohong Hu, Yi Wang, Yi Li, Geng Chen, Stefan Siwko, Alison Gartland, Ning Wang, Jianru Xiao, Mingyao Liu, Jian Luo

J Clin Invest. 2022 Jan 18; 132(2): e144579. Published online 2022 Jan 18. doi: 10.1172/JCI144579

PMCID:: PMC8759794

Abstract Article PDF–9.4M

Select item 87450908.

Clinical Significance of Stem Cell Biomarkers EpCAM, LGR5 and LGR4 mRNA Levels in Lymph Nodes of Colon Cancer Patients

Manar AbdelMageed, Hager Tarek H. Ismail, Lina Olsson, Gudrun Lindmark, Marie-Louise Hammarström, Sten Hammarström, Basel Sitohy

Int J Mol Sci. 2022 Jan; 23(1): 403. Published online 2021 Dec 30. doi: 10.3390/ijms23010403

PMCID:: PMC8745090

Abstract Article PDF–2.7M

Select item 85498269.

Lgr4 is crucial for skin carcinogenesis by regulating MEK/ERK and Wnt/β-catenin signaling pathways

Peng Xu, Yongyan Dang, Luyang Wang, Xia Liu, Xiaolin Ren, Jun Gu, Mingyao Liu, Xing Dai, Xiyun Ye

Cancer Lett. Author manuscript; available in PMC 2021 Oct 27.

Published in final edited form as: Cancer Lett. 2016 Dec 28; 383(2): 161–170. Published online 2016 Sep 30. doi: 10.1016/j.canlet.2016.09.005

PMCID:: PMC8549826

Abstract Article PDF–2.7M

Select item 854442110.

LGR4 Gene Polymorphisms Are Associated With Bone and Obesity Phenotypes in Chinese Female Nuclear Families

Su-qin Shi, Shan-shan Li, Xiao-ya Zhang, Zhe Wei, Wen-zhen Fu, Jin-wei He, Yun-qiu Hu, Miao Li, Li-li Zheng, Zhen-lin Zhang

Front Endocrinol (Lausanne) 2021; 12: 656077. Published online 2021 Oct 11. doi: 10.3389/fendo.2021.656077

PMCID:: PMC8544421

Abstract Article PDF–5.7M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 812567012.

The Role of LGR4 (GPR48) in Normal and Cancer Processes

Alejandro Ordaz-Ramos, Victor Hugo Rosales-Gallegos, Jorge Melendez-Zajgla, Vilma Maldonado, Karla Vazquez-Santillan

Int J Mol Sci. 2021 May; 22(9): 4690. Published online 2021 Apr 29. doi: 10.3390/ijms22094690

PMCID:: PMC8125670

Abstract Article PDF–1.7M

Select item 809733413.

USP42 protects ZNRF3/RNF43 from R‐spondin‐dependent clearance and inhibits Wnt signalling

Nicole Giebel, Anchel de Jaime‐Soguero, Ana García del Arco, Jonathan J M Landry, Marlene Tietje, Laura Villacorta, Vladimir Benes, Vanesa Fernández‐Sáiz, Sergio P Acebrón

EMBO Rep. 2021 May 5; 22(5): e51415. Published online 2021 Mar 30. doi: 10.15252/embr.202051415

PMCID:: PMC8097334

Abstract Article PDF–2.3M

Select item 790594414.

Unlike LGR4, LGR5 potentiates Wnt–β-catenin signaling without sequestering E3 ligases

Soohyun Park, Ling Wu, Jianghua Tu, Wangsheng Yu, Yukimatsu Toh, Kendra S. Carmon, Qingyun J. Liu

Sci Signal. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Sci Signal. 2020 Dec 1; 13(660): eaaz4051. Published online 2020 Dec 1. doi: 10.1126/scisignal.aaz4051

PMCID:: PMC7905944

Abstract Article PDF–2.3M

Select item 730804815.

LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling

Alessandra Mancini, Sasha R. Howard, Federica Marelli, Claudia P. Cabrera, Michael R. Barnes, Michael J.E. Sternberg, Morgane Leprovots, Irene Hadjidemetriou, Elena Monti, Alessia David, Karoliina Wehkalampi, Roberto Oleari, Antonella Lettieri, Valeria Vezzoli, Gilbert Vassart, Anna Cariboni, Marco Bonomi, Marie Isabelle Garcia, Leonardo Guasti, Leo Dunkel

JCI Insight. 2020 Jun 4; 5(11): e133434. Published online 2020 Jun 4. doi: 10.1172/jci.insight.133434

PMCID:: PMC7308048

Abstract Article PDF–8.2M

Select item 716998316.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 699656817.

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

Laura Novellasdemunt, Anna Kucharska, Cara Jamieson, Maria Prange‐Barczynska, Anna Baulies, Pedro Antas, Jelte van der Vaart, Helmuth Gehart, Madelon M Maurice, Vivian SW Li

EMBO J. 2020 Feb 3; 39(3): e102771. Published online 2019 Dec 23. doi: 10.15252/embj.2019102771

PMCID:: PMC6996568

Abstract Article PDF–3.1M

Select item 694204418.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 689700119.

Immunoexpression of LGR4 and Β-Catenin in Gastric Cancer and Normal Gastric Mucosa

Susana Moreira de Souza, Adriana Estela Flores Valiente, Kélvia Miranda Sá, Camila de Carvalho Juanes, Bruno Jucá Rodrigues, Amanda Cristina Crispim Farias, Caroline Cavalcante Campelo, Paulo Goberlânio de Barros Silva, Paulo Roberto Carvalho de Almeida

Asian Pac J Cancer Prev. 2019; 20(2): 519–527. doi: 10.31557/APJCP.2019.20.2.519

PMCID:: PMC6897001

Abstract Article PDF–1.0M

Select item 660380420.

R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling

Liping Zhang, Yan Song, Zihang Ling, Yuanyuan Li, Xianyue Ren, Jing Yang, Zhi Wang, Juan Xia, Weizhen Zhang, Bin Cheng

EBioMedicine. 2019 Jun; 44: 275–288. Published online 2019 May 13. doi: 10.1016/j.ebiom.2019.03.076

PMCID:: PMC6603804

Abstract Article PDF–7.4M

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