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Items: 20

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Low-dose metformin targets the lysosomal AMPK pathway through PEN2
Teng Ma, Xiao Tian, Baoding Zhang, Mengqi Li, Yu Wang, Chunyan Yang, Jianfeng Wu, Xiaoyan Wei, Qi Qu, Yaxin Yu, Shating Long, Jin-Wei Feng, Chun Li, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Junjie Chen, Yong Yu, Xi Huang, Ying He, Luming Yao, Lei Zhang, Mingxia Zhu, Wen Wang, Zhi-Chao Wang, Mingliang Zhang, Yuqian Bao, Weiping Jia, Shu-Yong Lin, Zhiyun Ye, Hai-Long Piao, Xianming Deng, Chen-Song Zhang, Sheng-Cai Lin
Nature. 2022; 603(7899): 159–165. Published online 2022 Feb 23. doi: 10.1038/s41586-022-04431-8
PMCID:
PMC8891018
AbstractArticlePDF–84M
3.
APH-1a Is the Principal Mammalian APH-1 Isoform Present in γ-Secretase Complexes during Embryonic Development
Guojun Ma, Tong Li, Donald L. Price, Philip C. Wong
J Neurosci. 2005 Jan 5; 25(1): 192–198. doi: 10.1523/JNEUROSCI.3814-04.2005
PMCID:
PMC6725209
AbstractArticlePDF–351K
4.
Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration
Hermien Acx, Lutgarde Serneels, Enrico Radaelli, Serge Muyldermans, Cécile Vincke, Elise Pepermans, Ulrike Müller, Lucía Chávez‐Gutiérrez, Bart De Strooper
EMBO Mol Med. 2017 Aug; 9(8): 1088–1099. Published online 2017 Jun 6. doi: 10.15252/emmm.201707561
PMCID:
PMC5538297
AbstractArticlePDF–5.8M
5.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
6.
Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia
Fabrizio Biundo, Keita Ishiwari, Dolores Del Prete, Luciano D'Adamio
Oncotarget. 2016 Mar 15; 7(11): 11923–11944. Published online 2016 Mar 1. doi: 10.18632/oncotarget.7389
PMCID:
PMC4914259
AbstractArticlePDF–2.3M
7.
Antagonistic Effects of BACE1 and APH1B-?-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse
Soraia Barão, Annette Gärtner, Eduardo Leyva-Díaz, Galina Demyanenko, Sebastian Munck, Tine Vanhoutvin, Lujia Zhou, Melitta Schachner, Guillermina López-Bendito, Patricia F. Maness, Bart De Strooper
Cell Rep. Author manuscript; available in PMC 2016 Apr 4.
Published in final edited form as: Cell Rep. 2015 Sep 1; 12(9): 1367–1376. Published online 2015 Aug 20. doi: 10.1016/j.celrep.2015.07.059
PMCID:
PMC4820248
AbstractArticlePDF–801K
8.
A high resolution spatiotemporal atlas of gene expression of the developing mouse brain
Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones
Neuron. Author manuscript; available in PMC 2015 Jul 16.
Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033
PMCID:
PMC4319559
AbstractArticlePDF–3.0M
9.
Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling
Pietro Fazzari, An Snellinx, Victor Sabanov, Tariq Ahmed, Lutgarde Serneels, Annette Gartner, S Ali M Shariati, Detlef Balschun, Bart De Strooper
eLife. 2014; 3: e02196. Published online 2014 Jun 2. doi: 10.7554/eLife.02196
PMCID:
PMC4073283
AbstractArticlePDF–2.5M
10.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
11.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
12.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
13.
Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin
Po-Min Chiang, Ryan R. Fortna, Donald L. Price, Tong Li, Philip C. Wong
Neurobiol Aging. Author manuscript; available in PMC 2013 Feb 1.
Published in final edited form as: Neurobiol Aging. 2012 Feb; 33(2): 277–285. Published online 2010 Apr 10. doi: 10.1016/j.neurobiolaging.2009.12.028
PMCID:
PMC2904414
AbstractArticlePDF–1023K
14.
?-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease
Lutgarde Serneels, Jérôme Van Biervliet, Katleen Craessaerts, Tim Dejaegere, Katrien Horré, Tine Van Houtvin, Hermann Esselmann, Sabine Paul, Martin K. Schäfer, Oksana Berezovska, Bradley T. Hyman, Ben Sprangers, Raf Sciot, Lieve Moons, Mathias Jucker, Zhixiang Yang, Patrick C. May, Eric Karran, Jens Wiltfang, Rudi D’Hooge, Bart De Strooper
Science. Author manuscript; available in PMC 2009 Sep 9.
Published in final edited form as: Science. 2009 May 1; 324(5927): 639–642. Published online 2009 Mar 19. doi: 10.1126/science.1171176
PMCID:
PMC2740474
AbstractArticlePDF–3.5M
15.
Deficiency of Aph1B/C-γ-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment
T. Dejaegere, L. Serneels, M. K. Schäfer, J. Van Biervliet, K. Horré, C. Depboylu, D. Alvarez-Fischer, A. Herreman, M. Willem, C. Haass, G. U. Höglinger, R. D'Hooge, B. De Strooper
Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28): 9775–9780. Published online 2008 Jul 14. doi: 10.1073/pnas.0800507105
PMCID:
PMC2474502
AbstractArticlePDF–1.0M
16.
Differential contribution of the three Aph1 genes to γ-secretase activity in vivo
Lutgarde Serneels, Tim Dejaegere, Katleen Craessaerts, Katrien Horré, Ellen Jorissen, Thomas Tousseyn, Sébastien Hébert, Marcel Coolen, Gerard Martens, An Zwijsen, Wim Annaert, Dieter Hartmann, Bart De Strooper
Proc Natl Acad Sci U S A. 2005 Feb 1; 102(5): 1719–1724. Published online 2005 Jan 21. doi: 10.1073/pnas.0408901102
PMCID:
PMC547495
AbstractArticlePDF–685K
17.
The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)
Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504
Correction in:
Genome Res. 2006 Jun; 16(6): 804.
PMCID:
PMC528928
AbstractArticlePDF–140K
18.
RIKEN Integrated Sequence Analysis (RISA) System—384-Format Sequencing Pipeline with 384 Multicapillary Sequencer
Kazuhiro Shibata, Masayoshi Itoh, Katsunori Aizawa, Sumiharu Nagaoka, Nobuya Sasaki, Piero Carninci, Hideaki Konno, Junichi Akiyama, Katsuo Nishi, Tokuji Kitsunai, Hideo Tashiro, Mari Itoh, Noriko Sumi, Yoshiyuki Ishii, Shin Nakamura, Makoto Hazama, Tsutomu Nishine, Akira Harada, Rintaro Yamamoto, Hiroyuki Matsumoto, Sumito Sakaguchi, Takashi Ikegami, Katsuya Kashiwagi, Syuji Fujiwake, Kouji Inoue, Yoshiyuki Togawa, Masaki Izawa, Eiji Ohara, Masanori Watahiki, Yuko Yoneda, Tomokazu Ishikawa, Kaori Ozawa, Takumi Tanaka, Shuji Matsuura, Jun Kawai, Yasushi Okazaki, Masami Muramatsu, Yorinao Inoue, Akira Kira, Yoshihide Hayashizaki
Genome Res. 2000 Nov; 10(11): 1757–1771. doi: 10.1101/gr.152600
PMCID:
PMC310992
AbstractArticlePDF–3.4M
19.
Normalization and Subtraction of Cap-Trapper-Selected cDNAs to Prepare Full-Length cDNA Libraries for Rapid Discovery of New Genes
Piero Carninci, Yuko Shibata, Norihito Hayatsu, Yuichi Sugahara, Kazuhiro Shibata, Masayoshi Itoh, Hideaki Konno, Yasushi Okazaki, Masami Muramatsu, Yoshihide Hayashizaki
Genome Res. 2000 Oct; 10(10): 1617–1630. doi: 10.1101/gr.145100
PMCID:
PMC310980
AbstractArticlePDF–1.4M
20.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Mammalian Gene Collection (MGC) Program Team
Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899
PMCID:
PMC139241
AbstractArticlePDF–118K

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