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Select item 98920311.

Extracellular vesicle-derived circCEBPZOS attenuates postmyocardial infarction remodeling by promoting angiogenesis via the miR-1178-3p/PDPK1 axis

Ling Yu, Yubin Liang, Minzhou Zhang, Phillip C. Yang, Aleksander Hinek, Shuai Mao

Commun Biol. 2023; 6: 133. Published online 2023 Feb 1. doi: 10.1038/s42003-023-04505-x

PMCID:: PMC9892031

Abstract Article PDF–3.1M

Select item 98685412.

Activation of long-non-coding RNA NEAT1 sponging microRNA-147 inhibits radiation damage by targeting PDPK1 in troxerutin radioprotection

Yong-jian Hu, Gui-yuan Song, Fan Zhang, Nan Zhang, Fei Wang, Jing-long Wang, Xia Wang, Tao-yang Wang, Yu-feng Li, Yi-di Yan, Wen-tao Dou, Chen-yi Cheng, Ping Xu

iScience. 2023 Feb 17; 26(2): 105932. Published online 2023 Jan 5. doi: 10.1016/j.isci.2023.105932

PMCID:: PMC9868541

Abstract Article PDF–4.4M

Select item 88038173.

MicroRNA-193b impairs muscle growth in mouse models of type 2 diabetes by targeting the PDK1/Akt signalling pathway

Shu Yang, Guangyan Yang, Han Wu, Lin Kang, Jiaqing Xiang, Peilin Zheng, Shanhu Qiu, Zhen Liang, Yan Lu, Lijing Jia

Diabetologia. 2022; 65(3): 563–581. Published online 2021 Dec 16. doi: 10.1007/s00125-021-05616-y

PMCID:: PMC8803817

Abstract Article PDF–7.9M

Select item 87824174.

A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro

Henry Querfurth, John Marshall, Keykavous Parang, Mengia S. Rioult-Pedotti, Rakesh Tiwari, Bumsup Kwon, Steve Reisinger, Han-Kyu Lee

PLoS One. 2022; 17(1): e0261696. Published online 2022 Jan 21. doi: 10.1371/journal.pone.0261696

Correction in:: PLoS One. 2024; 19(5): e0304731.

PMCID:: PMC8782417

Abstract Article PDF–2.0M

Select item 85998645.

TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway

Suhong Zhang, Haiting Dai, Wenya Li, Runming Wang, Hanyu Wu, Ming Shen, Ye Hu, Lixin Xie, Yiming Xing

Cell Death Dis. 2021 Dec; 12(12): 1086. Published online 2021 Nov 16. doi: 10.1038/s41419-021-04369-1

PMCID:: PMC8599864

Abstract Article PDF–5.8M

Select item 84905166.

The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis

Peiran Feng, Quanli Yang, Liang Luo, Yadong Sun, Wenkai Lv, Shuo Wan, Zerong Guan, Zhiqiang Xiao, Feng Liu, Zehua Li, Zhongjun Dong, Meixiang Yang

Theranostics. 2021; 11(19): 9503–9518. Published online 2021 Sep 13. doi: 10.7150/thno.63992

PMCID:: PMC8490516

Abstract Article PDF–3.9M

Select item 80346517.

Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns

Anouk M Olthof, Alisa K White, Stephen Mieruszynski, Karen Doggett, Madisen F Lee, Almahdi Chakroun, Alice K Abdel Aleem, Justine Rousseau, Cinzia Magnani, Chaim M Roifman, Philippe M Campeau, Joan K Heath, Rahul N Kanadia

Nucleic Acids Res. 2021 Apr 6; 49(6): 3524–3545. Published online 2021 Feb 28. doi: 10.1093/nar/gkab118

PMCID:: PMC8034651

Abstract Article PDF–7.2M

Select item 80266728.

PDK1 is required for maintenance of CD4+ FoxP3+ regulatory T cell function

Hyunju Oh, Jingyao Zhao, Yenkel Grinberg-Bleyer, Thomas S. Postler, Pingzhang Wang, Sung-Gyoo Park, Raul Rabadan, Matthew S. Hayden, Sankar Ghosh

J Immunol. Author manuscript; available in PMC 2022 Apr 15.

Published in final edited form as: J Immunol. 2021 Apr 15; 206(8): 1776–1783. Published online 2021 Mar 31. doi: 10.4049/jimmunol.2000051

PMCID:: PMC8026672

Abstract Article PDF–2.1M

Select item 79681449.

Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes

Ji Liao, Tie-Bo Zeng, Nicholas Pierce, Diana A. Tran, Purnima Singh, Jeffrey R. Mann, Piroska E. Szabó

Cell Rep. Author manuscript; available in PMC 2021 Mar 17.

Published in final edited form as: Cell Rep. 2021 Feb 9; 34(6): 108729. doi: 10.1016/j.celrep.2021.108729

PMCID:: PMC7968144

Abstract Article PDF–1.7M

Select item 793877010.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 788907411.

The kinase PDK1 is critical for promoting T follicular helper cell differentiation

Zhen Sun, Yingpeng Yao, Menghao You, Jingjing Liu, Wenhui Guo, Zhihong Qi, Zhao Wang, Fang Wang, Weiping Yuan, Shuyang Yu

eLife. 2021; 10: e61406. Published online 2021 Feb 17. doi: 10.7554/eLife.61406

PMCID:: PMC7889074

Abstract Article PDF–8.0M

Select item 788157012.

PDK1 is a negative regulator of axon regeneration

Hyemin Kim, Jinyoung Lee, Yongcheol Cho

Mol Brain. 2021; 14: 31. Published online 2021 Feb 12. doi: 10.1186/s13041-021-00748-z

PMCID:: PMC7881570

Abstract Article PDF–3.7M

Select item 787604613.

Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load

Naoki Kuramoto, Kazuhiro Nomura, Daisuke Kohno, Tadahiro Kitamura, Gerard Karsenty, Tetsuya Hosooka, Wataru Ogawa

Sci Rep. 2021; 11: 3447. Published online 2021 Feb 10. doi: 10.1038/s41598-021-83098-z

PMCID:: PMC7876046

Abstract Article PDF–4.1M

Select item 775148714.

Effects of inhibiting PDK-1 expression in bone marrow mesenchymal stem cells on osteoblast differentiation in vitro

Yiguang Bai, Qiong Zhang, Quan Zhou, Yanan Zhang, Haibin Nong, Mingfu Liu, Zhuohua Shi, Gaofeng Zeng, Shaohui Zong

Mol Med Rep. 2021 Feb; 23(2): 118. Published online 2020 Dec 4. doi: 10.3892/mmr.2020.11757

PMCID:: PMC7751487

Abstract Article PDF–1.0M

Select item 736346615.

PDK1 Regulates the Maintenance of Cell Body and the Development of Dendrites of Purkinje Cells by pS6 and PKCγ

Rui Liu, Min Xu, Xiao-Yang Zhang, Min-Jie Zhou, Bing-Yao Zhou, Cui Qi, Bo Song, Qi Fan, Wei-Yan You, Jing-Ning Zhu, Zhong-Zhou Yang, Jun Gao

J Neurosci. 2020 Jul 15; 40(29): 5531–5548. doi: 10.1523/JNEUROSCI.2496-19.2020

PMCID:: PMC7363466

Abstract Article PDF–14M

Select item 733962116.

Deficiency of PDK1 in osteoclasts delays fracture healing and repair

Dongliang Xiao, Quan Zhou, Yiguang Bai, Baichuan Cao, Qiong Zhang, Gaofeng Zeng, Shaohui Zong

Mol Med Rep. 2020 Aug; 22(2): 1536–1546. Published online 2020 Jun 3. doi: 10.3892/mmr.2020.11209

PMCID:: PMC7339621

Abstract Article PDF–747K

Select item 726108717.

The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase–leukotriene B₄ axis

Tetsuya Hosooka, Yusei Hosokawa, Kaku Matsugi, Masakazu Shinohara, Yoko Senga, Yoshikazu Tamori, Chikako Aoki, Sho Matsui, Tsutomu Sasaki, Tadahiro Kitamura, Masashi Kuroda, Hiroshi Sakaue, Kazuhiro Nomura, Kei Yoshino, Yuko Nabatame, Yoshito Itoh, Kanji Yamaguchi, Yoshitake Hayashi, Jun Nakae, Domenico Accili, Takehiko Yokomizo, Susumu Seino, Masato Kasuga, Wataru Ogawa

Proc Natl Acad Sci U S A. 2020 May 26; 117(21): 11674–11684. Published online 2020 May 11. doi: 10.1073/pnas.1921015117

PMCID:: PMC7261087

Abstract Article PDF–1.8M

Select item 722532718.

The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice

Lydia Giménez-Llort, Mikel Santana-Santana, José Ramón Bayascas

Front Behav Neurosci. 2020; 14: 61. Published online 2020 May 8. doi: 10.3389/fnbeh.2020.00061

PMCID:: PMC7225327

Abstract Article PDF–3.5M

Select item 719713819.

PDK1 regulates the survival of the developing cortical interneurons

Yongjie Wei, Xiaoning Han, Chunjie Zhao

Mol Brain. 2020; 13: 65. Published online 2020 May 4. doi: 10.1186/s13041-020-00604-6

PMCID:: PMC7197138

Abstract Article PDF–9.2M

Select item 674812820.

Stage-specific requirement of kinase PDK1 for NK cells development and activation

Junming He, Yuande Wang, Tian Liu, Guangao Liu, Shasha Chen, Qiaozhen Li, Yuhe Quan, Haoyan Yang, Jin Feng, Song Wang, Meixiang Yang, Zhongjun Dong

Cell Death Differ. 2019 Oct; 26(10): 1918–1928. Published online 2019 Jan 8. doi: 10.1038/s41418-018-0263-8

PMCID:: PMC6748128

Abstract Article PDF–2.6M

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