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Items: 1 to 20 of 52

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Mice
Michael B. Fessler, Jennifer H. Madenspacher, Paul J. Baker, Kerry L. Hilligan, Andrea C. Bohrer, Ehydel Castro, Julie Meacham, Shih-Heng Chen, Reed F. Johnson, Jeffrey G. McDonald, Negin P. Martin, Charles J. Tucker, Debabrata Mahapatra, Mark Cesta, Katrin D. Mayer-Barber
Am J Respir Cell Mol Biol. 2023 Dec 1; 69(6): 638–648. Published online 2023 Aug 14. doi: 10.1165/rcmb.2023-0007OC
PMCID:
PMC10704115
AbstractArticlePDF–1.6M
3.
The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus
Fang Zhang, Baokai Zhang, Huihua Ding, Xiangyue Li, Xilin Wang, Xiaomin Zhang, Qiaojie Liu, Qiuyun Feng, Mingshun Han, Longlong Chen, Linlin Qi, Dan Yang, Xiaojing Li, Xingguo Zhu, Qi Zhao, Jiaqian Qiu, Zhengjiang Zhu, Huiru Tang, Nan Shen, Hongyan Wang, Bin Wei
Adv Sci (Weinh) 2023 Sep; 10(27): 2207108. Published online 2023 Jul 19. doi: 10.1002/advs.202207108
PMCID:
PMC10520634
AbstractArticlePDF–8.9M
4.
Skin γδ T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol
Michela Frascoli, Enxhi Ferraj, Bing Miu, Justin Malin, Nicholas Spidale, Jennifer Cowan, Susannah C. Shissler, Robert Brink, Ying Xu, Jason G. Cyster, Avinash Bhandoola, Joonsoo Kang, Andrea Reboldi
Immunity. Author manuscript; available in PMC 2024 Mar 14.
Published in final edited form as: Immunity. 2023 Mar 14; 56(3): 562–575.e6. Published online 2023 Feb 25. doi: 10.1016/j.immuni.2023.01.025
PMCID:
PMC10306310
AbstractArticlePDF–1.8M
5.
An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut resident plasma cells
Simona Ceglia, Alyssa Berthelette, Kelsey Howley, Yun Li, Benedikt Mortzfeld, Shakti K. Bhattarai, Nicole K. H. Yiew, Ying Xu, Robert Brink, Jason G. Cyster, Lora V. Hooper, Gwendalyn J. Randolph, Vanni Bucci, Andrea Reboldi
Nat Immunol. Author manuscript; available in PMC 2023 Jun 6.
Published in final edited form as: Nat Immunol. 2023 Mar; 24(3): 531–544. Published online 2023 Jan 19. doi: 10.1038/s41590-022-01413-w
PMCID:
PMC10243503
AbstractArticlePDF–7.1M
6.
CD4+-mediated colitis in mice is independent of the GPR183 and GPR18 pathways
Martina Dicker, Yingcong Li, Daniel A. Giles, Greet Verstichel, Viankail Cedillo Castelan, Gabriel Ascui-Gac, Ting-Fang Chou, Tamara Perez-Jeldres, Hilde Cheroutre, Mitchell Kronenberg
Front Immunol. 2022; 13: 1034648. Published online 2022 Oct 28. doi: 10.3389/fimmu.2022.1034648
PMCID:
PMC9652117
AbstractArticlePDF–15M
7.
Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection
Andrea C. Bohrer, Ehydel Castro, Claire E. Tocheny, Maike Assmann, Benjamin Schwarz, Eric Bohrnsen, Michelle A. Makiya, Fanny Legrand, Kerry L. Hilligan, Paul J. Baker, Flor Torres-Juarez, Zhidong Hu, Hui Ma, Lin Wang, Liangfei Niu, Zilu Wen, Sang H. Lee, Olena Kamenyeva, Tuberculosis Imaging Program, Keith D. Kauffman, Michele Donato, Alan Sher, Daniel L. Barber, Laura E. Via, Thomas J. Scriba, Purvesh Khatri, Yanzheng Song, Ka-Wing Wong, Catharine M. Bosio, Amy D. Klion, Katrin D. Mayer-Barber
Cell Rep. Author manuscript; available in PMC 2022 Sep 9.
Published in final edited form as: Cell Rep. 2022 Jul 26; 40(4): 111144. doi: 10.1016/j.celrep.2022.111144
PMCID:
PMC9460869
AbstractArticlePDF–2.8M
8.
GPR183 Regulates 7α,25-Dihydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell
Jae-Sung Kim, HyangI Lim, Jeong-Yeon Seo, Kyeong-Rok Kang, Sun-Kyoung Yu, Chun Sung Kim, Do Kyung Kim, Heung-Joong Kim, Yo-Seob Seo, Gyeong-Je Lee, Jae-Seek You, Ji-Su Oh
Molecules. 2022 Aug; 27(15): 4798. Published online 2022 Jul 27. doi: 10.3390/molecules27154798
PMCID:
PMC9369580
AbstractArticlePDF–5.3M
9.
A Blunted GPR183/Oxysterol Axis During Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung During Mycobacterium tuberculosis Infection
Minh Dao Ngo, Stacey Bartlett, Helle Bielefeldt-Ohmann, Cheng Xiang Foo, Roma Sinha, Buddhika Jayakody Arachchige, Sarah Reed, Thomas Mandrup-Poulsen, Mette Marie Rosenkilde, Katharina Ronacher
J Infect Dis. 2022 Jun 15; 225(12): 2219–2228. Published online 2022 Mar 18. doi: 10.1093/infdis/jiac102
PMCID:
PMC9200159
AbstractArticlePDF–11M
10.
EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes
Francesca Copperi, Inna Schleis, Martin Roumain, Giulio G. Muccioli, Stefano Casola, Martin Klingenspor, Alexander Pfeifer, Thorsten Gnad
Commun Biol. 2022; 5: 280. Published online 2022 Mar 29. doi: 10.1038/s42003-022-03201-6
PMCID:
PMC8964700
AbstractArticlePDF–1.8M
11.
GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity
Line Barington, Liv von Voss Christensen, Kristian Kåber Pedersen, Kristine Niss Arfelt, Martin Roumain, Kristian Høj Reveles Jensen, Viktoria Madeline Skovgaard Kjær, Viktorija Daugvilaite, John F. Kearney, Jan Pravsgaard Christensen, Gertrud Malene Hjortø, Giulio G. Muccioli, Peter Johannes Holst, Mette Marie Rosenkilde
Cells. 2022 Feb; 11(3): 494. Published online 2022 Jan 31. doi: 10.3390/cells11030494
PMCID:
PMC8834096
AbstractArticlePDF–4.0M
12.
The cholesterol metabolite 25-hydroxycholesterol restricts activation of the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation
Bruno C. Trindade, Simona Ceglia, Alyssa Berthelette, Fiona Raso, Kelsey Howley, Jagan R. Muppidi, Andrea Reboldi
Immunity. Author manuscript; available in PMC 2022 Oct 12.
Published in final edited form as: Immunity. 2021 Oct 12; 54(10): 2273–2287.e6. doi: 10.1016/j.immuni.2021.09.004
PMCID:
PMC8570345
AbstractArticlePDF–2.0M
13.
Posttranslational modifications by ADAM10 shape myeloid antigen-presenting cell homeostasis in the splenic marginal zone
Nathalie Diener, Jean-Fred Fontaine, Matthias Klein, Thomas Hieronymus, Florian Wanke, Florian C. Kurschus, Andreas Ludwig, Carl Ware, Paul Saftig, Tobias Bopp, Björn E. Clausen, Ronald A. Backer
Proc Natl Acad Sci U S A. 2021 Sep 21; 118(38): e2111234118. Published online 2021 Sep 15. doi: 10.1073/pnas.2111234118
PMCID:
PMC8463803
AbstractArticlePDF–3.3M
14.
GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity
Stacey Bartlett, Adrian Tandhyka Gemiarto, Minh Dao Ngo, Haressh Sajiir, Semira Hailu, Roma Sinha, Cheng Xiang Foo, Léanie Kleynhans, Happy Tshivhula, Tariq Webber, Helle Bielefeldt-Ohmann, Nicholas P. West, Andriette M. Hiemstra, Candice E. MacDonald, Liv von Voss Christensen, Larry S. Schlesinger, Gerhard Walzl, Mette Marie Rosenkilde, Thomas Mandrup-Poulsen, Katharina Ronacher
Front Immunol. 2020; 11: 601534. Published online 2020 Nov 6. doi: 10.3389/fimmu.2020.601534
PMCID:
PMC7677584
AbstractArticlePDF–1.8M
15.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
16.
Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation
Jennifer H. Madenspacher, Eric D. Morrell, Kymberly M. Gowdy, Jeffrey G. McDonald, Bonne M. Thompson, Ginger Muse, Jennifer Martinez, Seddon Thomas, Carmen Mikacenic, Jerry A. Nick, Edward Abraham, Stavros Garantziotis, Renee D. Stapleton, Julie M. Meacham, Mary Jane Thomassen, William J. Janssen, Donald N. Cook, Mark M. Wurfel, Michael B. Fessler
JCI Insight. 2020 Jun 4; 5(11): e137189. Published online 2020 Jun 4. doi: 10.1172/jci.insight.137189
PMCID:
PMC7308063
AbstractArticlePDF–5.7M
17.
Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis
Tina Raselli, Tom Hearn, Annika Wyss, Kirstin Atrott, Alain Peter, Isabelle Frey-Wagner, Marianne R. Spalinger, Ewerton M. Maggio, Andreas W. Sailer, Johannes Schmitt, Philipp Schreiner, Anja Moncsek, Joachim Mertens, Michael Scharl, William J. Griffiths, Marco Bueter, Andreas Geier, Gerhard Rogler, Yuqin Wang, Benjamin Misselwitz
J Lipid Res. 2019 Jul; 60(7): 1270–1283. Published online 2019 May 21. doi: 10.1194/jlr.M093229
PMCID:
PMC6602130
AbstractArticlePDF–1.9M
18.
Antigen-presenting ILC3 regulate T cell–dependent IgA responses to colonic mucosal bacteria
Felipe Melo-Gonzalez, Hana Kammoun, Elza Evren, Emma E. Dutton, Markella Papadopoulou, Barry M. Bradford, Ceylan Tanes, Fahmina Fardus-Reid, Jonathan R. Swann, Kyle Bittinger, Neil A. Mabbott, Bruce A. Vallance, Tim Willinger, David R. Withers, Matthew R. Hepworth
J Exp Med. 2019 Apr 1; 216(4): 728–742. Published online 2019 Feb 27. doi: 10.1084/jem.20180871
PMCID:
PMC6446868
AbstractArticlePDF–3.0M
19.
Inhibition of B cell–dependent lymphoid follicle formation prevents lymphocytic bronchiolitis after lung transplantation
Natalia F. Smirnova, Thomas M. Conlon, Carmela Morrone, Peter Dorfmuller, Marc Humbert, Georgios T. Stathopoulos, Stephan Umkehrer, Franz Pfeiffer, Ali Ö. Yildirim, Oliver Eickelberg
JCI Insight. 2019 Feb 7; 4(3): e123971. Published online 2019 Feb 7. doi: 10.1172/jci.insight.123971
PMCID:
PMC6413786
AbstractArticlePDF–46M
20.
Anti-microbial Functions of Group 3 Innate Lymphoid Cells in Gut-Associated Lymphoid Tissues Are Regulated by G-Protein-Coupled Receptor 183
Coco Chu, Saya Moriyama, Zhi Li, Lei Zhou, Anne-Laure Flamar, Christoph S.N. Klose, Jesper B. Moeller, Gregory G. Putzel, David R. Withers, Gregory F. Sonnenberg, David Artis
Cell Rep. Author manuscript; available in PMC 2018 Oct 31.
Published in final edited form as: Cell Rep. 2018 Jun 26; 23(13): 3750–3758. doi: 10.1016/j.celrep.2018.05.099
PMCID:
PMC6209103
AbstractArticlePDF–965K

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