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Select item 104040241.

Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory

Joseph M. Martinez, Ao Shen, Bing Xu, Aleksandra Jovanovic, Josephine de Chabot, Jin Zhang, Yang K. Xiang

Sci Signal. Author manuscript; available in PMC 2023 Aug 5.

Published in final edited form as: Sci Signal. 2023 Mar 28; 16(778): eade3380. Published online 2023 Mar 28. doi: 10.1126/scisignal.ade3380

PMCID:: PMC10404024

Abstract Article PDF–1.9M

Select item 102612502.

Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology

Dean Paes, Melissa Schepers, Emily Willems, Ben Rombaut, Assia Tiane, Yevgeniya Solomina, Amy Tibbo, Connor Blair, Elka Kyurkchieva, George S. Baillie, Roberta Ricciarelli, Chiara Brullo, Ernesto Fedele, Olga Bruno, Daniel van den Hove, Tim Vanmierlo, Jos Prickaerts

Cell Mol Life Sci. 2023 Jul; 80(7): 178. Published online 2023 Jun 12. doi: 10.1007/s00018-023-04804-w

PMCID:: PMC10261250

Abstract Article PDF–3.1M

Select item 101133843.

Genetic deletion of phosphodiesterase 4D in the liver improves kidney damage in high-fat fed mice: liver-kidney crosstalk

Xiang Tao, Can Chen, Zheng Huang, Yu Lei, Muru Wang, Shuhui Wang, Dean Tian

Cell Death Dis. 2023 Apr; 14(4): 273. Published online 2023 Apr 18. doi: 10.1038/s41419-023-05792-2

PMCID:: PMC10113384

Abstract Article PDF–5.6M

Select item 94402144.

Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis

Ran Gao, Wenjun Guo, Tianfei Fan, Junling Pang, Yangfeng Hou, Xiaohang Feng, Bolun Li, Weipeng Ge, Tianhui Fan, Tiantian Zhang, Jiakai Lu, He Jing, Mu Jin, Chen Yan, Jing Wang

Exp Mol Med. 2022 Aug; 54(8): 1201–1213. Published online 2022 Aug 23. doi: 10.1038/s12276-022-00815-y

PMCID:: PMC9440214

Abstract Article PDF–5.8M

Select item 91714245.

MicroRNA-582-5p Contributes to the Maintenance of Neural Stem Cells Through Inhibiting Secretory Protein FAM19A1

Yu-Fei Zhang, Xin-Xin Li, Xiu-Li Cao, Chen-Chen Ji, Xiang-Yu Gao, Dan Gao, Hua Han, Fei Yu, Min-Hua Zheng

Front Cell Neurosci. 2022; 16: 866020. Published online 2022 May 24. doi: 10.3389/fncel.2022.866020

PMCID:: PMC9171424

Abstract Article PDF–13M

Select item 88630676.

FGF1 and insulin control lipolysis by convergent pathways

Gencer Sancar, Sihao Liu, Emanuel Gasser, Jacqueline G. Alvarez, Christopher Moutos, Kyeongkyu Kim, Tim van Zutphen, Yuhao Wang, Timothy F. Huddy, Brittany Ross, Yang Dai, David Zepeda, Brett Collins, Emma Tilley, Matthew J. Kolar, Ruth T. Yu, Annette R. Atkins, Theo H. van Dijk, Alan Saghatelian, Johan W. Jonker, Michael Downes, Ronald M Evans

Cell Metab. Author manuscript; available in PMC 2023 Jan 4.

Published in final edited form as: Cell Metab. 2022 Jan 4; 34(1): 171–183.e6. doi: 10.1016/j.cmet.2021.12.004

PMCID:: PMC8863067

Abstract Article PDF–2.1M

Select item 87767557.

Phosphodiesterase 4D promotes angiotensin II-induced hypertension in mice via smooth muscle cell contraction

Tianfei Fan, Yangfeng Hou, Weipeng Ge, Tianhui Fan, Xiaohang Feng, Wenjun Guo, Xiaomin Song, Ran Gao, Jing Wang

Commun Biol. 2022; 5: 81. Published online 2022 Jan 20. doi: 10.1038/s42003-022-03029-0

PMCID:: PMC8776755

Abstract Article PDF–6.2M

Select item 86982908.

Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice

Abigail Boyd, Ileana V. Aragon, Justin Rich, Will McDonough, Marianna Oditt, Daniel Irelan, Edward Fiedler, Lina Abou Saleh, Wito Richter

Biology (Basel) 2021 Dec; 10(12): 1355. Published online 2021 Dec 20. doi: 10.3390/biology10121355

PMCID:: PMC8698290

Abstract Article PDF–2.5M

Select item 83431409.

Genetic Modulation of Initial Sensitivity to Δ9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice

Cory Parks, Chris M. Rogers, Pjotr Prins, Robert W. Williams, Hao Chen, Byron C. Jones, Bob M. Moore, II, Megan K. Mulligan

Front Genet. 2021; 12: 659012. Published online 2021 Jul 23. doi: 10.3389/fgene.2021.659012

PMCID:: PMC8343140

Abstract Article PDF–2.0M

Select item 831323910.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 821888911.

The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.

Abigail Boyd, Ileana V. Aragon, Lina Abou Saleh, Dylan Southers, Wito Richter

Biochem J. Author manuscript; available in PMC 2022 May 28.

Published in final edited form as: Biochem J. 2021 May 28; 478(10): 1891–1906. doi: 10.1042/BCJ20210212

PMCID:: PMC8218889

Abstract Article PDF–2.0M

Select item 805228612.

Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice

Ileana V. Aragon, Abigail Boyd, Lina Abou Saleh, Justin Rich, Will McDonough, Anna Koloteva, Wito Richter

Biochem Pharmacol. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: Biochem Pharmacol. 2021 Apr; 186: 114477. Published online 2021 Feb 18. doi: 10.1016/j.bcp.2021.114477

PMCID:: PMC8052286

Abstract Article PDF–1.7M

Select item 795451313.

PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice

Will McDonough, Ileana V. Aragon, Justin Rich, James M. Murphy, Lina Abou Saleh, Abigail Boyd, Anna Koloteva, Wito Richter

FASEB J. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: FASEB J. 2020 Sep; 34(9): 12533–12548. Published online 2020 Aug 1. doi: 10.1096/fj.202001016RR

PMCID:: PMC7954513

Abstract Article PDF–852K

Select item 746081914.

Dominant-Negative Attenuation of cAMP-Selective Phosphodiesterase PDE4D Action Affects Learning and Behavior

Graeme B. Bolger, Lisa High Mitchell Smoot, Thomas van Groen

Int J Mol Sci. 2020 Aug; 21(16): 5704. Published online 2020 Aug 9. doi: 10.3390/ijms21165704

PMCID:: PMC7460819

Abstract Article PDF–1.8M

Select item 715758515.

Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development

Megha Agarwal, Akashi Sharma, Pankaj Kumar, Amit Kumar, Anushree Bharadwaj, Masum Saini, Gabrielle Kardon, Sam J. Mathew

Development. 2020 Apr 1; 147(7): dev184507. Published online 2020 Apr 6. doi: 10.1242/dev.184507

PMCID:: PMC7157585

Abstract Article

Select item 683200416.

Myc‐dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor‐2

Chiara Testini, Ross O Smith, Yi Jin, Pernilla Martinsson, Ying Sun, Marie Hedlund, Miguel Sáinz‐Jaspeado, Masabumi Shibuya, Mats Hellström, Lena Claesson‐Welsh

EMBO Rep. 2019 Nov 5; 20(11): e47845. Published online 2019 Sep 23. doi: 10.15252/embr.201947845

Correction in:: EMBO Rep. 2020 May 6; 21(5): e50409.

PMCID:: PMC6832004

Abstract Article PDF–5.2M

Select item 681911117.

Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis

Sanguk Yun, Rui Hu, Melanie E. Schwaemmle, Alexander N. Scherer, Zhenwu Zhuang, Anthony J. Koleske, David C. Pallas, Martin A. Schwartz

J Clin Invest. 2019 Nov 1; 129(11): 4863–4874. Published online 2019 Oct 7. doi: 10.1172/JCI127692

PMCID:: PMC6819111

Abstract Article PDF–7.9M

Select item 681593718.

Protection from Amyloid β Peptide–Induced Memory, Biochemical, and Morphological Deficits by a Phosphodiesterase-4D Allosteric Inhibitor

Su-Ying Cui, Ming-Xin Yang, Yong-He Zhang, Victor Zheng, Han-Ting Zhang, Mark E. Gurney, Ying Xu, James M. O’Donnell

J Pharmacol Exp Ther. 2019 Nov; 371(2): 250–259. Published online 2019 Nov. doi: 10.1124/jpet.119.259986

PMCID:: PMC6815937

Abstract Article PDF–1.0M

Select item 613586019.

Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice

Chong Zhang, Ying Xu, Anirudh Chowdhary, David Fox, 3rd, Mark E. Gurney, Han-Ting Zhang, Benjamin D. Auerbach, Richard J. Salvi, Mingxin Yang, Gaowen Li, James M. O’Donnell

Neuropsychopharmacology. 2018 Oct; 43(11): 2299–2309. Published online 2018 Aug 14. doi: 10.1038/s41386-018-0178-6

PMCID:: PMC6135860

Abstract Article PDF–1.7M

Select item 583285120.

PDE4D regulates Spine Plasticity and Memory in the Retrosplenial Cortex

Karsten Baumgärtel, Andrea Green, Diana Hornberger, Jennifer Lapira, Christopher Rex, Damian G. Wheeler, Marco Peters

Sci Rep. 2018; 8: 3895. Published online 2018 Mar 1. doi: 10.1038/s41598-018-22193-0

PMCID:: PMC5832851

Abstract Article PDF–5.4M

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