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Items: 1 to 20 of 92

1.
Upregulation of TCPTP in Macrophages Is Involved in IL-35 Mediated Attenuation of Experimental Colitis
Baoren Zhang, Chenglu Sun, Yanglin Zhu, Hong Qin, Dejun Kong, Jingyi Zhang, Bo Shao, Xiang Li, Shaohua Ren, Hongda Wang, Jingpeng Hao, Hao Wang
Mediators Inflamm. 2024; 2024: 3282679. Published online 2024 Jun 13. doi: 10.1155/2024/3282679
PMCID:
PMC11221972
AbstractArticlePDF–4.7M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice
Vinicius Canale, Marianne R. Spalinger, Rocio Alvarez, Anica Sayoc-Becerra, Golshid Sanati, Salomon Manz, Pritha Chatterjee, Alina N. Santos, Hillmin Lei, Sharon Jahng, Timothy Chu, Ali Shawki, Elaine Hanson, Lars Eckmann, André J. Ouellette, Declan F. McCole
Cell Mol Gastroenterol Hepatol. 2023; 16(1): 39–62. Published online 2023 Apr 7. doi: 10.1016/j.jcmgh.2023.03.009
PMCID:
PMC10213106
AbstractArticlePDF–8.7M
4.
PTPN2 regulates bacterial clearance in a mouse model of enteropathogenic and enterohemorrhagic E. coli infection
Marianne R. Spalinger, Vinicius Canale, Anica Becerra, Ali Shawki, Meli’sa Crawford, Alina N. Santos, Pritha Chatterjee, Jiang Li, Meera G. Nair, Declan F. McCole
JCI Insight. 2023 Feb 22; 8(4): e156909. Published online 2023 Feb 22. doi: 10.1172/jci.insight.156909
PMCID:
PMC9977497
AbstractArticlePDF–6.3M
5.
Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
Xu Wang, Chao Yang, Xuejie Wang, Jinmin Miao, Weitao Chen, Yiren Zhou, Ying Xu, Yongyan An, Aifang Cheng, Wenkang Ye, Mengxian Chen, Dong Song, Xue Yuan, Jiguang Wang, Peiyuan Qian, Angela Ruohao Wu, Zhong-Yin Zhang, Kai Liu
Neuron. Author manuscript; available in PMC 2023 Jan 20.
Published in final edited form as: Neuron. 2023 Jan 18; 111(2): 236–255.e7. Published online 2022 Nov 11. doi: 10.1016/j.neuron.2022.10.028
PMCID:
PMC9851977
AbstractArticlePDF–3.6M
6.
PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer
Pei Kee Goh, Florian Wiede, Mara N. Zeissig, Kara L. Britt, Shuwei Liang, Tim Molloy, Nathan Goode, Rachel Xu, Sherene Loi, Mathias Muller, Patrick O. Humbert, Catriona McLean, Tony Tiganis
Sci Adv. 2022 Feb; 8(8): eabk3338. Published online 2022 Feb 23. doi: 10.1126/sciadv.abk3338
PMCID:
PMC8865802
AbstractArticlePDF–5.2M
7.
Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation
Marianne R. Spalinger, Meli’sa Crawford, Sarah D. Bobardt, Jiang Li, Anica Sayoc-Becerra, Alina N. Santos, Ali Shawki, Pritha Chatterjee, Meera G. Nair, Declan F. McCole
Mucosal Immunol. 2022; 15(1): 74–83. Published online 2021 Aug 21. doi: 10.1038/s41385-021-00441-3
PMCID:
PMC8732276
AbstractArticlePDF–1.8M
8.
Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence
Marianne Rebecca Spalinger, Ali Shawki, Pritha Chatterjee, Vinicius Canale, Alina Santos, Anica Sayoc-Becerra, Michael Scharl, Michel L Tremblay, James Borneman, Declan F McCole
Gut. 2022 Jan; 71(1): 89–99. Published online 2021 Feb 9. doi: 10.1136/gutjnl-2020-323636
PMCID:
PMC8666829
AbstractArticlePDF–7.0M
9.
T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling
Ronald R. Marchelletta, Moorthy Krishnan, Marianne R. Spalinger, Taylaur W. Placone, Rocio Alvarez, Anica Sayoc-Becerra, Vinicius Canale, Ali Shawki, Young Su Park, Lucas H.P. Bernts, Stephen Myers, Michel L. Tremblay, Kim E. Barrett, Evan Krystofiak, Bechara Kachar, Dermot P.B. McGovern, Christopher R. Weber, Elaine M. Hanson, Lars Eckmann, Declan F. McCole
J Clin Invest. 2021 Sep 1; 131(17): e138230. Published online 2021 Sep 1. doi: 10.1172/JCI138230
PMCID:
PMC8409587
AbstractArticlePDF–18M
10.
Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis
Larissa Hering, Egle Katkeviciute, Marlene Schwarzfischer, Anna Niechcial, Julianne B. Riggs, Marcin Wawrzyniak, Kirstin Atrott, Marnix van de Sande, Silvia Lang, Burkhard Becher, Gerhard Rogler, Michael Scharl, Marianne R. Spalinger
Int J Mol Sci. 2021 Jul; 22(13): 6820. Published online 2021 Jun 25. doi: 10.3390/ijms22136820
PMCID:
PMC8269284
AbstractArticlePDF–2.7M
11.
Programmable Unlocking Nano‐Matryoshka‐CRISPR Precisely Reverses Immunosuppression to Unleash Cascade Amplified Adaptive Immune Response
Jin Yang, Zhike Li, Meiling Shen, Yan Wang, Li Wang, Jiamiao Li, Wen Yang, Jie Li, Haijun Li, Xinxin Wang, Qinjie Wu, Changyang Gong
Adv Sci (Weinh) 2021 Jul; 8(13): 2100292. Published online 2021 May 14. doi: 10.1002/advs.202100292
PMCID:
PMC8261501
AbstractArticlePDF–5.9M
12.
Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin
Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H. Enders, Moshe Olshansky, Brendan Russ, Simone Nüssing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L. Park, Claerwen M. Jones, Gayle M. Davey, David E. Gyorki, David Tscharke, Ian A. Parish, Stephen Turner, Marco J. Herold, Tony Tiganis, Sammy Bedoui, Thomas Gebhardt
J Exp Med. 2021 Jun 7; 218(6): e20200940. Published online 2021 Apr 29. doi: 10.1084/jem.20200940
PMCID:
PMC8091133
AbstractArticlePDF–5.0M
13.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
14.
Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance
Garron T. Dodd, Seung Jae Kim, Mathieu Méquinion, Chrysovalantou E. Xirouchaki, Jens C. Brüning, Zane B. Andrews, Tony Tiganis
Sci Adv. 2021 Feb; 7(9): eabf4100. Published online 2021 Feb 26. doi: 10.1126/sciadv.abf4100
PMCID:
PMC7909880
AbstractArticlePDF–8.4M
15.
PTPN2 negatively regulates macrophage inflammation in atherosclerosis
Xiaorong Hu, Ruisong Ma, Jianlei Cao, Xianjin Du, Xinyong Cai, Yongzhen Fan
Aging (Albany NY) 2021 Jan 31; 13(2): 2768–2779. Published online 2020 Dec 19. doi: 10.18632/aging.202326
PMCID:
PMC7880395
AbstractArticlePDF–1.6M
16.
Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells
Javier Conde, Marlene Schwarzfischer, Egle Katkeviciute, Janine Häfliger, Anna Niechcial, Nathalie Brillant, Roberto Manzini, Katharina Bäbler, Kirstin Atrott, Silvia Lang, Michael Scharl
Int J Mol Sci. 2021 Jan; 22(2): 772. Published online 2021 Jan 14. doi: 10.3390/ijms22020772
PMCID:
PMC7828807
AbstractArticlePDF–6.5M
17.
Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development
Egle Katkeviciute, Larissa Hering, Ana Montalban-Arques, Philipp Busenhart, Marlene Schwarzfischer, Roberto Manzini, Javier Conde, Kirstin Atrott, Silvia Lang, Gerhard Rogler, Elisabeth Naschberger, Vera S. Schellerer, Michael Stürzl, Andreas Rickenbacher, Matthias Turina, Achim Weber, Sebastian Leibl, Gabriel E. Leventhal, Mitchell Levesque, Onur Boyman, Michael Scharl, Marianne R. Spalinger
J Clin Invest. 2021 Jan 4; 131(1): e140281. Published online 2021 Jan 4. doi: 10.1172/JCI140281
PMCID:
PMC7773375
AbstractArticlePDF–22M
18.
Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells
Marianne R. Spalinger, Rong Hai, Jiang Li, Alina N. Santos, Tara M. Nordgren, Michel L. Tremblay, Lars Eckmann, Elaine Hanson, Michael Scharl, Xiwei Wu, Brigid S. Boland, Declan F. McCole
Version 1. bioRxiv. Preprint. 2020 Dec 9. doi: 10.1101/2020.12.09.416586
PMCID:
PMC7743066
AbstractArticlePDF–3.0M
19.
PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function.
Marianne R. Spalinger, Anica Sayoc-Becerra, Alina N. Santos, Ali Shawki, Vinicius Canale, Moorthy Krishnan, Anna Niechcial, Nicole Obialo, Michael Scharl, Jiang Li, Meera G. Nair, Declan F. McCole
Gastroenterology. Author manuscript; available in PMC 2021 Nov 1.
Published in final edited form as: Gastroenterology. 2020 Nov; 159(5): 1763–1777.e14. Published online 2020 Jul 9. doi: 10.1053/j.gastro.2020.07.004
PMCID:
PMC7680443
AbstractArticlePDF–2.4M
20.
Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells
Jason P. Twohig, Ana Cardus Figueras, Robert Andrews, Florian Wiede, Benjamin C. Cossins, Alicia Derrac Soria, Myles J. Lewis, Michael J. Townsend, David Millrine, Jasmine Li, David G. Hill, Javier Uceda Fernandez, Xiao Liu, Barbara Szomolay, Christopher J. Pepper, Philip R. Taylor, Costantino Pitzalis, Tony Tiganis, Nigel M. Williams, Gareth W. Jones, Simon A. Jones
Nat Immunol. Author manuscript; available in PMC 2021 Apr 20.
Published in final edited form as: Nat Immunol. 2019 Apr 1; 20(4): 458–470. Published online 2019 Mar 19. doi: 10.1038/s41590-019-0350-0
PMCID:
PMC7610646
AbstractArticlePDF–3.0M

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