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Items: 1 to 20 of 67

1.
PAK2 is necessary for myelination in the peripheral nervous system
Bo Hu, Daniel Moiseev, Isabella Schena, Bulat Faezov, Roland Dunbrack, Jonathan Chernoff, Jun Li
Brain. 2024 May; 147(5): 1809–1821. Published online 2023 Dec 11. doi: 10.1093/brain/awad413
PMCID:
PMC11068108
AbstractArticlePDF–1.6M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
PAK2 is essential for chromosome alignment in metaphase I oocytes
Juan Zeng, Shiwei Wang, Min Gao, Dian Lu, Shuang Song, Diyu Chen, Weimin Fan, Zhiliang Xu, Zhiguo Zhang, Xiaofang Sun
Cell Death Dis. 2023 Feb; 14(2): 150. Published online 2023 Feb 22. doi: 10.1038/s41419-023-05585-7
PMCID:
PMC9947007
AbstractArticlePDF–5.3M
4.
Loss‐of‐Function of p21‐Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects
Yan Wang, Kaifan Zhang, Jin Guo, Shuyan Yang, Xiaohui Shi, Jinrong Pan, Zheng Sun, Jizhen Zou, Yi Li, Yuanyuan Li, Tianda Fan, Wei Song, Fang Cheng, Cheng Zeng, Jinchen Li, Ting Zhang, Zhong Sheng Sun
Adv Sci (Weinh) 2023 Feb; 10(4): 2204018. Published online 2022 Dec 11. doi: 10.1002/advs.202204018
PMCID:
PMC9896034
AbstractArticlePDF–4.9M
5.
Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation
Mahesh Kathania, Ritesh Kumar, Elviche Taskem Lenou, Venkatesha Basrur, Arianne L. Theiss, Jonathan Chernoff, K. Venuprasad
Cell Rep. Author manuscript; available in PMC 2022 Sep 25.
Published in final edited form as: Cell Rep. 2022 Sep 13; 40(11): 111345. doi: 10.1016/j.celrep.2022.111345
PMCID:
PMC9510046
AbstractArticlePDF–1.4M
6.
Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling
Eleonora Sementino, Yuwaraj Kadariya, Mitchell Cheung, Craig W. Menges, Yinfei Tan, Anna-Mariya Kukuyan, Ujjawal Shrestha, Sofiia Karchugina, Kathy Q. Cai, Suraj Peri, James S. Duncan, Jonathan Chernoff, Joseph R. Testa
Mol Cancer Res. Author manuscript; available in PMC 2022 Nov 4.
Published in final edited form as: Mol Cancer Res. 2022 May 4; 20(5): 699–711. doi: 10.1158/1541-7786.MCR-21-0837
PMCID:
PMC9081258
AbstractArticlePDF–2.3M
7.
Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart
Pablo Binder, Binh Nguyen, Lucy Collins, Min Zi, Wei Liu, Foteini Christou, Xiaojing Luo, Susanne S. Hille, Norbert Frey, Elizabeth J. Cartwright, Jonathan Chernoff, Oliver J. Müller, Kaomei Guan, Xin Wang
Front Cardiovasc Med. 2022; 9: 851419. Published online 2022 Mar 8. doi: 10.3389/fcvm.2022.851419
PMCID:
PMC8957820
AbstractArticlePDF–3.8M
8.
Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy
Namrita Kaur, Andrea Ruiz-Velasco, Rida Raja, Gareth Howell, Jessica M. Miller, Riham R.E. Abouleisa, Qinghui Ou, Kimberly Mace, Susanne S. Hille, Norbert Frey, Pablo Binder, Craig P. Smith, Helene Fachim, Handrean Soran, Eileithyia Swanton, Tamer M.A. Mohamed, Oliver J. Müller, Xin Wang, Jonathan Chernoff, Elizabeth J. Cartwright, Wei Liu
iScience. 2022 Mar 18; 25(3): 103973. Published online 2022 Feb 23. doi: 10.1016/j.isci.2022.103973
PMCID:
PMC8905320
AbstractArticlePDF–6.4M
9.
Pak2 reduction induces a failure of early embryonic development in mice
Juan Zeng, Nengqing Liu, Yinghong Yang, Yi Cheng, Yuanshuai Li, Xiaoxia Guo, Qian Luo, Lifen Zhu, Hongmei Guan, Bing Song, Xiaofang Sun
Reprod Biol Endocrinol. 2021; 19: 181. Published online 2021 Dec 9. doi: 10.1186/s12958-021-00865-3
PMCID:
PMC8656077
AbstractArticlePDF–1.5M
10.
PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2)
Eric Hawley, Jeffrey Gehlhausen, Sofiia Karchugina, Hoi-Yee Chow, Daniela Araiza-Olivera, Maria Radu, Abbi Smith, Ciersten Burks, Li Jiang, Xiaohong Li, Waylan Bessler, Andrea Masters, Donna Edwards, Callie Burgin, David Jones, Charles Yates, D Wade Clapp, Jonathan Chernoff, Su-Jung Park
Hum Mol Genet. 2021 Sep 1; 30(17): 1607–1617. Published online 2021 Jun 1. doi: 10.1093/hmg/ddab106
PMCID:
PMC8369838
AbstractArticlePDF–1.6M
11.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
12.
Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons
Kazuhiro Hada, Bolati Wulaer, Taku Nagai, Norimichi Itoh, Masahito Sawahata, Akira Sobue, Hiroyuki Mizoguchi, Daisuke Mori, Itaru Kushima, Toshitaka Nabeshima, Norio Ozaki, Kiyofumi Yamada
Mol Brain. 2021; 14: 21. Published online 2021 Jan 22. doi: 10.1186/s13041-021-00735-4
PMCID:
PMC7821731
AbstractArticlePDF–2.8M
13.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
14.
The p21‐activated kinase 2 (PAK2), but not PAK1, regulates contraction‐stimulated skeletal muscle glucose transport
Lisbeth L. V. Møller, Ida L. Nielsen, Jonas R. Knudsen, Nicoline R. Andersen, Thomas E. Jensen, Lykke Sylow, Erik A. Richter
Physiol Rep. 2020 Jun; 8(12): e14460. Published online 2020 Jun 29. doi: 10.14814/phy2.14460
PMCID:
PMC7322983
AbstractArticlePDF–2.1M
15.
The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway
Yong Deok Lee, Bongjun Kim, Suhan Jung, Haemin Kim, Min Kyung Kim, Jun-Oh Kwon, Min-Kyoung Song, Zang Hee Lee, Hong-Hee Kim
Exp Mol Med. 2020 Mar; 52(3): 514–528. Published online 2020 Mar 24. doi: 10.1038/s12276-020-0406-0
PMCID:
PMC7156411
AbstractArticlePDF–7.4M
16.
MicroRNA-455-3p promotes TGF-β signaling and inhibits osteoarthritis development by directly targeting PAK2
Shu Hu, Xiaoyi Zhao, Guping Mao, Ziji Zhang, Xingzhao Wen, Chengyun Zhang, Weiming Liao, Zhiqi Zhang
Exp Mol Med. 2019 Oct; 51(10): 118. Published online 2019 Oct 4. doi: 10.1038/s12276-019-0322-3
PMCID:
PMC6802609
AbstractArticlePDF–2.4M
17.
Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion
Timothy P. Rutkowski, Ryan H. Purcell, Rebecca M. Pollak, Stephanie M. Grewenow, Georgette M. Gafford, Tamika Malone, Uswa A. Khan, Jason P. Schroeder, Michael P. Epstein, Gary J. Bassell, Stephen T. Warren, David Weinshenker, Tamara Caspary, Jennifer Gladys Mulle
Mol Psychiatry. 2021; 26(3): 772–783. Published online 2019 Apr 11. doi: 10.1038/s41380-019-0413-5
PMCID:
PMC6788962
AbstractArticlePDF–1.8M
18.
A GIT1/PIX/Rac/PAK Signaling Module Regulates Spine Morphogenesis and Synapse Formation through MLC
Huaye Zhang, Donna J. Webb, Hannelore Asmussen, Shuang Niu, Alan F. Horwitz
J Neurosci. 2005 Mar 30; 25(13): 3379–3388. doi: 10.1523/JNEUROSCI.3553-04.2005
PMCID:
PMC6724907
AbstractArticlePDF–1.0M
19.
Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation
Cheng-Yi Yang, Ting-Hsuan Yu, Wan-Ling Wen, Pin Ling, Kuei-Sen Hsu
J Neurosci. 2019 Jun 19; 39(25): 4959–4975. doi: 10.1523/JNEUROSCI.2395-18.2019
PMCID:
PMC6670244
AbstractArticlePDF–3.4M
20.
Pak2 kinase promotes cellular senescence and organismal aging
Jong-Sun Lee, Yan Mo, Haiyun Gan, Rebecca J. Burgess, Darren J. Baker, Jan M. van Deursen, Zhiguo Zhang
Proc Natl Acad Sci U S A. 2019 Jul 2; 116(27): 13311–13319. Published online 2019 Jun 17. doi: 10.1073/pnas.1903847116
PMCID:
PMC6613284
AbstractArticlePDF–2.0M

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