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Select item 114646571.

TRPM8 overexpression suppresses hepatocellular carcinoma progression and improves survival by modulating the RTP3/STAT3 pathway

Lichan Chen, Nansong Xu, DongMei Gou, Jianning Song, Mingqin Zhou, Yajun Zhang, Haohua Zhang, Liwen Zhu, Weihong Huang, Yue Zhu, Cheng Gao, Dayong Gu, Yong Xu, Hongzhong Zhou

Cancer Med. 2024 Oct; 13(19): e70109. Published online 2024 Oct 9. doi: 10.1002/cam4.70109

PMCID:: PMC11464657

Abstract Article PDF–15M

Select item 109115992.

Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets

Anastasiia Stratiievska, Olga Filippova, Tahsin Özpolat, Daire Byrne, S. Lawrence Bailey, Aastha Chauhan, Molly Y. Mollica, Jeff Harris, Kali Esancy, Junmei Chen, Ajay K. Dhaka, Nathan J. Sniadecki, José A. López, Moritz Stolla

PLoS One. 2024; 19(3): e0289395. Published online 2024 Mar 4. doi: 10.1371/journal.pone.0289395

PMCID:: PMC10911599

Abstract Article PDF–2.2M

Select item 109076043.

Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer

Alessandro Alaimo, Sacha Genovesi, Nicole Annesi, Dario De Felice, Saurav Subedi, Alice Macchia, Federico La Manna, Yari Ciani, Federico Vannuccini, Vera Mugoni, Michela Notarangelo, Michela Libergoli, Francesca Broso, Riccardo Taulli, Ugo Ala, Aurora Savino, Martina Cortese, Somayeh Mirzaaghaei, Valeria Poli, Ian Marc Bonapace, Mauro Giulio Papotti, Luca Molinaro, Claudio Doglioni, Orazio Caffo, Adriano Anesi, Michael Nagler, Giovanni Bertalot, Francesco Giuseppe Carbone, Mattia Barbareschi, Umberto Basso, Erik Dassi, Massimo Pizzato, Alessandro Romanel, Francesca Demichelis, Marianna Kruithof-de Julio, Andrea Lunardi

EMBO J. 2024 Mar; 43(5): 780–805. Published online 2024 Feb 5. doi: 10.1038/s44318-024-00040-5

PMCID:: PMC10907604

Abstract Article PDF–5.4M

Select item 108551324.

Joint CB1 and NGF Receptor Activation Suppresses TRPM8 Activation in Etoposide-Resistant Retinoblastoma Cells

Szymon Ludwiczak, Jacqueline Reinhard, Peter S. Reinach, Aruna Li, Jakub Oronowicz, Aisha Yousf, Vinodh Kakkassery, Stefan Mergler

Int J Mol Sci. 2024 Feb; 25(3): 1733. Published online 2024 Jan 31. doi: 10.3390/ijms25031733

PMCID:: PMC10855132

Abstract Article PDF–3.0M

Select item 106025805.

TCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via Inhibiting Cold‐Sensing TRPM8 Channel

Xiaobo Li, Qi Qi, Yong Li, Qun Miao, Wenqian Yin, Jinghua Pan, Zhan Zhao, Xiaoying Chen, Fan Yang, Xiaofeng Zhou, Maohua Huang, Chenran Wang, Lijuan Deng, Dandan Huang, Ming Qi, Shuran Fan, Yiran Zhang, Shenghui Qiu, Weiqing Deng, Tongzheng Liu, Minfeng Chen, Wencai Ye, Dongmei Zhang

Adv Sci (Weinh) 2023 Oct; 10(30): 2302717. Published online 2023 Aug 27. doi: 10.1002/advs.202302717

PMCID:: PMC10602580

Abstract Article PDF–5.6M

Select item 105872376.

Structure of human TRPM8 channel

Sergii Palchevskyi, Mariusz Czarnocki-Cieciura, Giulio Vistoli, Silvia Gervasoni, Elżbieta Nowak, Andrea R. Beccari, Marcin Nowotny, Carmine Talarico

Commun Biol. 2023; 6: 1065. Published online 2023 Oct 19. doi: 10.1038/s42003-023-05425-6

PMCID:: PMC10587237

Abstract Article PDF–4.1M

Select item 102297437.

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN

Kaini Zhang, Chen Yang, Xin Zhou, Jin Liang, Jianjin Guo, Min Li, Yi Zhang, Shulin Shao, Peng Sun, Kai Li, Jingjing Huang, Fang Chen, Xiubin Liang, Dongming Su

Cell Mol Life Sci. 2023 Jun; 80(6): 168. Published online 2023 May 30. doi: 10.1007/s00018-023-04820-w

PMCID:: PMC10229743

Abstract Article PDF–2.9M

Select item 100926588.

TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/β‐catenin signalling

Ester Pagano, Barbara Romano, Donatella Cicia, Fabio A. Iannotti, Tommaso Venneri, Giuseppe Lucariello, Maria Francesca Nanì, Fabio Cattaneo, Paola De Cicco, Maria D'Armiento, Marcello De Luca, Ruggiero Lionetti, Stefania Lama, Paola Stiuso, Pietro Zoppoli, Geppino Falco, Silvia Marchianò, Stefano Fiorucci, Raffaele Capasso, Vincenzo Di Marzo, Francesca Borrelli, Angelo A. Izzo

Br J Pharmacol. 2023 Jan; 180(2): 235–251. Published online 2022 Oct 17. doi: 10.1111/bph.15960

PMCID:: PMC10092658

Abstract Article PDF–2.8M

Select item 98650489.

Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells

Nathalie Baumlin, Neerupma Silswal, John S. Dennis, Asef J. Niloy, Michael D. Kim, Matthias Salathe

Int J Mol Sci. 2023 Jan; 24(2): 1694. Published online 2023 Jan 15. doi: 10.3390/ijms24021694

PMCID:: PMC9865048

Abstract Article PDF–2.4M

Select item 954390710.

The cation channel TRPM8 influences the differentiation and function of human monocytes

Eve Hornsby, Hamish W. King, Madusha Peiris, Roberto Buccafusca, Wing‐Yiu Jason Lee, Elinor S. Wing, L. Ashley Blackshaw, James O. Lindsay, Andrew J. Stagg

J Leukoc Biol. 2022 Sep; 112(3): 365–381. Published online 2022 Mar 1. doi: 10.1002/JLB.1HI0421-181R

PMCID:: PMC9543907

Abstract Article PDF–5.3M

Select item 954061411.

Cold sensor, hot topic: TRPM8 plays a role in monocyte function and differentiation

Brie Trusiano, Juselyn D. Tupik, Irving C. Allen

J Leukoc Biol. 2022 Sep; 112(3): 361–363. Published online 2022 May 15. doi: 10.1002/JLB.3CE0222-099R

PMCID:: PMC9540614

Abstract Article PDF–391K

Select item 928494712.

Current view of ligand and lipid recognition by the menthol receptor TRPM8

Ying Yin, Seok-Yong Lee

Trends Biochem Sci. Author manuscript; available in PMC 2022 Jul 15.

Published in final edited form as: Trends Biochem Sci. 2020 Sep; 45(9): 806–819. Published online 2020 Jun 9. doi: 10.1016/j.tibs.2020.05.008

PMCID:: PMC9284947

Abstract Article PDF–3.4M

Select item 922446313.

TRPM8 as an Anti–Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination

Guillaume P. Grolez, Giorgia Chinigò, Alexandre Barras, Mehdi Hammadi, Lucile Noyer, Kateryna Kondratska, Etmar Bulk, Thibauld Oullier, Séverine Marionneau-Lambot, Marilyne Le Mée, Stéphanie Rétif, Stéphanie Lerondel, Antonino Bongiovanni, Tullio Genova, Sébastien Roger, Rabah Boukherroub, Albrecht Schwab, Alessandra Fiorio Pla, Dimitra Gkika

Int J Mol Sci. 2022 Jun; 23(12): 6672. Published online 2022 Jun 15. doi: 10.3390/ijms23126672

PMCID:: PMC9224463

Abstract Article PDF–3.7M

Select item 903197114.

Deciphering the Role of the rs2651899, rs10166942, and rs11172113 Polymorphisms in Migraine: A Meta-Analysis

Vasileios Siokas, Ioannis Liampas, Athina-Maria Aloizou, Maria Papasavva, Christos Bakirtzis, Eleftherios Lavdas, Panagiotis Liakos, Nikolaos Drakoulis, Dimitrios P. Bogdanos, Efthimios Dardiotis

Medicina (Kaunas) 2022 Apr; 58(4): 491. Published online 2022 Mar 29. doi: 10.3390/medicina58040491

PMCID:: PMC9031971

Abstract Article PDF–5.7M

Select item 896166815.

Trpm8 Expression in Human and Mouse Castration Resistant Prostate Adenocarcinoma Paves the Way for the Preclinical Development of TRPM8-Based Targeted Therapies

Sacha Genovesi, Riccardo Moro, Beatrice Vignoli, Dario De Felice, Marco Canossa, Rodolfo Montironi, Francesco Giuseppe Carbone, Mattia Barbareschi, Andrea Lunardi, Alessandro Alaimo

Biomolecules. 2022 Feb; 12(2): 193. Published online 2022 Jan 23. doi: 10.3390/biom12020193