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Items: 18

1.
PI3Kγ inhibition combined with DNA vaccination unleashes a B-cell-dependent antitumor immunity that hampers pancreatic cancer
Claudia Curcio, Gianluca Mucciolo, Cecilia Roux, Silvia Brugiapaglia, Alessandro Scagliotti, Giorgia Guadagnin, Laura Conti, Dario Longo, Demis Grosso, Mauro Giulio Papotti, Emilio Hirsch, Paola Cappello, Judith A. Varner, Francesco Novelli
J Exp Clin Cancer Res. 2024; 43: 157. Published online 2024 Jun 1. doi: 10.1186/s13046-024-03080-1
PMCID:
PMC11143614
AbstractArticlePDF–4.1M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway
Guangying Yang, Shan Lu, Jia Jiang, Jun Weng, Xiaomei Zeng
Int J Mol Sci. 2022 Jun; 23(11): 6014. Published online 2022 May 27. doi: 10.3390/ijms23116014
PMCID:
PMC9181541
AbstractArticlePDF–4.4M
4.
Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils
Natalie K. Rynkiewicz, Karen E. Anderson, Sabine Suire, Daniel M. Collins, Eleftherios Karanasios, Oscar Vadas, Roger Williams, David Oxley, Jonathan Clark, Len R. Stephens, Phillip T. Hawkins
Sci Signal. Author manuscript; available in PMC 2021 May 3.
Published in final edited form as: Sci Signal. 2020 Nov 3; 13(656): eaaz4003. Published online 2020 Nov 3. doi: 10.1126/scisignal.aaz4003
PMCID:
PMC7610408
AbstractArticlePDF–1.9M
5.
Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)
Oscar Vadas, Hashem A. Dbouk, Aliaksei Shymanets, Olga Perisic, John E. Burke, Widian F. Abi Saab, Bassem D. Khalil, Christian Harteneck, Anne R. Bresnick, Bernd Nürnberg, Jonathan M. Backer, Roger L. Williams
Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47): 18862–18867. Published online 2013 Nov 4. doi: 10.1073/pnas.1304801110
PMCID:
PMC3839701
AbstractArticlePDF–1.2M
6.
PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control
Romy Walser, John E. Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L. Williams, Muriel Laffargue, Matthias P. Wymann
PLoS Biol. 2013 Jun; 11(6): e1001587. Published online 2013 Jun 25. doi: 10.1371/journal.pbio.1001587
PMCID:
PMC3692425
AbstractArticlePDF–3.8M
7.
GPCR activation of Ras and PI3Kγ in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4
Sabine Suire, Charlotte Lécureuil, Karen E Anderson, George Damoulakis, Izabella Niewczas, Keith Davidson, Hervé Guillou, Dingxin Pan, Jonathan Clark, Phillip T Hawkins, Len Stephens
EMBO J. 2012 Jul 18; 31(14): 3118–3129. Published online 2012 Jun 22. doi: 10.1038/emboj.2012.167
PMCID:
PMC3400018
AbstractArticlePDF–968K
8.
Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ)
Bolam Lee, Giannina Descalzi, Jinhee Baek, Jae-Ick Kim, Hye-Ryeon Lee, Kyungmin Lee, Bong-Kiun Kaang, Min Zhuo
Mol Pain. 2011; 7: 96. Published online 2011 Dec 14. doi: 10.1186/1744-8069-7-96
PMCID:
PMC3261823
AbstractArticlePDF–589K
9.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
10.
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3Kγ, a single convergent point promoting tumor inflammation and progression
Michael C. Schmid, Christie J. Avraamides, Holly C. Dippold, Irene Franco, Philippe Foubert, Lesley G. Ellies, Lissette M. Acevedo, Joan R.E. Manglicmot, Xiaodan Song, Wolfgang Wrasidlo, Sara L. Blair, Mark H. Ginsberg, David A. Cheresh, Emilio Hirsch, Seth J. Field, Judith A. Varner
Cancer Cell. Author manuscript; available in PMC 2012 Jun 14.
Published in final edited form as: Cancer Cell. 2011 Jun 14; 19(6): 715–727. doi: 10.1016/j.ccr.2011.04.016
PMCID:
PMC3144144
AbstractArticlePDF–3.4M
11.
Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110γ
Barbara Kurig, Aliaksei Shymanets, Thomas Bohnacker, Prajwal, Carsten Brock, Mohammad Reza Ahmadian, Michael Schaefer, Antje Gohla, Christian Harteneck, Matthias P. Wymann, Elisabeth Jeanclos, Bernd Nürnberg
Proc Natl Acad Sci U S A. 2009 Dec 1; 106(48): 20312–20317. Published online 2009 Nov 11. doi: 10.1073/pnas.0905506106
PMCID:
PMC2787109
AbstractArticlePDF–2.1M
12.
A Role for a CXCR2/Phosphatidylinositol 3-Kinase γ Signaling Axis in Acute and Chronic Vascular Permeability
Julie Gavard, Xu Hou, Yi Qu, Andrius Masedunskas, Daniel Martin, Roberto Weigert, Xuri Li, J. Silvio Gutkind
Mol Cell Biol. 2009 May; 29(9): 2469–2480. Published online 2009 Mar 2. doi: 10.1128/MCB.01304-08
PMCID:
PMC2668372
AbstractArticlePDF–2.7M
13.
PI3Kgamma (PI3Kγ) is essential for efficient induction of CXCR3 on activated T cells
Joseph Barbi, Hannah E. Cummings, Bao Lu, Steve Oghumu, Thomas Rückle, Christian Rommel, William Lafuse, Caroline C. Whitacre, Abhay R. Satoskar
Blood. 2008 Oct 15; 112(8): 3048–3051. Prepublished online 2008 Jul 24. doi: 10.1182/blood-2008-02-135715
PMCID:
PMC2569163
AbstractArticle
14.
The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)
Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504
Correction in:
Genome Res. 2006 Jun; 16(6): 804.
PMCID:
PMC528928
AbstractArticlePDF–140K
15.
RIKEN Integrated Sequence Analysis (RISA) System—384-Format Sequencing Pipeline with 384 Multicapillary Sequencer
Kazuhiro Shibata, Masayoshi Itoh, Katsunori Aizawa, Sumiharu Nagaoka, Nobuya Sasaki, Piero Carninci, Hideaki Konno, Junichi Akiyama, Katsuo Nishi, Tokuji Kitsunai, Hideo Tashiro, Mari Itoh, Noriko Sumi, Yoshiyuki Ishii, Shin Nakamura, Makoto Hazama, Tsutomu Nishine, Akira Harada, Rintaro Yamamoto, Hiroyuki Matsumoto, Sumito Sakaguchi, Takashi Ikegami, Katsuya Kashiwagi, Syuji Fujiwake, Kouji Inoue, Yoshiyuki Togawa, Masaki Izawa, Eiji Ohara, Masanori Watahiki, Yuko Yoneda, Tomokazu Ishikawa, Kaori Ozawa, Takumi Tanaka, Shuji Matsuura, Jun Kawai, Yasushi Okazaki, Masami Muramatsu, Yorinao Inoue, Akira Kira, Yoshihide Hayashizaki
Genome Res. 2000 Nov; 10(11): 1757–1771. doi: 10.1101/gr.152600
PMCID:
PMC310992
AbstractArticlePDF–3.4M
16.
Normalization and Subtraction of Cap-Trapper-Selected cDNAs to Prepare Full-Length cDNA Libraries for Rapid Discovery of New Genes
Piero Carninci, Yuko Shibata, Norihito Hayatsu, Yuichi Sugahara, Kazuhiro Shibata, Masayoshi Itoh, Hideaki Konno, Yasushi Okazaki, Masami Muramatsu, Yoshihide Hayashizaki
Genome Res. 2000 Oct; 10(10): 1617–1630. doi: 10.1101/gr.145100
PMCID:
PMC310980
AbstractArticlePDF–1.4M
17.
Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention
Brian P. Zambrowicz, Alejandro Abuin, Ramiro Ramirez-Solis, Lizabeth J. Richter, James Piggott, Hector BeltrandelRio, Eric C. Buxton, Joel Edwards, Rick A. Finch, Carl J. Friddle, Anupma Gupta, Gwenn Hansen, Yi Hu, Wenhu Huang, Crystal Jaing, Billie Wayne Key, Jr., Peter Kipp, Buckley Kohlhauff, Zhi-Qing Ma, Diane Markesich, Robert Payne, David G. Potter, Ny Qian, Joseph Shaw, Jeff Schrick, Zheng-Zheng Shi, Mary Jean Sparks, Isaac Van Sligtenhorst, Peter Vogel, Wade Walke, Nianhua Xu, Qichao Zhu, Christophe Person, Arthur T. Sands
Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24): 14109–14114. Published online 2003 Nov 10. doi: 10.1073/pnas.2336103100
Correction in:
Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12): 4332.
PMCID:
PMC283554
AbstractArticlePDF–481K
18.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Mammalian Gene Collection (MGC) Program Team
Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899
PMCID:
PMC139241
AbstractArticlePDF–118K

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