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Select item 114857421.

HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis

Meihui Deng, Xiao Tan, Xiaojie Peng, Weimin Zheng, Rui Fu, Shanshan Tao

Ren Fail. 2024; 46(2): 2415517. Published online 2024 Oct 16. doi: 10.1080/0886022X.2024.2415517

PMCID:: PMC11485742

Abstract Article PDF–3.0M

Select item 113745282.

Histone deacetylase 6 controls cardiac fibrosis and remodelling through the modulation of TGF‐β1/Smad2/3 signalling in post‐infarction mice

Junqiao Fang, Shangzhi Shu, Hui Dong, Xueling Yue, Jinshun Piao, Shuyan Li, Lan Hong, Xian Wu Cheng

J Cell Mol Med. 2024 Sep; 28(17): e70063. Published online 2024 Sep 4. doi: 10.1111/jcmm.70063

PMCID:: PMC11374528

Abstract Article PDF–42M

Select item 111057703.

Bardet–Biedl Syndrome proteins regulate cilia disassembly during tissue maturation

Sarita Rani Patnaik, Viola Kretschmer, Lena Brücker, Sandra Schneider, Ann-Kathrin Volz, Liliana del Rocio Oancea-Castillo, Helen Louise May-Simera

Cell Mol Life Sci. 2019 Feb; 76(4): 757–775. Published online 2018 Nov 16. doi: 10.1007/s00018-018-2966-x

PMCID:: PMC11105770

Abstract Article PDF–3.0M

Select item 110731234.

Upregulation of MDH1 acetylation by HDAC6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage

Miao Wang, Chao Zhou, Lu Yu, Delian Kong, Weijing Ma, Bingchen Lv, Yan Wang, Weifeng Wu, Mingyue Zhou, Guiyun Cui

Cell Mol Life Sci. 2022 Jul; 79(7): 356. Published online 2022 Jun 9. doi: 10.1007/s00018-022-04341-y

PMCID:: PMC11073123

Abstract Article PDF–3.2M

Select item 110248605.

HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy

Tuo Zhang, Yuntong Tong, Rengguang Zhu, Yaoyun Liang, Jixian Zhang, Chujiao Hu, Meina He, Zhu Hu, Zhiyi Shen, Jin Niu, Jingjing Zhang, Yuanyuan Yu, Bangming Jin, Shan Lei, Zhirui Zeng, Yingmin Wu, Zengmei Cheng, Ziwen Xiao, Bing Guo, Shuyun Zhao, Guoqiang Xu, Wei Pan, Tengxiang Chen

Theranostics. 2024; 14(6): 2345–2366. Published online 2024 Mar 25. doi: 10.7150/thno.95164

PMCID:: PMC11024860

Abstract Article PDF–13M

Select item 109366006.

The role of HDAC6 in enhancing macrophage autophagy via the autophagolysosomal pathway to alleviate legionella pneumophila-induced pneumonia

Minjia Chen, Xiuqin Cao, Ronghui Zheng, Haixia Chen, Ruixia He, Hao Zhou, Zhiwei Yang

Virulence. 2024; 15(1): 2327096. Published online 2024 Mar 11. doi: 10.1080/21505594.2024.2327096

PMCID:: PMC10936600

Abstract Article PDF–7.6M

Select item 108980707.

Targeting HDAC6 improves anti-CD47 immunotherapy

Maria Gracia-Hernandez, Ashutosh S. Yende, Nithya Gajendran, Zubaydah Alahmadi, Xintang Li, Zuleima Munoz, Karen Tan, Satish Noonepalle, Maho Shibata, Alejandro Villagra

J Exp Clin Cancer Res. 2024; 43: 60. Published online 2024 Feb 27. doi: 10.1186/s13046-024-02982-4

PMCID:: PMC10898070

Abstract Article PDF–2.6M

Select item 108971568.

Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice

Sara Ranjbarvaziri, Aliya Zeng, Iris Wu, Amara Greer-Short, Farshad Farshidfar, Ana Budan, Emma Xu, Reva Shenwai, Matthew Kozubov, Cindy Li, Melissa Van Pell, Francis Grafton, Charles E MacKay, Xiaomei Song, James R Priest, Gretchen Argast, Mohammad A. Mandegar, Timothy Hoey, Jin Yang

Nat Commun. 2024; 15: 1352. Published online 2024 Feb 26. doi: 10.1038/s41467-024-45440-7

Correction in:: Nat Commun. 2024; 15: 8749.

PMCID:: PMC10897156

Abstract Article PDF–2.0M

Select item 108800359.

Male histone deacetylase 6 (HDAC6) knockout mice have enhanced ventilatory responses to hypoxic challenge

Paulina M. Getsy, Gregory A. Coffee, Thomas J. Kelley, Stephen J. Lewis

Front Physiol. 2023; 14: 1332810. Published online 2024 Feb 6. doi: 10.3389/fphys.2023.1332810

PMCID:: PMC10880035

Abstract Article PDF–3.3M

Select item 1085095410.

HDAC6/aggresome processing pathway importance for inflammasome formation is context-dependent

Longlong Wang, Shihua Shi, Adeline Unterreiner, Ronan Kapetanovic, Sucheta Ghosh, Jacint Sanchez, Selma Aslani, Yuan Xiong, Chi-Lin Hsu, Katherine A. Donovan, Christopher J. Farady, Eric S. Fischer, Frédéric Bornancin, Patrick Matthias

J Biol Chem. 2024 Feb; 300(2): 105638. Published online 2024 Jan 8. doi: 10.1016/j.jbc.2024.105638

PMCID:: PMC10850954

Abstract Article PDF–1.9M

Select item 1056136011.

HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells

Jia Yang, Yang Liu, Hanxiao Yin, Songbo Xie, Linlin Zhang, Xifeng Dong, Hua Ni, Weiwen Bu, Hongbo Ma, Peng Liu, Haiyan Zhu, Rongxia Guo, Lei Sun, Yue Wu, Juan Qin, Baofa Sun, Dengwen Li, Hongbo R Luo, Min Liu, Chenghao Xuan, Jun Zhou

EMBO Rep. 2023 Oct; 24(10): e56009. Published online 2023 Aug 29. doi: 10.15252/embr.202256009

PMCID:: PMC10561360

Abstract Article PDF–3.9M

Select item 1033230112.

Histone deacetylase 6 inhibition exploits selective metabolic vulnerabilities in LKB1 mutant, KRAS driven non-small cell lung cancer

Hua Zhang, Christopher S. Nabel, Dezhi Li, Ruth Í. O’Connor, Caroline R. Crosby, Sarah M. Chang, Yuan Hao, Robyn Stanley, Soumyadip Sahu, Daniel S. Levin, Ting Chen, Sittinon Tang, Hsin-Yi Huang, Mary Meynardie, Janaye Stephens, Fiona Sherman, Alison Chafitz, Naoise Costelloe, Daniel A. Rodrigues, Hilda Fogarty, Miranda G. Kiernan, Fiona Cronin, Eleni Papadopoulos, Magdalena Ploszaj, Vajira Weerasekara, Jiehui Deng, Patrick Kiely, Nabeel Bardeesy, Matthew G. Vander Heiden, Triona Ni Chonghaile, Catríona M. Dowling, Kwok-Kin Wong

J Thorac Oncol. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: J Thorac Oncol. 2023 Jul; 18(7): 882–895. Published online 2023 Mar 22. doi: 10.1016/j.jtho.2023.03.014

PMCID:: PMC10332301

Abstract Article PDF–1.5M

Select item 1029868913.

HDAC6 Deficiency Has Moderate Effects on Behaviors and Parkinson’s Disease Pathology in Mice

Jiayin Zhao, Yongtao He, Yufei Duan, Yuanyuan Ma, Hongtian Dong, Xiaoshuang Zhang, Rong Fang, Yunhe Zhang, Mei Yu, Fang Huang

Int J Mol Sci. 2023 Jun; 24(12): 9975. Published online 2023 Jun 9. doi: 10.3390/ijms24129975

PMCID:: PMC10298689

Abstract Article PDF–5.5M

Select item 981161914.

The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6

Kohei Tsujimoto, Tatsunori Jo, Daiki Nagira, Hachiro Konaka, Jeong Hoon Park, Shin‐ichiro Yoshimura, Akinori Ninomiya, Fuminori Sugihara, Takehiro Hirayama, Eri Itotagawa, Yusei Matsuzaki, Yuki Takaichi, Wataru Aoki, Shotaro Saita, Shuhei Nakamura, Andrea Ballabio, Shigeyuki Nada, Masato Okada, Hyota Takamatsu, Atsushi Kumanogoh

EMBO J. 2023 Jan; 42(1): e111389. Published online 2022 Nov 29. doi: 10.15252/embj.2022111389

PMCID:: PMC9811619

Abstract Article PDF–4.2M

Select item 980057815.

Histone deacetylase 6 plays an important role in TGF-β-induced murine Treg cell differentiation by regulating cell proliferation

Ji Hyeon Lee, Hyeong Su Kim, Sung Woong Jang, Gap Ryol Lee

Sci Rep. 2022; 12: 22550. Published online 2022 Dec 29. doi: 10.1038/s41598-022-27230-7

PMCID:: PMC9800578

Abstract Article PDF–3.4M

Select item 961761716.

HDAC6 Inhibition Reverses Cisplatin-Induced Mechanical Hypersensitivity via Tonic Delta Opioid Receptor Signaling

Jixiang Zhang, Jazzmine M. Junigan, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen, Peter M. Grace

J Neurosci. 2022 Oct 19; 42(42): 7862–7874. doi: 10.1523/JNEUROSCI.1182-22.2022

PMCID:: PMC9617617

Abstract Article PDF–11M

Select item 952523617.

Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

René Winkler, Ann-Sophie Mägdefrau, Eva-Maria Piskor, Markus Kleemann, Mandy Beyer, Kevin Linke, Lisa Hansen, Anna-Maria Schaffer, Marina E. Hoffmann, Simon Poepsel, Florian Heyd, Petra Beli, Tarik Möröy, Siavosh Mahboobi, Oliver H. Krämer, Christian Kosan

Oncogene. 2022; 41(40): 4560–4572. Published online 2022 Sep 6. doi: 10.1038/s41388-022-02450-3

PMCID:: PMC9525236

Abstract Article PDF–2.6M

Select item 928788818.

H19 inhibition increases HDAC6 and regulates IRS1 levels and insulin signaling in the skeletal muscle during diabetes

Amit Kumar, Malabika Datta

Mol Med. 2022; 28: 81. Published online 2022 Jul 16. doi: 10.1186/s10020-022-00507-3

PMCID:: PMC9287888

Abstract Article PDF–2.9M

Select item 927726719.

Opposing roles of HDAC6 in liver regeneration and hepatocarcinogenesis

Sophors Phorl, Azra Memon, Yuri Seo, Thi Oanh Hoang, Trung Nghia Tran, Le Minh Tri Nguyen, Chang Hoon Lee, Woon Kyu Lee, Joo‐Yong Lee

Cancer Sci. 2022 Jul; 113(7): 2311–2322. Published online 2022 Jun 29. doi: 10.1111/cas.15391

PMCID:: PMC9277267

Abstract Article PDF–28M

Select item 916876220.

ARID1A‐deficient cells require HDAC6 for progression of endometrial carcinoma

Cristina Megino‐Luque, Pol Sisó, Natalia Mota‐Martorell, Raúl Navaridas, Inés de la Rosa, Izaskun Urdanibia, Manel Albertí‐Valls, Maria Santacana, Miquel Pinyol, Núria Bonifaci, Anna Macià, David Llobet‐Navas, Sònia Gatius, Xavier Matias‐Guiu, Núria Eritja

Mol Oncol. 2022 Jun; 16(11): 2235–2259. Published online 2022 Mar 2. doi: 10.1002/1878-0261.13193

PMCID:: PMC9168762

Abstract Article PDF–13M

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