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Select item 107649581.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 102794692.

Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein

Sean A. Burnap, Ana Maria Ortega-Prieto, Jose M. Jimenez-Guardeño, Hashim Ali, Kaloyan Takov, Matthew Fish, Manu Shankar-Hari, Mauro Giacca, Michael H. Malim, Manuel Mayr

Mol Cell Proteomics. 2023 Aug; 22(8): 100600. Published online 2023 Jun 19. doi: 10.1016/j.mcpro.2023.100600

PMCID:: PMC10279469

Abstract Article PDF–3.2M

Select item 101400313.

Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction

Hagen Sülzen, Jakub Began, Arun Dhillon, Sami Kereïche, Petr Pompach, Jitka Votrubova, Farnaz Zahedifard, Adriana Šubrtova, Marie Šafner, Martin Hubalek, Maaike Thompson, Martin Zoltner, Sebastian Zoll

Nat Commun. 2023; 14: 2403. Published online 2023 Apr 27. doi: 10.1038/s41467-023-37988-7

PMCID:: PMC10140031

Abstract Article PDF–3.7M

Select item 100395114.

Study of FOXO1-interacting proteins using TurboID-based proximity labeling technology

Yanting Su, Yuanyuan Guo, Jieyu Guo, Ting Zeng, Ting Wang, Wu Liu

BMC Genomics. 2023; 24: 146. Published online 2023 Mar 24. doi: 10.1186/s12864-023-09238-z

PMCID:: PMC10039511

Abstract Article PDF–2.0M

Select item 99902445.

Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth

Leanna M. Hernandez, Minsoo Kim, Pan Zhang, Richard A. I. Bethlehem, Gil Hoftman, Robert Loughnan, Diana Smith, Susan Y. Bookheimer, Chun Chieh Fan, Carrie E. Bearden, Wesley K. Thompson, Michael J. Gandal

Genome Biol. 2023; 24: 42. Published online 2023 Mar 7. doi: 10.1186/s13059-023-02878-0

PMCID:: PMC9990244

Abstract Article PDF–2.0M

Select item 99224686.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 97725587.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 96336098.

Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia

Jessica Gracias, Funda Orhan, Elin Hörbeck, Jessica Holmén-Larsson, Neda Khanlarkani, Susmita Malwade, Sravan K. Goparaju, Lilly Schwieler, İlknur Ş. Demirel, Ting Fu, Helena Fatourus-Bergman, Aurimantas Pelanis, Carleton P. Goold, Anneli Goulding, Kristina Annerbrink, Anniella Isgren, Timea Sparding, Martin Schalling, Viviana A. Carcamo Yañez, Jens C. Göpfert, Johanna Nilsson, Ann Brinkmalm, Kaj Blennow, Henrik Zetterberg, Göran Engberg, Fredrik Piehl, Steven D. Sheridan, Roy H. Perlis, Simon Cervenka, Sophie Erhardt, Mikael Landen, Carl M. Sellgren

Nat Commun. 2022; 13: 6427. Published online 2022 Nov 3. doi: 10.1038/s41467-022-33797-6

PMCID:: PMC9633609

Abstract Article PDF–1.6M

Select item 95829959.

Association of complement component 4 with neuroimmune abnormalities in the subventricular zone in schizophrenia and autism spectrum disorders

Ta-Chung M. Mou, Malcolm V. Lane, Derek D.C. Ireland, Daniela Verthelyi, Leonardo H. Tonelli, Sarah M. Clark

Neurobiol Dis. Author manuscript; available in PMC 2022 Oct 20.

Published in final edited form as: Neurobiol Dis. 2022 Oct 15; 173: 105840. Published online 2022 Aug 19. doi: 10.1016/j.nbd.2022.105840

PMCID:: PMC9582995

Abstract Article PDF–1.9M

Select item 954351010.

Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases

Christian Lundtoft, Pascal Pucholt, Myriam Martin, Matteo Bianchi, Emeli Lundström, Maija‐Leena Eloranta, Johanna K. Sandling, Christopher Sjöwall, Andreas Jönsen, Iva Gunnarsson, Solbritt Rantapää‐Dahlqvist, Anders A. Bengtsson, Dag Leonard, Eva Baecklund, Roland Jonsson, Daniel Hammenfors, Helena Forsblad‐d'Elia, Per Eriksson, Thomas Mandl, Sara Magnusson Bucher, Katrine B. Norheim, Svein Joar Auglænd Johnsen, Roald Omdal, Marika Kvarnström, Marie Wahren‐Herlenius, Antonella Notarnicola, Helena Andersson, Øyvind Molberg, Louise Pyndt Diederichsen, Jonas Almlöf, Ann‐Christine Syvänen, Sergey V. Kozyrev, Kerstin Lindblad‐Toh, the DISSECT Consortium , the ImmunoArray Development Consortium , Bo Nilsson, Anna M. Blom, Ingrid E. Lundberg, Gunnel Nordmark, Lina Marcela Diaz‐Gallo, Elisabet Svenungsson, Lars Rönnblom

Arthritis Rheumatol. 2022 Aug; 74(8): 1440–1450. Published online 2022 Jun 27. doi: 10.1002/art.42122

PMCID:: PMC9543510

Abstract Article PDF–1.1M

Select item 952399711.

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer

Natsumi Tsuboyama, Aileen Patricia Szczepanski, Zibo Zhao, Lu Wang

Genome Biol. 2022; 23: 206. Published online 2022 Sep 30. doi: 10.1186/s13059-022-02776-x

PMCID:: PMC9523997

Abstract Article PDF–6.9M

Select item 949923812.

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein

Marius Walter, Irene P. Chen, Albert Vallejo-Gracia, Ik-Jung Kim, Olga Bielska, Victor L. Lam, Jennifer M. Hayashi, Andrew Cruz, Samah Shah, Frank W. Soveg, John D. Gross, Nevan J. Krogan, Keith R. Jerome, Birgit Schilling, Melanie Ott, Eric Verdin

PLoS Pathog. 2022 Sep; 18(9): e1010811. Published online 2022 Sep 12. doi: 10.1371/journal.ppat.1010811

PMCID:: PMC9499238

Abstract Article PDF–3.7M

Select item 947067513.

Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation

Ting Gao, Lin Zhu, Hainan Liu, Xiaopeng Zhang, Tingting Wang, Yangbo Fu, Hongzhen Li, Qincai Dong, Yong Hu, Zhang Zhang, Jing Jin, Zijing Liu, Weihong Yang, Yaoning Liu, Yanwen Jin, Kaitong Li, Yongjiu Xiao, Junli Liu, Huailong Zhao, Yue Liu, Ping Li, Jibo Song, Lu Zhang, Yuwei Gao, Sisi Kang, Shoudeng Chen, Qingjun Ma, Xiuwu Bian, Wei Chen, Xuan Liu, Qing Mao, Cheng Cao

Signal Transduct Target Ther. 2022; 7: 318. Published online 2022 Sep 14. doi: 10.1038/s41392-022-01133-5

PMCID:: PMC9470675

Abstract Article PDF–6.1M

Select item 936019014.

Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease

Gyungah R. Jun, Yang You, Congcong Zhu, Gaoyuan Meng, Jaeyoon Chung, Rebecca Panitch, Junming Hu, Weiming Xia, The Alzheimer's Disease Genetics Consortium, David A. Bennett, Tatiana M. Foroud, Li‐San Wang, Jonathan L. Haines, Richard Mayeux, Margaret A. Pericak‐Vance, Gerard D. Schellenberg, Rhoda Au, Kathryn L. Lunetta, Tsuneya Ikezu, Thor D. Stein, Lindsay A. Farrer

Alzheimers Dement. 2022 Nov; 18(11): 2042–2054. Published online 2022 Feb 9. doi: 10.1002/alz.12607

PMCID:: PMC9360190

Abstract Article PDF–1.4M

Select item 930932915.

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD

Liuyu Lin, Yuqing Wu, Hailun Hang, Jie Lu, Yuanliang Ding

Front Immunol. 2022; 13: 853891. Published online 2022 Jul 11. doi: 10.3389/fimmu.2022.853891

PMCID:: PMC9309329

Abstract Article PDF–2.1M

Select item 929024116.

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer

Annamaria Salvati, Viola Melone, Assunta Sellitto, Francesca Rizzo, Roberta Tarallo, Tuula A. Nyman, Giorgio Giurato, Giovanni Nassa, Alessandro Weisz

Breast Cancer Res. 2022; 24: 52. Published online 2022 Jul 18. doi: 10.1186/s13058-022-01547-7

PMCID:: PMC9290241

Abstract Article PDF–8.2M

Select item 923162317.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 901471118.

Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

Fabian Hosp, Hannes Vossfeldt, Matthias Heinig, Djordje Vasiljevic, Anup Arumughan, Emanuel Wyler, Genetic and Environmental Risk for Alzheimer’s Disease (GERAD1) Consortium, Markus Landthaler, Norbert Hubner, Erich E. Wanker, Lars Lannfelt, Martin Ingelsson, Maciej Lalowski, Aaron Voigt, Matthias Selbach

Cell Rep. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Cell Rep. 2015 May 19; 11(7): 1134–1146. Published online 2015 May 7. doi: 10.1016/j.celrep.2015.04.030

PMCID:: PMC9014711

Abstract Article PDF–2.2M

Select item 875929119.

EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3

Ziwen Pan, Rongrong Zhao, Boyan Li, Yanhua Qi, Wei Qiu, Qindong Guo, Shouji Zhang, Shulin Zhao, Hao Xu, Ming Li, Zijie Gao, Yang Fan, Jianye Xu, Huizhi Wang, Shaobo Wang, Jiawei Qiu, Qingtong Wang, Xing Guo, Lin Deng, Ping Zhang, Hao Xue, Gang Li

Mol Cancer. 2022; 21: 16. Published online 2022 Jan 14. doi: 10.1186/s12943-021-01485-6

PMCID:: PMC8759291

Abstract Article PDF–16M

Select item 875848520.

Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease

Rebecca Panitch, Junming Hu, Jaeyoon Chung, Congcong Zhu, Gaoyuan Meng, Weiming Xia, David A. Bennett, Kathryn L. Lunetta, Tsuneya Ikezu, Rhoda Au, Thor D. Stein, Lindsay A. Farrer, Gyungah R. Jun

Mol Psychiatry. 2021; 26(10): 6054–6064. Published online 2021 Sep 3. doi: 10.1038/s41380-021-01266-z

PMCID:: PMC8758485

Abstract Article PDF–2.1M

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