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Select item 109794581.

Copy number variation analysis in 138 families with steroid-resistant nephrotic syndrome identifies causal homozygous deletions in PLCE1 and NPHS2 in two families

Dalia Pantel, Nils D. Mertens, Ronen Schneider, Selina Hölzel, Jameela A. Kari, Sherif El Desoky, Mohamed A. Shalaby, Tze Y. Lim, Simone Sanna-Cherchi, Shirlee Shril, Friedhelm Hildebrandt

Pediatr Nephrol. Author manuscript; available in PMC 2024 Mar 29.

Published in final edited form as: Pediatr Nephrol. 2024 Feb; 39(2): 455–461. Published online 2023 Sep 5. doi: 10.1007/s00467-023-06134-2

PMCID:: PMC10979458

Abstract Article PDF–827K

Select item 97446562.

Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection

Douglas K. Atchison, Christopher L. O’Connor, Kimber Converso-Baran, Ingrid L. Bergin, Hongyu Zhang, Yu Wang, John R. Hartman, Wenjun Ju, Alan V. Smrcka, Santhi K. Ganesh, Markus Bitzer

Am J Physiol Heart Circ Physiol. 2022 Dec 1; 323(6): H1376–H1387. Published online 2022 Nov 11. doi: 10.1152/ajpheart.00262.2022

PMCID:: PMC9744656

Abstract Article

Select item 95893063.

PLCE1 is a poor prognostic marker and may promote immune escape from osteosarcoma by the CD70-CD27 signaling pathway

Linhai Huang, Chundi Liao, Hanhua Wu, Piwei Huang

Bosn J Basic Med Sci. 2022 Dec; 22(6): 992–1004. Published online 2022 Jun 26. doi: 10.17305/bjbms.2022.7416

PMCID:: PMC9589306

Abstract Article PDF–9.2M

Select item 83750794.

A novel NF-κB regulator encoded by circPLCE1 inhibits colorectal carcinoma progression by promoting RPS3 ubiquitin-dependent degradation

Zhen-xing Liang, Hua-shan Liu, Li Xiong, Xin Yang, Feng-wei Wang, Zi-wei Zeng, Xiao-wen He, Xian-rui Wu, Ping Lan

Mol Cancer. 2021; 20: 103. Published online 2021 Aug 19. doi: 10.1186/s12943-021-01404-9

PMCID:: PMC8375079

Abstract Article PDF–6.5M

Select item 83356895.

CircPLCE1 facilitates the malignant progression of colorectal cancer by repressing the SRSF2‐dependent PLCE1 pre‐RNA splicing

Zhilei Chen, Hongyu Chen, Lei Yang, Xiangnan Li, Zhenjun Wang

J Cell Mol Med. 2021 Aug; 25(15): 7244–7256. Published online 2021 Jun 26. doi: 10.1111/jcmm.16753

PMCID:: PMC8335689

Abstract Article PDF–1.9M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78912407.

Maternal Hypertension-Related Genotypes and Congenital Heart Defects

Yunping Lei, Katherine L Ludorf, Xiao Yu, Renata H Benjamin, Xue Gu, Ying Lin, Richard H Finnell, Laura E Mitchell, Fadi I Musfee, Sadia Malik, Mark A Canfield, Alanna C Morrison, Charlotte A Hobbs, Alissa R Van Zutphen, Sarah Fisher, A J Agopian

Am J Hypertens. 2021 Jan; 34(1): 82–91. Published online 2020 Jul 25. doi: 10.1093/ajh/hpaa116

PMCID:: PMC7891240

Abstract Article PDF–229K

Select item 78640568.

Functional and structural characterization of allosteric activation of phospholipase Cε by Rap1A

Monita Sieng, Arielle F. Selvia, Elisabeth E. Garland-Kuntz, Jesse B. Hopkins, Isaac J. Fisher, Andrea T. Marti, Angeline M. Lyon

J Biol Chem. 2020 Dec 4; 295(49): 16562–16571. Published online 2021 Jan 13. doi: 10.1074/jbc.RA120.015685

PMCID:: PMC7864056

Abstract Article PDF–2.2M

Select item 78599209.

Identification of a PLCE1-regulated competing endogenous RNA regulatory network for esophageal squamous cell carcinoma

Zhihao Yang, Yi Hui, Hao Peng, Hongpan Zhang, Menglu Li, Lingxie Song, Feng Li, Xiaobin Cui

Oncol Rep. 2021 Mar; 45(3): 857–868. Published online 2021 Jan 4. doi: 10.3892/or.2021.7921

PMCID:: PMC7859920

Abstract Article PDF–1.1M

Select item 764533210.

The PLCE1 rs2274223 variant is associated with the risk of laryngeal squamous cell carcinoma

Yi Zhang, Wei Li, Ying Wang, Ningyu Wang

Int J Med Sci. 2020; 17(17): 2826–2830. Published online 2020 Oct 8. doi: 10.7150/ijms.49012

PMCID:: PMC7645332

Abstract Article PDF–298K

Select item 754958711.

Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer

Rong Wang, Lining Si, Derui Zhu, Guoping Shen, Qifu Long, Yanli Zhao

Mol Genet Genomic Med. 2020 Oct; 8(10): e1474. Published online 2020 Aug 31. doi: 10.1002/mgg3.1474

PMCID:: PMC7549587

Abstract Article PDF–537K

Select item 742732712.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 721030713.

PLCE1 regulates the migration, proliferation, and differentiation of podocytes

Seyoung Yu, Won-Il Choi, Yo Jun Choi, Hye-Youn Kim, Friedhelm Hildebrandt, Heon Yung Gee

Exp Mol Med. 2020 Apr; 52(4): 594–603. Published online 2020 Apr 1. doi: 10.1038/s12276-020-0410-4

PMCID:: PMC7210307

Abstract Article PDF–3.0M

Select item 689109714.

Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability

Divya Achuthankutty, Roshan Singh Thakur, Peter Haahr, Saskia Hoffmann, Alexandros P. Drainas, Anna H. Bizard, Joachim Weischenfeldt, Ian D. Hickson, Niels Mailand

J Cell Biol. 2019 Dec 2; 218(12): 3943–3953. Published online 2019 Oct 15. doi: 10.1083/jcb.201905064

PMCID:: PMC6891097

Abstract Article PDF–2.7M

Select item 672663215.

Phospholipase C-related catalytically inactive protein regulates cytokinesis by protecting phosphatidylinositol 4,5-bisphosphate from metabolism in the cleavage furrow

Satoshi Asano, Yasuka Ikura, Mitsuki Nishimoto, Yosuke Yamawaki, Kozue Hamao, Keiju Kamijo, Masato Hirata, Takashi Kanematsu

Sci Rep. 2019; 9: 12729. Published online 2019 Sep 4. doi: 10.1038/s41598-019-49156-3

PMCID:: PMC6726632

Abstract Article PDF–2.3M

Select item 668338216.

PLCε regulates prostate cancer mitochondrial oxidative metabolism and migration via upregulation of Twist1

Jiaxin Fan, Yanru Fan, Xiao Wang, Lingfang Niu, Limei Duan, Jinxiao Yang, Luo Li, Yingying Gao, Xiaohou Wu, Chunli Luo

J Exp Clin Cancer Res. 2019; 38: 337. Published online 2019 Aug 5. doi: 10.1186/s13046-019-1323-8

PMCID:: PMC6683382

Abstract Article PDF–13M

Select item 646566117.

Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis

Qingfa Chen, Yu Wang, Yan Xu, Hai Lin, Fangxi Xue, Xingtian Chen

Mol Genet Genomic Med. 2019 Apr; 7(4): e00589. Published online 2019 Feb 19. doi: 10.1002/mgg3.589

PMCID:: PMC6465661

Abstract Article PDF–431K

Select item 644812418.

Combination of phospholipase Cε knockdown with GANT61 sensitizes castration-resistant prostate cancer cells to enzalutamide by suppressing the androgen receptor signaling pathway

Wei Sun, Luo Li, Zhongbo Du, Zhen Quan, Mengjuan Yuan, Honglin Cheng, Yingying Gao, Chunli Luo, Xiaohou Wu

Oncol Rep. 2019 May; 41(5): 2689–2702. Published online 2019 Mar 7. doi: 10.3892/or.2019.7054

Correction in:: Oncol Rep. 2022 Dec; 48(6): 211.

PMCID:: PMC6448124

Abstract Article PDF–1.7M

Select item 644809619.

PLCε promotes urinary bladder cancer cells proliferation through STAT3/LDHA pathway-mediated glycolysis

Honglin Cheng, Yanni Hao, Yingying Gao, Yunfeng He, Chunli Luo, Wei Sun, Mengjuan Yuan, Xiaohou Wu

Oncol Rep. 2019 May; 41(5): 2844–2854. Published online 2019 Mar 13. doi: 10.3892/or.2019.7056

PMCID:: PMC6448096

Abstract Article PDF–964K

Select item 641339120.

PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population

Ping Liang, Wentao Zhang, Weihua Wang, Peng Dai, Qin Wang, Wei Yan, Wei Wang, Xiaoying Lei, Daxiang Cui, Zhen Yan

Biomed Res Int. 2019; 2019: 9765191. Published online 2019 Feb 25. doi: 10.1155/2019/9765191

PMCID:: PMC6413391

Abstract Article PDF–2.9M

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