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Items: 1 to 20 of 39

1.
The protective effect of DNase I in retinal vein occlusion
Guohua Deng, Xi Zou, Zhinan Liu, Hang Ren, Yanting Li, Bin Chen, Jun Zhang
Biomol Biomed. 2024 Apr 1; 24(2): 387–394. Published online 2024 Apr 1. doi: 10.17305/bb.2023.9780
PMCID:
PMC10950336
AbstractArticlePDF–4.5M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
DNases improve effectiveness of antibiotic treatment in murine polymicrobial sepsis
Jan-Fritjof Willemsen, Julia Wenskus, Moritz Lenz, Holger Rhode, Madgalena Trochimiuk, Birgit Appl, Laia Pagarol-Raluy, Daniela Börnigen, Corinna Bang, Konrad Reinshagen, Martin Herrmann, Julia Elrod, Michael Boettcher
Front Immunol. 2023; 14: 1254838. Published online 2024 Jan 8. doi: 10.3389/fimmu.2023.1254838
PMCID:
PMC10801052
AbstractArticlePDF–8.2M
4.
Neutrophil extracellular traps and DNases orchestrate formation of peritoneal adhesions
Julia Elrod, Annika Heuer, Jasmin Knopf, Janina Schoen, Lavinia Schönfeld, Magdalena Trochimiuk, Carolin Stiel, Birgit Appl, Laia Pagerols Raluy, Ceren Saygi, Leticija Zlatar, Sami Hosari, Dmytro Royzman, Thomas H. Winkler, Günter Lochnit, Moritz Leppkes, Robert Grützmann, Georg Schett, Christian Tomuschat, Konrad Reinshagen, Martin Herrmann, Tobias A. Fuchs, Michael Boettcher
iScience. 2023 Dec 15; 26(12): 108289. Published online 2023 Oct 27. doi: 10.1016/j.isci.2023.108289
PMCID:
PMC10682263
AbstractArticlePDF–7.0M
5.
Targeting NETs using dual-active DNase1 variants
Hanna Englert, Josephine Göbel, Danika Khong, Maryam Omidi, Nina Wolska, Sandra Konrath, Maike Frye, Reiner K. Mailer, Manu Beerens, Julian C. Gerwers, Roger J. S. Preston, Jacob Odeberg, Lynn M. Butler, Coen Maas, Evi X. Stavrou, Tobias A. Fuchs, Thomas Renné
Front Immunol. 2023; 14: 1181761. Published online 2023 May 23. doi: 10.3389/fimmu.2023.1181761
PMCID:
PMC10242134
AbstractArticlePDF–7.6M
6.
Secreted mammalian DNases protect against systemic bacterial infection by digesting biofilms
Keenan A. Lacey, Lee Serpas, Sohei Makita, Yueyang Wang, Ali Rashidfarrokhi, Chetna Soni, Sandra Gonzalez, Andre Moreira, Victor J. Torres, Boris Reizis
J Exp Med. 2023 Jun 5; 220(6): e20221086. Published online 2023 Mar 16. doi: 10.1084/jem.20221086
PMCID:
PMC10037111
AbstractArticlePDF–9.4M
7.
Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus
Marina A. Korn, Marie Steffensen, Carolin Brandl, Dmytro Royzman, Christoph Daniel, Thomas H. Winkler, Lars Nitschke
Front Immunol. 2023; 14: 1095830. Published online 2023 Mar 8. doi: 10.3389/fimmu.2023.1095830
PMCID:
PMC10030676
AbstractArticlePDF–5.8M
8.
Effects of nucleases on cell-free extrachromosomal circular DNA
Sarah T.K. Sin, Jiaen Deng, Lu Ji, Masashi Yukawa, Rebecca W.Y. Chan, Stefano Volpi, Augusto Vaglio, Paride Fenaroli, Paola Bocca, Suk Hang Cheng, Danny K.L. Wong, Kathy O. Lui, Peiyong Jiang, K.C. Allen Chan, Rossa W.K. Chiu, Y.M. Dennis Lo
JCI Insight. 2022 Apr 22; 7(8): e156070. Published online 2022 Apr 22. doi: 10.1172/jci.insight.156070
PMCID:
PMC9089787
AbstractArticlePDF–917K
9.
Nuclease deficiencies alter plasma cell-free DNA methylation profiles
Diana S.C. Han, Meng Ni, Rebecca W.Y. Chan, Danny K.L. Wong, Linda T. Hiraki, Stefano Volpi, Peiyong Jiang, Kathy O. Lui, K.C. Allen Chan, Rossa W.K. Chiu, Y.M. Dennis Lo
Genome Res. 2021 Nov; 31(11): 2008–2021. doi: 10.1101/gr.275426.121
PMCID:
PMC8559716
AbstractArticlePDF–3.1M
10.
Comparison of the secretory murine DNase1 family members expressed in Pichia pastoris
Lukas Verhülsdonk, Hans Georg Mannherz, Markus Napirei
PLoS One. 2021; 16(7): e0253476. Published online 2021 Jul 30. doi: 10.1371/journal.pone.0253476
PMCID:
PMC8323900
AbstractArticlePDF–4.0M
11.
Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus
Johannes Hartl, Lee Serpas, Yueyang Wang, Ali Rashidfarrokhi, Oriana A. Perez, Benjamin Sally, Vanja Sisirak, Chetna Soni, Alireza Khodadadi-Jamayran, Aristotelis Tsirigos, Ivan Caiello, Claudia Bracaglia, Stefano Volpi, Gian Marco Ghiggeri, Asiya Seema Chida, Ignacio Sanz, Mimi Y. Kim, H. Michael Belmont, Gregg J. Silverman, Robert M. Clancy, Peter M. Izmirly, Jill P. Buyon, Boris Reizis
J Exp Med. 2021 May 3; 218(5): e20201138. Published online 2021 Mar 30. doi: 10.1084/jem.20201138
PMCID:
PMC8020718
AbstractArticlePDF–4.6M
12.
Renal Dnase1 expression is regulated by FGF23 but loss of Dnase1 does not alter renal phosphate handling
Daniela Egli-Spichtig, Martin Y. H. Zhang, Alfred Li, Eva Maria Pastor Arroyo, Nati Hernando, Carsten A. Wagner, Wenhan Chang, Farzana Perwad
Sci Rep. 2021; 11: 6175. Published online 2021 Mar 17. doi: 10.1038/s41598-021-84735-3
PMCID:
PMC7969776
AbstractArticlePDF–2.1M
13.
Deoxyribonuclease 1-Mediated Clearance of Circulating Chromatin Prevents From Immune Cell Activation and Pro-inflammatory Cytokine Production, a Phenomenon Amplified by Low Trap1 Activity: Consequences for Systemic Lupus Erythematosus
Jasmin Felux, Annika Erbacher, Magali Breckler, Roxane Hervé, Delphine Lemeiter, Hans Georg Mannherz, Markus Napirei, Hans-Georg Rammensee, Patrice Decker
Front Immunol. 2021; 12: 613597. Published online 2021 Mar 4. doi: 10.3389/fimmu.2021.613597
PMCID:
PMC7969502
AbstractArticlePDF–6.0M
14.
Therapeutic Targeting of Neutrophil Extracellular Traps Improves Primary and Secondary Intention Wound Healing in Mice
Annika Heuer, Carolin Stiel, Julia Elrod, Ingo Königs, Deirdre Vincent, Patrick Schlegel, Magdalena Trochimiuk, Birgit Appl, Konrad Reinshagen, Laia Pagerols Raluy, Michael Boettcher
Front Immunol. 2021; 12: 614347. Published online 2021 Feb 25. doi: 10.3389/fimmu.2021.614347
PMCID:
PMC7947714
AbstractArticlePDF–2.8M
15.
The Biology of Cell-free DNA Fragmentation and the Roles of DNASE1, DNASE1L3, and DFFB
Diana S.C. Han, Meng Ni, Rebecca W.Y. Chan, Vicken W.H. Chan, Kathy O. Lui, Rossa W.K. Chiu, Y.M. Dennis Lo
Am J Hum Genet. 2020 Feb 6; 106(2): 202–214. Published online 2020 Jan 30. doi: 10.1016/j.ajhg.2020.01.008
PMCID:
PMC7010979
AbstractArticlePDF–4.0M
16.
Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA
Lee Serpas, Rebecca W. Y. Chan, Peiyong Jiang, Meng Ni, Kun Sun, Ali Rashidfarrokhi, Chetna Soni, Vanja Sisirak, Wing-Shan Lee, Suk Hang Cheng, Wenlei Peng, K. C. Allen Chan, Rossa W. K. Chiu, Boris Reizis, Y. M. Dennis Lo
Proc Natl Acad Sci U S A. 2019 Jan 8; 116(2): 641–649. Published online 2018 Dec 28. doi: 10.1073/pnas.1815031116
PMCID:
PMC6329986
AbstractArticlePDF–864K
17.
Extrinsic Phagocyte-Dependent STING-Signaling Dictates the Immunogenicity of Dying Cells
Jeonghyun Ahn, Tianli Xia, Ailem Rabasa Capote, Dillon Betancourt, Glen N Barber
Cancer Cell. Author manuscript; available in PMC 2019 May 14.
Published in final edited form as: Cancer Cell. 2018 May 14; 33(5): 862–873.e5. Published online 2018 Apr 26. doi: 10.1016/j.ccell.2018.03.027
PMCID:
PMC6177226
AbstractArticlePDF–1.0M
18.
Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis
Heinz Fischer, Maria Buchberger, Markus Napirei, Erwin Tschachler, Leopold Eckhart
Sci Rep. 2017; 7: 6433. Published online 2017 Jul 25. doi: 10.1038/s41598-017-06652-8
PMCID:
PMC5527052
AbstractArticlePDF–1.8M
19.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
20.
HMGN1 Modulates Nucleosome Occupancy and DNase I Hypersensitivity at the CpG Island Promoters of Embryonic Stem Cells
Tao Deng, Z. Iris Zhu, Shaofei Zhang, Fenfei Leng, Srujana Cherukuri, Loren Hansen, Leonardo Mariño-Ramírez, Eran Meshorer, David Landsman, Michael Bustin
Mol Cell Biol. 2013 Aug; 33(16): 3377–3389. doi: 10.1128/MCB.00435-13
Correction in:
Mol Cell Biol. 2018 Jun 15; 38(12): e00185-18.
PMCID:
PMC3753902
AbstractArticlePDF–4.2M

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