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Select item 110417661.

Ancestral allele of DNA polymerase gamma modifies antiviral tolerance

Yilin Kang, Jussi Hepojoki, Rocio Sartori Maldonado, Takayuki Mito, Mügen Terzioglu, Tuula Manninen, Ravi Kant, Sachin Singh, Alaa Othman, Rohit Verma, Johanna Uusimaa, Kirmo Wartiovaara, Lauri Kareinen, Nicola Zamboni, Tuula Anneli Nyman, Anders Paetau, Anja Kipar, Olli Vapalahti, Anu Suomalainen

Nature. 2024; 628(8009): 844–853. Published online 2024 Apr 3. doi: 10.1038/s41586-024-07260-z

PMCID:: PMC11041766

Abstract Article PDF–25M

Select item 110023022.

Absence of both MGME1 and POLG EXO abolishes mtDNA whereas absence of either creates unique mtDNA duplications

Christian D. Gonzalez, Nadee Nissanka, Derek Van Booven, Anthony J. Griswold, Carlos T. Moraes

J Biol Chem. 2024 Apr; 300(4): 107128. Published online 2024 Mar 1. doi: 10.1016/j.jbc.2024.107128

PMCID:: PMC11002302

Abstract Article PDF–3.2M

Select item 108867863.

Mitochondrial Dysfunction and Protein Homeostasis in Aging: Insights from a Premature-Aging Mouse Model

Jaime M. Ross, Lars Olson, Giuseppe Coppotelli

Biomolecules. 2024 Feb; 14(2): 162. Published online 2024 Jan 30. doi: 10.3390/biom14020162

PMCID:: PMC10886786

Abstract Article PDF–5.5M

Select item 107916634.

NAD⁺ dependent UPR^mt activation underlies intestinal aging caused by mitochondrial DNA mutations

Liang Yang, Zifeng Ruan, Xiaobing Lin, Hao Wang, Yanmin Xin, Haite Tang, Zhijuan Hu, Yunhao Zhou, Yi Wu, Junwei Wang, Dajiang Qin, Gang Lu, Kerry M. Loomes, Wai-Yee Chan, Xingguo Liu

Nat Commun. 2024; 15: 546. Published online 2024 Jan 16. doi: 10.1038/s41467-024-44808-z

PMCID:: PMC10791663

Abstract Article PDF–5.0M

Select item 100679105.

Effective differentiation of double negative thymocytes requires high fidelity replication of mitochondrial DNA in an age dependent manner

Candice B. Limper, Narda Bondah, Daphne Zhu, Alanis N. Villanueva, Uchenna K. Chukwukere, Weishan Huang, Avery August

Front Immunol. 2023; 14: 1128626. Published online 2023 Mar 20. doi: 10.3389/fimmu.2023.1128626

PMCID:: PMC10067910

Abstract Article PDF–4.9M

Select item 97616766.

The Absence of Parkin Does Not Promote Dopamine or Mitochondrial Dysfunction in PolgA^D257A/D257A Mitochondrial Mutator Mice

Laura Scott, Senthilkumar S. Karuppagounder, Stewart Neifert, Bong Gu Kang, Hu Wang, Valina L. Dawson, Ted M. Dawson

J Neurosci. 2022 Dec 7; 42(49): 9263–9277. doi: 10.1523/JNEUROSCI.0545-22.2022

PMCID:: PMC9761676

Abstract Article PDF–4.1M

Select item 86921327.

DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53

Pengbo Wang, Boquan Wu, Shilong You, Saien Lu, Shengjun Xiong, Yuanming Zou, Pengyu Jia, Xiaofan Guo, Ying Zhang, Liu Cao, Yingxian Sun, Naijin Zhang

Int J Biol Sci. 2022; 18(1): 409–425. Published online 2022 Jan 1. doi: 10.7150/ijbs.65030

PMCID:: PMC8692132

Abstract Article PDF–3.2M

Select item 81367768.

DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion

Pedro Silva-Pinheiro, Carlos Pardo-Hernández, Aurelio Reyes, Lisa Tilokani, Anup Mishra, Raffaele Cerutti, Shuaifeng Li, Dieu-Hien Rozsivalova, Sebastian Valenzuela, Sukru A Dogan, Bradley Peter, Patricio Fernández-Silva, Aleksandra Trifunovic, Julien Prudent, Michal Minczuk, Laurence Bindoff, Bertil Macao, Massimo Zeviani, Maria Falkenberg, Carlo Viscomi

Nucleic Acids Res. 2021 May 21; 49(9): 5230–5248. Published online 2021 May 6. doi: 10.1093/nar/gkab282

Correction in:: Nucleic Acids Res. 2021 Oct 11; 49(18): 10803.

PMCID:: PMC8136776

Abstract Article PDF–8.7M

Select item 79633269.

Age‐associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon

Craig Stamp, Julia C. Whitehall, Anna L. M. Smith, David Houghton, Carla Bradshaw, Elizabeth A. Stoll, Alasdair P. Blain, Doug M. Turnbull, Laura C. Greaves

Aging Cell. 2021 Mar; 20(3): e13321. Published online 2021 Feb 24. doi: 10.1111/acel.13321

PMCID:: PMC7963326

Abstract Article PDF–1.1M

Select item 793877010.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 776960511.

Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing

Swaraj Basu, Xie Xie, Jay P. Uhler, Carola Hedberg-Oldfors, Dusanka Milenkovic, Olivier R. Baris, Sammy Kimoloi, Stanka Matic, James B. Stewart, Nils-Göran Larsson, Rudolf J. Wiesner, Anders Oldfors, Claes M. Gustafsson, Maria Falkenberg, Erik Larsson

PLoS Genet. 2020 Dec; 16(12): e1009242. Published online 2020 Dec 14. doi: 10.1371/journal.pgen.1009242

PMCID:: PMC7769605

Abstract Article PDF–2.0M

Select item 752518612.

Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition

Ryota Kuroki, Yui Murata, Satoshi Fuke, Yutaka Nakachi, Jun Nakashima, Gregory C. Kujoth, Tomas A. Prolla, Miki Bundo, Tadafumi Kato, Kazuya Iwamoto

Front Genet. 2020; 11: 519206. Published online 2020 Sep 16. doi: 10.3389/fgene.2020.519206

PMCID:: PMC7525186

Abstract Article PDF–1.1M

Select item 751188513.

Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD⁺ redox

Liang Yang, Xiaobing Lin, Haite Tang, Yuting Fan, Sheng Zeng, Lei Jia, Yukun Li, Yanan Shi, Shujing He, Hao Wang, Zhijuan Hu, Xiao Gong, Xiaoyan Liang, Yi Yang, Xingguo Liu

Aging Cell. 2020 Sep; 19(9): e13206. Published online 2020 Aug 3. doi: 10.1111/acel.13206

PMCID:: PMC7511885

Abstract Article PDF–1.8M

Select item 736389214.

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

Philip F. Dobson, Ella P. Dennis, Daniel Hipps, Amy Reeve, Alex Laude, Carla Bradshaw, Craig Stamp, Anna Smith, David J. Deehan, Doug M. Turnbull, Laura C. Greaves

Sci Rep. 2020; 10: 11643. Published online 2020 Jul 15. doi: 10.1038/s41598-020-68566-2

PMCID:: PMC7363892

Abstract Article PDF–8.5M

Select item 736234215.

Parkin and PINK1 mitigate STING-induced inflammation

Danielle A. Sliter, Jennifer Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D. Fischer, Jonathon L. Burman, Yan Li, Zhe Zhang, Derek P. Narendra, Huaibin Cai, Max Borsche, Christine Klein, Richard J. Youle

Nature. Author manuscript; available in PMC 2020 Jul 15.

Published in final edited form as: Nature. 2018 Sep; 561(7722): 258–262. Published online 2018 Aug 22. doi: 10.1038/s41586-018-0448-9

PMCID:: PMC7362342

Abstract Article PDF–3.9M

Select item 706811416.

Deleterious mtDNA mutations are common in mature oocytes

Hong Ma, Tomonari Hayama, Crystal Van Dyken, Hayley Darby, Amy Koski, Yeonmi Lee, Nuria Marti Gutierrez, Satsuki Yamada, Ying Li, Michael Andrews, Riffat Ahmed, Dan Liang, Thanasup Gonmanee, Eunju Kang, Mohammed Nasser, Beth Kempton, John Brigande, Trevor J McGill, Andre Terzic, Paula Amato, Shoukhrat Mitalipov

Biol Reprod. 2020 Mar; 102(3): 607–619. Published online 2019 Oct 17. doi: 10.1093/biolre/ioz202

PMCID:: PMC7068114

Abstract Article PDF–1.6M

Select item 705106417.

Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging

Kendra D. Maclaine, Kevin A. Stebbings, Daniel A. Llano, Justin S. Rhodes

PLoS One. 2020; 15(3): e0226860. Published online 2020 Mar 2. doi: 10.1371/journal.pone.0226860

PMCID:: PMC7051064

Abstract Article PDF–2.1M

Select item 704663418.

Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of proofreading-deficient mitochondrial polymerase

Kelsey L. McLaughlin, Kimberly A. Kew, Joseph M. McClung, Kelsey H. Fisher-Wellman

Sci Rep. 2020; 10: 3603. Published online 2020 Feb 27. doi: 10.1038/s41598-020-60536-y

PMCID:: PMC7046634

Abstract Article PDF–2.8M

Select item 698723219.

Prematurely aging mitochondrial DNA mutator mice display subchondral osteopenia and chondrocyte hypertrophy without further osteoarthritis features

Jeroen Geurts, Sonia Nasi, Pascal Distel, Magdalena Müller-Gerbl, Tomas A. Prolla, Gregory C. Kujoth, Ulrich A. Walker, Thomas Hügle

Sci Rep. 2020; 10: 1296. Published online 2020 Jan 28. doi: 10.1038/s41598-020-58385-w

PMCID:: PMC6987232

Abstract Article PDF–6.9M

Select item 685781220.

Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice

Mi-Jung Kim, Suraiya Haroon, Guang-Di Chen, Dalian Ding, Jonathan Wanagat, Lijie Liu, Yanping Zhang, Karessa White, Hyo-Jin Park, Chul Han, Kevin Boyd, Isabela Caicedo, Kaitlyn Evans, Paul J. Linser, Masaru Tanokura, Tomas Prolla, Richard Salvi, Marc Vermulst, Shinichi Someya

Exp Gerontol. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Exp Gerontol. 2019 Oct 1; 125: 110675. Published online 2019 Jul 22. doi: 10.1016/j.exger.2019.110675

PMCID:: PMC6857812

Abstract Article PDF–2.0M

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