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Select item 110531691.

Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects

Yu Shi, Daochao Huang, Cui Song, Ruixue Cao, Zhao Wang, Dan Wang, Li Zhao, Xiaolu Xu, Congyu Lu, Feng Xiong, Haowen Zhao, Shuxiang Li, Quansheng Zhou, Shuyue Luo, Dongjie Hu, Yun Zhang, Cui Wang, Yiping Shen, Weiting Su, Yili Wu, Karl Schmitz, Shuo Wei, Weihong Song

Nat Commun. 2024; 15: 3301. Published online 2024 Apr 26. doi: 10.1038/s41467-024-47670-1

PMCID:: PMC11053169

Abstract Article PDF–5.8M

Select item 109715462.

P53 and BCL-2 family proteins PUMA and NOXA define competitive fitness in pluripotent cell competition

Jose A. Valverde-Lopez, Lin Li-Bao, Rocío Sierra, Elisa Santos, Giovanna Giovinazzo, Covadonga Díaz-Díaz, Miguel Torres

PLoS Genet. 2024 Mar; 20(3): e1011193. Published online 2024 Mar 15. doi: 10.1371/journal.pgen.1011193

PMCID:: PMC10971546

Abstract Article PDF–5.1M

Select item 108504903.

Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice

Margs S. Brennan, Kerstin Brinkmann, Gerard Romero Sola, Geraldine Healey, Leonie Gibson, Lahiru Gangoda, Margaret A. Potts, Elizabeth Lieschke, Stephen Wilcox, Andreas Strasser, Marco J. Herold, Ana Janic

Cell Death Differ. 2024 Feb; 31(2): 159–169. Published online 2023 Dec 18. doi: 10.1038/s41418-023-01250-w

PMCID:: PMC10850490

Abstract Article PDF–3.2M

Select item 105298794.

Autophagy collaborates with apoptosis pathways to control oligodendrocyte number

Tingxin Zhang, Aksheev Bhambri, Yihe Zhang, Daniela Barbosa, Han-Gyu Bae, Jumin Xue, Sabeen Wazir, Sara B. Mulinyawe, Jun Hee Kim, Lu O. Sun

Cell Rep. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: Cell Rep. 2023 Aug 29; 42(8): 112943. Published online 2023 Aug 6. doi: 10.1016/j.celrep.2023.112943

PMCID:: PMC10529879

Abstract Article PDF–3.5M

Select item 104474335.

Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis

Fenyong Yao, Shisheng Huang, Jiahui Liu, Chunhua Tan, Mengqi Xu, Dengkui Wang, Maoqing Huang, Yiyao Zhu, Xingxu Huang, Shuijin He

Cell Death Dis. 2023 Aug; 14(8): 543. Published online 2023 Aug 23. doi: 10.1038/s41419-023-06071-w

PMCID:: PMC10447433

Abstract Article PDF–9.2M

Select item 99740956.

TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis

Chengzi Huang, Simin Zhao, Yajuan Yang, Ting Guo, Hanni Ke, Xin Mi, Yingying Qin, Zi-Jiang Chen, Shidou Zhao

J Clin Invest. 2023 Mar 1; 133(5): e162315. Published online 2023 Mar 1. doi: 10.1172/JCI162315

PMCID:: PMC9974095

Abstract Article PDF–3.1M

Select item 93044087.

Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex

Tamar Sapir, Aditya Kshirsagar, Anna Gorelik, Tsviya Olender, Ziv Porat, Ingrid E. Scheffer, David B. Goldstein, Orrin Devinsky, Orly Reiner

Nat Commun. 2022; 13: 4209. Published online 2022 Jul 21. doi: 10.1038/s41467-022-31752-z

PMCID:: PMC9304408

Abstract Article PDF–13M

Select item 91779548.

Contribution of Puma to Inflammatory Resolution During Early Pneumococcal Pneumonia

Daniel E. Kennedy II, Perceus Mody, Jean-Francois Gout, Wei Tan, Keun Seok Seo, Alicia K. Olivier, Jason W. Rosch, Justin A. Thornton

Front Cell Infect Microbiol. 2022; 12: 886901. Published online 2022 May 26. doi: 10.3389/fcimb.2022.886901

PMCID:: PMC9177954

Abstract Article PDF–4.2M

Select item 90912179.

Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death

Farrah El-Saafin, Maria I. Bergamasco, Yunshun Chen, Rose E. May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J. Davis, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Anne K. Voss

Cell Death Differ. 2022 May; 29(5): 1013–1027. Published online 2022 Mar 31. doi: 10.1038/s41418-022-00982-5

PMCID:: PMC9091217

Abstract Article PDF–7.2M

Select item 906196610.

Disulfiram Protects Against Radiation-Induced Intestinal Injury in Mice

Qingwen Yuan, Renjun Peng, Huijie Yu, Sinian Wang, Zhongmin Chen, Suhe Dong, Wei Li, Bo Cheng, Qisheng Jiang, Yuwen Cong, Fengsheng Li, Changzheng Li

Front Pharmacol. 2022; 13: 852669. Published online 2022 Apr 19. doi: 10.3389/fphar.2022.852669

PMCID:: PMC9061966

Abstract Article PDF–3.9M

Select item 826698511.

DNA repair in primordial follicle oocytes following cisplatin treatment

Quynh-Nhu Nguyen, Nadeen Zerafa, Jock K. Findlay, Martha Hickey, Karla J. Hutt

J Assist Reprod Genet. 2021 Jun; 38(6): 1405–1417. Published online 2021 Apr 16. doi: 10.1007/s10815-021-02184-3

PMCID:: PMC8266985

Abstract Article PDF–1.5M

Select item 825773712.

Puma- and Caspase9-mediated apoptosis is dispensable for p53-driven neural crest-based developmental defects

Margot E. Bowen, Abigail S. Mulligan, Aryo Sorayya, Laura D. Attardi

Cell Death Differ. 2021 Jul; 28(7): 2083–2094. Published online 2021 Feb 11. doi: 10.1038/s41418-021-00738-7

PMCID:: PMC8257737

Abstract Article PDF–2.8M

Select item 802656313.

Robust p53 stabilization is dispensable for its activation and tumor suppressor function

Ning Kon, Michael Churchill, Huan Li, Siddhartha Mukherjee, James J. Manfredi, Wei Gu

Cancer Res. Author manuscript; available in PMC 2021 Aug 15.

Published in final edited form as: Cancer Res. 2021 Feb 15; 81(4): 935–944. Published online 2020 Dec 15. doi: 10.1158/0008-5472.CAN-20-1804

PMCID:: PMC8026563

Abstract Article PDF–1.5M

Select item 794122414.

Nbs1‐mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis

Yu Chen, Jie Sun, Zhenyu Ju, Zhao‐Qi Wang, Tangliang Li

Cell Prolif. 2021 Mar; 54(3): e12972. Published online 2021 Feb 14. doi: 10.1111/cpr.12972

PMCID:: PMC7941224

Abstract Article PDF–1.3M

Select item 788870915.

Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling

Pauline Antonie Ulmke, Yuanbin Xie, Godwin Sokpor, Linh Pham, Orr Shomroni, Tea Berulava, Joachim Rosenbusch, Uttiya Basu, Andre Fischer, Huu Phuc Nguyen, Jochen F. Staiger, Tran Tuoc

Development. 2021 Feb 1; 148(3): dev188276. Published online 2021 Feb 8. doi: 10.1242/dev.188276

PMCID:: PMC7888709

Abstract Article

Select item 788601816.

p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)

Maya Maor-Nof, Zohar Shipony, Rodrigo Lopez-Gonzalez, Lisa Nakayama, Yong-Jie Zhang, Julien Couthouis, Jacob A. Blum, Patricia A. Castruita, Gabriel R. Linares, Kai Ruan, Gokul Ramaswami, David J. Simon, Aviv Nof, Manuel Santana, Kyuho Han, Nasa Sinnott-Armstrong, Michael C. Bassik, Daniel H. Geschwind, Marc Tessier-Lavigne, Laura D. Attardi, Thomas E. Lloyd, Justin K. Ichida, Fen-Biao Gao, William J. Greenleaf, Jennifer S. Yokoyama, Leonard Petrucelli, Aaron D. Gitler

Cell. Author manuscript; available in PMC 2022 Feb 4.

Published in final edited form as: Cell. 2021 Feb 4; 184(3): 689–708.e20. Published online 2021 Jan 21. doi: 10.1016/j.cell.2020.12.025

PMCID:: PMC7886018

Abstract Article PDF–2.7M

Select item 777826117.

Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice

Timothy J. Humpton, Koji Nomura, Julia Weber, Helge M. Magnussen, Andreas K. Hock, Colin Nixon, Sandeep Dhayade, David Stevenson, Danny T. Huang, Douglas Strathdee, Karen Blyth, Karen H. Vousden

Genes Dev. 2021 Jan 1; 35(1-2): 117–132. doi: 10.1101/gad.341875.120

Correction in:: Genes Dev. 2021 Jul 1; 35(13-14): 1071.

PMCID:: PMC7778261

Abstract Article PDF–9.6M

Select item 773761618.

BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage

Kerstin Brinkmann, Paul Waring, Stefan P Glaser, Verena Wimmer, Denny L Cottle, Ming Shen Tham, Duong Nhu, Lachlan Whitehead, Alex RD Delbridge, Guillaume Lessene, Ian M Smyth, Marco J Herold, Gemma L Kelly, Stephanie Grabow, Andreas Strasser

EMBO J. 2020 Dec 15; 39(24): e105561. Published online 2020 Nov 25. doi: 10.15252/embj.2020105561

PMCID:: PMC7737616

Abstract Article PDF–3.8M

Select item 764135819.

Loss of hepatocyte cell division leads to liver inflammation and fibrosis

Matthew R. Dewhurst, Jin Rong Ow, Gözde Zafer, Noémi K. M. van Hul, Heike Wollmann, Xavier Bisteau, David Brough, Hyungwon Choi, Philipp Kaldis

PLoS Genet. 2020 Nov; 16(11): e1009084. Published online 2020 Nov 4. doi: 10.1371/journal.pgen.1009084

PMCID:: PMC7641358

Abstract Article PDF–5.9M

Select item 740630820.

MYSM1 maintains ribosomal protein gene expression in hematopoietic stem cells to prevent hematopoietic dysfunction

Jad I. Belle, HanChen Wang, Amanda Fiore, Jessica C. Petrov, Yun Hsiao Lin, Chu-Han Feng, Thi Tuyet Mai Nguyen, Jacky Tung, Philippe M. Campeau, Uta Behrends, Theresa Brunet, Gloria Sarah Leszinski, Philippe Gros, David Langlais, Anastasia Nijnik

JCI Insight. 2020 Jul 9; 5(13): e125690. Published online 2020 Jul 9. doi: 10.1172/jci.insight.125690

PMCID:: PMC7406308

Abstract Article PDF–5.8M

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