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Select item 113721241.

Acid-sensing ion channel 3 is a new potential therapeutic target for the control of glioblastoma cancer stem cells growth

Andrea Balboni, Camilla D’Angelo, Nicoletta Collura, Simone Brusco, Claudia Di Berardino, Altea Targa, Beatrice Massoti, Eloise Mastrangelo, Mario Milani, Pierfausto Seneci, Vania Broccoli, Luca Muzio, Rossella Galli, Andrea Menegon

Sci Rep. 2024; 14: 20421. Published online 2024 Sep 3. doi: 10.1038/s41598-024-71623-9

PMCID:: PMC11372124

Abstract Article PDF–2.2M

Select item 94790402.

Lysophosphatidylcholine 16:0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3

Florian Jacquot, Spiro Khoury, Bonnie Labrum, Kévin Delanoe, Ludivine Pidoux, Julie Barbier, Lauriane Delay, Agathe Bayle, Youssef Aissouni, David A. Barriere, Kim Kultima, Eva Freyhult, Anders Hugo, Eva Kosek, Aisha S. Ahmed, Alexandra Jurczak, Eric Lingueglia, Camilla I. Svensson, Véronique Breuil, Thierry Ferreira, Fabien Marchand, Emmanuel Deval

Pain. 2022 Oct; 163(10): 1999–2013. Published online 2022 Jan 27. doi: 10.1097/j.pain.0000000000002596

PMCID:: PMC9479040

Abstract Article PDF–1.6M

Select item 87159813.

Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD

Xu Han, Yawen Zhang, Allen Lee, Zhaoshen Li, Jun Gao, Xiaoyin Wu, Jiulong Zhao, Hui Wang, Di Chen, Duowu Zou, Chung Owyang

FASEB J. 2022 Jan; 36(1): e22083. Published online 2021 Dec 17. doi: 10.1096/fj.202100606R

PMCID:: PMC8715981

Abstract Article PDF–1.6M

Select item 81260514.

TRPV1 Responses in the Cerebellum Lobules VI, VII, VIII Using Electroacupuncture Treatment for Chronic Pain and Depression Comorbidity in a Murine Model

Bernice Lottering, Yi-Wen Lin

Int J Mol Sci. 2021 May; 22(9): 5028. Published online 2021 May 10. doi: 10.3390/ijms22095028

PMCID:: PMC8126051

Abstract Article PDF–3.7M

Select item 80642235.

ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration

Jingyu Ding, Renjie Zhang, Huimin Li, Qiang Ji, Xiaomin Cheng, Rick Francis Thorne, Hubert Hondermarck, Xiaoying Liu, Cailiang Shen

Aging (Albany NY) 2021 Apr 15; 13(7): 10703–10723. Published online 2021 Apr 6. doi: 10.18632/aging.202850

PMCID:: PMC8064223

Abstract Article PDF–2.0M

Select item 67302146.

Acid-Induced Pain and Its Modulation in Humans

Nicholas G. Jones, Rebeccah Slater, Herve Cadiou, Peter McNaughton, Stephen B. McMahon

J Neurosci. 2004 Dec 1; 24(48): 10974–10979. doi: 10.1523/JNEUROSCI.2619-04.2004

PMCID:: PMC6730214

Abstract Article PDF–232K

Select item 55207107.

ASIC1 and ASIC3 contribute to acidity-induced EMT of pancreatic cancer through activating Ca²⁺/RhoA pathway

Shuai Zhu, Hai-Yun Zhou, Shi-Chang Deng, Shi-Jiang Deng, Chi He, Xiang Li, Jing-Yuan Chen, Yan Jin, Zhuang-Li Hu, Fang Wang, Chun-You Wang, Gang Zhao

Cell Death Dis. 2017 May; 8(5): e2806. Published online 2017 May 18. doi: 10.1038/cddis.2017.189

PMCID:: PMC5520710

Abstract Article PDF–7.0M

Select item 53024168.

Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells

Shadia Omar, Rebecca Clarke, Haniah Abdullah, Clare Brady, John Corry, Hanagh Winter, Olivier Touzelet, Ultan F. Power, Fionnuala Lundy, Lorcan P. A. McGarvey, S. Louise Cosby

PLoS One. 2017; 12(2): e0171681. Published online 2017 Feb 10. doi: 10.1371/journal.pone.0171681

PMCID:: PMC5302416

Abstract Article PDF–2.7M

Select item 51125919.

Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target

Hamish T. J. Gilbert, Nathan Hodson, Pauline Baird, Stephen M. Richardson, Judith A. Hoyland

Sci Rep. 2016; 6: 37360. Published online 2016 Nov 17. doi: 10.1038/srep37360

PMCID:: PMC5112591

Abstract Article PDF–1.5M

Select item 475511510.

Non‐acidic activation of pain‐related Acid‐Sensing Ion Channel 3 by lipids

Sébastien Marra, Romain Ferru‐Clément, Véronique Breuil, Anne Delaunay, Marine Christin, Valérie Friend, Stéphane Sebille, Christian Cognard, Thierry Ferreira, Christian Roux, Liana Euller‐Ziegler, Jacques Noel, Eric Lingueglia, Emmanuel Deval

EMBO J. 2016 Feb 15; 35(4): 414–428. Published online 2016 Jan 15. doi: 10.15252/embj.201592335

PMCID:: PMC4755115

Abstract Article PDF–805K

Select item 374348411.

Sea Anemone Peptide with Uncommon β-Hairpin Structure Inhibits Acid-sensing Ion Channel 3 (ASIC3) and Reveals Analgesic Activity

Dmitry I. Osmakov, Sergey A. Kozlov, Yaroslav A. Andreev, Sergey G. Koshelev, Nadezhda P. Sanamyan, Karen E. Sanamyan, Igor A. Dyachenko, Dmitry A. Bondarenko, Arkadii N. Murashev, Konstantin S. Mineev, Alexander S. Arseniev, Eugene V. Grishin

J Biol Chem. 2013 Aug 9; 288(32): 23116–23127. Published online 2013 Jun 25. doi: 10.1074/jbc.M113.485516

PMCID:: PMC3743484

Abstract Article PDF–2.3M

Select item 346333112.

Lignan from Thyme Possesses Inhibitory Effect on ASIC3 Channel Current

Maxim A. Dubinnyi, Dmitry I. Osmakov, Sergey G. Koshelev, Sergey A. Kozlov, Yaroslav A. Andreev, Naira A. Zakaryan, Igor A. Dyachenko, Dmitry A. Bondarenko, Alexander S. Arseniev, Eugene V. Grishin

J Biol Chem. 2012 Sep 21; 287(39): 32993–33000. Published online 2012 Aug 1. doi: 10.1074/jbc.M112.366427

PMCID:: PMC3463331

Abstract Article PDF–939K

Select item 342354413.

Coxsackievirus and Adenovirus Receptor (CAR) Mediates Trafficking of Acid-Sensing Ion Channel 3 (ASIC3) via PSD-95

Katherine J.D.A. Excoffon, Abimbola O. Kolawole, Nobuyoshi Kusama, Nicholas D. Gansemer, Priyanka Sharma, Alesia M. Hruska-Hageman, Elena Petroff, Christopher J. Benson

Biochem Biophys Res Commun. Author manuscript; available in PMC 2013 Aug 17.

Published in final edited form as: Biochem Biophys Res Commun. 2012 Aug 17; 425(1): 13–18. Published online 2012 Jul 15. doi: 10.1016/j.bbrc.2012.07.033

PMCID:: PMC3423544

Abstract Article PDF–1.3M

Select item 342019414.

Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions

Anne Delaunay, Xavier Gasull, Miguel Salinas, Jacques Noël, Valérie Friend, Eric Lingueglia, Emmanuel Deval

Proc Natl Acad Sci U S A. 2012 Aug 7; 109(32): 13124–13129. Published online 2012 Jul 24. doi: 10.1073/pnas.1120350109

PMCID:: PMC3420194

Abstract Article PDF–2.1M

Select item 336970615.

ASIC3 Channels in Multimodal Sensory Perception

Wei-Guang Li, Tian-Le Xu

ACS Chem Neurosci. 2011 Jan 19; 2(1): 26–37. Published online 2010 Nov 12. doi: 10.1021/cn100094b

PMCID:: PMC3369706

Abstract Article PDF–4.0M

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 313707317.

Atomic Level Characterization of the Nonproton Ligand-sensing Domain of ASIC3 Channels

Ye Yu, Wei-Guang Li, Zhi Chen, Hui Cao, Huaiyu Yang, Hualiang Jiang, Tian-Le Xu

J Biol Chem. 2011 Jul 15; 286(28): 24996–25006. Published online 2011 May 17. doi: 10.1074/jbc.M111.239558

PMCID:: PMC3137073

Abstract Article PDF–3.6M

Select item 300079318.

Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels

William T. Birdsong, Leonardo Fierro, Frank G. Williams, Valeria Spelta, Ligia A. Naves, Michelle Knowles, Josephine Marsh-Haffner, John P. Adelman, Wolfhard Almers, Robert P. Elde, Edwin W. McCleskey

Neuron. Author manuscript; available in PMC 2011 Nov 18.

Published in final edited form as: Neuron. 2010 Nov 18; 68(4): 739–749. doi: 10.1016/j.neuron.2010.09.029

PMCID:: PMC3000793

Abstract Article PDF–2.3M

Select item 288296119.

Human Chromosome 7: DNA Sequence and Biology

Stephen W. Scherer, Joseph Cheung, Jeffrey R. MacDonald, Lucy R. Osborne, Kazuhiko Nakabayashi, Jo-Anne Herbrick, Andrew R. Carson, Layla Parker-Katiraee, Jennifer Skaug, Razi Khaja, Junjun Zhang, Alexander K. Hudek, Martin Li, May Haddad, Gavin E. Duggan, Bridget A. Fernandez, Emiko Kanematsu, Simone Gentles, Constantine C. Christopoulos, Sanaa Choufani, Dorota Kwasnicka, Xiangqun H. Zheng, Zhongwu Lai, Deborah Nusskern, Qing Zhang, Zhiping Gu, Fu Lu, Susan Zeesman, Malgorzata J. Nowaczyk, Ikuko Teshima, David Chitayat, Cheryl Shuman, Rosanna Weksberg, Elaine H. Zackai, Theresa A. Grebe, Sarah R. Cox, Susan J. Kirkpatrick, Nazneen Rahman, Jan M. Friedman, Henry H. Q. Heng, Pier Giuseppe Pelicci, Francesco Lo-Coco, Elena Belloni, Lisa G. Shaffer, Barbara Pober, Cynthia C. Morton, James F. Gusella, Gail A. P. Bruns, Bruce R. Korf, Bradley J. Quade, Azra H. Ligon, Heather Ferguson, Anne W. Higgins, Natalia T. Leach, Steven R. Herrick, Emmanuelle Lemyre, Chantal G. Farra, Hyung-Goo Kim, Anne M. Summers, Karen W. Gripp, Wendy Roberts, Peter Szatmari, Elizabeth J. T. Winsor, Karl-Heinz Grzeschik, Ahmed Teebi, Berge A. Minassian, Juha Kere, Lluis Armengol, Miguel Angel Pujana, Xavier Estivill, Michael D. Wilson, Ben F. Koop, Sabrina Tosi, Gudrun E. Moore, Andrew P. Boright, Eitan Zlotorynski, Batsheva Kerem, Peter M. Kroisel, Erwin Petek, David G. Oscier, Sarah J. Mould, Hartmut Döhner, Konstanze Döhner, Johanna M. Rommens, John B. Vincent, J. Craig Venter, Peter W. Li, Richard J. Mural, Mark D. Adams, Lap-Chee Tsui

Science. Author manuscript; available in PMC 2010 Jun 9.

Published in final edited form as: Science. 2003 May 2; 300(5620): 767–772. Published online 2003 Apr 10. doi: 10.1126/science.1083423

PMCID:: PMC2882961

Abstract Article PDF–1.2M

Select item 275452620.

Sour Ageusia in Two Individuals Implicates Ion Channels of the ASIC and PKD Families in Human Sour Taste Perception at the Anterior Tongue

Taufiqul Huque, Beverly J. Cowart, Luba Dankulich-Nagrudny, Edmund A. Pribitkin, Douglas L. Bayley, Andrew I. Spielman, Roy S. Feldman, Scott A. Mackler, Joseph G. Brand

PLoS One. 2009; 4(10): e7347. Published online 2009 Oct 8. doi: 10.1371/journal.pone.0007347

PMCID:: PMC2754526

Abstract Article PDF–533K

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