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Select item 110057111.

Mfn2/Hsc70 Complex Mediates the Formation of Mitochondria‐Lipid Droplets Membrane Contact and Regulates Myocardial Lipid Metabolism

Lang Hu, Daishi Tang, Bingchao Qi, Dong Guo, Ying Wang, Jing Geng, Xiaoliang Zhang, Liqiang Song, Pan Chang, Wensheng Chen, Feng Fu, Yan Li

Adv Sci (Weinh) 2024 Apr; 11(14): 2307749. Published online 2024 Feb 4. doi: 10.1002/advs.202307749

PMCID:: PMC11005711

Abstract Article PDF–7.8M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107693503.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders

Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz

Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700

PMCID:: PMC10769350

Abstract Article PDF–11M

Select item 107170244.

Mitofusin-2 regulates inflammation-mediated mouse neuroblastoma N2a cells dysfunction and endoplasmic reticulum stress via the Yap-Hippo pathway

Shu Hou, Lili Wang, Guoping Zhang

J Physiol Sci. 2019 Sep; 69(5): 697–709. Published online 2019 May 27. doi: 10.1007/s12576-019-00685-6

PMCID:: PMC10717024

Abstract Article PDF–7.0M

Select item 106199785.

A human mitofusin 2 mutation can cause mitophagic cardiomyopathy

Antonietta Franco, Jiajia Li, Daniel P Kelly, Ray E Hershberger, Ali J Marian, Renate M Lewis, Moshi Song, Xiawei Dang, Alina D Schmidt, Mary E Mathyer, John R Edwards, Cristina de Guzman Strong, Gerald W Dorn

eLife. 2023; 12: e84235. Published online 2023 Nov 1. doi: 10.7554/eLife.84235

PMCID:: PMC10619978

Abstract Article PDF–15M

Select item 105206376.

NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte‐to‐Embryo Transition

Tie‐Gang Meng, Jia‐Ni Guo, Liu Zhu, Yike Yin, Feng Wang, Zhi‐Ming Han, Lei Lei, Xue‐Shan Ma, Yue Xue, Wei Yue, Xiao‐Qing Nie, Zheng‐Hui Zhao, Hong‐Yong Zhang, Si‐Min Sun, Ying‐Chun Ouyang, Yi Hou, Heide Schatten, Zhenyu Ju, Xiang‐Hong Ou, Zhen‐Bo Wang, Catherine C. L. Wong, Zhonghan Li, Qing‐Yuan Sun

Adv Sci (Weinh) 2023 Sep; 10(27): 2301940. Published online 2023 Jul 26. doi: 10.1002/advs.202301940

PMCID:: PMC10520637

Abstract Article PDF–6.6M

Select item 104704207.

LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity

Shun Zhang, Subo Qian, Hailong Liu, Ding Xu, Weimin Xia, Huangqi Duan, Chen Wang, Shenggen Yu, Yingying Chen, Ping Ji, Shujun Wang, Xingang Cui, Ying Wang, Haibo Shen

Redox Biol. 2023 Oct; 66: 102860. Published online 2023 Aug 22. doi: 10.1016/j.redox.2023.102860

PMCID:: PMC10470420

Abstract Article PDF–24M

Select item 103989398.

Decreased MFN2 activates the cGAS-STING pathway in diabetic myocardial ischaemia–reperfusion by triggering the release of mitochondrial DNA

Yonghong Xiong, Yan Leng, Hao Tian, Xinqi Deng, Wenyuan Li, Wei Li, Zhongyuan Xia

Cell Commun Signal. 2023; 21: 192. Published online 2023 Aug 3. doi: 10.1186/s12964-023-01216-y

PMCID:: PMC10398939

Abstract Article PDF–5.7M

Select item 103544179.

MFN2 suppresses clear cell renal cell carcinoma progression by modulating mitochondria‐dependent dephosphorylation of EGFR

Li Luo, Denghui Wei, Yihui Pan, Qiu‐Xia Wang, Jian‐Xiong Feng, Bing Yu, Tiebang Kang, Junhang Luo, Jiefeng Yang, Song Gao

Cancer Commun (Lond) 2023 Jul; 43(7): 808–833. Published online 2023 Jun 28. doi: 10.1002/cac2.12428

PMCID:: PMC10354417

Abstract Article PDF–12M

Select item 993821610.

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Jr., Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes

Nat Commun. 2023; 14: 825. Published online 2023 Feb 17. doi: 10.1038/s41467-023-36087-x

PMCID:: PMC9938216

Abstract Article PDF–5.3M

Select item 981238411.

Lactate metabolism is essential in early-onset mitochondrial myopathy

Zhenkang Chen, Bogdan Bordieanu, Rushendhiran Kesavan, Nicholas P. Lesner, Siva Sai Krishna Venigalla, Spencer D. Shelton, Ralph J. DeBerardinis, Prashant Mishra

Sci Adv. 2023 Jan; 9(1): eadd3216. Published online 2023 Jan 4. doi: 10.1126/sciadv.add3216

PMCID:: PMC9812384

Abstract Article PDF–2.8M

Select item 972703612.

Role of cardiac mitofusins in cardiac conduction following simulated ischemia–reperfusion

Xiu-Yi Kwek, Andrew R. Hall, Wei-Wen Lim, Khairunnisa Katwadi, Poh Loong Soong, Elina Grishina, Kun-Han Lin, Gustavo Crespo-Avilan, En Ping Yap, Nur Izzah Ismail, Kroekkiat Chinda, Ying Ying Chung, Heming Wei, Winston Shim, David Montaigne, Andrew Tinker, Sang-Bing Ong, Derek J. Hausenloy

Sci Rep. 2022; 12: 21049. Published online 2022 Dec 6. doi: 10.1038/s41598-022-25625-0

PMCID:: PMC9727036

Abstract Article PDF–1.7M

Select item 971188313.

A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle

Xun Wang, Yuemeng Jia, Jiawei Zhao, Nicholas P. Lesner, Cameron J. Menezes, Spencer D. Shelton, Siva Sai Krishna Venigalla, Jian Xu, Chunyu Cai, Prashant Mishra

J Clin Invest. 2022 Dec 1; 132(23): e161638. Published online 2022 Dec 1. doi: 10.1172/JCI161638

PMCID:: PMC9711883

Abstract Article PDF–56M

Select item 951514414.

Mitochondrial function and intracellular distribution is severely affected in in vitro cultured mouse embryos

Marta Czernik, Dawid Winiarczyk, Silvestre Sampino, Paweł Gręda, Salvatore Parillo, Jacek Andrzej Modliński, Pasqualino Loi

Sci Rep. 2022; 12: 16152. Published online 2022 Sep 27. doi: 10.1038/s41598-022-20374-6

Correction in:: Sci Rep. 2022; 12: 21276.

PMCID:: PMC9515144

Abstract Article PDF–1.6M

Select item 943695715.

Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism

Yohko Yoshida, Ippei Shimizu, Atsuhiro Shimada, Keita Nakahara, Sachiko Yanagisawa, Minoru Kubo, Shinji Fukuda, Chiharu Ishii, Hiromitsu Yamamoto, Takamasa Ishikawa, Kuniyuki Kano, Junken Aoki, Goro Katsuumi, Masayoshi Suda, Kazuyuki Ozaki, Yutaka Yoshida, Shujiro Okuda, Shigeo Ohta, Shiki Okamoto, Yasuhiko Minokoshi, Kanako Oda, Toshikuni Sasaoka, Manabu Abe, Kenji Sakimura, Yoshiaki Kubota, Norihiko Yoshimura, Shingo Kajimura, Maria Zuriaga, Kenneth Walsh, Tomoyoshi Soga, Tohru Minamino

Sci Rep. 2022; 12: 14883. Published online 2022 Sep 1. doi: 10.1038/s41598-022-19245-x

PMCID:: PMC9436957

Abstract Article PDF–8.2M

Select item 932773716.

Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice

Esteban Salazar-Petres, Daniela Pereira-Carvalho, Jorge Lopez-Tello, Amanda Nancy Sferruzzi-Perri

Biol Reprod. 2022 Jun; 106(6): 1292–1311. Published online 2022 Mar 16. doi: 10.1093/biolre/ioac056

PMCID:: PMC9327737

Abstract Article PDF–3.0M

Select item 923329817.

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Eleni Georgiadou, Charanya Muralidharan, Michelle Martinez, Pauline Chabosseau, Elina Akalestou, Alejandra Tomas, Fiona Yong Su Wern, Theodoros Stylianides, Asger Wretlind, Cristina Legido-Quigley, Ben Jones, Livia Lopez-Noriega, Yanwen Xu, Guoqiang Gu, Nour Alsabeeh, Céline Cruciani-Guglielmacci, Christophe Magnan, Mark Ibberson, Isabelle Leclerc, Yusuf Ali, Scott A. Soleimanpour, Amelia K. Linnemann, Tristan A. Rodriguez, Guy A. Rutter

Diabetes. 2022 Jul; 71(7): 1472–1489. Published online 2022 Apr 26. doi: 10.2337/db21-0800

PMCID:: PMC9233298

Abstract Article PDF–82M

Select item 919018018.

Reduced electron transport chain complex I protein abundance and function in Mfn2-deficient myogenic progenitors lead to oxidative stress and mitochondria swelling

Nanjian Luo, Feng Yue, Zhihao Jia, Jingjuan Chen, Qing Deng, Yongju Zhao, Shihuan Kuang

FASEB J. Author manuscript; available in PMC 2022 Jun 13.

Published in final edited form as: FASEB J. 2021 Apr; 35(4): e21426. doi: 10.1096/fj.202002464R

PMCID:: PMC9190180

Abstract Article PDF–3.2M

Select item 904693219.

MFN2 Deficiency Impairs Mitochondrial Functions and PPAR Pathway During Spermatogenesis and Meiosis in Mice

Tianren Wang, Yuan Xiao, Zhe Hu, Jingkai Gu, Renwu Hua, Zhuo Hai, Xueli Chen, Jian V. Zhang, Zhiying Yu, Ting Wu, William S. B. Yeung, Kui Liu, Chenxi Guo

Front Cell Dev Biol. 2022; 10: 862506. Published online 2022 Apr 14. doi: 10.3389/fcell.2022.862506

PMCID:: PMC9046932

Abstract Article PDF–4.5M

Select item 903869220.

Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis

Divya Bhatia, Allyson Capili, Kiichi Nakahira, Thangamani Muthukumar, Lisa K. Torres, Augustine M. K. Choi, Mary E. Choi

Kidney Int. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Kidney Int. 2022 May; 101(5): 963–986. Published online 2022 Feb 26. doi: 10.1016/j.kint.2022.01.030

PMCID:: PMC9038692

Abstract Article PDF–5.3M

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