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Select item 116121381.

TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia

Jenny Bröker-Lai, José Rego Terol, Christin Richter, Ilka Mathar, Angela Wirth, Stefan Kopf, Ana Moreno-Pérez, Michael Büttner, Linette Liqi Tan, Mazen Makke, Gernot Poschet, Julia Hermann, Volodymyr Tsvilovskyy, Uwe Haberkorn, Philipp Wartenberg, Sebastian Susperreguy, Michael Berlin, Roger Ottenheijm, Koenraad Philippaert, Moya Wu, Tobias Wiedemann, Stephan Herzig, Anouar Belkacemi, Rebecca T Levinson, Nitin Agarwal, Juan E Camacho Londoño, Bert Klebl, Klaus Dinkel, Frank Zufall, Peter Nussbaumer, Ulrich Boehm, Rüdiger Hell, Peter Nawroth, Lutz Birnbaumer, Trese Leinders-Zufall, Rohini Kuner, Markus Zorn, Dieter Bruns, Yvonne Schwarz, Marc Freichel

EMBO J. 2024 Dec; 43(23): 5813–5836. Published online 2024 Oct 7. doi: 10.1038/s44318-024-00231-0

PMCID:: PMC11612138

Article PDF–3.4M

Select item 113170932.

Normotensive metabolic syndrome in Transient Receptor Potential Canonical Channel type 1 Trpc1^−/− mice.

Richard Matthew Atkins, Meghan Pantalia, Christopher Skaggs, Alexander Ku Lau, Muhammad Bilal Mahmood, Muhammad Mubeen Anwar, Lindsay Barron, Bonnie Eby, Usman Khan, Leo Tsiokas, Kai Lau

Biol Open. 2024 Jul 15; 13(7): bio060280. Published online 2024 Jul 31. doi: 10.1242/bio.060280

PMCID:: PMC11317093

Article PDF–1.0M

Select item 111482823.

TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer

Yanting Lin, Rui Gao, Dongquan Jing, Yiming Liu, Huijuan Da, Lutz Birnbaumer, Yong Yang, Xinghua Gao, Zhenhua Gao, Qiuhua Cao

Front Pharmacol. 2024; 15: 1392328. Published online 2024 May 21. doi: 10.3389/fphar.2024.1392328

PMCID:: PMC11148282

Article PDF–5.1M

Select item 111156294.

Functional interaction between TRPC1 channel and connexin-43 protein: a novel pathway underlying S1P action on skeletal myogenesis

Elisabetta Meacci, Francesca Bini, Chiara Sassoli, Maria Martinesi, Roberta Squecco, Flaminia Chellini, Sandra Zecchi-Orlandini, Fabio Francini, Lucia Formigli

Cell Mol Life Sci. 2010 Dec; 67(24): 4269–4285. Published online 2010 Jul 8. doi: 10.1007/s00018-010-0442-3

PMCID:: PMC11115629

Article PDF–1.3M

Select item 109176605.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Article PDF–4.8M

Select item 106826446.

Loss of Ca²⁺ entry via Orai–TRPC1 induces ER stress, initiating immune activation in macrophages

Viviane Nascimento Da Conceicao, Yuyang Sun, Emily K. Zboril, Jorge J. De la Chapa, Brij B. Singh

J Cell Sci. 2020 Mar 1; 133(5): jcs237610. Published online 2019 Dec 18. doi: 10.1242/jcs.237610

PMCID:: PMC10682644

Article

Select item 97683287.

Deletion of classical transient receptor potential 1, 3 and 6 alters pulmonary vasoconstriction in chronic hypoxia-induced pulmonary hypertension in mice

Kathrin Malkmus, Monika Brosien, Fenja Knoepp, Lisa Schaffelhofer, Friedrich Grimminger, Christoph Rummel, Thomas Gudermann, Alexander Dietrich, Lutz Birnbaumer, Norbert Weissmann, Simone Kraut

Front Physiol. 2022; 13: 1080875. Published online 2022 Dec 7. doi: 10.3389/fphys.2022.1080875

PMCID:: PMC9768328

Article PDF–2.4M

Select item 97188418.

TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca²⁺ leakage

Na Tang, Wen Tian, Guang-Yuan Ma, Xiong Xiao, Lei Zhou, Ze-Zhi Li, Xiao-Xiao Liu, Chong-Yao Li, Ke-Han Wu, Wenjuan Liu, Xue-Ying Wang, Yuan-Yuan Gao, Xin Yang, Jianzhao Qi, Ding Li, Yang Liu, Wen-Sheng Chen, Jinming Gao, Xiao-Qiang Li, Wei Cao

Nat Commun. 2022; 13: 7455. Published online 2022 Dec 2. doi: 10.1038/s41467-022-35242-0

PMCID:: PMC9718841

Article PDF–4.7M

Select item 95747779.

Store-operated Ca²⁺ entry and Ca²⁺ responses to hypothalamic releasing hormones in anterior pituitary cells from Orai1−/− and heptaTRPC knockout mice

Lucía Núñez, Gary S. Bird, Elena Hernando-Pérez, Enrique Pérez-Riesgo, James W. Putney, Jr, Carlos Villalobos

Biochim Biophys Acta Mol Cell Res. Author manuscript; available in PMC 2022 Oct 17.

Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2019 Jul; 1866(7): 1124–1136. Published online 2018 Nov 17. doi: 10.1016/j.bbamcr.2018.11.006

PMCID:: PMC9574777

Article PDF–1.8M

Select item 911991910.

TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Müller cells

Andrew O. Jo, Monika Lakk, Christopher N. Rudzitis, David Križaj

Cell Calcium. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Cell Calcium. 2022 Jun; 104: 102588. Published online 2022 Apr 5. doi: 10.1016/j.ceca.2022.102588

PMCID:: PMC9119919

Article PDF–764K

Select item 896092711.

Lipidomic Analysis of TRPC1 Ca²⁺-Permeable Channel-Knock Out Mouse Demonstrates a Vital Role in Placental Tissue Sphingolipid and Triacylglycerol Homeostasis Under Maternal High-Fat Diet

Michael R. Bukowski, Brij B. Singh, James N. Roemmich, Kate J. Claycombe-Larson

Front Endocrinol (Lausanne) 2022; 13: 854269. Published online 2022 Mar 10. doi: 10.3389/fendo.2022.854269

Correction in:: Front Endocrinol (Lausanne). 2022; 13: 949419.

PMCID:: PMC8960927

Article PDF–2.5M

Select item 859142312.

Resolving macrophage polarization through distinct Ca²⁺ entry channel that maintains intracellular signaling and mitochondrial bioenergetics

Viviane Nascimento Da Conceicao, Yuyang Sun, Karthik Ramachandran, Arun Chauhan, Amritha Raveendran, Manigandan Venkatesan, Bony DeKumar, Soumya Maity, Neelanjan Vishnu, George A. Kotsakis, Paul F. Worley, Donald L. Gill, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh

iScience. 2021 Nov 19; 24(11): 103339. Published online 2021 Oct 23. doi: 10.1016/j.isci.2021.103339

PMCID:: PMC8591423

Article PDF–5.5M

Select item 823328313.

Mapping the expression of transient receptor potential channels across murine placental development

Katrien De Clercq, Vicente Pérez-García, Rieta Van Bree, Federica Pollastro, Karen Peeraer, Thomas Voets, Joris Vriens

Cell Mol Life Sci. 2021 Jun; 78(11): 4993–5014. Published online 2021 Apr 21. doi: 10.1007/s00018-021-03837-3

PMCID:: PMC8233283

Article PDF–4.1M

Select item 742601614.

Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1^−/- mice

Harry Z.E. Greenberg, Simonette R.E. Carlton-Carew, Alexander K. Zargaran, Kazi S. Jahan, Lutz Birnbaumer, Anthony P. Albert

Channels (Austin) 2019; 13(1): 410–423. Published online 2019 Oct 11. doi: 10.1080/19336950.2019.1673131

PMCID:: PMC7426016

Article PDF–2.0M

Select item 732635315.

TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations

John J. O'Malley, Frederik Seibt, Jeannie Chin, Michael Beierlein

J Neurosci. 2020 Jun 17; 40(25): 4813–4823. doi: 10.1523/JNEUROSCI.0324-20.2020

PMCID:: PMC7326353

Article PDF–2.0M

Select item 719087416.

RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways

Karina Formoso, Sebastian Susperreguy, Marc Freichel, Lutz Birnbaumer

Sci Rep. 2020; 10: 7227. Published online 2020 Apr 29. doi: 10.1038/s41598-020-61177-x

PMCID:: PMC7190874

Article PDF–4.0M

Select item 717663917.

Store-operated Ca²⁺ entry in primary murine lung fibroblasts is independent of classical transient receptor potential (TRPC) channels and contributes to cell migration

Larissa Bendiks, Fabienne Geiger, Thomas Gudermann, Stefan Feske, Alexander Dietrich

Sci Rep. 2020; 10: 6812. Published online 2020 Apr 22. doi: 10.1038/s41598-020-63677-2

PMCID:: PMC7176639

Article PDF–1.6M

Select item 715660118.

Analysis of Mrgprb2 Receptor-Evoked Ca²⁺ Signaling in Bone Marrow Derived (BMMC) and Peritoneal (PMC) Mast Cells of TRPC-Deficient Mice

Volodymyr Tsvilovskyy, Alejandra Solis-Lopez, Julia Almering, Christin Richter, Lutz Birnbaumer, Alexander Dietrich, Marc Freichel

Front Immunol. 2020; 11: 564. Published online 2020 Apr 8. doi: 10.3389/fimmu.2020.00564

PMCID:: PMC7156601

Article PDF–1.6M

Select item 714053019.

Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis

Jizheng Guo, Jie Li, Lin Xia, Yang Wang, Jinhang Zhu, Juan Du, Yungang Lu, Guodong Liu, Xiaoqiang Yao, Bing Shen

Cells. 2020 Mar; 9(3): 547. Published online 2020 Feb 26. doi: 10.3390/cells9030547

PMCID:: PMC7140530

Article PDF–4.0M

Select item 707279420.

TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons

Frauke Kepura, Eva Braun, Alexander Dietrich, Tim D. Plant

Cells. 2020 Feb; 9(2): 459. Published online 2020 Feb 18. doi: 10.3390/cells9020459

PMCID:: PMC7072794

Article PDF–2.4M

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