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Select item 111740931.

IGF2BP2 Maintains Retinal Pigment Epithelium Homeostasis by Stabilizing PAX6 and OTX2

Siqi Wu, Fuxi Li, Kunlun Mo, Huaxing Huang, Yankun Yu, Ying Huang, Jiafeng Liu, Mingsen Li, Jieying Tan, Zesong Lin, Zhuo Han, Li Wang, Hong Ouyang

Invest Ophthalmol Vis Sci. 2024 Jun; 65(6): 17. Published online 2024 Jun 11. doi: 10.1167/iovs.65.6.17

PMCID:: PMC11174093

Abstract Article PDF–8.6M

Select item 110229282.

Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice

Miaomiao Suo, Megan K. Rommelfanger, Yulin Chen, Elias Moris Amro, Bing Han, Zhiyang Chen, Karol Szafranski, Sundaram Reddy Chakkarappan, Bernhard O. Boehm, Adam L. MacLean, K. Lenhard Rudolph

Blood. 2022 Apr 28; 139(17): 2653–2665. Published online 2022 Mar 3. doi: 10.1182/blood.2021012197

PMCID:: PMC11022928

Abstract Article

Select item 108236333.

FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer

Zhiyuan Zhou, Bin Zhang, Yue Deng, Suke Deng, Jie Li, Wenwen Wei, Yijun Wang, Jiacheng Wang, Zishan Feng, Mengjie Che, Xiao Yang, Jingshu Meng, Yan Li, Yan Hu, Yajie Sun, Lu Wen, Fang Huang, Yuhan Sheng, Chao Wan, Kunyu Yang

J Exp Clin Cancer Res. 2024; 43: 34. Published online 2024 Jan 29. doi: 10.1186/s13046-024-02959-3

PMCID:: PMC10823633

Abstract Article PDF–10M

Select item 107878374.

METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner

Fei Cao, Guojun Chen, Yixin Xu, Xintong Wang, Xiaole Tang, Wenyu Zhang, Xiong Song, Xiaohua Yang, Weian Zeng, Jingdun Xie

Cell Death Dis. 2024 Jan; 15(1): 43. Published online 2024 Jan 13. doi: 10.1038/s41419-023-06407-6

PMCID:: PMC10787837

Abstract Article PDF–8.2M

Select item 106980105.

RNA binding protein IGF2BP2 expression is induced by stress in the heart and mediates dilated cardiomyopathy

Miriam Krumbein, Froma Oberman, Yuval Cinnamon, Mordechai Golomb, Dalit May, Gilad Vainer, Vitali Belzer, Karen Meir, Irina Fridman, Johannes Haybaeck, Gerhard Poelzl, Izhak Kehat, Ronen Beeri, Sonja M. Kessler, Joel K. Yisraeli

Commun Biol. 2023; 6: 1229. Published online 2023 Dec 5. doi: 10.1038/s42003-023-05547-x

PMCID:: PMC10698010

Abstract Article PDF–2.8M

Select item 105169496.

A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

Anna Laddach, Song Hui Chng, Reena Lasrado, Fränze Progatzky, Michael Shapiro, Alek Erickson, Marisol Sampedro Castaneda, Artem V. Artemov, Ana Carina Bon-Frauches, Eleni-Maria Amaniti, Jens Kleinjung, Stefan Boeing, Sila Ultanir, Igor Adameyko, Vassilis Pachnis

Nat Commun. 2023; 14: 5904. Published online 2023 Sep 22. doi: 10.1038/s41467-023-41492-3

PMCID:: PMC10516949

Abstract Article PDF–4.8M

Select item 104936657.

Degradation of NLRP3 by p62‐dependent‐autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia

Dongyuan Zhang, Yu Zhang, Jirong Pan, Jingjing Cao, Xiuping Sun, Xianglei Li, Ling Zhang, Chuan Qin

CNS Neurosci Ther. 2023 Oct; 29(10): 2826–2842. Published online 2023 Apr 18. doi: 10.1111/cns.14219

PMCID:: PMC10493665

Abstract Article PDF–29M

Select item 96706068.

LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis

Tingwei Peng, Mingchuan Liu, Lang Hu, Dong Guo, Di Wang, Bingchao Qi, Gaotong Ren, Chenchen Hu, Feng Zhang, Hyung J. Chun, Liqiang Song, Jianqiang Hu, Yan Li

Biol Direct. 2022; 17: 32. Published online 2022 Nov 16. doi: 10.1186/s13062-022-00346-6

PMCID:: PMC9670606

Abstract Article PDF–7.2M

Select item 92353199.

Loss of Hilnc prevents the development of diet-induced hepatic steatosis through IGF2BP2

Yiao Jiang, Jiayin Peng, Jiawen Song, Juan He, Man Jiang, Jia Wang, Liya Ma, Yuang Wang, Moubin Lin, Hailong Wu, Zhao Zhang, Dong Gao, Yun Zhao

Nat Metab. Author manuscript; available in PMC 2022 Jun 27.

Published in final edited form as: Nat Metab. 2021 Nov; 3(11): 1569–1584. Published online 2021 Nov 8. doi: 10.1038/s42255-021-00488-3

PMCID:: PMC9235319

Abstract Article PDF–4.0M

Select item 885581110.

The RNA-binding protein IMP2 drives a stromal-Th17 cell circuit in autoimmune neuroinflammation

Rami Bechara, Nilesh Amatya, Saikat Majumder, Chunsheng Zhou, Yang Li, Qixing Liu, Mandy J. McGeachy, Sarah L. Gaffen

JCI Insight. 2022 Feb 8; 7(3): e152766. Published online 2022 Feb 8. doi: 10.1172/jci.insight.152766

PMCID:: PMC8855811

Abstract Article PDF–4.8M

Select item 874102411.

Let-7e-5p Regulates IGF2BP2, and Induces Muscle Atrophy

Takuro Okamura, Hiroshi Okada, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Naoko Nakanishi, Mai Asano, Masahiro Yamazaki, Masahide Hamaguchi, Michiaki Fukui

Front Endocrinol (Lausanne) 2021; 12: 791363. Published online 2021 Dec 24. doi: 10.3389/fendo.2021.791363

PMCID:: PMC8741024

Abstract Article PDF–17M

Select item 853460712.

Neuron-Specific IMP2 Overexpression by Synapsin Promoter-Driven AAV9: A Tool to Study Its Role in Axon Regeneration

Sarah Blizard, Danielle Park, Natalie O’Toole, Sheeva Norooz, Martin Dela Torre, Young Son, Adam Holstein, Scarlett Austin, Joshua Harman, Samantha Haraszti, Daved Fared, Mei Xu

Cells. 2021 Oct; 10(10): 2654. Published online 2021 Oct 5. doi: 10.3390/cells10102654

PMCID:: PMC8534607

Abstract Article PDF–1.2M

Select item 840428113.

The m⁶A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis

Rami Bechara, Nilesh Amatya, Rachel D. Bailey, Yang Li, Felix EY Aggor, De-Dong Li, Chetan V. Jawale, Bianca M. Coleman, Ning Dai, Nandan S. Gokhale, Tiffany C. Taylor, Stacy M. Horner, Amanda C. Poholek, Anita Bansal, Partha S. Biswas, Sarah L. Gaffen

Sci Immunol. Author manuscript; available in PMC 2022 Jan 2.

Published in final edited form as: Sci Immunol. 2021 Jul 2; 6(61): eabd1287. doi: 10.1126/sciimmunol.abd1287

PMCID:: PMC8404281

Abstract Article PDF–2.5M

Select item 828911614.

Lnc-ORA interacts with microRNA-532-3p and IGF2BP2 to inhibit skeletal muscle myogenesis

Rui Cai, Que Zhang, Yingqian Wang, Wenlong Yong, Rui Zhao, Weijun Pang

J Biol Chem. 2021 Jan-Jun; 296: 100376. Published online 2021 Feb 4. doi: 10.1016/j.jbc.2021.100376

PMCID:: PMC8289116

Abstract Article PDF–6.3M

Select item 826661715.

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

Benjamin Lang, Jae-Seong Yang, Mireia Garriga-Canut, Silvia Speroni, Moritz Aschern, Maria Gili, Tobias Hoffmann, Gian Gaetano Tartaglia, Sebastian P Maurer

Nucleic Acids Res. 2021 Jul 9; 49(12): 6702–6721. Published online 2021 Jun 16. doi: 10.1093/nar/gkab490

PMCID:: PMC8266617

Abstract Article PDF–4.0M

Select item 826149116.

The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ

Xia Wang, Yuge Ji, Panpan Feng, Rucheng Liu, Guosheng Li, Junjie Zheng, Yaqiang Xue, Yaxun Wei, Chunyan Ji, Dawei Chen, Jingxin Li

Adv Sci (Weinh) 2021 Jul; 8(13): 2100209. Published online 2021 May 3. doi: 10.1002/advs.202100209

PMCID:: PMC8261491

Abstract Article PDF–5.3M

Select item 807671317.

RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression

Laura Regué, Liping Zhao, Fei Ji, Hua Wang, Joseph Avruch, Ning Dai

Mol Metab. 2021 Jun; 48: 101209. Published online 2021 Mar 9. doi: 10.1016/j.molmet.2021.101209

PMCID:: PMC8076713

Abstract Article PDF–2.3M

Select item 796892518.

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

Xiaochen Fan, V Pragathi Masamsetti, Jane QJ Sun, Kasper Engholm-Keller, Pierre Osteil, Joshua Studdert, Mark E Graham, Nicolas Fossat, Patrick PL Tam

eLife. 2021; 10: e62873. Published online 2021 Feb 8. doi: 10.7554/eLife.62873

PMCID:: PMC7968925

Abstract Article PDF–4.0M

Select item 673700519.

IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis

Beate Czepukojc, Ali Abuhaliema, Ahmad Barghash, Sascha Tierling, Norbert Naß, Yvette Simon, Christina Körbel, Cristina Cadenas, Noemi van Hul, Agapios Sachinidis, Jan G. Hengstler, Volkhard Helms, Matthias W. Laschke, Jörn Walter, Johannes Haybaeck, Isabelle Leclercq, Alexandra K. Kiemer, Sonja M. Kessler

Front Med (Lausanne) 2019; 6: 179. Published online 2019 Sep 4. doi: 10.3389/fmed.2019.00179