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Select item 105574931.

Inflammation-mediated fibroblast activation and immune dysregulation in collagen VII-deficient skin

Morgan Anderson-Crannage, Alex M. Ascensión, Olga Ibanez-Solé, Hongwen Zhu, Edo Schaefer, Darcy Ottomanelli, Bruno Hochberg, Jian Pan, Wen Luo, Meijuan Tian, Yaya Chu, Mitchell S. Cairo, Ander Izeta, Yanling Liao

Front Immunol. 2023; 14: 1211505. Published online 2023 Sep 20. doi: 10.3389/fimmu.2023.1211505

PMCID:: PMC10557493

Abstract Article PDF–16M

Select item 93723172.

Therapeutic base editing and prime editing of COL7A1 mutations in recessive dystrophic epidermolysis bullosa

Sung-Ah Hong, Song-Ee Kim, A-Young Lee, Gue-Ho Hwang, Jong Hoon Kim, Hiroaki Iwata, Soo-Chan Kim, Sangsu Bae, Sang Eun Lee

Mol Ther. 2022 Aug 3; 30(8): 2664–2679. Published online 2022 Jun 10. doi: 10.1016/j.ymthe.2022.06.005

PMCID:: PMC9372317

Abstract Article PDF–4.7M

Select item 84954543.

Pro‐inflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang‐(1‐7)

Rocco Bernasconi, Kerstin Thriene, Elena Romero‐Fernández, Christine Gretzmeier, Tobias Kühl, Mareike Maler, Pauline Nauroy, Svenja Kleiser, Anne‐Catherine Rühl‐Muth, Michael Stumpe, Dimitra Kiritsi, Stefan F Martin, Boris Hinz, Leena Bruckner‐Tuderman, Jörn Dengjel, Alexander Nyström

EMBO Mol Med. 2021 Oct 7; 13(10): e14392. Published online 2021 Aug 30. doi: 10.15252/emmm.202114392

PMCID:: PMC8495454

Abstract Article PDF–3.9M

Select item 82147324.

Mouse models for dominant dystrophic epidermolysis bullosa carrying common human point mutations recapitulate the human disease

Blake R. C. Smith, Alexander Nyström, Cameron J. Nowell, Ingrid Hausser, Christine Gretzmeier, Susan J. Robertson, George A. Varigos, Cristina Has, Johannes S. Kern, Ken C. Pang

Dis Model Mech. 2021 Jun 1; 14(6): dmm048082. Published online 2021 Jun 4. doi: 10.1242/dmm.048082

PMCID:: PMC8214732

Abstract Article

Select item 79572655.

FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex

Chen Zhou, Danying Chen, Jianhan Ren, Delan Huang, Runze Li, Haotian Luo, Chenyu Guan, Yang Cao, Weicai Wang

J Cell Mol Med. 2021 Mar; 25(6): 3051–3062. Published online 2021 Feb 13. doi: 10.1111/jcmm.16351

PMCID:: PMC7957265

Abstract Article PDF–2.4M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 57899087.

Impaired lymphoid extracellular matrix impedes antibacterial immunity in epidermolysis bullosa

Alexander Nyström, Olivier Bornert, Tobias Kühl, Christine Gretzmeier, Kerstin Thriene, Jörn Dengjel, Andrea Pfister-Wartha, Dimitra Kiritsi, Leena Bruckner-Tuderman

Proc Natl Acad Sci U S A. 2018 Jan 23; 115(4): E705–E714. Published online 2018 Jan 5. doi: 10.1073/pnas.1709111115

PMCID:: PMC5789908

Abstract Article PDF–2.1M

Select item 56231568.

Rapid generation of Col7a1^-/- mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells

Beau R. Webber, Kyle T. O’Connor, Ron T. McElmurry, Elise N. Durgin, Cindy Eide, Christopher J. Lees, Megan J. Riddle, Wendy Mathews, Natasha Y. Frank, Mark A. Kluth, Christoph Ganss, Branden S. Moriarity, Markus H. Frank, Mark J. Osborn, Jakub Tolar

Lab Invest. Author manuscript; available in PMC 2018 Mar 11.

Published in final edited form as: Lab Invest. 2017 Oct; 97(10): 1218–1224. Published online 2017 Sep 11. doi: 10.1038/labinvest.2017.85

PMCID:: PMC5623156

Abstract Article PDF–720K

Select item 54845199.

p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate

Rose Richardson, Karen Mitchell, Nigel L. Hammond, Maria Rosaria Mollo, Evelyn N. Kouwenhoven, Niki D. Wyatt, Ian J. Donaldson, Leo Zeef, Tim Burgis, Rognvald Blance, Simon J. van Heeringen, Hendrik G. Stunnenberg, Huiqing Zhou, Caterina Missero, Rose Anne Romano, Satrajit Sinha, Michael J. Dixon, Jill Dixon

PLoS Genet. 2017 Jun; 13(6): e1006828. Published online 2017 Jun 12. doi: 10.1371/journal.pgen.1006828

PMCID:: PMC5484519

Abstract Article PDF–22M

Select item 534138210.

miR-29 Regulates Type VII Collagen in Recessive Dystrophic Epidermolysis Bullosa

Michael Vanden Oever, Daniel Muldoon, Wendy Mathews, Ron McElmurry, Jakub Tolar

J Invest Dermatol. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: J Invest Dermatol. 2016 Oct; 136(10): 2013–2021. Published online 2016 Jun 18. doi: 10.1016/j.jid.2016.05.115

PMCID:: PMC5341382

Abstract Article PDF–1.4M

Select item 522315911.

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression

Alexandra Naba, Karl R. Clauser, D. R. Mani, Steven A. Carr, Richard O. Hynes

Sci Rep. 2017; 7: 40495. Published online 2017 Jan 10. doi: 10.1038/srep40495

PMCID:: PMC5223159

Abstract Article PDF–2.3M

Select item 513178312.

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα

Katherine A. Fantauzzo, Philippe Soriano

Genes Dev. 2016 Nov 1; 30(21): 2443–2458. doi: 10.1101/gad.288746.116

PMCID:: PMC5131783

Abstract Article PDF–2.5M

Select item 456895313.

Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms

Alexander Nyström, Kerstin Thriene, Venugopal Mittapalli, Johannes S Kern, Dimitra Kiritsi, Jörn Dengjel, Leena Bruckner-Tuderman

EMBO Mol Med. 2015 Sep; 7(9): 1211–1228. Published online 2015 Jul 20. doi: 10.15252/emmm.201505061

PMCID:: PMC4568953

Abstract Article PDF–3.5M

Select item 436173714.

AMACO is a novel component of the basement membrane associated Fraser complex

Rebecca J. Richardson, Jan M. Gebauer, Jin-Li Zhang, Birgit Kobbe, Douglas R. Keene, Kristina Røkenes Karlsen, Stefânia Richetti, Alexander P. Wohl, Gerhard Sengle, Wolfram F. Neiss, Mats Paulsson, Matthias Hammerschmidt, Raimund Wagener

J Invest Dermatol. Author manuscript; available in PMC 2015 Mar 17.

Published in final edited form as: J Invest Dermatol. 2014 May; 134(5): 1313–1322. Published online 2013 Nov 14. doi: 10.1038/jid.2013.492

PMCID:: PMC4361737

Abstract Article PDF–2.1M

Select item 393104815.

The Cysteine-rich Region of Type VII Collagen Is a Cystine Knot with a New Topology

Henrik Wegener, Hauke Paulsen, Karsten Seeger

J Biol Chem. 2014 Feb 21; 289(8): 4861–4869. Published online 2014 Jan 2. doi: 10.1074/jbc.M113.531327

PMCID:: PMC3931048

Abstract Article PDF–1.8M

Select item 385539016.

Transforming growth factor-β3 is required for secondary palate fusion

Gabriele Proetzel, Sharon A. Pawlowski, Michael V. Wiles, Moying Yin, Gregory P. Boivin, Philip N. Howles, Jixang Ding, Mark W. J. Ferguson, Thomas Doetschman

Nat Genet. Author manuscript; available in PMC 2013 Dec 7.

Published in final edited form as: Nat Genet. 1995 Dec; 11(4): 10.1038/ng1295-409. doi: 10.1038/ng1295-409

PMCID:: PMC3855390

Abstract Article PDF–2.3M

Select item 372616717.

Collagen VII plays a dual role in wound healing

Alexander Nyström, Daniela Velati, Venugopal R. Mittapalli, Anja Fritsch, Johannes S. Kern, Leena Bruckner-Tuderman

J Clin Invest. 2013 Aug 1; 123(8): 3498–3509. Published online 2013 Jul 8. doi: 10.1172/JCI68127

PMCID:: PMC3726167

Abstract Article PDF–7.1M

Select item 357241018.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 355121819.

Analysis of chemotactic molecules in bone marrow-derived mesenchymal stem cells and the skin: Ccl27-Ccr10 axis as a basis for targeting to cutaneous tissues

Vitali Alexeev, Adele Donahue, Jouni Uitto, Olga Igoucheva

Cytotherapy. Author manuscript; available in PMC 2014 Feb 1.

Published in final edited form as: Cytotherapy. 2013 Feb; 15(2): 171–184.e1. doi: 10.1016/j.jcyt.2012.11.006

PMCID:: PMC3551218

Abstract Article PDF–2.2M

Select item 336550120.

Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome–associated proteins

Daiji Kiyozumi, Makiko Takeichi, Itsuko Nakano, Yuya Sato, Tomohiko Fukuda, Kiyotoshi Sekiguchi

J Cell Biol. 2012 May 28; 197(5): 677–689. doi: 10.1083/jcb.201203065

PMCID:: PMC3365501

Abstract Article PDF–2.9M

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