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Items: 1 to 20 of 158

1.
Genetic polymorphism in untranslated regions of PRKCZ influences mRNA structure, stability and binding sites
Aneela Mustafa, Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Fizzah Abid, Janeen H. Trembley, Tayyaba Afsar, Ali Almajwal, Suhail Razak
BMC Cancer. 2024; 24: 1147. Published online 2024 Sep 13. doi: 10.1186/s12885-024-12900-8
PMCID:
PMC11401371
AbstractArticlePDF–2.0M
2.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer
Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740
PMCID:
PMC11109483
AbstractArticlePDF–2.9M
3.
PKC-ζ mediated reduction of the extracellular vesicles-associated TGF-β1 overcomes radiotherapy resistance in breast cancer
Fayun Zhang, Zifeng Zheng, Luoyang Wang, Wenfeng Zeng, Wenjing Wei, Chunling Zhang, Ziran Zhao, Wei Liang
Breast Cancer Res. 2023; 25: 38. Published online 2023 Apr 7. doi: 10.1186/s13058-023-01641-4
PMCID:
PMC10082517
AbstractArticlePDF–5.7M
4.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
5.
Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma
Eijiro Shimada, Yoshihiro Matsumoto, Makoto Nakagawa, Yosuke Susuki, Makoto Endo, Nokitaka Setsu, Toshifumi Fujiwara, Keiichiro Iida, Akira Nabeshima, Kenichiro Yahiro, Atsushi Kimura, Takeshi Hirose, Masaya Kanahori, Ryunosuke Oyama, Yoshinao Oda, Yasuharu Nakashima
Br J Cancer. 2022 May 18; 126(9): 1289–1300. Published online 2022 Jan 11. doi: 10.1038/s41416-021-01695-1
PMCID:
PMC9042856
AbstractArticlePDF–4.8M
6.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang
Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003
PMCID:
PMC8897022
AbstractArticlePDF–3.0M
7.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
8.
Cord Blood T Cells Expressing High and Low PKCζ Levels Develop into Cells with a Propensity to Display Th1 and Th9 Cytokine Profiles, Respectively
Khalida Perveen, Alex Quach, Andrew McPhee, Susan L. Prescott, Simon C. Barry, Charles S. Hii, Antonio Ferrante
Int J Mol Sci. 2021 May; 22(9): 4907. Published online 2021 May 5. doi: 10.3390/ijms22094907
PMCID:
PMC8124775
AbstractArticlePDF–2.4M
9.
SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors
Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M. Miller Jenkins, Yves Pommier
Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2015654118. Published online 2021 Feb 3. doi: 10.1073/pnas.2015654118
PMCID:
PMC8017720
AbstractArticlePDF–1.9M
10.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger
Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001
PMCID:
PMC7427327
AbstractArticle
11.
A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity
Wei Dong, Juan Lu, Xuejing Zhang, Yan Wu, Kaela Lettieri, Gerald R. Hammond, Yang Hong
J Cell Biol. 2020 Jul 6; 219(7): e201903031. Published online 2020 Jun 24. doi: 10.1083/jcb.201903031
PMCID:
PMC7337507
AbstractArticlePDF–6.5M
12.
The Deubiquitinating Enzyme USP20 Regulates the TNFα-Induced NF-κB Signaling Pathway through Stabilization of p62
Jihoon Ha, Minbeom Kim, Dongyeob Seo, Jin Seok Park, Jaewon Lee, Jinjoo Lee, Seok Hee Park
Int J Mol Sci. 2020 May; 21(9): 3116. Published online 2020 Apr 28. doi: 10.3390/ijms21093116
PMCID:
PMC7247158
AbstractArticlePDF–3.3M
13.
Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21WAF1-PKCζ pathway in p16INK4a-silenced cells
Yun Yeong Lee, Yeon Seung Choi, Do Wan Kim, Jae Youn Cheong, Kye Yong Song, Min Sook Ryu, In Kyoung Lim
Aging (Albany NY) 2020 Apr 30; 12(8): 6700–6732. Published online 2020 Apr 24. doi: 10.18632/aging.103029
PMCID:
PMC7202532
AbstractArticlePDF–3.9M
14.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
15.
NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1
Birendra Kumar Shrestha, Mads Skytte Rasmussen, Yakubu Princely Abudu, Jack-Ansgar Bruun, Kenneth Bowitz Larsen, Endalkachew A. Alemu, Eva Sjøttem, Trond Lamark, Terje Johansen
J Biol Chem. 2020 Jan 31; 295(5): 1240–1260. Published online 2019 Dec 19. doi: 10.1074/jbc.RA119.010068
PMCID:
PMC6996884
AbstractArticlePDF–4.6M
16.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D
Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch
Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9
PMCID:
PMC6981206
AbstractArticlePDF–3.7M
17.
Activation of Atypical Protein Kinase C by Sphingosine 1-Phosphate Revealed by Atypical Protein Kinase C-Specific Activity Reporter
Taketoshi Kajimoto, Alisha D. Caliman, Irene S. Tobias, Taro Okada, Caila A. Pilo, An-Angela N. Van, J. Andrew McCammon, Shun-ichi Nakamura, Alexandra C. Newton
Sci Signal. Author manuscript; available in PMC 2019 Jul 25.
Published in final edited form as: Sci Signal. 2019 Jan 1; 12(562): eaat6662. Published online 2019 Jan 1. doi: 10.1126/scisignal.aat6662
PMCID:
PMC6657501
AbstractArticlePDF–1.1M
18.
PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling
Adnan Shami Shah, Alex G. Batrouni, Dongsung Kim, Amith Punyala, Wendy Cao, Chun Han, Michael L. Goldberg, Marcus B. Smolka, Jeremy M. Baskin
Cell Rep. Author manuscript; available in PMC 2019 Jun 26.
Published in final edited form as: Cell Rep. 2019 May 14; 27(7): 2157–2170.e8. doi: 10.1016/j.celrep.2019.04.060
PMCID:
PMC6594551
AbstractArticlePDF–1.4M
19.
Indomethacin impairs mitochondrial dynamics by activating the PKCζ–p38–DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells
Somnath Mazumder, Rudranil De, Subhashis Debsharma, Samik Bindu, Pallab Maity, Souvik Sarkar, Shubhra Jyoti Saha, Asim Azhar Siddiqui, Chinmoy Banerjee, Shiladitya Nag, Debanjan Saha, Saikat Pramanik, Kalyan Mitra, Uday Bandyopadhyay
J Biol Chem. 2019 May 17; 294(20): 8238–8258. Published online 2019 Apr 2. doi: 10.1074/jbc.RA118.004415
PMCID:
PMC6527165
AbstractArticlePDF–5.6M
20.
Simultaneous Loss of both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance
Yuki Nakanishi, Angeles Duran, Antoine L’Hermitte, Phillip M. Shelton, Naoko Nakanishi, Miguel Reina-Campos, Jianfeng Huang, Ferran Soldevila, Bas J.G. Baaten, Daniele V.F. Tauriello, Elias A. Castilla, Munveer S. Bhangoo, Fei Bao, Darren Sigal, Maria T. Diaz-Meco, Jorge Moscat
Immunity. Author manuscript; available in PMC 2019 Dec 18.
Published in final edited form as: Immunity. 2018 Dec 18; 49(6): 1132–1147.e7. Published online 2018 Dec 11. doi: 10.1016/j.immuni.2018.09.013
PMCID:
PMC6301096
AbstractArticlePDF–2.2M

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