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Select item 112582381.

Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis

Danyang Li, Oliver Pain, Chiara Fabbri, Win Lee Edwin Wong, Chris Wai Hang Lo, Stephan Ripke, Annamaria Cattaneo, Daniel Souery, Mojca Z. Dernovsek, Neven Henigsberg, Joanna Hauser, Glyn Lewis, Ole Mors, Nader Perroud, Marcella Rietschel, Rudolf Uher, Wolfgang Maier, Bernhard T. Baune, Joanna M. Biernacka, Guido Bondolfi, Katharina Domschke, Masaki Kato, Yu-Li Liu, Alessandro Serretti, Shih-Jen Tsai, Richard Weinshilboum, the GSRD Consortium, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Andrew M. McIntosh, Cathryn M. Lewis

Transl Psychiatry. 2024; 14: 296. Published online 2024 Jul 19. doi: 10.1038/s41398-024-02981-1

Correction in:: Transl Psychiatry. 2024; 14: 350.

PMCID:: PMC11258238

Abstract Article PDF–940K

Select item 112557572.

CYP2C19 Genotype Is Associated With Adverse Cardiovascular Outcomes in Black Patients Treated With Clopidogrel Undergoing Percutaneous Coronary Intervention

Kayla R. Tunehag, Cameron D. Thomas, Francesco Franchi, Joseph S. Rossi, Ellen C. Keeley, R. David Anderson, Amber L. Beitelshees, Julio D. Duarte, Yan Gong, Richard A. Kerensky, Caitrin W. McDonough, Anh B. Nguyen, Luis Ortega‐Paz, Sanjay Venkatesh, Yehua Wang, Julie A. Johnson, Almut G. Winterstein, George A. Stouffer, Dominick J. Angiolillo, Larisa H. Cavallari, Craig R. Lee

J Am Heart Assoc. 2024 Jun 18; 13(12): e033791. Published online 2024 Jun 11. doi: 10.1161/JAHA.123.033791

PMCID:: PMC11255757

Abstract Article PDF–1.0M

Select item 111594333.

Phase I pharmacokinetic and pharmacogenomic study of E7070 administered once every 21 days

Yasuhide Yamada, Noboru Yamamoto, Tatsu Shimoyama, Atsushi Horiike, Yasuhito Fujisaka, Kyoko Takayama, Terumi Sakamoto, Yuki Nishioka, Sanae Yasuda, Tomohide Tamura

Cancer Sci. 2005 Oct; 96(10): 721–728. Published online 2005 Oct 13. doi: 10.1111/j.1349-7006.2005.00109.x

PMCID:: PMC11159433

Abstract Article PDF–208K

Select item 110794814.

Utility of the ACD-GENE-CLI Score in Asian Patients with Critical Limb Ischemia Undergoing Endovascular Interventions

Wei-Ting Chang, Po-Sen Huang, Li-Wei Su, Chia-Te Liao, Han Siong Toh, Yi-Chen Chen, Ho Chung‑Han, Zhih-Cherng Chen, Po-Chao Hsu, Chon-Seng Hong

J Atheroscler Thromb. 2024 May 1; 31(5): 572–586. Published online 2023 Dec 12. doi: 10.5551/jat.64326

PMCID:: PMC11079481

Abstract Article PDF–881K

Select item 110552215.

Genetic variability in stroke patients: CYP2C19 polymorphisms unraveled

Peiyi Peng, Yingxiu Xiao, Xuehong Peng, Jianqiang Chen, Nuan Chen

BMC Med Genomics. 2024; 17: 109. Published online 2024 Apr 26. doi: 10.1186/s12920-024-01886-8

PMCID:: PMC11055221

Abstract Article PDF–1.1M

Select item 109978456.

The association of CYP2C19LoF alleles with adverse clinical outcomes in stroke patients taking clopidogrel: An updated meta‐analysis

Mohitosh Biswas, Md. Shahadat Hossain, Tahsin Ahmed Rupok, Md. Sabbir Hossain, Chonlaphat Sukasem

Clin Transl Sci. 2024 Apr; 17(4): e13792. Published online 2024 Apr 5. doi: 10.1111/cts.13792

PMCID:: PMC10997845

Abstract Article PDF–1.5M

Select item 106667317.

CYP2C19*17 association with higher plasma 4-hydroxy tamoxifen in Pakistani (estrogen-positive) breast cancer patients

Muhammad Usman Tareen, Sana Riaz, Saima Shakil Malik, Sana Zahid, Anum Khursheed, Fizza Tariq, Faiza Abbas, Muhammad Nouman Malik, Riffat Aysha Anis, Mariam Anees, Iram Murtaza, Aneesa Sultan

Exp Biol Med (Maywood) 2023 Sep; 248(17): 1507–1517. Published online 2023 Sep 9. doi: 10.1177/15353702231187640

PMCID:: PMC10666731

Abstract Article PDF–1.2M

Select item 106516378.

CYP2C19 genotypes and osteoporotic fractures in long‐term users of proton pump inhibitors: A hospital‐based study

Yi‐Ju Liao, Yu‐Ting Chen, Tzu‐Hung Hsiao, Ching‐Heng Lin, Ming‐Fen Wu, Chiann‐Yi Hsu, Yi‐Ming Chen, Chun‐Sheng Hsu

Clin Transl Sci. 2023 Nov; 16(11): 2198–2208. Published online 2023 Sep 5. doi: 10.1111/cts.13620

PMCID:: PMC10651637

Abstract Article PDF–849K

Select item 106142049.

The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β‐eudesmol in human liver: Reaction phenotyping and enzyme kinetics

Nadda Muhamad, Kesara Na‐Bangchang

Pharmacol Res Perspect. 2023 Dec; 11(6): e01149. Published online 2023 Oct 30. doi: 10.1002/prp2.1149

PMCID:: PMC10614204

Abstract Article PDF–1.3M

Select item 1058268210.

CYP2C19 loss‐of‐function alleles and use of omeprazole or esomeprazole increase the risk of cardiovascular outcomes in patients using clopidogrel

Markus Ramste, Markus Ritvos, Sergei Häyrynen, Johanna I. Kiiski, Mikko Niemi, Juha Sinisalo

Clin Transl Sci. 2023 Oct; 16(10): 2010–2020. Published online 2023 Aug 16. doi: 10.1111/cts.13608

PMCID:: PMC10582682

Abstract Article PDF–1.3M

Select item 1049500411.

Population pharmacokinetics of voriconazole and the role of CYP2C19 genotype on treatment optimization in pediatric patients

Lin Hu, Shiqiong Huang, Qi Huang, Juanjuan Huang, Zeying Feng, Gefei He

PLoS One. 2023; 18(9): e0288794. Published online 2023 Sep 11. doi: 10.1371/journal.pone.0288794

PMCID:: PMC10495004

Abstract Article PDF–711K

Select item 1030224712.

Pharmacogenomics fail to explain proton pump inhibitor refractory esophagitis in pediatric esophageal atresia

Jessica L. Yasuda, Steven J. Staffa, Samuel Nurko, Madeline Kane, Stephanie Wall, Edward B. Mougey, James P. Franciosi, Michael A. Manfredi, Rachel Rosen

Neurogastroenterol Motil. Author manuscript; available in PMC 2023 Jun 28.

Published in final edited form as: Neurogastroenterol Motil. 2022 Jan; 34(1): e14217. Published online 2021 Aug 1. doi: 10.1111/nmo.14217

PMCID:: PMC10302247

Abstract Article PDF–407K

Select item 1024519513.

Association of CYP2C19 Loss-of-Function Metabolizer Status With Stroke Risk Among Chinese Patients Treated With Ticagrelor-Aspirin vs Clopidogrel-Aspirin: A Prespecified Secondary Analysis of a Randomized Clinical Trial

Xuewei Xie, S. Claiborne Johnston, Anxin Wang, Qin Xu, Philip M. Bath, Yuesong Pan, Hao Li, Jinxi Lin, Yilong Wang, Xingquan Zhao, Zixiao Li, Yong Jiang, Liping Liu, Anding Xu, Jing Jing, Xia Meng, Yongjun Wang

JAMA Netw Open. 2023 Jun; 6(6): e2317037. Published online 2023 Jun 6. doi: 10.1001/jamanetworkopen.2023.17037

PMCID:: PMC10245195

Abstract Article

Select item 1020489514.

Prevalence of CYP2C9 and CYP2C19 variants and the impact on clopidogrel efficacy in patients having CYPC19*2 variant

Meha P. Mehta, Normi D. Gajjar, Rutvi J. Patel, Lipi P. Joshi, Gaurang B. Shah

Indian J Pharmacol. 2023 Jan-Feb; 55(1): 27–33. Published online 2023 Mar 20. doi: 10.4103/ijp.ijp_706_22

PMCID:: PMC10204895

Abstract Article

Select item 1019898615.

Baseline P2Y12 reactivity, kidney function, and CYP2C19 genotype determine clopidogrel responsiveness in acute stroke

Yi-Chung Lee, Yi-Chu Liao, Chun-Jen Lin, Chih-Ping Chung

Sci Rep. 2023; 13: 8085. Published online 2023 May 19. doi: 10.1038/s41598-023-34481-5

PMCID:: PMC10198986

Abstract Article PDF–1.3M

Select item 1014903516.

Pharmacokinetics of the new proton pump inhibitor ilaprazole in Chinese healthy subjects in relation to CYP3A5 and CYP2C19 genotypes

Yalin Li, Wei Zhang, Dong Guo, Gan Zhou, Honghao Zhou, Zhousheng Xiao

Clin Chim Acta. Author manuscript; available in PMC 2023 Apr 30.

Published in final edited form as: Clin Chim Acta. 2008 May; 391(1-2): 60–67. Published online 2008 Feb 14. doi: 10.1016/j.cca.2008.02.003

PMCID:: PMC10149035

Abstract Article PDF–913K

Select item 1010823217.

The humanised CYP2C19 transgenic mouse exhibits cerebellar atrophy and movement impairment reminiscent of ataxia

Filip Milosavljević, Irene Brusini, Andrea Atanasov, Marina Manojlović, Marija Vučić, Zorana Oreščanin‐Dušić, Jelena Brkljačić, Čedo Miljević, Aleksandra Nikolić‐Kokić, Duško Blagojević, Chunliang Wang, Peter Damberg, Vesna Pešić, Rachel F. Tyndale, Magnus Ingelman‐Sundberg, Marin M. Jukić

Neuropathol Appl Neurobiol. 2023 Feb; 49(1): e12867. Published online 2023 Jan 17. doi: 10.1111/nan.12867

PMCID:: PMC10108232

Abstract Article PDF–2.7M

Select item 1008078518.

CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study

Nan Cai, Cunren Li, Xianfang Gu, Wenfeng Zeng, Jiawei Zhong, Jingfeng Liu, Guopeng Zeng, Junxing Zhu, Haifeng Hong

BMC Cardiovasc Disord. 2023; 23: 185. Published online 2023 Apr 6. doi: 10.1186/s12872-023-03207-w

PMCID:: PMC10080785

Abstract Article PDF–1.0M

Select item 1001842919.

CYP2C19 metabolic estrogen phenotypes and endometriosis risk in Brazilian women

Jamila Alessandra Perini, Daniel Escorsim Machado, Jéssica Vilarinho Cardoso, Vanessa Camara Fernandes, Claudio José Struchiner, Guilherme Suarez-Kurtz

Clinics (Sao Paulo) 2023 Jan-Dec; 78: 100176. Published online 2023 Mar 7. doi: 10.1016/j.clinsp.2023.100176

PMCID:: PMC10018429

Article PDF–304K

Select item 992537620.

Effect of CYP2C19 polymorphisms on antidepressant prescription patterns and treatment emergent mania in bipolar disorder

Erik Joas, Lina Jonsson, Alexander Viktorin, Erik Smedler, Erik Pålsson, Guy M. Goodwin, Mikael Landén

Pharmacogenomics J. 2023; 23(1): 28–35. Published online 2022 Nov 4. doi: 10.1038/s41397-022-00294-4

PMCID:: PMC9925376

Abstract Article PDF–612K

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