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Select item 111675211.

Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo

Kevin Toussaint, Aline Appert-Collin, Laetitia Vanalderwiert, Camille Bour, Christine Terryn, Caroline Spenlé, Michaël Van Der Heyden, Mathilde Roumieux, Pascal Maurice, Béatrice Romier-Crouzet, Hervé Sartelet, Laurent Duca, Sébastien Blaise, Amar Bennasroune

J Biol Chem. 2024 Jun; 300(6): 107316. Published online 2024 Apr 23. doi: 10.1016/j.jbc.2024.107316

PMCID:: PMC11167521

Abstract Article PDF–2.4M

Select item 106195042.

Severe kidney dysfunction in sialidosis mice reveals an essential role for neuraminidase 1 in reabsorption

Ikhui Kho, Ekaterina P. Demina, Xuefang Pan, Irene Londono, Christopher W. Cairo, Luisa Sturiale, Angelo Palmigiano, Angela Messina, Domenico Garozzo, Roth-Visal Ung, Fabrice Mac-Way, Éric Bonneil, Pierre Thibault, Mathieu Lemaire, Carlos R. Morales, Alexey V. Pshezhetsky

JCI Insight. 2023 Oct 23; 8(20): e166470. Published online 2023 Oct 23. doi: 10.1172/jci.insight.166470

PMCID:: PMC10619504

Abstract Article PDF–6.1M

Select item 101986343.

Structure of the immunoregulatory sialidase NEU1

Alexei Gorelik, Katalin Illes, Mohammad T. Mazhab-Jafari, Bhushan Nagar

Sci Adv. 2023 May; 9(20): eadf8169. Published online 2023 May 19. doi: 10.1126/sciadv.adf8169

PMCID:: PMC10198634

Abstract Article PDF–1.1M

Select item 100432834.

Neuraminidase 1 promotes renal fibrosis development in male mice

Qian-Qian Chen, Kang Liu, Ning Shi, Gaoxiang Ma, Peipei Wang, Hua-Mei Xie, Si-Jia Jin, Ting-Ting Wei, Xiang-Yu Yu, Yi Wang, Jun-Yuan Zhang, Ping Li, Lian-Wen Qi, Lei Zhang

Nat Commun. 2023; 14: 1713. Published online 2023 Mar 27. doi: 10.1038/s41467-023-37450-8

PMCID:: PMC10043283

Abstract Article PDF–6.7M

Select item 94897005.

Haploinsufficiency of the lysosomal sialidase NEU1 results in a model of pleomorphic rhabdomyosarcoma in mice

Eda R. Machado, Diantha van de Vlekkert, Heather S. Sheppard, Scott Perry, Susanna M. Downing, Jonathan Laxton, Richard Ashmun, David B. Finkelstein, Geoffrey A. Neale, Huimin Hu, Frank C. Harwood, Selene C. Koo, Gerard C. Grosveld, Alessandra d’Azzo

Commun Biol. 2022; 5: 992. Published online 2022 Sep 20. doi: 10.1038/s42003-022-03968-8

PMCID:: PMC9489700

Abstract Article PDF–13M

Select item 93234736.

The Janus‐like role of neuraminidase isoenzymes in inflammation

Md. Amran Howlader, Ekaterina P. Demina, Suzanne Samarani, Tianlin Guo, Antoine Caillon, Ali Ahmad, Alexey V. Pshezhetsky, Christopher W. Cairo

FASEB J. 2022 May; 36(5): e22285. Published online 2022 Apr 1. doi: 10.1096/fj.202101218R

PMCID:: PMC9323473

Abstract Article PDF–2.3M

Select item 90546617.

Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1

Daniel J. García-Domínguez, Nabil Hajji, Roser López-Alemany, Sara Sánchez-Molina, Elisabet Figuerola-Bou, Francisco J. Morón Civanto, Santiago Rello-Varona, Eduardo Andrés-León, Adrián Benito, Hector C. Keun, Jaume Mora, Óscar M. Tirado, Enrique de Álava, Lourdes Hontecillas-Prieto

Oncogene. 2022; 41(18): 2638–2650. Published online 2022 Mar 30. doi: 10.1038/s41388-022-02279-w

PMCID:: PMC9054661

Abstract Article PDF–5.4M

Select item 87418378.

Neuraminidase 1 deficiency attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory via AMPK-SIRT3 pathway in diabetic cardiomyopathy mice

Zhen Guo, Hu Tuo, Nan Tang, Fang-Yuan Liu, Shu-Qing Ma, Peng An, Dan Yang, Min-Yu Wang, Di Fan, Zheng Yang, Qi-Zhu Tang

Int J Biol Sci. 2022; 18(2): 826–840. Published online 2022 Jan 1. doi: 10.7150/ijbs.65938

PMCID:: PMC8741837

Abstract Article PDF–2.5M

Select item 84100359.

Early defects in mucopolysaccharidosis type IIIC disrupt excitatory synaptic transmission

Camila Pará, Poulomee Bose, Luigi Bruno, Erika Freemantle, Mahsa Taherzadeh, Xuefang Pan, Chanshuai Han, Peter S. McPherson, Jean-Claude Lacaille, Éric Bonneil, Pierre Thibault, Claire O’Leary, Brian Bigger, Carlos Ramon Morales, Graziella Di Cristo, Alexey V. Pshezhetsky

JCI Insight. 2021 Aug 9; 6(15): e142073. Published online 2021 Aug 9. doi: 10.1172/jci.insight.142073

PMCID:: PMC8410035

Abstract Article PDF–26M

Select item 800864410.

Acacetin ameliorates insulin resistance in obesity mice through regulating Treg/Th17 balance via MiR-23b-3p/NEU1 Axis

Yan Wei, Jianhong Jing, Zhiping Peng, Xiaoqian Liu, Xueyang Wang

BMC Endocr Disord. 2021; 21: 57. Published online 2021 Mar 29. doi: 10.1186/s12902-021-00688-8

PMCID:: PMC8008644

Abstract Article PDF–2.6M

Select item 751900611.

Neuraminidase-1 promotes heart failure after ischemia/reperfusion injury by affecting cardiomyocytes and invading monocytes/macrophages

Maren Heimerl, Irina Sieve, Melanie Ricke-Hoch, Sergej Erschow, Karin Battmer, Michaela Scherr, Denise Hilfiker-Kleiner

Basic Res Cardiol. 2020; 115(6): 62. Published online 2020 Sep 25. doi: 10.1007/s00395-020-00821-z

PMCID:: PMC7519006

Abstract Article PDF–9.2M

Select item 679446212.

Modulation of TLR4 Sialylation Mediated by a Sialidase Neu1 and Impairment of Its Signaling in Leishmania donovani Infected Macrophages

Joyshree Karmakar, Saptarshi Roy, Chitra Mandal

Front Immunol. 2019; 10: 2360. Published online 2019 Oct 9. doi: 10.3389/fimmu.2019.02360

PMCID:: PMC6794462

Abstract Article PDF–2.0M

Select item 657722613.

DLX-2, MASH-1, and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain

MH Porteus, A Bulfone, JK Liu, L Puelles, LC Lo, JL Rubenstein

J Neurosci. 1994 Nov 1; 14(11): 6370–6383. doi: 10.1523/JNEUROSCI.14-11-06370.1994

PMCID:: PMC6577226

Abstract PDF–5.6M

Select item 657710814.

Expression of neuron-specific tubulin defines a novel population in the proliferative layers of the developing telencephalon

JR Menezes, MB Luskin

J Neurosci. 1994 Sep 1; 14(9): 5399–5416. doi: 10.1523/JNEUROSCI.14-09-05399.1994

PMCID:: PMC6577108

Abstract PDF–4.8M

Select item 633388815.

Neuraminidase 1–mediated desialylation of the mucin 1 ectodomain releases a decoy receptor that protects against Pseudomonas aeruginosa lung infection

Erik P. Lillehoj, Wei Guang, Sang W. Hyun, Anguo Liu, Nicolas Hegerle, Raphael Simon, Alan S. Cross, Hideharu Ishida, Irina G. Luzina, Sergei P. Atamas, Simeon E. Goldblum

J Biol Chem. 2019 Jan 11; 294(2): 662–678. Published online 2018 Nov 14. doi: 10.1074/jbc.RA118.006022

PMCID:: PMC6333888

Abstract Article PDF–2.3M

Select item 622366116.

Accelerated aging and clearance of host anti-inflammatory enzymes by discrete pathogens fuels sepsis

Won Ho Yang, Douglas M. Heithoff, Peter V. Aziz, Benjamin Haslund-Gourley, Julia S. Westman, Sonoko Narisawa, Anthony B. Pinkerton, José Luis Millán, Victor Nizet, Michael J. Mahan, Jamey D. Marth

Cell Host Microbe. Author manuscript; available in PMC 2019 Oct 10.

Published in final edited form as: Cell Host Microbe. 2018 Oct 10; 24(4): 500–513.e5. doi: 10.1016/j.chom.2018.09.011

PMCID:: PMC6223661

Article PDF–1.8M

Select item 615328517.

Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice

Elizabeth J. White, Gabriel Gyulay, Šárka Lhoták, Magdalena M. Szewczyk, Taryne Chong, Mark T. Fuller, Omid Dadoo, Alison E. Fox-Robichaud, Richard C. Austin, Bernardo L. Trigatti, Suleiman A. Igdoura

J Biol Chem. 2018 Sep 21; 293(38): 14689–14706. Published online 2018 Aug 10. doi: 10.1074/jbc.RA118.004589

PMCID:: PMC6153285

Abstract Article PDF–3.9M

Select item 596676118.

Neuraminidase activity mediates IL-6 production by activated lupus-prone mesangial cells

Kamala Sundararaj, Jessalyn I. Rodgers, Subathra Marimuthu, Leah J. Siskind, Evelyn Bruner, Tamara K. Nowling

Am J Physiol Renal Physiol. 2018 Apr 1; 314(4): F630–F642. Published online 2017 Dec 20. doi: 10.1152/ajprenal.00421.2017

PMCID:: PMC5966761

Abstract Article

Select item 561763619.

Neuraminidase-1 mediates skeletal muscle regeneration

Juliana de Carvalho Neves, Vanessa Rodrigues Rizzato, Alan Fappi, Mariana Miranda Garcia, Gerson Chadi, Diantha van de Vlekkert, Alessandra d’Azzo, Edmar Zanoteli

Biochim Biophys Acta. Author manuscript; available in PMC 2017 Sep 27.

Published in final edited form as: Biochim Biophys Acta. 2015 Sep; 1852(9): 1755–1764. Published online 2015 May 19. doi: 10.1016/j.bbadis.2015.05.006

PMCID:: PMC5617636

Abstract Article PDF–1.6M

Select item 473084320.

Regulated lysosomal exocytosis mediates cancer progression

Eda Machado, Shai White-Gilbertson, Diantha van de Vlekkert, Laura Janke, Simon Moshiach, Yvan Campos, David Finkelstein, Elida Gomero, Rosario Mosca, Xiaohui Qiu, Christopher L. Morton, Ida Annunziata, Alessandra d’Azzo

Sci Adv. 2015 Dec; 1(11): e1500603. Published online 2015 Dec 18. doi: 10.1126/sciadv.1500603