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Items: 1 to 20 of 47

1.
Converging roles of PSENEN/PEN2 and CLN3 in the autophagy-lysosome system
Marcel Klein, Abuzar Kaleem, Sandra Oetjen, Daniela Wünkhaus, Lars Binkle, Sandra Schilling, Milena Gjorgjieva, Ralf Scholz, Doris Gruber-Schoffnegger, Stephan Storch, Stefan Kins, Gerard Drewes, Sabine Hoffmeister-Ullerich, Dietmar Kuhl, Guido Hermey
Autophagy. 2022; 18(9): 2068–2085. Published online 2021 Dec 29. doi: 10.1080/15548627.2021.2016232
PMCID:
PMC9397472
AbstractArticlePDF–4.5M
2.
Human Papillomavirus L2 Capsid Protein Stabilizes γ-Secretase during Viral Infection
Mac Crite, Daniel DiMaio
Viruses. 2022 Apr; 14(4): 804. Published online 2022 Apr 13. doi: 10.3390/v14040804
PMCID:
PMC9027364
AbstractArticlePDF–2.1M
3.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
4.
Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface
Abril Angélica Escamilla-Ayala, Ragna Sannerud, Magali Mondin, Karin Poersch, Wendy Vermeire, Laura Paparelli, Caroline Berlage, Marcelle Koenig, Lucia Chavez-Gutierrez, Maximilian H Ulbrich, Sebastian Munck, Hideaki Mizuno, Wim Annaert
eLife. 2020; 9: e56679. Published online 2020 Jul 7. doi: 10.7554/eLife.56679
PMCID:
PMC7340497
AbstractArticlePDF–3.7M
5.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
6.
Proteolytic Processing of the p75 Neurotrophin Receptor and Two Homologs Generates C-Terminal Fragments with Signaling Capability
Kevin C. Kanning, Mark Hudson, Paul S. Amieux, Jesse C. Wiley, Mark Bothwell, Leslayann C. Schecterson
J Neurosci. 2003 Jul 2; 23(13): 5425–5436. doi: 10.1523/JNEUROSCI.23-13-05425.2003
PMCID:
PMC6741218
AbstractArticlePDF–745K
7.
Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of γ-Secretase-Mediated Intramembrane Proteolysis
Akio Fukumori, Regina Fluhrer, Harald Steiner, Christian Haass
J Neurosci. 2010 Jun 9; 30(23): 7853–7862. doi: 10.1523/JNEUROSCI.1443-10.2010
PMCID:
PMC6632680
AbstractArticlePDF–1.3M
8.
Cooperative Roles of Hydrophilic Loop 1 and the C-Terminus of Presenilin 1 in the Substrate-Gating Mechanism of γ-Secretase
Shizuka Takagi-Niidome, Tomoki Sasaki, Satoko Osawa, Takeshi Sato, Kanan Morishima, Tetsuo Cai, Takeshi Iwatsubo, Taisuke Tomita
J Neurosci. 2015 Feb 11; 35(6): 2646–2656. doi: 10.1523/JNEUROSCI.3164-14.2015
PMCID:
PMC6605612
AbstractArticlePDF–3.2M
9.
Bax inhibitor 1 is a γ-secretase–independent presenilin-binding protein
Shenjie Wu, Wenqi Song, Catherine C. L. Wong, Yigong Shi
Proc Natl Acad Sci U S A. 2019 Jan 2; 116(1): 141–147. Published online 2018 Dec 17. doi: 10.1073/pnas.1810870116
PMCID:
PMC6320538
AbstractArticlePDF–1.8M
10.
ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas
Christopher G. Abraham, Michael P. Ludwig, Zdenek Andrysik, Ahwan Pandey, Molishree Joshi, Matthew D. Galbraith, Kelly D. Sullivan, Joaquin M. Espinosa
Cell Rep. Author manuscript; available in PMC 2018 Nov 6.
Published in final edited form as: Cell Rep. 2018 Sep 18; 24(12): 3224–3236. doi: 10.1016/j.celrep.2018.08.058
PMCID:
PMC6219633
AbstractArticlePDF–1.1M
11.
Mutations in γ-secretase subunit–encoding PSENEN underlie Dowling-Degos disease associated with acne inversa
Damian J. Ralser, F. Buket Ü. Basmanav, Aylar Tafazzoli, Jade Wititsuwannakul, Sarah Delker, Sumita Danda, Holger Thiele, Sabrina Wolf, Michélle Busch, Susanne A. Pulimood, Janine Altmüller, Peter Nürnberg, Didier Lacombe, Uwe Hillen, Jörg Wenzel, Jorge Frank, Benjamin Odermatt, Regina C. Betz
J Clin Invest. 2017 Apr 3; 127(4): 1485–1490. Published online 2017 Mar 13. doi: 10.1172/JCI90667
PMCID:
PMC5373890
AbstractArticlePDF–2.2M
12.
Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production
Hermeto Gerber, Fang Wu, Mitko Dimitrov, Guillermo M. Garcia Osuna, Patrick C. Fraering
J Biol Chem. 2017 Mar 3; 292(9): 3751–3767. Published online 2017 Jan 17. doi: 10.1074/jbc.M116.754101
PMCID:
PMC5339758
AbstractArticlePDF–3.6M
13.
The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
David M Bolduc, Daniel R Montagna, Matthew C Seghers, Michael S Wolfe, Dennis J Selkoe
eLife. 2016; 5: e17578. Published online 2016 Aug 31. doi: 10.7554/eLife.17578
PMCID:
PMC5134833
AbstractArticlePDF–3.2M
14.
Substrate recruitment of γ‐secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping
Akio Fukumori, Harald Steiner
EMBO J. 2016 Aug 1; 35(15): 1628–1643. Published online 2016 May 24. doi: 10.15252/embj.201694151
PMCID:
PMC4883025
AbstractArticlePDF–2.7M
15.
Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities
Eugene Futai, Satoko Osawa, Tetsuo Cai, Tomoya Fujisawa, Shoichi Ishiura, Taisuke Tomita
J Biol Chem. 2016 Jan 1; 291(1): 435–446. Published online 2015 Nov 11. doi: 10.1074/jbc.M114.629287
PMCID:
PMC4697183
AbstractArticlePDF–2.1M
16.
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production
Junfeng Wang, Rui Lu, Jian Yang, Hongyu Li, Zhuohao He, Naihe Jing, Xiaomin Wang, Yizheng Wang
Nat Commun. 2015; 6: 8876. Published online 2015 Nov 19. doi: 10.1038/ncomms9876
PMCID:
PMC4696454
AbstractArticlePDF–2.1M
17.
Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease
Maria Szaruga, Sarah Veugelen, Manasi Benurwar, Sam Lismont, Diego Sepulveda-Falla, Alberto Lleo, Natalie S. Ryan, Tammaryn Lashley, Nick C. Fox, Shigeo Murayama, Harrie Gijsen, Bart De Strooper, Lucía Chávez-Gutiérrez
J Exp Med. 2015 Nov 16; 212(12): 2003–2013. doi: 10.1084/jem.20150892
PMCID:
PMC4647268
AbstractArticlePDF–1.4M
18.
An atomic structure of human γ-secretase
Xiao-chen Bai, Chuangye Yan, Guanghui Yang, Peilong Lu, Dan Ma, Linfeng Sun, Rui Zhou, Sjors H.W. Scheres, Yigong Shi
Nature. Author manuscript; available in PMC 2016 Mar 10.
Published in final edited form as: Nature. 2015 Sep 10; 525(7568): 212–217. Published online 2015 Aug 17. doi: 10.1038/nature14892
PMCID:
PMC4568306
AbstractArticlePDF–6.7M
19.
The topology of pen-2, a γ-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain
Xulun Zhang, Chunjiang J. Yu, Sangram S. Sisodia
Mol Neurodegener. 2015; 10: 39. Published online 2015 Aug 22. doi: 10.1186/s13024-015-0037-4
PMCID:
PMC4546279
AbstractArticlePDF–934K
20.
Cellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced γ-Secretase-dependent and -independent Apoptosis, Respectively
Linlin Zeng, Chen Hu, Fuqiang Zhang, Daniel C. Xu, Mei-Zhen Cui, Xuemin Xu
J Biol Chem. 2015 Jul 24; 290(30): 18269–18280. Published online 2015 May 29. doi: 10.1074/jbc.M115.640177
PMCID:
PMC4513088
AbstractArticlePDF–2.2M

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