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Items: 1 to 20 of 47

1.
HTRA2/OMI-Mediated Mitochondrial Quality Control Alters Macrophage Polarization Affecting Systemic Chronic Inflammation
Qingqing Liu, Xiaoyu Yan, Yuan Yuan, Runyuan Li, Yuanxin Zhao, Jiaying Fu, Jian Wang, Jing Su
Int J Mol Sci. 2024 Feb; 25(3): 1577. Published online 2024 Jan 27. doi: 10.3390/ijms25031577
PMCID:
PMC10855076
AbstractArticlePDF–1.3M
2.
Insufficient HtrA2 causes meiotic defects in aging germinal vesicle oocytes
Min Gao, Yanling Qiu, Tianqi Cao, Dungao Li, Jingwen Wang, Yiren Jiao, Zhiyun Chen, Junjiu Huang
Reprod Biol Endocrinol. 2022; 20: 173. Published online 2022 Dec 20. doi: 10.1186/s12958-022-01048-4
PMCID:
PMC9764539
AbstractArticlePDF–3.7M
3.
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt
Hongyu Sun, Luyan Shen, Ping Zhang, Fu Lin, Jiaoyan Ma, Ying Wu, Huimei Yu, Liankun Sun
Int J Mol Sci. 2022 Oct; 23(19): 11761. Published online 2022 Oct 4. doi: 10.3390/ijms231911761
PMCID:
PMC9569504
AbstractArticlePDF–5.2M
4.
ACAA2 is a Ligand-dependent Coactivator for Thyroid Hormone Receptor β1
Wesley Wang, Dolena Ledee
Biochem Biophys Res Commun. Author manuscript; available in PMC 2022 Oct 22.
Published in final edited form as: Biochem Biophys Res Commun. 2021 Oct 22; 576: 15–21. Published online 2021 Aug 28. doi: 10.1016/j.bbrc.2021.08.073
PMCID:
PMC8446338
AbstractArticlePDF–830K
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi
Hea-Jong Chung, Mohammad Abu Hena Mostofa Jamal, Seong-Tshool Hong
Sci Rep. 2020; 10: 5284. Published online 2020 Mar 24. doi: 10.1038/s41598-020-62309-z
PMCID:
PMC7093540
AbstractArticlePDF–6.8M
7.
Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart
Dan Liu, Linguo Wu, Ye Wu, Xin Wei, Wen Wang, Suli Zhang, Ming Yi, Jing Li, Huirong Liu, Xinliang Ma
Aging (Albany NY) 2019 Oct 31; 11(20): 8982–8997. Published online 2019 Oct 18. doi: 10.18632/aging.102361
PMCID:
PMC6834417
AbstractArticlePDF–5.5M
8.
Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells
Wonhee Hur, Byung Yoon Kang, Sung Min Kim, Gil Won Lee, Jung-Hee Kim, Min-Kyung Nam, Hyangshuk Rhim, Seung Kew Yoon
Cells. 2019 Oct; 8(10): 1119. Published online 2019 Sep 20. doi: 10.3390/cells8101119
PMCID:
PMC6829542
AbstractArticlePDF–4.6M
9.
The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes
Ian Gaël Rodrigue-Gervais, Karine Doiron, Claudia Champagne, Lindsey Mayes, Gabriel André Leiva-Torres, Paulin Vanié, Jr, Todd Douglas, Silvia M. Vidal, Emad S. Alnemri, Maya Saleh
Sci Rep. 2018; 8: 8446. Published online 2018 May 31. doi: 10.1038/s41598-018-26603-1
PMCID:
PMC5981608
AbstractArticlePDF–2.6M
10.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
11.
HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3
Seung Hoon Lee, Young-Mee Moon, Hyeon-Beom Seo, Se-Young Kim, Eun-Kyung Kim, Junyeong Yi, Min-Kyung Nam, Jun-Ki Min, Sung-Hwan Park, Hyangshuk Rhim, Mi-La Cho
Sci Rep. 2016; 6: 39393. Published online 2016 Dec 23. doi: 10.1038/srep39393
PMCID:
PMC5180098
AbstractArticlePDF–2.3M
12.
Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction
Ke Wang, Yuexing Yuan, Xin Liu, Wayne Bond Lau, Lin Zuo, Xiaoliang Wang, Lu Ma, Kun Jiao, Jianyu Shang, Wen Wang, Xinliang Ma, Huirong Liu
Sci Rep. 2016; 6: 37927. Published online 2016 Dec 7. doi: 10.1038/srep37927
PMCID:
PMC5141441
AbstractArticlePDF–1.6M
13.
Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1
Qi Ma, Qing-song Hu, Ran-jie Xu, Xue-chu Zhen, Guang-hui Wang
Acta Pharmacol Sin. 2015 Aug; 36(8): 966–975. Published online 2015 Aug 4. doi: 10.1038/aps.2015.48
PMCID:
PMC4564885
AbstractArticlePDF–2.3M
14.
Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice
Jia-yuan Wu, Mei Li, Li-juan Cao, Mei-ling Sun, Dong Chen, Hai-gang Ren, Qin Xia, Zhou-teng Tao, Zheng-hong Qin, Qing-song Hu, Guang-hui Wang
Acta Pharmacol Sin. 2015 Sep; 36(9): 1043–1052. Published online 2015 Aug 24. doi: 10.1038/aps.2015.50
PMCID:
PMC4561969
AbstractArticlePDF–3.2M
15.
The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2
Frank Maus, Dominik Sakry, Fabien Binamé, Khalad Karram, Krishnaraj Rajalingam, Colin Watts, Richard Heywood, Rejko Krüger, Judith Stegmüller, Hauke B. Werner, Klaus-Armin Nave, Eva-Maria Krämer-Albers, Jacqueline Trotter
PLoS One. 2015; 10(9): e0137311. Published online 2015 Sep 4. doi: 10.1371/journal.pone.0137311
PMCID:
PMC4560422
AbstractArticlePDF–3.1M
16.
The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway
R Xu, Q Hu, Q Ma, C Liu, G Wang
Cell Death Dis. 2014 Aug; 5(8): e1373. Published online 2014 Aug 14. doi: 10.1038/cddis.2014.328
PMCID:
PMC4454303
AbstractArticlePDF–3.0M
17.
BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella
Maria Andree, Jens M Seeger, Stephan Schüll, Oliver Coutelle, Diana Wagner-Stippich, Katja Wiegmann, Claudia M Wunderlich, Kerstin Brinkmann, Pia Broxtermann, Axel Witt, Melanie Fritsch, Paola Martinelli, Harald Bielig, Tobias Lamkemeyer, Elena I Rugarli, Thomas Kaufmann, Anja Sterner-Kock, F Thomas Wunderlich, Andreas Villunger, L Miguel Martins, Martin Krönke, Thomas A Kufer, Olaf Utermöhlen, Hamid Kashkar
EMBO J. 2014 Oct 1; 33(19): 2171–2187. Published online 2014 Jul 23. doi: 10.15252/embj.201387244
PMCID:
PMC4282505
AbstractArticlePDF–2.2M
18.
Neural-Specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1
Victoria L. Patterson, Alfred J. Zullo, Claire Koenig, Sean Stoessel, Hakryul Jo, Xinran Liu, Jinah Han, Murim Choi, Andrew T. DeWan, Jean-Leon Thomas, Chia-Yi Kuan, Josephine Hoh
PLoS One. 2014; 9(12): e115789. Published online 2014 Dec 22. doi: 10.1371/journal.pone.0115789
PMCID:
PMC4274161
AbstractArticlePDF–14M
19.
p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion
Shota Yamauchi, Yan Yan Hou, Alvin Kunyao Guo, Hiroaki Hirata, Wataru Nakajima, Ai Kia Yip, Cheng-han Yu, Ichiro Harada, Keng-Hwee Chiam, Yasuhiro Sawada, Nobuyuki Tanaka, Keiko Kawauchi
J Cell Biol. 2014 Mar 31; 204(7): 1191–1207. doi: 10.1083/jcb.201309107
PMCID:
PMC3971739
AbstractArticlePDF–5.0M
20.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M

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