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Items: 1 to 20 of 30

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Sestrin1, 2, and 3 are dispensable for female fertility in mice
Mengchen Wang, Wenhui Chen, Xinxin Zeng, Taojun Wang, Yingpu Sun, Qingling Yang
J Ovarian Res. 2024; 17: 28. Published online 2024 Feb 1. doi: 10.1186/s13048-024-01345-z
PMCID:
PMC10832176
AbstractArticlePDF–4.8M
3.
Sestrins induce natural killer function in senescent-like CD8+ T cells
Branca I. Pereira, Roel P. H. De Maeyer, Luciana P. Covre, Djamel Nehar-Belaid, Alessio Lanna, Sophie Ward, Radu Marches, Emma S. Chambers, Daniel C. O. Gomes, Natalie E. Riddell, Mala K. Maini, Vitor H. Teixeira, Samuel M. Janes, Derek W. Gilroy, Anis Larbi, Neil A. Mabbott, Duygu Ucar, George A. Kuchel, Sian M. Henson, Jessica Strid, Jun H. Lee, Jacques Banchereau, Arne N. Akbar
Nat Immunol. Author manuscript; available in PMC 2023 Jun 8.
Published in final edited form as: Nat Immunol. 2020 Jun; 21(6): 684–694. Published online 2020 Mar 30. doi: 10.1038/s41590-020-0643-3
PMCID:
PMC10249464
AbstractArticlePDF–4.1M
4.
Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine
Andrew L. Cangelosi, Anna M. Puszynska, Justin M. Roberts, Andrea Armani, Thao P. Nguyen, Jessica B. Spinelli, Tenzin Kunchok, Brianna Wang, Sze Ham Chan, Caroline A. Lewis, William C. Comb, George W. Bell, Aharon Helman, David M. Sabatini
Science. Author manuscript; available in PMC 2023 Mar 28.
Published in final edited form as: Science. 2022 Jul; 377(6601): 47–56. Published online 2022 Jun 30. doi: 10.1126/science.abi9547
PMCID:
PMC10049859
AbstractArticlePDF–1.7M
5.
MiR-200c-3p targets SESN1 and represses the IL-6/AKT loop to prevent cholangiocyte activation and cholestatic liver fibrosis
Yongfeng Song, Melanie Tran, Li Wang, Dong-Ju Shin, Jianguo Wu
Lab Invest. 2022; 102(5): 485–493. Published online 2021 Dec 8. doi: 10.1038/s41374-021-00710-6
PMCID:
PMC9042705
AbstractArticlePDF–3.9M
6.
Forkhead box protein 1 transcriptionally activates sestrin1 to alleviate oxidized low-density lipoprotein-induced inflammation and lipid accumulation in macrophages
Feng Gao, Yongcheng Zhao, Bin Zhang, Chunwei Xiao, Zhanfa Sun, Yuan Gao, Xueyong Dou
Bioengineered. 2022; 13(2): 2917–2926. Published online 2022 Jan 19. doi: 10.1080/21655979.2021.2000228
PMCID:
PMC8974195
AbstractArticlePDF–2.9M
7.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
8.
Integrating mouse and human genetic data to move beyond GWAS and identify causal genes in cholesterol metabolism
Zhonggang Li, James A. Votava, Gregory J.M. Zajac, Jenny N. Nguyen, Fernanda B. Leyva Jaimes, Sophia M. Ly, Jacqueline A. Brinkman, Marco De Giorgi, Sushma Kaul, Cara L. Green, Samantha L. St. Clair, Sabrina L. Belisle, Julia M. Rios, David W. Nelson, Mary G. Sorci-Thomas, William R. Lagor, Dudley W. Lamming, Chi-Liang Eric Yen, Brian W. Parks
Cell Metab. Author manuscript; available in PMC 2021 Apr 7.
Published in final edited form as: Cell Metab. 2020 Apr 7; 31(4): 741–754.e5. Published online 2020 Mar 19. doi: 10.1016/j.cmet.2020.02.015
PMCID:
PMC7184639
AbstractArticlePDF–1.9M
9.
Sestrins are evolutionarily conserved mediators of exercise benefits
Myungjin Kim, Alyson Sujkowski, Sim Namkoong, Bondong Gu, Tyler Cobb, Boyoung Kim, Allison H. Kowalsky, Chun-Seok Cho, Ian Semple, Seung-Hyun Ro, Carol Davis, Susan V. Brooks, Michael Karin, Robert J. Wessells, Jun Hee Lee
Nat Commun. 2020; 11: 190. Published online 2020 Jan 13. doi: 10.1038/s41467-019-13442-5
PMCID:
PMC6955242
AbstractArticlePDF–2.4M
10.
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
Jessica Segalés, Eusebio Perdiguero, Antonio L. Serrano, Pedro Sousa-Victor, Laura Ortet, Mercè Jardí, Andrei V. Budanov, Laura Garcia-Prat, Marco Sandri, David M. Thomson, Michael Karin, Jun Hee Lee, Pura Muñoz-Cánoves
Nat Commun. 2020; 11: 189. Published online 2020 Jan 13. doi: 10.1038/s41467-019-13832-9
PMCID:
PMC6955241
AbstractArticlePDF–1.5M
11.
p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis
Boxiao Ding, Alexander Haidurov, Ayesha Chawla, Anita Parmigiani, Gerarda van de Kamp, Alexandra Dalina, Fang Yuan, Jun Hee Lee, Peter M. Chumakov, Steven R. Grossman, Andrei V. Budanov
Oncotarget. 2019 Dec 10; 10(65): 6997–7009. Published online 2019 Dec 10. doi: 10.18632/oncotarget.27367
PMCID:
PMC6916756
AbstractArticlePDF–9.1M
12.
Cardioprotective roles of sestrin 1 and sestrin 2 against doxorubicin cardiotoxicity
Ruiting Li, Yin Huang, Ian Semple, Myungjin Kim, Zunjian Zhang, Jun Hee Lee
Am J Physiol Heart Circ Physiol. 2019 Jul 1; 317(1): H39–H48. Published online 2019 Apr 26. doi: 10.1152/ajpheart.00008.2019
PMCID:
PMC6692737
AbstractArticle
13.
Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation
Ruicong Xue, Junyi Zeng, Yili Chen, Cong Chen, Weiping Tan, Jingjing Zhao, Bin Dong, Yu Sun, Yugang Dong, Chen Liu
J Cell Mol Med. 2017 Jun; 21(6): 1193–1205. Published online 2017 Feb 9. doi: 10.1111/jcmm.13052
PMCID:
PMC5431155
AbstractArticlePDF–1.1M
14.
A sestrin-dependent Erk/Jnk/p38 MAPK activation complex inhibits immunity during ageing
Alessio Lanna, Daniel C O Gomes, Bojana Muller-Durovic, Thomas McDonnell, David Escors, Derek W Gilroy, Jun Hee Lee, Michael Karin, Arne N Akbar
Nat Immunol. Author manuscript; available in PMC 2017 Jul 23.
Published in final edited form as: Nat Immunol. 2017 Mar; 18(3): 354–363. Published online 2017 Jan 23. doi: 10.1038/ni.3665
PMCID:
PMC5321575
AbstractArticlePDF–2.4M
15.
Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development
Lina Zhou, Huifang Dai, Jian Wu, Mian Zhou, Hua Yuan, Juan Du, Lu Yang, Xiwei Wu, Hong Xu, Yuejin Hua, Jian Xu, Li Zheng, Binghui Shen
FASEB J. 2017 Jan; 31(1): 132–147. Published online 2016 Sep 30. doi: 10.1096/fj.201600631R
PMCID:
PMC5161519
AbstractArticle
16.
Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling
Min Peng, Na Yin, Ming O. Li
Cell. Author manuscript; available in PMC 2015 Sep 25.
Published in final edited form as: Cell. 2014 Sep 25; 159(1): 122–133. doi: 10.1016/j.cell.2014.08.038
PMCID:
PMC4181352
AbstractArticlePDF–2.7M
17.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
18.
Maintenance of metabolic homeostasis by Sestrin 2 and 3
Jun Hee Lee, Andrei V. Budanov, Saswata Talukdar, Eek Joong Park, Hae Li Park, Hwan-Woo Park, Gautam Bandyopadhyay, Ning Li, Mariam Aghajan, Insook Jang, Amber M. Wolfe, Guy A. Perkins, Mark H. Ellisman, Ethan Bier, Miriam Scadeng, Marc Foretz, Benoit Viollet, Jerrold Olefsky, Michael Karin
Cell Metab. Author manuscript; available in PMC 2013 Jun 20.
Published in final edited form as: Cell Metab. 2012 Sep 5; 16(3): 311–321. doi: 10.1016/j.cmet.2012.08.004
PMCID:
PMC3687365
AbstractArticlePDF–5.0M
19.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
20.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M

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