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Select item 108282691.

In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes

Richard Venz, Anita Goyala, Abel Soto-Gamez, Tugce Yenice, Marco Demaria, Collin Y. Ewald

GeroScience. 2024 Apr; 46(2): 1499–1514. Published online 2023 Aug 29. doi: 10.1007/s11357-023-00909-z

PMCID:: PMC10828269

Abstract Article PDF–3.0M

Select item 108029522.

Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly

Marcos Schaan Profes, Araven Tiroumalechetty, Neel Patel, Stephanie S. Lauar, Simone Sidoli, Peri T. Kurshan

PLoS Biol. 2024 Jan; 22(1): e3002466. Published online 2024 Jan 22. doi: 10.1371/journal.pbio.3002466

PMCID:: PMC10802952

Abstract Article PDF–2.7M

Select item 106619123.

Maintenance of appropriate size scaling of the C. elegans pharynx by YAP-1

Klement Stojanovski, Ioana Gheorghe, Peter Lenart, Anne Lanjuin, William B. Mair, Benjamin D. Towbin

Nat Commun. 2023; 14: 7564. Published online 2023 Nov 20. doi: 10.1038/s41467-023-43230-1

PMCID:: PMC10661912

Abstract Article PDF–7.1M

Select item 106176264.

SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans

Valerie J. Robert, Matthieu Caron, Loic Gely, Annie Adrait, Victoria Pakulska, Yohann Couté, Manon Chevalier, Christian G. Riedel, Cecile Bedet, Francesca Palladino

Development. 2023 Nov 1; 150(21): dev201755. Published online 2023 Oct 17. doi: 10.1242/dev.201755

PMCID:: PMC10617626

Abstract Article

Select item 105386575.

Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans

Hannah J. Smith, Anne Lanjuin, Arpit Sharma, Aditi Prabhakar, Ewelina Nowak, Peter G. Stine, Rohan Sehgal, Klement Stojanovski, Benjamin D. Towbin, William B. Mair

PLoS Genet. 2023 Sep; 19(9): e1010938. Published online 2023 Sep 18. doi: 10.1371/journal.pgen.1010938

PMCID:: PMC10538657

Abstract Article PDF–2.1M

Select item 104418036.

Rege-1 promotes C. elegans survival by modulating IIS and TOR pathways

Yi-Ting Tsai, Chen-Hsi Chang, Hsin-Yue Tsai

PLoS Genet. 2023 Aug; 19(8): e1010869. Published online 2023 Aug 9. doi: 10.1371/journal.pgen.1010869

PMCID:: PMC10441803

Abstract Article PDF–3.9M

Select item 101542367.

Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity

Wenming Huang, Chun Kew, Stephanie de Alcantara Fernandes, Anna Löhrke, Lynn Han, Constantinos Demetriades, Adam Antebi

Nat Aging. 2022; 2(9): 796–808. Published online 2022 Sep 19. doi: 10.1038/s43587-022-00275-z

PMCID:: PMC10154236

Abstract Article PDF–17M

Select item 98854408.

Intracellular lipid surveillance by small G protein geranylgeranylation

Abigail Watterson, Lexus Tatge, Naureen Wajahat, Sonja L. B. Arneaud, Rene Solano Fonseca, Shaghayegh T. Beheshti, Patrick Metang, Melina Mihelakis, Kielen R. Zuurbier, Chase D. Corley, Ishmael Dehghan, Jeffrey G. McDonald, Peter M. Douglas

Nature. Author manuscript; available in PMC 2023 Jan 30.

Published in final edited form as: Nature. 2022 May; 605(7911): 736–740. Published online 2022 May 18. doi: 10.1038/s41586-022-04729-7

PMCID:: PMC9885440

Abstract Article PDF–4.2M

Select item 97108739.

Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression

Robyn Branicky, Ying Wang, Arman Khaki, Ju-Ling Liu, Maximilian Kramer-Drauberg, Siegfried Hekimi

Sci Adv. 2022 Dec; 8(48): eadc9851. Published online 2022 Nov 30. doi: 10.1126/sciadv.adc9851

PMCID:: PMC9710873

Abstract Article PDF–2.2M

Select item 949559710.

Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction

Kerry C. Ryan, Jocelyn T. Laboy, Kenneth R. Norman

Antioxidants (Basel) 2022 Sep; 11(9): 1642. Published online 2022 Aug 24. doi: 10.3390/antiox11091642

PMCID:: PMC9495597

Abstract Article PDF–2.2M

Select item 943784811.

Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans

Murat Artan, Markus Hartl, Weiqiang Chen, Mario de Bono

J Biol Chem. 2022 Sep; 298(9): 102343. Published online 2022 Aug 3. doi: 10.1016/j.jbc.2022.102343

PMCID:: PMC9437848

Abstract Article PDF–2.0M

Select item 903611812.

The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy

Aileen K. Sewell, Zachary C. Poss, Christopher C. Ebmeier, Jeremy R. Jacobsen, William M. Old, Min Han

iScience. 2022 May 20; 25(5): 104186. Published online 2022 Mar 31. doi: 10.1016/j.isci.2022.104186

PMCID:: PMC9036118

Abstract Article PDF–2.4M

Select item 885722613.

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

Cyril Statzer, Jin Meng, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole Haynes, William B. Mair, Alban Longchamp, Milos R. Filipovic, T. Keith Blackwell, Collin Y. Ewald

Nat Commun. 2022; 13: 967. Published online 2022 Feb 18. doi: 10.1038/s41467-022-28599-9

PMCID:: PMC8857226

Abstract Article PDF–2.5M

Select item 852071314.

Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration

Kerry C. Ryan, Zahra Ashkavand, Shaarika Sarasija, Jocelyn T. Laboy, Rohan Samarakoon, Kenneth R. Norman

Aging Cell. 2021 Oct; 20(10): e13472. Published online 2021 Sep 9. doi: 10.1111/acel.13472

PMCID:: PMC8520713

Abstract Article PDF–1.6M

Select item 844679315.

Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling

Murat Artan, Stephen Barratt, Sean M. Flynn, Farida Begum, Mark Skehel, Armel Nicolas, Mario de Bono

J Biol Chem. 2021 Sep; 297(3): 101094. Published online 2021 Aug 18. doi: 10.1016/j.jbc.2021.101094

Correction in:: J Biol Chem. 2022 Jun; 298(6): 102081.

PMCID:: PMC8446793

Abstract Article PDF–1.6M

Select item 844560316.

Lamin regulates the dietary restriction response via the mTOR pathway in Caenorhabditis elegans

Chayki Charar, Sally Metsuyanim-Cohen, Daniel Z. Bar

J Cell Sci. 2021 Sep 1; 134(17): jcs258428. Published online 2021 Sep 6. doi: 10.1242/jcs.258428

PMCID:: PMC8445603

Abstract Article

Select item 833118317.

Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

Patricia Giselle Cipriani, Olivia Bay, John Zinno, Michelle Gutwein, Hin Hark Gan, Vinay K Mayya, George Chung, Jia-Xuan Chen, Hala Fahs, Yu Guan, Thomas F Duchaine, Matthias Selbach, Fabio Piano, Kristin C Gunsalus

eLife. 2021; 10: e60833. Published online 2021 Jul 5. doi: 10.7554/eLife.60833

PMCID:: PMC8331183

Abstract Article PDF–8.5M

Select item 799517618.

EPIC: Software Toolkit for Elution Profile-Based Inference of Protein Complexes

Lucas ZhongMing Hu, Florian Goebels, June H. Tan, Eric Wolf, Uros Kuzmanov, Cuihong Wan, Sadhna Phanse, Changjiang Xu, Mike Schertzberg, Andrew G. Fraser, Gary D. Bader, Andrew Emili

Nat Methods. Author manuscript; available in PMC 2021 Mar 26.

Published in final edited form as: Nat Methods. 2019 Aug; 16(8): 737–742. Published online 2019 Jul 15. doi: 10.1038/s41592-019-0461-4