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Select item 111600021.

Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma

Hironori Betsunoh, Shoichiro Mukai, Yutaka Akiyama, Tsuyoshi Fukushima, Naoki Minamiguchi, Yoshihiro Hasui, Yukio Osada, Hiroaki Kataoka

Cancer Sci. 2007 Apr; 98(4): 491–498. Published online 2007 Feb 16. doi: 10.1111/j.1349-7006.2007.00412.x

PMCID:: PMC11160002

Abstract Article PDF–741K

Select item 109200822.

Hepsin promotes breast tumor growth signaling via the TGFβ‐EGFR axis

Denis Belitškin, Pauliina Munne, Shishir M. Pant, Johanna M. Anttila, Ilida Suleymanova, Kati Belitškina, Daniel Kirchhofer, James Janetka, Taivo Käsper, Sami Jalil, Jeroen Pouwels, Topi A. Tervonen, Juha Klefström

Mol Oncol. 2024 Mar; 18(3): 547–561. Published online 2023 Nov 13. doi: 10.1002/1878-0261.13545

PMCID:: PMC10920082

Abstract Article PDF–9.8M

Select item 88429123.

The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics

Yan Fang, Hongming Yang, Guiming Hu, Jiakun Lu, Jun Zhou, Na Gao, Yuhan Gu, Cunzhen Zhang, Jinhuan Qiu, Yuanyuan Guo, Yunfei Zhang, Qiang Wen, Hailing Qiao

J Transl Med. 2022; 20: 88. Published online 2022 Feb 14. doi: 10.1186/s12967-022-03282-1

PMCID:: PMC8842912

Abstract Article PDF–6.4M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71699835.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 69420446.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 66890707.

Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells

Ramona Willbold, Katharina Wirth, Thomas Martini, Holger Sültmann, Christian Bolenz, Rainer Wittig

Cell Death Dis. 2019 Aug; 10(8): 601. Published online 2019 Aug 9. doi: 10.1038/s41419-019-1830-8

Correction in:: Cell Death Dis. 2020 Feb; 11(2): 120.

PMCID:: PMC6689070

Abstract Article PDF–5.9M

Select item 54952258.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 54152359.

The Identification of Novel Proteins That Interact With the GLP-1 Receptor and Restrain its Activity

X. Huang, F. F. Dai, G. Gaisano, K. Giglou, J. Han, M. Zhang, S. Kittanakom, V. Wong, L. Wei, A. D. Showalter, K. W. Sloop, I. Stagljar, M. B. Wheeler

Mol Endocrinol. September 1, 2013; 27(9): 1550–1563. Published online 2013 Jul 17. doi: 10.1210/me.2013-1047

PMCID:: PMC5415235

Abstract Article

Select item 510794210.

High Hepsin expression predicts poor prognosis in Gastric Cancer

Mingming Zhang, Junjie Zhao, Wenyi Tang, Yanru Wang, Peike Peng, Lili Li, Shushu Song, Hao Wu, Can Li, Caiting Yang, Xuefei Wang, Chunyi Zhang, Jianxin Gu

Sci Rep. 2016; 6: 36902. Published online 2016 Nov 14. doi: 10.1038/srep36902

PMCID:: PMC5107942

Abstract Article PDF–1.8M

Select item 475574111.

The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin

Martina Brunati, Simone Perucca, Ling Han, Angela Cattaneo, Francesco Consolato, Annapaola Andolfo, Céline Schaeffer, Eric Olinger, Jianhao Peng, Sara Santambrogio, Romain Perrier, Shuo Li, Marcel Bokhove, Angela Bachi, Edith Hummler, Olivier Devuyst, Qingyu Wu, Luca Jovine, Luca Rampoldi

eLife. 2015; 4: e08887. Published online 2015 Dec 17. doi: 10.7554/eLife.08887

PMCID:: PMC4755741

Abstract Article PDF–4.1M

Select item 444581312.

Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival

Mikko Pelkonen, Kaisa Luostari, Maria Tengström, Hermanni Ahonen, Bozena Berdel, Vesa Kataja, Ylermi Soini, Veli-Matti Kosma, Arto Mannermaa

BMC Cancer. 2015; 15: 431. Published online 2015 May 27. doi: 10.1186/s12885-015-1440-5

PMCID:: PMC4445813

Abstract Article PDF–1.0M

Select item 391167213.

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

Adeline Heurich, Heike Hofmann-Winkler, Stefanie Gierer, Thomas Liepold, Olaf Jahn, Stefan Pöhlmann

J Virol. 2014 Jan; 88(2): 1293–1307. doi: 10.1128/JVI.02202-13

PMCID:: PMC3911672

Abstract Article PDF–3.4M

Select item 377350514.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

Simona Principe, E. Ellen Jones, Yunee Kim, Ankit Sinha, Julius O. Nyalwidhe, Jasmin Brooks, O. John Semmes, Dean A. Troyer, Raymond S. Lance, Thomas Kislinger, Richard R. Drake

Proteomics. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Proteomics. 2013 May; 13(0): 1667–1671. Published online 2013 Apr 23. doi: 10.1002/pmic.201200561

PMCID:: PMC3773505

Abstract Article PDF–630K

Select item 348464815.

Discovery and Fine Mapping of Serum Protein Loci through Transethnic Meta-analysis

Nora Franceschini, Frank J.A. van Rooij, Bram P. Prins, Mary F. Feitosa, Mahir Karakas, John H. Eckfeldt, Aaron R. Folsom, Jeffrey Kopp, Ahmad Vaez, Jeanette S. Andrews, Jens Baumert, Vesna Boraska, Linda Broer, Caroline Hayward, Julius S. Ngwa, Yukinori Okada, Ozren Polasek, Harm-Jan Westra, Ying A. Wang, Fabiola Del Greco M., Nicole L. Glazer, Karen Kapur, Ido P. Kema, Lorna M. Lopez, Arne Schillert, Albert V. Smith, Cheryl A. Winkler, Lina Zgaga, The LifeLines Cohort Study, Stefania Bandinelli, Sven Bergmann, Mladen Boban, Murielle Bochud, Y.D. Chen, Gail Davies, Abbas Dehghan, Jingzhong Ding, Angela Doering, J. Peter Durda, Luigi Ferrucci, Oscar H. Franco, Lude Franke, Grog Gunjaca, Albert Hofman, Fang-Chi Hsu, Ivana Kolcic, Aldi Kraja, Michiaki Kubo, Karl J. Lackner, Lenore Launer, Laura R. Loehr, Guo Li, Christa Meisinger, Yusuke Nakamura, Christine Schwienbacher, John M. Starr, Atsushi Takahashi, Vesela Torlak, André G. Uitterlinden, Veronique Vitart, Melanie Waldenberger, Philipp S. Wild, Mirna Kirin, Tanja Zeller, Tatijana Zemunik, Qunyuan Zhang, Andreas Ziegler, Stefan Blankenberg, Eric Boerwinkle, Ingrid B. Borecki, Harry Campbell, Ian J. Deary, Timothy M. Frayling, Christian Gieger, Tamara B. Harris, Andrew A. Hicks, Wolfgang Koenig, Christopher J. O’Donnell, Caroline S. Fox, Peter P. Pramstaller, Bruce M. Psaty, Alex P. Reiner, Jerome I. Rotter, Igor Rudan, Harold Snieder, Toshihiro Tanaka, Cornelia M. van Duijn, Peter Vollenweider, Gerard Waeber, James F. Wilson, Jacqueline C.M. Witteman, Bruce H.R. Wolffenbuttel, Alan F. Wright, Qingyu Wu, Yongmei Liu, Nancy S. Jenny, Kari E. North, Janine F. Felix, Behrooz Z. Alizadeh, L. Adrienne Cupples, John R.B. Perry, Andrew P. Morris

Am J Hum Genet. 2012 Oct 5; 91(4): 744–753. doi: 10.1016/j.ajhg.2012.08.021

PMCID:: PMC3484648

Abstract Article PDF–788K

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 313284417.

Matrix-Dependent Regulation of AKT in Hepsin-Overexpressing PC3 Prostate Cancer Cells

Stephanie M Wittig-Blaich, Lukasz A Kacprzyk, Thorsten Eismann, Melanie Bewerunge-Hudler, Petra Kruse, Eva Winkler, Wolfgang S L Strauss, Raimund Hibst, Rudolf Steiner, Mark Schrader, Daniel Mertens, Holger Sültmann, Rainer Wittig

Neoplasia. 2011 Jul; 13(7): 579–589. doi: 10.1593/neo.11294

PMCID:: PMC3132844

Abstract Article PDF–2.0M

Select item 287531618.

Hepsin Gene Variants Association with Prostate Cancer Risk and Prognosis

Sarah K. Holt, Erika M. Kwon, Daniel W. Lin, Elaine A. Ostrander, Janet L. Stanford

Prostate. Author manuscript; available in PMC 2011 Jun 15.

Published in final edited form as: Prostate. 2010 Jun 15; 70(9): 1012–1019. doi: 10.1002/pros.21135

PMCID:: PMC2875316

Abstract Article PDF–317K

Select item 270988419.

Detection of Early Prostate Cancer using a Hepsin Targeted Imaging Agent

Kimberly A. Kelly, Sunita R. Setlur, Robert Ross, Rajesh Anbazhagan, Peter Waterman, Mark A. Rubin, Ralph Weissleder

Cancer Res. Author manuscript; available in PMC 2009 Jul 14.

Published in final edited form as: Cancer Res. 2008 Apr 1; 68(7): 2286–2291. doi: 10.1158/0008-5472.CAN-07-1349

PMCID:: PMC2709884

Abstract Article PDF–1.1M

Select item 265960920.

Identification and characterization of small-molecule inhibitors of hepsin

John R. Chevillet, Gemma J. Park, Antonio Bedalov, Julian A. Simon, Valeri I. Vasioukhin

Mol Cancer Ther. Author manuscript; available in PMC 2009 Oct 1.

Published in final edited form as: Mol Cancer Ther. 2008 Oct; 7(10): 3343–3351. doi: 10.1158/1535-7163.MCT-08-0446

PMCID:: PMC2659609

Abstract Article PDF–944K

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