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Select item 106248221.

Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria

Runshuai Zhang, Jinan Fang, Ting Qi, Shihao Zhu, Luxia Yao, Guicun Fang, Yunsheng Li, Xiao Zang, Weina Xu, Wanyu Hao, Shouye Liu, Dan Yang, Di Chen, Jian Yang, Xianjue Ma, Lianfeng Wu

Cell Res. 2023 Nov; 33(11): 821–834. Published online 2023 Jul 27. doi: 10.1038/s41422-023-00854-8

PMCID:: PMC10624822

Abstract Article PDF–5.2M

Select item 104573902.

Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans

Elite Possik, Laura-Lee Klein, Perla Sanjab, Ruyuan Zhu, Laurence Côté, Ying Bai, Dongwei Zhang, Howard Sun, Anfal Al-Mass, Abel Oppong, Rasheed Ahmad, Alex Parker, S.R. Murthy Madiraju, Fahd Al-Mulla, Marc Prentki

Nat Commun. 2023; 14: 5214. Published online 2023 Aug 25. doi: 10.1038/s41467-023-40857-y

PMCID:: PMC10457390

Abstract Article PDF–3.3M

Select item 103207663.

A transcriptional cofactor regulatory network for the C. elegans intestine

Brent B Horowitz, Shivani Nanda, Albertha J M Walhout

G3 (Bethesda) 2023 Jul; 13(7): jkad096. Published online 2023 Apr 29. doi: 10.1093/g3journal/jkad096

PMCID:: PMC10320766

Abstract Article PDF–1.9M

Select item 101542364.

Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity

Wenming Huang, Chun Kew, Stephanie de Alcantara Fernandes, Anna Löhrke, Lynn Han, Constantinos Demetriades, Adam Antebi

Nat Aging. 2022; 2(9): 796–808. Published online 2022 Sep 19. doi: 10.1038/s43587-022-00275-z

PMCID:: PMC10154236

Abstract Article PDF–17M

Select item 101326615.

Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway

Christopher Wong, Pratik Kadekar, Elena Jurczak, Richard Roy

PLoS Genet. 2023 Apr; 19(4): e1010716. Published online 2023 Apr 14. doi: 10.1371/journal.pgen.1010716

PMCID:: PMC10132661

Abstract Article PDF–2.4M

Select item 100818526.

Starvation-induced changes in somatic insulin/IGF-1R signaling drive metabolic programming across generations

Merly C. Vogt, Oliver Hobert

Sci Adv. 2023 Apr; 9(14): eade1817. Published online 2023 Apr 7. doi: 10.1126/sciadv.ade1817

PMCID:: PMC10081852

Abstract Article PDF–3.2M

Select item 99920957.

A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes

Gholamreza Fazeli, Roni Levin-Konigsberg, Michael C. Bassik, Christian Stigloher, Ann M. Wehman

Curr Biol. Author manuscript; available in PMC 2024 Feb 27.

Published in final edited form as: Curr Biol. 2023 Feb 27; 33(4): 607–621.e7. Published online 2023 Jan 17. doi: 10.1016/j.cub.2022.12.041

PMCID:: PMC9992095

Abstract Article PDF–2.5M

Select item 99249488.

Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1‐imidazoline receptor

Dominic F. Bennett, Anita Goyala, Cyril Statzer, Charles W. Beckett, Alexander Tyshkovskiy, Vadim N. Gladyshev, Collin Y. Ewald, João Pedro de Magalhães

Aging Cell. 2023 Feb; 22(2): e13774. Published online 2023 Jan 20. doi: 10.1111/acel.13774

PMCID:: PMC9924948

Abstract Article PDF–4.3M

Select item 98854409.

Intracellular lipid surveillance by small G protein geranylgeranylation

Abigail Watterson, Lexus Tatge, Naureen Wajahat, Sonja L. B. Arneaud, Rene Solano Fonseca, Shaghayegh T. Beheshti, Patrick Metang, Melina Mihelakis, Kielen R. Zuurbier, Chase D. Corley, Ishmael Dehghan, Jeffrey G. McDonald, Peter M. Douglas

Nature. Author manuscript; available in PMC 2023 Jan 30.

Published in final edited form as: Nature. 2022 May; 605(7911): 736–740. Published online 2022 May 18. doi: 10.1038/s41586-022-04729-7

PMCID:: PMC9885440

Abstract Article PDF–4.2M

Select item 984940210.

A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity

Jin-Hyuck Jeong, Jun-Seok Han, Youngae Jung, Seung-Min Lee, So-Hyun Park, Mooncheol Park, Min-Gi Shin, Nami Kim, Mi Sun Kang, Seokho Kim, Kwang-Pyo Lee, Ki-Sun Kwon, Chun-A. Kim, Yong Ryoul Yang, Geum-Sook Hwang, Eun-Soo Kwon

Nat Commun. 2023; 14: 288. Published online 2023 Jan 18. doi: 10.1038/s41467-023-35952-z

PMCID:: PMC9849402

Abstract Article PDF–2.5M

Select item 984141511.

Unscheduled epigenetic modifications cause genome instability and sterility through aberrant R-loops following starvation

Bing Sun, McLean Sherrin, Richard Roy

Nucleic Acids Res. 2023 Jan 11; 51(1): 84–98. Published online 2022 Dec 12. doi: 10.1093/nar/gkac1155

PMCID:: PMC9841415

Abstract Article PDF–5.4M

Select item 982067012.

Isocitrate Dehydrogenase Alpha-1 Modulates Lifespan and Oxidative Stress Tolerance in Caenorhabditis elegans

Zhi-Han Lin, Shun-Ya Chang, Wen-Chi Shen, Yen-Hung Lin, Chiu-Lun Shen, Sin-Bo Liao, Yu-Chun Liu, Chang-Shi Chen, Tsui-Ting Ching, Horng-Dar Wang

Int J Mol Sci. 2023 Jan; 24(1): 612. Published online 2022 Dec 29. doi: 10.3390/ijms24010612

PMCID:: PMC9820670

Abstract Article PDF–2.9M

Select item 971087313.

Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression

Robyn Branicky, Ying Wang, Arman Khaki, Ju-Ling Liu, Maximilian Kramer-Drauberg, Siegfried Hekimi

Sci Adv. 2022 Dec; 8(48): eadc9851. Published online 2022 Nov 30. doi: 10.1126/sciadv.adc9851

PMCID:: PMC9710873

Abstract Article PDF–2.2M

Select item 958481514.

The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

Chen-Song Zhang, Mengqi Li, Yu Wang, Xiaoyang Li, Yue Zong, Shating Long, Mingliang Zhang, Jin-Wei Feng, Xiaoyan Wei, Yan-Hui Liu, Baoding Zhang, Jianfeng Wu, Cixiong Zhang, Wenhua Lian, Teng Ma, Xiao Tian, Qi Qu, Yaxin Yu, Jinye Xiong, Dong-Tai Liu, Zhenhua Wu, Mingxia Zhu, Changchuan Xie, Yaying Wu, Zheni Xu, Chunyan Yang, Junjie Chen, Guohong Huang, Qingxia He, Xi Huang, Lei Zhang, Xiufeng Sun, Qingfeng Liu, Abdul Ghafoor, Fu Gui, Kaili Zheng, Wen Wang, Zhi-Chao Wang, Yong Yu, Qingliang Zhao, Shu-Yong Lin, Zhi-Xin Wang, Hai-Long Piao, Xianming Deng, Sheng-Cai Lin

Nat Metab. 2022; 4(10): 1369–1401. Published online 2022 Oct 10. doi: 10.1038/s42255-022-00640-7

PMCID:: PMC9584815

Abstract Article PDF–9.0M

Select item 949559715.

Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction

Kerry C. Ryan, Jocelyn T. Laboy, Kenneth R. Norman

Antioxidants (Basel) 2022 Sep; 11(9): 1642. Published online 2022 Aug 24. doi: 10.3390/antiox11091642

PMCID:: PMC9495597

Abstract Article PDF–2.2M

Select item 948099016.

Nutrient sensing pathways regulating adult reproductive diapause in C. elegans

Moriah Eustice, Daniel Konzman, Jeff M. Reece, Salil Ghosh, Jhullian Alston, Tyler Hansen, Andy Golden, Michelle R. Bond, Lara K. Abramowitz, John A. Hanover

PLoS One. 2022; 17(9): e0274076. Published online 2022 Sep 16. doi: 10.1371/journal.pone.0274076