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Select item 108226691.

Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18

Sayuri Miyauchi, Kei-ichiro Arimoto, Mengdan Liu, Yue Zhang, Dong-Er Zhang

Cell Rep. Author manuscript; available in PMC 2024 Jan 28.

Published in final edited form as: Cell Rep. 2023 Dec 26; 42(12): 113560. Published online 2023 Dec 13. doi: 10.1016/j.celrep.2023.113560

PMCID:: PMC10822669

Abstract Article PDF–2.5M

Select item 98427602.

Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis

Kei-ichiro Arimoto, Sayuri Miyauchi, Ty D. Troutman, Yue Zhang, Mengdan Liu, Samuel A. Stoner, Amanda G. Davis, Jun-Bao Fan, Yi-Jou Huang, Ming Yan, Christopher K. Glass, Dong-Er Zhang

Nat Commun. 2023; 14: 251. Published online 2023 Jan 17. doi: 10.1038/s41467-022-35348-5

PMCID:: PMC9842760

Abstract Article PDF–4.8M

Select item 89931033.

Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis

Zibo Chen, Lin Zheng, Yulong Chen, Xiuxia Liu, Masanori Kawakami, Lisa Maria Mustachio, Jason Roszik, Katherine V. Ferry-Galow, Ralph E. Parchment, Xin Liu, Thorkell Andresson, Gerard Duncan, Jonathan M. Kurie, Jaime Rodriguez-Canales, Xi Liu, Ethan Dmitrovsky

Cancer Biol Ther. 2022; 23(1): 265–280. Published online 2022 Apr 7. doi: 10.1080/15384047.2022.2054242

PMCID:: PMC8993103

Abstract Article PDF–19M

Select item 81377024.

USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS

Jinxiu Hou, Lulu Han, Ze Zhao, Huiqing Liu, Lei Zhang, Chunhong Ma, Fan Yi, Bingyu Liu, Yi Zheng, Chengjiang Gao

Nat Commun. 2021; 12: 2970. Published online 2021 May 20. doi: 10.1038/s41467-021-23219-4

PMCID:: PMC8137702

Abstract Article PDF–2.2M

Select item 80265295.

The Ubiquitin Specific Protease USP18 Promotes Lipolysis, Fatty Acid Oxidation and Lung Cancer Growth

Xi Liu, Yun Lu, Zibo Chen, Xiuxia Liu, Weiguo Hu, Lin Zheng, Yulong Chen, Jonathan M. Kurie, Mi Shi, Lisa Maria Mustachio, Thorkell Adresson, Stephen Fox, Jason Roszik, Masanori Kawakami, Sarah Freemantle, Ethan Dmitrovsky

Mol Cancer Res. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Mol Cancer Res. 2021 Apr; 19(4): 667–677. Published online 2020 Dec 30. doi: 10.1158/1541-7786.MCR-20-0579

PMCID:: PMC8026529

Abstract Article PDF–1.2M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 71167797.

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

Donghyuk Shin, Rukmini Mukherjee, Diana Grewe, Denisa Bojkova, Kheewoong Baek, Anshu Bhattacharya, Laura Schulz, Marek Widera, Ahmad Reza Mehdipour, Georg Tascher, Paul P. Geurink, Alexander Wilhelm, Gerbrand J. van der Heden van Noort, Huib Ovaa, Stefan Müller, Klaus-Peter Knobeloch, Krishnaraj Rajalingam, Brenda A. Schulman, Jindrich Cinatl, Gerhard Hummer, Sandra Ciesek, Ivan Dikic

Nature. Author manuscript; available in PMC 2021 Feb 17.

Published in final edited form as: Nature. 2020 Nov 1; 587(7835): 657–662. Published online 2020 Jul 29. doi: 10.1038/s41586-020-2601-5

PMCID:: PMC7116779

Abstract Article PDF–5.2M

Select item 70658788.

Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming

Meike Kespohl, Clara Bredow, Karin Klingel, Martin Voß, Anna Paeschke, Martin Zickler, Wolfgang Poller, Ziya Kaya, Johannes Eckstein, Henry Fechner, Joachim Spranger, Michael Fähling, Eva Katrin Wirth, Lilliana Radoshevich, Fabien Thery, Francis Impens, Nikolaus Berndt, Klaus-Peter Knobeloch, Antje Beling

Sci Adv. 2020 Mar; 6(11): eaay1109. Published online 2020 Mar 11. doi: 10.1126/sciadv.aay1109

PMCID:: PMC7065878

Abstract Article PDF–8.0M

Select item 70584999.

Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing

Jun-Bao Fan, Sayuri Miyauchi, Hui-Zhong Xu, Dan Liu, Leo J.Y. Kim, Christoph Burkart, Hua Cheng, Kei-ichiro Arimoto, Ming Yan, Yu Zhou, Balázs Győrffy, Klaus-Peter Knobeloch, Jeremy N. Rich, Hu Cang, Xiang-Dong Fu, Dong-Er Zhang

Cancer Discov. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Cancer Discov. 2020 Mar; 10(3): 382–393. Published online 2020 Jan 23. doi: 10.1158/2159-8290.CD-19-0608

PMCID:: PMC7058499

Abstract Article PDF–1.8M

Select item 687947710.

The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection

Yifeng Zhang, Fabien Thery, Nicholas C. Wu, Emma K. Luhmann, Olivier Dussurget, Mariko Foecke, Clara Bredow, Daniel Jiménez-Fernández, Kevin Leandro, Antje Beling, Klaus-Peter Knobeloch, Francis Impens, Pascale Cossart, Lilliana Radoshevich

Nat Commun. 2019; 10: 5383. Published online 2019 Nov 26. doi: 10.1038/s41467-019-13393-x

PMCID:: PMC6879477

Abstract Article PDF–3.3M

Select item 661095311.

Loss of USP18 in microglia induces white matter pathology

Marius Schwabenland, Omar Mossad, Adam G. Peres, Franziska Kessler, Feres Jose Mocayar Maron, Laura-Adela Harsan, Thomas Bienert, Dominik von Elverfeldt, Klaus-Peter Knobeloch, Ori Staszewski, Frank L. Heppner, Marije E. C. Meuwissen, Grazia M. S. Mancini, Marco Prinz, Thomas Blank

Acta Neuropathol Commun. 2019; 7: 106. Published online 2019 Jul 4. doi: 10.1186/s40478-019-0757-8

PMCID:: PMC6610953

Article PDF–8.2M

Select item 640813712.

The probacterial effect of type I interferon signaling requires its own negative regulator USP18

Namir Shaabani, Nadine Honke, Nhan Nguyen, Zhe Huang, Kei-ichiro Arimoto, Daniel Lazar, Taylor K. Loe, Karl S. Lang, Marco Prinz, Klaus-Peter Knobeloch, Dong-Er Zhang, John R. Teijaro

Sci Immunol. Author manuscript; available in PMC 2019 Mar 8.

Published in final edited form as: Sci Immunol. 2018 Sep 28; 3(27): eaau2125. doi: 10.1126/sciimmunol.aau2125

PMCID:: PMC6408137

Abstract Article PDF–950K

Select item 563599913.

Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer

Lisa Maria Mustachio, Yun Lu, Laura J. Tafe, Vincent Memoli, Jaime Rodriguez-Canales, Barbara Mino, Pamela Andrea Villalobos, Ignacio Wistuba, Hiroyuki Katayama, Samir M. Hanash, Jason Roszik, Masanori Kawakami, Kwang-jin Cho, John F. Hancock, Fadzai Chinyengetere, Shanhu Hu, Xi Liu, Sarah J. Freemantle, Ethan Dmitrovsky

Mol Cancer Res. Author manuscript; available in PMC 2018 Jul 1.

Published in final edited form as: Mol Cancer Res. 2017 Jul; 15(7): 905–914. Published online 2017 Feb 27. doi: 10.1158/1541-7786.MCR-16-0369

PMCID:: PMC5635999

Abstract Article PDF–1.1M

Select item 540586714.

Structural basis of the specificity of USP18 toward ISG15

Anja Basters, Paul P Geurink, Annika Röcker, Katharina F Witting, Roya Tadayon, Sandra Hess, Marta S Semrau, Paola Storici, Huib Ovaa, Klaus-Peter Knobeloch, Günter Fritz

Nat Struct Mol Biol. 2017; 24(3): 270–278. Published online 2017 Feb 6. doi: 10.1038/nsmb.3371

PMCID:: PMC5405867

Abstract Article PDF–2.0M

Select item 536507415.

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

Kei-ichiro Arimoto, Sara Löchte, Samuel A. Stoner, Christoph Burkart, Yue Zhang, Sayuri Miyauchi, Stephan Wilmes, Jun-Bao Fan, Jürgen J. Heinisch, Zhi Li, Ming Yan, Sandra Pellegrini, Frédéric Colland, Jacob Piehler, Dong-Er Zhang

Nat Struct Mol Biol. Author manuscript; available in PMC 2017 Aug 6.

Published in final edited form as: Nat Struct Mol Biol. 2017 Mar; 24(3): 279–289. Published online 2017 Feb 6. doi: 10.1038/nsmb.3378

PMCID:: PMC5365074

Abstract Article PDF–2.3M

Select item 514341416.

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA

Man Zhang, Meng-Xin Zhang, Qiang Zhang, Gao-Feng Zhu, Lei Yuan, Dong-Er Zhang, Qiyun Zhu, Jing Yao, Hong-Bing Shu, Bo Zhong

Cell Res. 2016 Dec; 26(12): 1302–1319. Published online 2016 Nov 1. doi: 10.1038/cr.2016.125

PMCID:: PMC5143414

Abstract Article PDF–5.5M

Select item 512306817.

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

Carolina Villarroya-Beltri, Francesc Baixauli, María Mittelbrunn, Irene Fernández-Delgado, Daniel Torralba, Olga Moreno-Gonzalo, Sara Baldanta, Carlos Enrich, Susana Guerra, Francisco Sánchez-Madrid

Nat Commun. 2016; 7: 13588. Published online 2016 Nov 24. doi: 10.1038/ncomms13588

PMCID:: PMC5123068

Abstract Article PDF–3.1M

Select item 499020618.

Resveratrol improves health and survival of mice on a high-calorie diet

Joseph A. Baur, Kevin J. Pearson, Nathan L. Price, Hamish A. Jamieson, Carles Lerin, Avash Kalra, Vinayakumar V. Prabhu, Joanne S. Allard, Guillermo Lopez-Lluch, Kaitlyn Lewis, Paul J. Pistell, Suresh Poosala, Kevin G. Becker, Olivier Boss, Dana Gwinn, Mingyi Wang, Sharan Ramaswamy, Kenneth W. Fishbein, Richard G. Spencer, Edward G. Lakatta, David Le Couteur, Reuben J. Shaw, Placido Navas, Pere Puigserver, Donald K. Ingram, Rafael de Cabo, David A. Sinclair

Nature. Author manuscript; available in PMC 2016 Aug 18.

Published in final edited form as: Nature. 2006 Nov 16; 444(7117): 337–342. Published online 2006 Nov 1. doi: 10.1038/nature05354

PMCID:: PMC4990206

Abstract Article PDF–598K

Select item 488678419.

Lipopolysaccharide and Tumor Necrosis Factor Alpha Inhibit Interferon Signaling in Hepatocytes by Increasing Ubiquitin-Like Protease 18 (USP18) Expression

Sonya A. MacParland, Xue-Zhong Ma, Limin Chen, Ramzi Khattar, Vera Cherepanov, Markus Selzner, Jordan J. Feld, Nazia Selzner, Ian D. McGilvray

J Virol. 2016 Jun 15; 90(12): 5549–5560. Prepublished online 2016 Mar 23. Published online 2016 May 27. doi: 10.1128/JVI.02557-15

PMCID:: PMC4886784

Abstract Article PDF–1.7M

Select item 464038220.

Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas

Fadzai Chinyengetere, David J. Sekula, Yun Lu, Andrew J. Giustini, Aarti Sanglikar, Masanori Kawakami, Tian Ma, Sandra S. Burkett, Burton L. Eisenberg, Wendy A. Wells, Paul J. Hoopes, Elizabeth G. Demicco, Alexander J Lazar, Keila E. Torres, Vincent Memoli, Sarah J. Freemantle, Ethan Dmitrovsky

BMC Cancer. 2015; 15: 886. Published online 2015 Nov 10. doi: 10.1186/s12885-015-1883-8

PMCID:: PMC4640382

Abstract Article PDF–1.4M

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