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Select item 106939151.

Murine myeloid derived suppressor cells possess a range of suppressive mechanisms—Granzyme B is not among them

Ellis Tibbs, Xuefang Cao

Cancer Immunol Immunother. 2022 Sep; 71(9): 2255–2266. Published online 2022 Feb 7. doi: 10.1007/s00262-022-03162-z

PMCID:: PMC10693915

Abstract Article PDF–2.0M

Select item 103877412.

Impaired regulatory function of granzyme B-producing B cells against T cell inflammatory responses in lupus mice

Jimeng Xue, Liling Xu, Hua Zhong, Mingxin Bai, Xin Li, Ranran Yao, Ziye Wang, Zhen Zhao, Hongchao Li, Huaqun Zhu, Fanlei Hu, Yin Su

Lupus Sci Med. 2023; 10(2): e000974. Published online 2023 Jul 27. doi: 10.1136/lupus-2023-000974

PMCID:: PMC10387741

Abstract Article PDF–2.4M

Select item 102535143.

Inhibitory Effect of Zinc on Colorectal Cancer by Granzyme B Transcriptional Regulation in Cytotoxic T Cells

Naoya Nakagawa, Yutaka Fujisawa, Huihui Xiang, Hidemitsu Kitamura, Keigo Nishida

Int J Mol Sci. 2023 Jun; 24(11): 9457. Published online 2023 May 29. doi: 10.3390/ijms24119457

PMCID:: PMC10253514

Abstract Article PDF–38M

Select item 102296084.

Antigen recognition detains CD8⁺ T cells at the blood-brain barrier and contributes to its breakdown

Sidar Aydin, Javier Pareja, Vivianne M. Schallenberg, Armelle Klopstein, Thomas Gruber, Nicolas Page, Elisa Bouillet, Nicolas Blanchard, Roland Liblau, Jakob Körbelin, Markus Schwaninger, Aaron J. Johnson, Mirjam Schenk, Urban Deutsch, Doron Merkler, Britta Engelhardt

Nat Commun. 2023; 14: 3106. Published online 2023 May 30. doi: 10.1038/s41467-023-38703-2

PMCID:: PMC10229608

Abstract Article PDF–12M

Select item 101727885.

Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed oligodendrocytes in PLP1 mutant mice

Tassnim Abdelwahab, David Stadler, Konrad Knöpper, Panagiota Arampatzi, Antoine-Emmanuel Saliba, Wolfgang Kastenmüller, Rudolf Martini, Janos Groh

iScience. 2023 May 19; 26(5): 106698. Published online 2023 Apr 19. doi: 10.1016/j.isci.2023.106698

PMCID:: PMC10172788

Abstract Article PDF–8.0M

Select item 101403716.

CD4⁺ T cell memory is impaired by species-specific cytotoxic differentiation, but not by TCF-1 loss

Tom Hofland, Luca Danelli, Georgina Cornish, Tiziano Donnarumma, Deborah M. Hunt, Luiz P. S. de Carvalho, George Kassiotis

Front Immunol. 2023; 14: 1168125. Published online 2023 Apr 14. doi: 10.3389/fimmu.2023.1168125

PMCID:: PMC10140371

Abstract Article PDF–4.5M

Select item 92470467.

Caspase-7 activates ASM to repair gasdermin and perforin pores

Kengo Nozaki, Vivien I. Maltez, Manira Rayamajhi, Alan L. Tubbs, Joseph E. Mitchell, Carolyn A. Lacey, Carissa K. Harvest, Lupeng Li, William T. Nash, Heather N. Larson, Benjamin D. McGlaughon, Nathaniel J. Moorman, Michael G. Brown, Jason K. Whitmire, Edward A. Miao

Nature. Author manuscript; available in PMC 2022 Dec 15.

Published in final edited form as: Nature. 2022 Jun; 606(7916): 960–967. Published online 2022 Jun 15. doi: 10.1038/s41586-022-04825-8

PMCID:: PMC9247046

Abstract Article PDF–9.4M

Select item 92209398.

EBAG9 controls CD8⁺ T cell memory formation responding to tumor challenge in mice

Armin Rehm, Anthea Wirges, Dana Hoser, Cornelius Fischer, Stefanie Herda, Kerstin Gerlach, Sascha Sauer, Gerald Willimsky, Uta E. Höpken

JCI Insight. 2022 Jun 8; 7(11): e155534. Published online 2022 Jun 8. doi: 10.1172/jci.insight.155534

PMCID:: PMC9220939

Abstract Article PDF–6.3M

Select item 88813489.

γδ intraepithelial lymphocytes facilitate pathological epithelial cell shedding via CD103-mediated granzyme release

Madeleine D. Hu, Natasha B. Golovchenko, Grace L. Burns, Prema M. Nair, Thomas J. Kelly, IV, Jonathan Agos, Mudar Zand Irani, Wai Sinn Soh, Matthew R. Zeglinski, Alexander Lemenze, Edward M. Bonder, Inga Sandrock, Immo Prinz, David J. Granville, Simon Keely, Alastair J.M. Watson, Karen L. Edelblum

Gastroenterology. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: Gastroenterology. 2022 Mar; 162(3): 877–889.e7. Published online 2021 Dec 1. doi: 10.1053/j.gastro.2021.11.028

PMCID:: PMC8881348

Abstract Article PDF–1.3M

Select item 887349010.

Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

Hsin-Fang Chang, Claudia Schirra, Momchil Ninov, Ulrike Hahn, Keerthana Ravichandran, Elmar Krause, Ute Becherer, Štefan Bálint, Maria Harkiolaki, Henning Urlaub, Salvatore Valitutti, Cosima T. Baldari, Michael L. Dustin, Reinhard Jahn, Jens Rettig

Nat Commun. 2022; 13: 1029. Published online 2022 Feb 24. doi: 10.1038/s41467-022-28596-y

PMCID:: PMC8873490

Abstract Article PDF–3.9M

Select item 881638011.

Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies

Daniel J Rawle, Thuy T Le, Troy Dumenil, Cameron Bishop, Kexin Yan, Eri Nakayama, Phillip I Bird, Andreas Suhrbier

eLife. 2022; 11: e70207. Published online 2022 Feb 4. doi: 10.7554/eLife.70207

PMCID:: PMC8816380

Abstract Article PDF–7.7M

Select item 842840912.

Mechanisms of Antiviral Cytotoxic CD4 T Cell Differentiation

Cory J. Knudson, Maria Férez, Pedro Alves-Peixoto, Dan A. Erkes, Carolina R. Melo-Silva, Lingjuan Tang, Christopher M. Snyder, Luis J. Sigal

J Virol. 2021 Oct; 95(19): e00566-21. Prepublished online 2021 Jul 14. Published online 2021 Sep 9. doi: 10.1128/JVI.00566-21

PMCID:: PMC8428409

Abstract Article PDF–2.9M

Select item 838071713.

Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4⁺ T cells

Kristen L. Hoek, Michael J. Greer, Kathleen G. McClanahan, Ali Nazmi, M. Blanca Piazuelo, Kshipra Singh, Keith T. Wilson, Danyvid Olivares-Villagómez

Mucosal Immunol. Author manuscript; available in PMC 2021 Dec 28.

Published in final edited form as: Mucosal Immunol. 2021 Sep; 14(5): 1088–1099. Published online 2021 Jun 28. doi: 10.1038/s41385-021-00427-1

PMCID:: PMC8380717

Abstract Article PDF–1.7M

Select item 793597314.

Cytotoxic CD8⁺ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling

Icia Santos-Zas, Jeremie Lemarié, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim Benamer, Pascal Goube, Marie Vandestienne, Raphael Cohen, Maya Ezzo, Vincent Duval, Yujiao Zhang, Jin-Bo Su, Alain Bizé, Lucien Sambin, Philippe Bonnin, Maxime Branchereau, Christophe Heymes, Corinne Tanchot, José Vilar, Clement Delacroix, Jean-Sebastien Hulot, Clement Cochain, Patrick Bruneval, Nicolas Danchin, Alain Tedgui, Ziad Mallat, Tabassome Simon, Bijan Ghaleh, Jean-Sébastien Silvestre, Hafid Ait-Oufella

Nat Commun. 2021; 12: 1483. Published online 2021 Mar 5. doi: 10.1038/s41467-021-21737-9

PMCID:: PMC7935973

Abstract Article PDF–5.4M

Select item 780432115.

Granzyme B inhibition reduces disease severity in autoimmune blistering diseases

Sho Hiroyasu, Matthew R. Zeglinski, Hongyan Zhao, Megan A. Pawluk, Christopher T. Turner, Anika Kasprick, Chiharu Tateishi, Wataru Nishie, Angela Burleigh, Peter A. Lennox, Nancy Van Laeken, Nick J. Carr, Frank Petersen, Richard I. Crawford, Hiroshi Shimizu, Daisuke Tsuruta, Ralf J. Ludwig, David J. Granville

Nat Commun. 2021; 12: 302. Published online 2021 Jan 12. doi: 10.1038/s41467-020-20604-3

PMCID:: PMC7804321

Abstract Article PDF–3.3M

Select item 745813916.

Control of Viral Infection by Natural Killer Cell Inhibitory Receptors

Bijal A. Parikh, Michael D. Bern, Sytse J. Piersma, Liping Yang, Diana L. Beckman, Jennifer Poursine-Laurent, Béatrice Plougastel-Douglas, Wayne M. Yokoyama

Cell Rep. Author manuscript; available in PMC 2021 Jul 28.

Published in final edited form as: Cell Rep. 2020 Jul 28; 32(4): 107969. doi: 10.1016/j.celrep.2020.107969

PMCID:: PMC7458139

Abstract Article PDF–1.4M

Select item 741005317.

Maternal diesel particle exposure promotes offspring asthma through NK cell–derived granzyme B

Qian Qian, Bidisha Paul Chowdhury, Zehua Sun, Jerica Lenberg, Rafeul Alam, Eric Vivier, Magdalena M. Gorska

J Clin Invest. 2020 Aug 3; 130(8): 4133–4151. Published online 2020 Jun 29. doi: 10.1172/JCI130324

PMCID:: PMC7410053

Abstract Article PDF–18M

Select item 737581118.

Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse

Praneeth Chitirala, Hsin-Fang Chang, Paloma Martzloff, Christiane Harenberg, Keerthana Ravichandran, Midhat H Abdulreda, Per-Olof Berggren, Elmar Krause, Claudia Schirra, Trese Leinders-Zufall, Fritz Benseler, Nils Brose, Jens Rettig

eLife. 2020; 9: e58065. Published online 2020 Jul 22. doi: 10.7554/eLife.58065

PMCID:: PMC7375811

Abstract Article PDF–3.6M

Select item 695952319.

Granulysin Delivered by Cytotoxic Cells Damages Endoplasmic Reticulum and Activates Caspase-7 in Target Cells

Reena V. Saini, Christine Wilson, Michael W. Finn, Tianhong Wang, Alan M. Krensky, Carol Clayberger

J Immunol. Author manuscript; available in PMC 2020 Jan 14.

Published in final edited form as: J Immunol. 2011 Mar 15; 186(6): 3497–3504. Published online 2011 Feb 4. doi: 10.4049/jimmunol.1003409

PMCID:: PMC6959523

Abstract Article PDF–1.6M

Select item 673882120.

Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia

M. Isabel García-Laorden, Ingrid Stroo, Dana C. Blok, Sandrine Florquin, Jan Paul Medema, Alex F. de Vos, Tom van der Poll

J Innate Immun. 2016 Apr; 8(3): 258–268. Published online 2016 Feb 20. doi: 10.1159/000443401

PMCID:: PMC6738821

Abstract Article PDF–707K

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