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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106509732.

Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing

James M Fulcher, Adam C Swensen, Yi-Chun Chen, C Bruce Verchere, Vladislav A Petyuk, Wei-Jun Qian

Endocrinology. 2023 Dec; 164(12): bqad160. Published online 2023 Nov 15. doi: 10.1210/endocr/bqad160

PMCID:: PMC10650973

Abstract Article

Select item 104928423.

NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development

Romana Bohuslavova, Valeria Fabriciova, Ondrej Smolik, Laura Lebrón-Mora, Pavel Abaffy, Sarka Benesova, Daniel Zucha, Lukas Valihrach, Zuzana Berkova, Frantisek Saudek, Gabriela Pavlinkova

Nat Commun. 2023; 14: 5554. Published online 2023 Sep 9. doi: 10.1038/s41467-023-41306-6

PMCID:: PMC10492842

Abstract Article PDF–15M

Select item 104508244.

Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice

Yi-Chun Chen, Austin J. Taylor, James M. Fulcher, Adam C. Swensen, Xiao-Qing Dai, Mitsuhiro Komba, Kenzie L.C. Wrightson, Kenny Fok, Annette E. Patterson, Ramon I. Klein Geltink, Patrick E. MacDonald, Wei-Jun Qian, C. Bruce Verchere

Diabetes. 2023 Sep; 72(9): 1277–1288. Published online 2023 Jun 26. doi: 10.2337/db22-0945

PMCID:: PMC10450824

Abstract Article PDF–63M

Select item 101652555.

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression

Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui

iScience. 2023 May 19; 26(5): 106670. Published online 2023 Apr 14. doi: 10.1016/j.isci.2023.106670

PMCID:: PMC10165255

Abstract Article PDF–8.2M

Select item 101333196.

Carboxypeptidase E conditional knockout mice exhibit learning and memory deficits and neurodegeneration

Fang-Cheng Fan, Yang Du, Wen-Hui Zheng, Y. Peng Loh, Yong Cheng

Transl Psychiatry. 2023; 13: 135. Published online 2023 Apr 26. doi: 10.1038/s41398-023-02429-y

PMCID:: PMC10133319

Abstract Article PDF–3.9M

Select item 83720237.

Carboxypeptidase E Regulates Activity-Dependent TrkB Neuronal Surface Insertion and Hippocampal Memory

Na Li, Shuai-Wen Teng, Ling Zhao, Jing-Rui Li, Jia-Ling Xu, Na Li, Jia-Cheng Shuai, Zhe-Yu Chen

J Neurosci. 2021 Aug 18; 41(33): 6987–7002. doi: 10.1523/JNEUROSCI.0236-21.2021

PMCID:: PMC8372023

Abstract Article PDF–4.7M

Select item 82913798.

Functional identity of hypothalamic melanocortin neurons depends on Tbx3

Carmelo Quarta, Alexandre Fisette, Yanjun Xu, Gustav Colldén, Beata Legutko, Yu-Ting Tseng, Alexander Reim, Michael Wierer, Maria C. De Rosa, Valentina Klaus, Rick Rausch, Vidhu V. Thaker, Elisabeth Graf, Tim M. Strom, Anne-Laure Poher, Tim Gruber, Ophélia Le Thuc, Alberto Cebrian-Serrano, Dhiraj Kabra, Luigi Bellocchio, Stephen C. Woods, Gert O. Pflugfelder, Rubén Nogueiras, Lori Zeltser, Ilona C. Grunwald Kadow, Anne Moon, Cristina García-Cáceres, Matthias Mann, Mathias Treier, Claudia A. Doege, Matthias H. Tschöp

Nat Metab. Author manuscript; available in PMC 2021 Jul 20.

Published in final edited form as: Nat Metab. 2019 Feb; 1(2): 222–235. Published online 2019 Jan 28. doi: 10.1038/s42255-018-0028-1

PMCID:: PMC8291379

Abstract Article PDF–2.4M

Select item 79387709.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 785629210.

Neuropeptidomic analysis of a genetically-defined cell-type in mouse brain and pituitary

Lloyd D. Fricker, Alexandre K. Tashima, Amanda K. Fakira, Ute Hochgeschwender, William C. Wetsel, Lakshmi A. Devi

Cell Chem Biol. Author manuscript; available in PMC 2022 Jan 21.

Published in final edited form as: Cell Chem Biol. 2021 Jan 21; 28(1): 105–112.e4. Published online 2020 Nov 19. doi: 10.1016/j.chembiol.2020.11.003

PMCID:: PMC7856292

Abstract Article PDF–666K

Select item 729503311.

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely

Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089

PMCID:: PMC7295033

Abstract Article PDF–2.7M

Select item 711694412.

PC2/CPE-mediated pro-protein processing in tumor cells and its differentiated cells or tissues

Song-Shan Tang, Juan-Hui Zhang, Huan-Xin Liu, Hong-Zhi Li

Mol Cell Endocrinol. 2009 May 6; 303(1): 43–49. Published online 2009 Feb 7. doi: 10.1016/j.mce.2009.01.020

PMCID:: PMC7116944

Abstract Article PDF–2.1M

Select item 672193613.

eIF4G1 and carboxypeptidase E axis dysregulation in O-GlcNAc transferase–deficient pancreatic β-cells contributes to hyperproinsulinemia in mice

Seokwon Jo, Amber Lockridge, Emilyn U. Alejandro

J Biol Chem. 2019 Aug 30; 294(35): 13040–13050. Published online 2019 Jul 12. doi: 10.1074/jbc.RA119.008670

PMCID:: PMC6721936

Abstract Article PDF–2.9M

Select item 635506614.

Cloning, gene regulation, and neuronal proliferation functions of novel N-terminal–truncated carboxypeptidase E/neurotrophic factor-αl variants in embryonic mouse brain

Lan Xiao, Xuyu Yang, Vinay Kumar Sharma, Y. Peng Loh

FASEB J. 2019 Jan; 33(1): 808–820. Published online 2018 Jul 31. doi: 10.1096/fj.201800359R

PMCID:: PMC6355066

Abstract Article

Select item 613100715.

Neurotrophic factor-α1: A key Wnt-β-catenin dependent anti-proliferation factor and ERK-Sox9 activated inducer of embryonic neural stem cell differentiation to astrocytes in neurodevelopment

Prabhuanand Selvaraj, Lan Xiao, Cheol Lee, Saravana R. K. Murthy, Niamh X. Cawley, Malcolm Lane, Istvan Merchenthaler, Sohyun Ahn, Y. Peng Loh

Stem Cells. Author manuscript; available in PMC 2018 Sep 10.

Published in final edited form as: Stem Cells. 2017 Mar; 35(3): 557–571. Published online 2016 Oct 26. doi: 10.1002/stem.2511

PMCID:: PMC6131007

Abstract Article PDF–1006K

Select item 585495516.

Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-Releasing Peptide

Joel A. Mathews, Nandini Krishnamoorthy, David I. Kasahara, John Hutchinson, Youngji Cho, Jeffrey D. Brand, Alison S. Williams, Allison P. Wurmbrand, Luiza Ribeiro, Frank Cuttitta, Mary E. Sunday, Bruce D. Levy, Stephanie A. Shore

Am J Respir Cell Mol Biol. 2018 Mar; 58(3): 341–351. doi: 10.1165/rcmb.2017-0071OC

PMCID:: PMC5854955

Abstract Article PDF–894K

Select item 529582117.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 497937118.

A Comparative Study of Lung Host Defense in Murine Obesity Models. Insights into Neutrophil Function

Niki D. J. Ubags, Elianne Burg, Maryellen Antkowiak, Aaron M. Wallace, Estee Dilli, Jenna Bement, Matthew J. Wargo, Matthew E. Poynter, Emiel F. M. Wouters, Benjamin T. Suratt

Am J Respir Cell Mol Biol. 2016 Aug; 55(2): 188–200. doi: 10.1165/rcmb.2016-0042OC

PMCID:: PMC4979371

Abstract Article PDF–1.0M

Select item 469562719.

Carboxypeptidase E and Secretogranin III Coordinately Facilitate Efficient Sorting of Proopiomelanocortin to the Regulated Secretory Pathway in AtT20 Cells

Niamh X. Cawley, Trushar Rathod, Sigrid Young, Hong Lou, Nigel Birch, Y. Peng Loh

Mol Endocrinol. 2016 Jan; 30(1): 37–47. Published online 2015 Dec 8. doi: 10.1210/me.2015-1166

PMCID:: PMC4695627

Abstract Article

Select item 445140120.

Innate and ozone-induced airway hyperresponsiveness in obese mice: role of TNF-α

Alison Suzanne Williams, Joel Andrew Mathews, David Itiro Kasahara, Allison Patricia Wurmbrand, Lucas Chen, Stephanie Ann Shore

Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1; 308(11): L1168–L1177. Published online 2015 Apr 3. doi: 10.1152/ajplung.00393.2014

PMCID:: PMC4451401

Abstract Article

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