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Select item 116307641.

SHC-3: a previously unidentified C. elegans Shc family member functions in the insulin-like signaling pathway to enhance survival during L1 arrest

Mercedes Di Bernardo, Victoria L León Guerrero, Jacob C Sutoski, William Rod Hardy, Lesley T MacNeil

Genetics. 2024 Oct; 228(2): iyae093. Published online 2024 Jun 11. doi: 10.1093/genetics/iyae093

PMCID:: PMC11630764

Abstract Article PDF–1.5M

Select item 113882642.

Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing

Qin Xia, Penglin Li, José C. Casas-Martinez, Antonio Miranda-Vizuete, Emma McDermott, Peter Dockery, Katarzyna Goljanek-Whysall, Brian McDonagh

Mol Metab. 2024 Oct; 88: 102003. Published online 2024 Aug 6. doi: 10.1016/j.molmet.2024.102003

PMCID:: PMC11388264

Abstract Article PDF–4.0M

Select item 112584803.

Combinatorial transcriptomic and genetic dissection of insulin/IGF‐1 signaling‐regulated longevity in Caenorhabditis elegans

Seokjin Ham, Sieun S. Kim, Sangsoon Park, Hyunwoo C. Kwon, Seokjun G. Ha, Yunkyu Bae, Gee‐Yoon Lee, Seung‐Jae V. Lee

Aging Cell. 2024 Jul; 23(7): e14151. Published online 2024 Mar 26. doi: 10.1111/acel.14151

PMCID:: PMC11258480

Abstract Article PDF–1.4M

Select item 112080494.

The neuron-specific IIS/FOXO transcriptome in aged animals reveals regulatory mechanisms of cognitive aging

Yifei Weng, Shiyi Zhou, Katherine Morillo, Rachel Kaletsky, Sarah Lin, Coleen T Murphy

eLife. 2024; 13: RP95621. Published online 2024 Jun 26. doi: 10.7554/eLife.95621

PMCID:: PMC11208049

Abstract Article PDF–4.7M

Select item 111789305.

Jujubae Fructus extract prolongs lifespan and improves stress tolerance in Caenorhabditis elegans dependent on DAF-16/SOD-3

Zhi Zhang, Jiajia Li, Feng Li, Tao Wang, Xiaoyan Luo, Bing Li, Yilin You, Changjing Wu, Xiaomeng Liu

Sci Rep. 2024; 14: 13713. Published online 2024 Jun 14. doi: 10.1038/s41598-024-64045-0

PMCID:: PMC11178930

Abstract Article PDF–2.1M

Select item 111624196.

DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells

Zhifei Zhang, Haiyan Yang, Lei Fang, Guangrong Zhao, Jun Xiang, Jialin C. Zheng, Zhao Qin

Nat Commun. 2024; 15: 4904. Published online 2024 Jun 8. doi: 10.1038/s41467-024-49318-6

PMCID:: PMC11162419

Abstract Article PDF–4.2M

Select item 111574847.

2-Butoxytetrahydrofuran, Isolated from Holothuria scabra, Attenuates Aggregative and Oxidative Properties of α-Synuclein and Alleviates Its Toxicity in a Transgenic Caenorhabditis elegans Model of Parkinson’s Disease

Sukrit Promtang, Tanatcha Sanguanphun, Pawanrat Chalorak, Laurence S. Pe, Nakorn Niamnont, Prasert Sobhon, Krai Meemon

ACS Chem Neurosci. 2024 Jun 5; 15(11): 2182–2197. Published online 2024 May 10. doi: 10.1021/acschemneuro.4c00008

PMCID:: PMC11157484

Abstract Article PDF–8.0M

Select item 111568748.

Time-course swRNA-seq uncovers a hierarchical gene regulatory network in controlling the response-repair-remodeling after wounding

Xinghai Yu, Jinghua Zhou, Wenkai Ye, Jingxiu Xu, Rui Li, Li Huang, Yi Chai, Miaomiao Wen, Suhong Xu, Yu Zhou

Commun Biol. 2024; 7: 694. Published online 2024 Jun 6. doi: 10.1038/s42003-024-06352-w

PMCID:: PMC11156874

Abstract Article PDF–10M

Select item 111455419.

Loss of the ceramide synthase HYL-2 from Caenorhabditis elegans impairs stress responses and alters sphingolipid composition

Huaiyi Zhu, Yunfei You, Boming Yu, Zhitao Deng, Min Liu, Zhenying Hu, Jingjing Duan

J Biol Chem. 2024 Jun; 300(6): 107320. Published online 2024 Apr 25. doi: 10.1016/j.jbc.2024.107320

PMCID:: PMC11145541

Abstract Article PDF–1.6M

Select item 1113528710.

Nicotine-mediated therapy for Parkinson’s disease in transgenic Caenorhabditis elegans model

Inam Ullah, Longhe Zhao, Shahab Uddin, Yangtao Zhou, Xin Wang, Hongyu Li

Front Aging Neurosci. 2024; 16: 1358141. Published online 2024 May 15. doi: 10.3389/fnagi.2024.1358141

PMCID:: PMC11135287

Abstract Article PDF–5.5M

Select item 1113165211.

Interaction of aging-associated signaling cascades: Inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1

A. Salminen, J. Ojala, J. Huuskonen, A. Kauppinen, T. Suuronen, K. Kaarniranta

Cell Mol Life Sci. 2008 Apr; 65(7-8): 1049–1058. Published online 2008 Jan 15. doi: 10.1007/s00018-008-7461-3

PMCID:: PMC11131652

Abstract Article PDF–368K

Select item 1111775912.

Sulforaphane Exposure Prevents Cadmium-Induced Toxicity and Mitochondrial Dysfunction in the Nematode Caenorhabditis elegans by Regulating the Insulin/Insulin-like Growth Factor Signaling (IIS) Pathway

Estefani Yaquelin Hernández-Cruz, Omar Emiliano Aparicio-Trejo, Dianelena Eugenio-Pérez, Elí Juárez-Peredo, Mariana Zurita-León, Víctor Julián Valdés, José Pedraza-Chaverri

Antioxidants (Basel) 2024 May; 13(5): 584. Published online 2024 May 9. doi: 10.3390/antiox13050584

PMCID:: PMC11117759

Abstract Article PDF–5.2M

Select item 1101993213.

LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans

Taruna Pandey, Bingying Wang, Changnan Wang, Jenny Zu, Huichao Deng, Kang Shen, Goncalo Dias do Vale, Jeffrey G. McDonald, Dengke K. Ma

Cell Rep. Author manuscript; available in PMC 2024 Apr 16.

Published in final edited form as: Cell Rep. 2024 Mar 26; 43(3): 113899. Published online 2024 Mar 5. doi: 10.1016/j.celrep.2024.113899

PMCID:: PMC11019932

Abstract Article PDF–1.8M

Select item 1100434214.

Phloretic acid requires the insulin/IGF-1 pathway and autophagy to enhance stress resistance and extend the lifespan of Caenorhabditis elegans

Bo Li, Li Dong, Wei Meng, Shi-Ying Xiong, Gui-Sheng Wu, Wen-Zhe Ma, Huai-Rong Luo

Front Pharmacol. 2024; 15: 1384227. Published online 2024 Mar 27. doi: 10.3389/fphar.2024.1384227

PMCID:: PMC11004342

Abstract Article PDF–3.0M

Select item 1100395815.

An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress

Carlos A. Vergani-Junior, Raíssa De P. Moro, Silas Pinto, Evandro A. De-Souza, Henrique Camara, Deisi L. Braga, Guilherme Tonon-da-Silva, Thiago L. Knittel, Gabriel P. Ruiz, Raissa G. Ludwig, Katlin B. Massirer, William B. Mair, Marcelo A. Mori

Nat Commun. 2024; 15: 3070. Published online 2024 Apr 9. doi: 10.1038/s41467-024-47306-4

PMCID:: PMC11003958

Abstract Article PDF–1.9M

Select item 1099679816.

DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans

Alyssa Johnson, Cristian Ricaurte-Perez, P. Wall, Olga Dubuisson, K. Bohnert

Version 1. Res Sq. Preprint. 2024 Mar 29. doi: 10.21203/rs.3.rs-4049366/v1

PMCID:: PMC10996798

Abstract Article PDF–1.6M

Select item 1095937317.

Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans

Dingxia Feng, Long Qu, Jo Anne Powell-Coffman

PLoS One. 2024; 19(3): e0295093. Published online 2024 Mar 22. doi: 10.1371/journal.pone.0295093

PMCID:: PMC10959373

Abstract Article PDF–1.0M

Select item 1095790118.

VDR and deubiquitination control neuronal oxidative stress and microglial inflammation in Parkinson’s disease

Zihui Zheng, Miao Chen, Shengliang Feng, Huanhuan Zhao, Tiange Qu, Xudong Zhao, Qinli Ruan, Lei Li, Jun Guo

Cell Death Discov. 2024; 10: 150. Published online 2024 Mar 21. doi: 10.1038/s41420-024-01912-9

PMCID:: PMC10957901

Abstract Article PDF–4.9M

Select item 1094633019.

Cell non-autonomous control of autophagy and metabolism by glial cells

Melissa G. Metcalf, Samira Monshietehadi, Arushi Sahay, Jenni Durieux, Ashley E. Frakes, Martina Velichkovska, Cesar Mena, Amelia Farinas, Melissa Sanchez, Andrew Dillin

iScience. 2024 Apr 19; 27(4): 109354. Published online 2024 Feb 28. doi: 10.1016/j.isci.2024.109354