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Select item 109012391.

Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity

Yaoyuan Zhang, Rhiannon Morris, Grant J. Brown, Ayla May D. Lorenzo, Xiangpeng Meng, Nadia J. Kershaw, Pamudika Kiridena, Gaétan Burgio, Simon Gross, Jean Y. Cappello, Qian Shen, Hao Wang, Cynthia Turnbull, Tom Lea-Henry, Maurice Stanley, Zhijia Yu, Fiona D. Ballard, Aaron Chuah, James C. Lee, Ann-Maree Hatch, Anselm Enders, Seth L. Masters, Alexander P. Headley, Peter Trnka, Dominic Mallon, Jeffery T. Fletcher, Giles D. Walters, Mario Šestan, Marija Jelušić, Matthew C. Cook, Vicki Athanasopoulos, David A. Fulcher, Jeffrey J. Babon, Carola G. Vinuesa, Julia I. Ellyard

J Exp Med. 2024 Apr 1; 221(4): e20221080. Published online 2024 Feb 28. doi: 10.1084/jem.20221080

PMCID:: PMC10901239

Abstract Article PDF–6.2M

Select item 89455792.

Nf1 and Sh2b3 mutations cooperate in vivo in a mouse model of juvenile myelomonocytic leukemia

Carolina E. Morales, Elliot Stieglitz, Scott C. Kogan, Mignon L. Loh, Benjamin S. Braun

Blood Adv. 2021 Sep 28; 5(18): 3587–3591. Prepublished online 2021 Aug 31. Published online 2021 Sep 22. doi: 10.1182/bloodadvances.2020003754

PMCID:: PMC8945579

Abstract Article PDF–937K

Select item 86635403.

Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency

Huijuan Dou, Andriana Kotini, Wenli Liu, Trevor Fidler, Kaori Endo-Umeda, Xiaoli Sun, Malgorzata Olszewska, Tong Xiao, Sandra Abramowicz, Mustafa Yalcinkaya, Brian Hardaway, Sotirios Tsimikas, Xuchu Que, Alexander Bick, Conor Emdin, Pradeep Natarajan, Eirini P. Papapetrou, Joseph L. Witztum, Nan Wang, Alan R. Tall

Circulation. 2021 Dec 14; 144(24): 1940–1954. Published online 2021 Nov 30. doi: 10.1161/CIRCULATIONAHA.121.056414

Correction in:: Circulation. 2022 Jul 26; 146(4): e13.

PMCID:: PMC8663540

Abstract Article PDF–4.4M

Select item 86129724.

The autoimmune risk R262W variant of the adaptor SH2B3 improves survival in sepsis

Eric J. Allenspach, Nicholas J. Shubin, Karen Cerosaletti, Carmen Mikacenic, Jacquelyn A Gorman, Matthew A. MacQuivey, Aaron B.I. Rosen, Andrew E. Timms, Michelle N. Wray-Dutra, Kerri Niino, Denny Liggitt, Mark M. Wurfel, Jane H. Buckner, Adrian M. Piliponsky, David J. Rawlings

J Immunol. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: J Immunol. 2021 Dec 1; 207(11): 2710–2719. Published online 2021 Nov 5. doi: 10.4049/jimmunol.2100454

PMCID:: PMC8612972

Abstract Article PDF–2.5M

Select item 79061735.

LNK promotes granulosa cell apoptosis in PCOS via negatively regulating insulin-stimulated AKT-FOXO3 pathway

Min Tan, Yanxiang Cheng, Xiaozhu Zhong, Dongyong Yang, Sushi Jiang, Yang Ye, Miao Ding, Guijun Guan, Dongzi Yang, Xiaomiao Zhao

Aging (Albany NY) 2021 Feb 15; 13(3): 4617–4633. Published online 2021 Jan 20. doi: 10.18632/aging.202421

PMCID:: PMC7906173

Abstract Article PDF–1.2M

Select item 73390126.

Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3

Markus Wolfien, Denise Klatt, Amankeldi A. Salybekov, Masaaki Ii, Miki Komatsu-Horii, Ralf Gaebel, Julia Philippou-Massier, Eric Schrinner, Hiroshi Akimaru, Erika Akimaru, Robert David, Jens Garbade, Jan Gummert, Axel Haverich, Holger Hennig, Hiroto Iwasaki, Alexander Kaminski, Atsuhiko Kawamoto, Christian Klopsch, Johannes T. Kowallick, Stefan Krebs, Julia Nesteruk, Hermann Reichenspurner, Christian Ritter, Christof Stamm, Ayumi Tani-Yokoyama, Helmut Blum, Olaf Wolkenhauer, Axel Schambach, Takayuki Asahara, Gustav Steinhoff

EBioMedicine. 2020 Jul; 57: 102862. Published online 2020 Jul 4. doi: 10.1016/j.ebiom.2020.102862

PMCID:: PMC7339012

Abstract Article PDF–3.9M

Select item 66220837.

Adaptor Protein LNK Is a Negative Regulator of Brain Neural Stem Cell Proliferation after Stroke

Henrik Ahlenius, Karthikeyan Devaraju, Emanuela Monni, Koichi Oki, Somsak Wattananit, Vladimer Darsalia, Robert E. Iosif, Olof Torper, James C. Wood, Sebastian Braun, Lucas Jagemann, Ulrike A. Nuber, Elisabet Englund, Sten-Eirik W. Jacobsen, Olle Lindvall, Zaal Kokaia

J Neurosci. 2012 Apr 11; 32(15): 5151–5164. doi: 10.1523/JNEUROSCI.0474-12.2012

PMCID:: PMC6622083

Abstract Article PDF–3.6M

Select item 65275658.

LNK suppresses interferon signaling in melanoma

Ling-Wen Ding, Qiao-Yang Sun, Jarem J. Edwards, Lucia Torres Fernández, Xue-Bin Ran, Si-Qin Zhou, Richard A. Scolyer, James S. Wilmott, John F. Thompson, Ngan Doan, Jonathan W. Said, Nachiyappan Venkatachalam, Jin-Fen Xiao, Xin-Yi Loh, Maren Pein, Liang Xu, David W. Mullins, Henry Yang, De-Chen Lin, H. Phillip Koeffler

Nat Commun. 2019; 10: 2230. Published online 2019 May 20. doi: 10.1038/s41467-019-09711-y

PMCID:: PMC6527565

Abstract Article PDF–2.9M

Select item 64504309.

The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination

Ryan Donaghy, Xu Han, Krasimira Rozenova, Kaosheng Lv, Qinqin Jiang, Miriam Doepner, Roger A. Greenberg, Wei Tong

Blood. 2019 Apr 4; 133(14): 1560–1571. Prepublished online 2019 Feb 12. doi: 10.1182/blood-2018-10-877563

PMCID:: PMC6450430

Abstract Article

Select item 623747810.

LNK deficiency promotes acute aortic dissection and rupture

Fanny Laroumanie, Arina Korneva, Matthew R. Bersi, Matthew R. Alexander, Liang Xiao, Xue Zhong, Justin P. Van Beusecum, Yuhan Chen, Mohamed A. Saleh, William G. McMaster, Kyle A. Gavulic, Bethany L. Dale, Shilin Zhao, Yan Guo, Yu Shyr, Daniel S. Perrien, Nancy J. Cox, John A. Curci, Jay D. Humphrey, Meena S. Madhur

JCI Insight. 2018 Oct 18; 3(20): e122558. Published online 2018 Oct 18. doi: 10.1172/jci.insight.122558

PMCID:: PMC6237478

Abstract Article PDF–2.2M

Select item 615642211.

Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia

Joanna Balcerek, Jing Jiang, Yang Li, Qinqin Jiang, Nicholas Holdreith, Brijendra Singh, Vemika Chandra, Kaosheng Lv, Jian-gang Ren, Krasimira Rozenova, Weihua Li, Roger A. Greenberg, Wei Tong

Nat Commun. 2018; 9: 3915. Published online 2018 Sep 25. doi: 10.1038/s41467-018-06380-1

PMCID:: PMC6156422

Abstract Article PDF–1.4M

Select item 556227912.

Lnk Deficiency leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype

David J. Olivos, III, Marta Alvarez, Ying-Hua Cheng, R. Adam Hooker, Wendy A. Ciovacco, Monique Bethel, Haley McGough, Christopher Yim, Brahmananda R. Chitteti, Pierre P. Eleniste, Mark C. Horowitz, Edward F. Srour, Angela Bruzzaniti, Robyn K. Fuchs, Melissa A. Kacena

J Cell Biochem. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: J Cell Biochem. 2017 Aug; 118(8): 2231–2240. Published online 2017 Apr 18. doi: 10.1002/jcb.25874

PMCID:: PMC5562279

Abstract Article PDF–963K

Select item 549511813.

CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies

Kaosheng Lv, Jing Jiang, Ryan Donaghy, Christopher R. Riling, Ying Cheng, Vemika Chandra, Krasimira Rozenova, Wei An, Bhopal C. Mohapatra, Benjamin T. Goetz, Vinodh Pillai, Xu Han, Emily A. Todd, Grace R. Jeschke, Wallace Y. Langdon, Suresh Kumar, Elizabeth O. Hexner, Hamid Band, Wei Tong

Genes Dev. 2017 May 15; 31(10): 1007–1023. doi: 10.1101/gad.297135.117

PMCID:: PMC5495118

Abstract Article PDF–728K

Select item 529169614.

Control of B Cell Production by the Adaptor Protein Lnk: Definition of a Conserved Family of Signal-Modulating Proteins

Satoshi Takaki, Karsten Sauer, Brian M. Iritani, Sylvia Chien, Yasuhiro Ebihara, Kohichiro Tsuji, Kiyoshi Takatsu, Roger M. Perlmutter

Immunity. Author manuscript; available in PMC 2017 Feb 3.

Published in final edited form as: Immunity. 2000 Nov; 13(5): 599–609. doi: 10.1016/s1074-7613(00)00060-1

PMCID:: PMC5291696

Abstract Article PDF–1.3M

Select item 508451415.

Specific disruption of Lnk in murine endothelial progenitor cells promotes dermal wound healing via enhanced vasculogenesis, activation of myofibroblasts, and suppression of inflammatory cell recruitment

Jun Hee Lee, Seung Taek Ji, Jaeho Kim, Satoshi Takaki, Takayuki Asahara, Young-Joon Hong, Sang-Mo Kwon

Stem Cell Res Ther. 2016; 7: 158. Published online 2016 Oct 28. doi: 10.1186/s13287-016-0403-3

Correction in:: Stem Cell Res Ther. 2017; 8: 50.

PMCID:: PMC5084514

Abstract Article PDF–2.0M

Select item 501608316.

LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis

Wei Wang, Yang Tang, Ying Wang, Liana Tascau, Joanna Balcerek, Wei Tong, Ross L. Levine, Carrie Welch, Alan R. Tall, Nan Wang

Circ Res. Author manuscript; available in PMC 2017 Sep 2.

Published in final edited form as: Circ Res. 2016 Sep 2; 119(6): e91–e103. Published online 2016 Jul 18. doi: 10.1161/CIRCRESAHA.116.308955

PMCID:: PMC5016083

Abstract Article PDF–1.3M

Select item 481111717.

LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors

Ying Cheng, Kudakwashe Chikwava, Chao Wu, Haibing Zhang, Anchit Bhagat, Dehua Pei, John K. Choi, Wei Tong

J Clin Invest. 2016 Apr 1; 126(4): 1267–1281. Published online 2016 Mar 14. doi: 10.1172/JCI81468

PMCID:: PMC4811117

Abstract Article PDF–3.0M

Select item 442255618.

Integrative network analysis reveals molecular mechanisms of blood pressure regulation

Tianxiao Huan, Qingying Meng, Mohamed A Saleh, Allison E Norlander, Roby Joehanes, Jun Zhu, Brian H Chen, Bin Zhang, Andrew D Johnson, Saixia Ying, Paul Courchesne, Nalini Raghavachari, Richard Wang, Poching Liu, The International Consortium for Blood Pressure GWAS (ICBP), Christopher J O'Donnell, Ramachandran Vasan, Peter J Munson, Meena S Madhur, David G Harrison, Xia Yang, Daniel Levy

Mol Syst Biol. 2015 Apr; 11(4): 799. Published online 2015 Apr 16. doi: 10.15252/msb.20145399

PMCID:: PMC4422556

Abstract Article PDF–1.1M

Select item 436226619.

Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation

Mohamed A. Saleh, William G. McMaster, Jing Wu, Allison E. Norlander, Samuel A. Funt, Salim R. Thabet, Annet Kirabo, Liang Xiao, Wei Chen, Hana A. Itani, Danielle Michell, Tianxiao Huan, Yahua Zhang, Satoshi Takaki, Jens Titze, Daniel Levy, David G. Harrison, Meena S. Madhur

J Clin Invest. 2015 Mar 2; 125(3): 1189–1202. Published online 2015 Feb 9. doi: 10.1172/JCI76327

PMCID:: PMC4362266

Abstract Article PDF–4.7M

Select item 416558320.

Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and capns1 as potential mediator of caveolin-1-induced apoptosis

Yogesh M Kulkarni, Changxing Liu, Qi Qi, Yanmei Zhu, David J Klinke, Jun Liu

Analyst. Author manuscript; available in PMC 2014 Sep 21.

Published in final edited form as: Analyst. 2013 Nov 21; 138(22): 6986–6996. doi: 10.1039/c3an36819j

PMCID:: PMC4165583

Abstract Article PDF–2.9M

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