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Select item 112391761.

Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome

Filipa M Lopes, Celine Grenier, Benjamin W Jarvis, Sara Al Mahdy, Adrian Lène-McKay, Alison M Gurney, William G Newman, Simon N Waddington, Adrian S Woolf, Neil A Roberts

eLife. 2024; 13: RP91828. Published online 2024 Jul 11. doi: 10.7554/eLife.91828

PMCID:: PMC11239176

Abstract Article PDF–6.6M

Select item 110305992.

Cytotoxic T lymphocyte epitopes from human heparanase can elicit a potent anti-tumor immune response in mice

Xu-Dong Tang, Guang-Ping Liang, Chuan Li, Ying Wan, Ting Chen, Ling Chen, Song-Tao Yu, Zhen Xiong, Dian-Chun Fang, Guo-Zheng Wang, Shi-Ming Yang

Cancer Immunol Immunother. 2010 Jul; 59(7): 1041–1047. Published online 2010 Feb 25. doi: 10.1007/s00262-010-0829-x

PMCID:: PMC11030599

Abstract Article PDF–308K

Select item 109599653.

Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis

Maram Hilwi, Katherina Shulman, Inna Naroditsky, Sari Feld, Miriam Gross-Cohen, Ilanit Boyango, Soaad Soboh, Olga Vornicova, Malik Farhoud, Preeti Singh, Gil Bar-Sela, Hadassah Goldberg, Martin Götte, Andrew D. Sharrocks, Yaoyong Li, Ralph D. Sanderson, Neta Ilan, Israel Vlodavsky

Cell Death Dis. 2024 Mar; 15(3): 232. Published online 2024 Mar 22. doi: 10.1038/s41419-024-06596-8

PMCID:: PMC10959965

Abstract Article PDF–5.2M

Select item 100477834.

Effect of HPSE and HPSE2 SNPs on the Risk of Developing Primary Paraskeletal Multiple Myeloma

Olga Ostrovsky, Katia Beider, Hila Magen, Merav Leiba, Ralph D. Sanderson, Israel Vlodavsky, Arnon Nagler

Cells. 2023 Mar; 12(6): 913. Published online 2023 Mar 16. doi: 10.3390/cells12060913

PMCID:: PMC10047783

Abstract Article PDF–1.4M

Select item 99868175.

METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m⁶A homeostasis

Zhan‐Cheng Zeng, Qi Pan, Yu‐Meng Sun, Heng‐Jing Huang, Xiao‐Tong Chen, Tian‐Qi Chen, Bo He, Hua Ye, Shun‐Xin Zhu, Ke‐Jia Pu, Ke Fang, Wei Huang, Yue‐Qin Chen, Wen‐Tao Wang

EMBO Rep. 2023 Mar; 24(3): e55762. Published online 2023 Jan 4. doi: 10.15252/embr.202255762

PMCID:: PMC9986817

Abstract Article PDF–3.5M

Select item 88633086.

A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factors

Florian Thibord, Melissa V. Chan, Ming-Huei Chen, Andrew D. Johnson

HGG Adv. 2022 Apr 14; 3(2): 100095. Published online 2022 Feb 22. doi: 10.1016/j.xhgg.2022.100095

PMCID:: PMC8863308

Abstract Article PDF–1.0M

Select item 88211457.

Induction of heparanase 2 (Hpa2) expression by stress is mediated by ATF3

Ibrahim Knani, Preeti Singh, Miriam Gross-Cohen, Sharon Aviram, Neta Ilan, Ralph D Sanderson, Ami Aronheim, Israel Vlodavsky

Matrix Biol. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Matrix Biol. 2022 Jan; 105: 17–30. Published online 2021 Nov 20. doi: 10.1016/j.matbio.2021.11.001

PMCID:: PMC8821145

Abstract Article PDF–1.9M

Select item 83499178.

Role of heparanase 2 (Hpa2) in gastric cancer

Jingjing Liu, Ibrahim Knani, Miriam Gross-Cohen, Jiaxi Hu, Sumin Wang, Li Tang, Neta Ilan, Shiming Yang, Israel Vlodavsky

Neoplasia. 2021 Sep; 23(9): 966–978. Published online 2021 Jul 31. doi: 10.1016/j.neo.2021.07.010

PMCID:: PMC8349917

Abstract Article PDF–2.7M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 793427310.

Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis

Hui Zhang, Chenxin Xu, Chen Shi, Junying Zhang, Ting Qian, Zhuo Wang, Rong Ma, Jianzhong Wu, Feng Jiang, Jifeng Feng

J Transl Med. 2021; 19: 98. Published online 2021 Mar 5. doi: 10.1186/s12967-021-02770-0

PMCID:: PMC7934273

Abstract Article PDF–2.3M

Select item 675309611.

Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling

Yulia Kiyan, Sergey Tkachuk, Kestutis Kurselis, Nelli Shushakova, Klaus Stahl, Damilola Dawodu, Roman Kiyan, Boris Chichkov, Hermann Haller

Sci Rep. 2019; 9: 13591. Published online 2019 Sep 19. doi: 10.1038/s41598-019-50068-5

Correction in:: Sci Rep. 2021; 11: 14049.

PMCID:: PMC6753096

Abstract Article PDF–9.3M

Select item 648128812.

Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder

Neil A. Roberts, Emma N. Hilton, Filipa M. Lopes, Subir Singh, Michael J. Randles, Natalie J. Gardiner, Karl Chopra, Riccardo Coletta, Zunera Bajwa, Robert J. Hall, Wyatt W. Yue, Franz Schaefer, Stefanie Weber, Roger Henriksson, Helen M. Stuart, Håkan Hedman, William G. Newman, Adrian S. Woolf

Kidney Int. 2019 May; 95(5): 1138–1152. doi: 10.1016/j.kint.2018.11.040

PMCID:: PMC6481288

Abstract Article

Select item 646186413.

LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition

Qingsong Hu, Chunlai Li, Shouyu Wang, Yajuan Li, Bo Wen, Yanyan Zhang, Ke Liang, Jun Yao, Youqiong Ye, Heidi Hsiao, Tina K. Nguyen, Peter K. Park, Sergey D. Egranov, David H. Hawke, Jeffrey R. Marks, Leng Han, Mien-Chie Hung, Bing Zhang, Chunru Lin, Liuqing Yang

Cell Res. 2019 Apr; 29(4): 286–304. Published online 2019 Jan 10. doi: 10.1038/s41422-018-0134-3

PMCID:: PMC6461864

Abstract Article PDF–11M

Select item 643999614.

Crosstalk between tumor cells and lymphocytes modulates heparanase expression

Thérèse Rachell Theodoro, Leandro Luongo Matos, Renan Pelluzzi Cavalheiro, Giselle Zenker Justo, Helena Bonciani Nader, Maria Aparecida Silva Pinhal

J Transl Med. 2019; 17: 103. Published online 2019 Mar 29. doi: 10.1186/s12967-019-1853-z

PMCID:: PMC6439996

Abstract Article PDF–1.6M

Select item 616668215.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 500838116.

Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage

Miriam Gross-Cohen, Sari Feld, Inna Naroditsky, Ofer Nativ, Neta Ilan, Israel Vlodavsky

Oncotarget. 2016 Apr 19; 7(16): 22556–22565. Published online 2016 Mar 9. doi: 10.18632/oncotarget.8003

PMCID:: PMC5008381

Abstract Article PDF–5.7M

Select item 487338917.

Heparanase 2 attenuates head and neck tumor vascularity and growth

Miriam Gross-Cohen, Sari Feld, Ilana Doweck, Gera Neufeld, Peleg Hasson, Gil Arvatz, Uri Barash, Inna Naroditsky, Neta Ilan, Israel Vlodavsky

Cancer Res. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: Cancer Res. 2016 May 1; 76(9): 2791–2801. Published online 2016 Mar 24. doi: 10.1158/0008-5472.CAN-15-1975

PMCID:: PMC4873389

Abstract Article PDF–2.4M

Select item 447731618.

Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression

Junjie Fu, Ravil Khaybullin, Yanping Zhang, Amy Xia, Xin Qi

BMC Cancer. 2015; 15: 473. Published online 2015 Jun 18. doi: 10.1186/s12885-015-1410-y

PMCID:: PMC4477316

Abstract Article PDF–1.2M

Select item 437809219.

Urinary Tract Effects of HPSE2 Mutations

Helen M. Stuart, Neil A. Roberts, Emma N. Hilton, Edward A. McKenzie, Sarah B. Daly, Kristen D. Hadfield, Jeffery S. Rahal, Natalie J. Gardiner, Simon W. Tanley, Malcolm A. Lewis, Emily Sites, Brad Angle, Cláudia Alves, Teresa Lourenço, Márcia Rodrigues, Angelina Calado, Marta Amado, Nancy Guerreiro, Inês Serras, Christian Beetz, Rita-Eva Varga, Mesrur Selcuk Silay, John M. Darlow, Mark G. Dobson, David E. Barton, Manuela Hunziker, Prem Puri, Sally A. Feather, Judith A. Goodship, Timothy H.J. Goodship, Heather J. Lambert, Heather J. Cordell, the UK VUR Study Group, Anand Saggar, Maria Kinali, the 4C Study Group, Christian Lorenz, Kristina Moeller, Franz Schaefer, Aysun K. Bayazit, Stefanie Weber, William G. Newman, Adrian S. Woolf

J Am Soc Nephrol. 2015 Apr; 26(4): 797–804. Published online 2014 Aug 21. doi: 10.1681/ASN.2013090961

PMCID:: PMC4378092

Abstract Article

Select item 411451920.

Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384

Paul D. Leger, Daniel H. Johnson, Gregory K. Robbins, Robert W. Shafer, David B. Clifford, Jun Li, Paul J. McLaren, David W. Haas

J Neurovirol. 2014; 20(3): 304–308. Published online 2014 Feb 20. doi: 10.1007/s13365-014-0235-9

PMCID:: PMC4114519

Abstract Article PDF–233K

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