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Select item 113042341.

Cholesterol 25‐Hydroxylase Protects Against Diabetic Kidney Disease by Regulating ADP Ribosylation Factor 4

Lu Zhang, Zhengying Fang, Qingqing Zhu, Shumin Yang, Jia Fu, Zeguo Sun, Geming Lu, Chengguo Wei, Zhi Zhang, Kyung Lee, Yifei Zhong, Ruijie Liu, John Cijiang He

Adv Sci (Weinh) 2024 Aug; 11(29): 2309642. Published online 2024 May 30. doi: 10.1002/advs.202309642

PMCID:: PMC11304234

Abstract Article PDF–6.2M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109083593.

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

Danira Toral-Rios, Justin M. Long, Jason D. Ulrich, Jinsheng Yu, Michael R. Strickland, Xianlin Han, David M. Holtzman, Anil G. Cashikar, Steven M. Paul

J Exp Med. 2024 Apr 1; 221(4): e20232000. Published online 2024 Mar 1. doi: 10.1084/jem.20232000

PMCID:: PMC10908359

Abstract Article PDF–8.3M

Select item 109010984.

Pathogenic mycobacterium upregulates cholesterol 25-hydroxylase to promote granuloma development via foam cell formation

Shuang Zhou, Ding Zhang, Dan Li, Hankun Wang, Cairong Ding, Jingrui Song, Weifeng Huang, Xuan Xia, Ziwei Zhou, Shanshan Han, Zhu Jin, Bo Yan, Jacqueline Gonzales, Laura E. Via, Lu Zhang, Decheng Wang

iScience. 2024 Mar 15; 27(3): 109204. Published online 2024 Feb 12. doi: 10.1016/j.isci.2024.109204

PMCID:: PMC10901098

Abstract Article PDF–8.0M

Select item 107670585.

Disruption of cholesterol homeostasis triggers periodontal inflammation and alveolar bone loss

Thanh-Tam Tran, Gyuseok Lee, Yun Hyun Huh, Ki-Ho Chung, Sun Young Lee, Ka Hyon Park, Seung Hee Kwon, Min-Suk Kook, Jang-Soo Chun, Jeong-Tae Koh, Je-Hwang Ryu

Exp Mol Med. 2023 Dec; 55(12): 2553–2563. Published online 2023 Dec 1. doi: 10.1038/s12276-023-01122-w

PMCID:: PMC10767058

Abstract Article PDF–2.3M

Select item 107041156.

Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Mice

Michael B. Fessler, Jennifer H. Madenspacher, Paul J. Baker, Kerry L. Hilligan, Andrea C. Bohrer, Ehydel Castro, Julie Meacham, Shih-Heng Chen, Reed F. Johnson, Jeffrey G. McDonald, Negin P. Martin, Charles J. Tucker, Debabrata Mahapatra, Mark Cesta, Katrin D. Mayer-Barber

Am J Respir Cell Mol Biol. 2023 Dec 1; 69(6): 638–648. Published online 2023 Aug 14. doi: 10.1165/rcmb.2023-0007OC

PMCID:: PMC10704115

Abstract Article PDF–1.6M

Select item 104964617.

ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes

Zhen Lu, Noreen McBrearty, Jinyun Chen, Vivek S. Tomar, Hongru Zhang, Gianluca De Rosa, Aiwen Tan, Aalim M. Weljie, Daniel P. Beiting, Zhen Miao, Subin S. George, Allison Berger, Gurpanna Saggu, J. Alan Diehl, Constantinos Koumenis, Serge Y. Fuchs

Cell Metab. Author manuscript; available in PMC 2023 Sep 12.

Published in final edited form as: Cell Metab. 2022 Sep 6; 34(9): 1342–1358.e7. doi: 10.1016/j.cmet.2022.08.007

Correction in:: Cell Metab. 2024 Apr 10

PMCID:: PMC10496461

Abstract Article PDF–3.6M

Select item 103063108.

Skin γδ T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol

Michela Frascoli, Enxhi Ferraj, Bing Miu, Justin Malin, Nicholas Spidale, Jennifer Cowan, Susannah C. Shissler, Robert Brink, Ying Xu, Jason G. Cyster, Avinash Bhandoola, Joonsoo Kang, Andrea Reboldi

Immunity. Author manuscript; available in PMC 2024 Mar 14.

Published in final edited form as: Immunity. 2023 Mar 14; 56(3): 562–575.e6. Published online 2023 Feb 25. doi: 10.1016/j.immuni.2023.01.025

PMCID:: PMC10306310

Abstract Article PDF–1.8M

Select item 102435039.

An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut resident plasma cells

Simona Ceglia, Alyssa Berthelette, Kelsey Howley, Yun Li, Benedikt Mortzfeld, Shakti K. Bhattarai, Nicole K. H. Yiew, Ying Xu, Robert Brink, Jason G. Cyster, Lora V. Hooper, Gwendalyn J. Randolph, Vanni Bucci, Andrea Reboldi

Nat Immunol. Author manuscript; available in PMC 2023 Jun 6.

Published in final edited form as: Nat Immunol. 2023 Mar; 24(3): 531–544. Published online 2023 Jan 19. doi: 10.1038/s41590-022-01413-w

PMCID:: PMC10243503

Abstract Article PDF–7.1M

Select item 995387510.

Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection

Soo Jung Cho, Alexander Pronko, Jianjun Yang, Kassandra Pagan, Heather Stout-Delgado

Cells. 2023 Feb; 12(4): 570. Published online 2023 Feb 10. doi: 10.3390/cells12040570

PMCID:: PMC9953875

Abstract Article PDF–2.1M

Select item 978073911.

Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin

Hayato Takahashi, Hisashi Nomura, Hisato Iriki, Akiko Kubo, Koichi Isami, Yohei Mikami, Miho Mukai, Takashi Sasaki, Jun Yamagami, Jun Kudoh, Hiromi Ito, Aki Kamata, Yutaka Kurebayashi, Hiroki Yoshida, Akihiko Yoshimura, Hong-Wei Sun, Makoto Suematsu, Jonh J. O’Shea, Yuka Kanno, Masayuki Amagai

Sci Immunol. Author manuscript; available in PMC 2022 Dec 23.

Published in final edited form as: Sci Immunol. 2021 Oct 15; 6(64): eabb6444. Published online 2021 Oct 8. doi: 10.1126/sciimmunol.abb6444

PMCID:: PMC9780739

Abstract Article PDF–2.3M

Select item 965211712.

CD4⁺-mediated colitis in mice is independent of the GPR183 and GPR18 pathways

Martina Dicker, Yingcong Li, Daniel A. Giles, Greet Verstichel, Viankail Cedillo Castelan, Gabriel Ascui-Gac, Ting-Fang Chou, Tamara Perez-Jeldres, Hilde Cheroutre, Mitchell Kronenberg

Front Immunol. 2022; 13: 1034648. Published online 2022 Oct 28. doi: 10.3389/fimmu.2022.1034648

PMCID:: PMC9652117

Abstract Article PDF–15M

Select item 963620213.

Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer

Zhen Lu, Jinyun Chen, Pengfei Yu, Matthew J. Atherton, Jun Gui, Vivek S. Tomar, Justin D. Middleton, Neil T. Sullivan, Sunil Singhal, Subin S. George, Ashley G. Woolfork, Aalim M. Weljie, Tsonwin Hai, Evgeniy B. Eruslanov, Serge Y. Fuchs

Nat Commun. 2022; 13: 6623. Published online 2022 Nov 4. doi: 10.1038/s41467-022-34428-w

PMCID:: PMC9636202

Abstract Article PDF–6.2M

Select item 866005114.

A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol

Yukitoshi Izumi, Anil G. Cashikar, Kathiresan Krishnan, Steven M. Paul, Douglas F. Covey, Steven J. Mennerick, Charles F. Zorumski

J Neurosci. 2021 Dec 8; 41(49): 10054–10064. doi: 10.1523/JNEUROSCI.1502-21.2021

PMCID:: PMC8660051

Abstract Article PDF–1.9M

Select item 857034515.

The cholesterol metabolite 25-hydroxycholesterol restricts activation of the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation

Bruno C. Trindade, Simona Ceglia, Alyssa Berthelette, Fiona Raso, Kelsey Howley, Jagan R. Muppidi, Andrea Reboldi

Immunity. Author manuscript; available in PMC 2022 Oct 12.

Published in final edited form as: Immunity. 2021 Oct 12; 54(10): 2273–2287.e6. doi: 10.1016/j.immuni.2021.09.004

PMCID:: PMC8570345

Abstract Article PDF–2.0M

Select item 845747716.

Tumor Necrosis Factor-alpha utilizes MAPK/NFκB pathways to induce cholesterol-25 hydroxylase for amplifying pro-inflammatory response via 25-hydroxycholesterol-integrin-FAK pathway

Swechha M. Pokharel, Kim Chiok, Niraj K. Shil, Indira Mohanty, Santanu Bose

PLoS One. 2021; 16(9): e0257576. Published online 2021 Sep 22. doi: 10.1371/journal.pone.0257576

PMCID:: PMC8457477

Abstract Article PDF–1.5M

Select item 812152917.

Regulation of intercellular biomolecule transfer–driven tumor angiogenesis and responses to anticancer therapies

Zhen Lu, Angelica Ortiz, Ioannis I. Verginadis, Amy R. Peck, Farima Zahedi, Christina Cho, Pengfei Yu, Rachel M. DeRita, Hongru Zhang, Ryan Kubanoff, Yunguang Sun, Andrew T. Yaspan, Elise Krespan, Daniel P. Beiting, Enrico Radaelli, Sandra W. Ryeom, J. Alan Diehl, Hallgeir Rui, Constantinos Koumenis, Serge Y. Fuchs

J Clin Invest. 2021 May 17; 131(10): e144225. Published online 2021 May 17. doi: 10.1172/JCI144225

PMCID:: PMC8121529

Abstract Article PDF–9.0M

Select item 777804018.

Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins

Quan D. Zhou, Xun Chi, Min Sub Lee, Wei Yuan Hsieh, Jonathan J. Mkrtchyan, An-Chieh Feng, Cuiwen He, Autumn G York, Viet L. Bui, Eliza B. Kronenberger, Alessandra Ferrari, Xu Xiao, Allison E. Daly, Elizabeth J. Tarling, Robert Damoiseaux, Philip O. Scumpia, Stephen T. Smale, Kevin J. Williams, Peter Tontonoz, Steven J. Bensinger

Nat Immunol. Author manuscript; available in PMC 2021 Jan 2.

Published in final edited form as: Nat Immunol. 2020 Jul; 21(7): 746–755. Published online 2020 Jun 8. doi: 10.1038/s41590-020-0695-4

PMCID:: PMC7778040

Abstract Article PDF–4.4M

Select item 745572819.

Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function

Na Sheng, Zhongnan Ma, Yi Zhou, Juan Xu, Yan Gao, Xin-Yuan Fu

Sci Rep. 2020; 10: 14246. Published online 2020 Aug 28. doi: 10.1038/s41598-020-71198-1

PMCID:: PMC7455728

Abstract Article PDF–6.8M

Select item 730806320.

Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation

Jennifer H. Madenspacher, Eric D. Morrell, Kymberly M. Gowdy, Jeffrey G. McDonald, Bonne M. Thompson, Ginger Muse, Jennifer Martinez, Seddon Thomas, Carmen Mikacenic, Jerry A. Nick, Edward Abraham, Stavros Garantziotis, Renee D. Stapleton, Julie M. Meacham, Mary Jane Thomassen, William J. Janssen, Donald N. Cook, Mark M. Wurfel, Michael B. Fessler

JCI Insight. 2020 Jun 4; 5(11): e137189. Published online 2020 Jun 4. doi: 10.1172/jci.insight.137189

PMCID:: PMC7308063

Abstract Article PDF–5.7M

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