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Select item 113159291.

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex

Marisa Bedir, Emily Outwin, Rita Colnaghi, Lydia Bassett, Iga Abramowicz, Mark O’Driscoll

EMBO Rep. 2024 Aug; 25(8): 3432–3455. Published online 2024 Jun 28. doi: 10.1038/s44319-024-00184-9

PMCID:: PMC11315929

Abstract Article PDF–3.4M

Select item 112969142.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112379303.

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein

Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo

J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390

PMCID:: PMC11237930

Abstract Article PDF–3.8M

Select item 112099354.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 109727485.

The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Pengbiao Xu, Ying Liu, Chong Liu, Baptiste Guey, Lingyun Li, Pauline Melenec, Jonathan Ricci, Andrea Ablasser

Nature. 2024; 627(8005): 873–879. Published online 2024 Feb 28. doi: 10.1038/s41586-024-07112-w

PMCID:: PMC10972748

Abstract Article PDF–17M

Select item 103128046.

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

Avi J. Samelson, Nabeela Ariqat, Justin McKetney, Gita Rohanitazangi, Celeste Parra Bravo, Rudra Bose, Kyle J. Travaglini, Victor L. Lam, Darrin Goodness, Gary Dixon, Emily Marzette, Julianne Jin, Ruilin Tian, Eric Tse, Romany Abskharon, Henry Pan, Emma C. Carroll, Rosalie E. Lawrence, Jason E. Gestwicki, David Eisenberg, Nicholas M. Kanaan, Daniel R. Southworth, John D. Gross, Li Gan, Danielle L. Swaney, Martin Kampmann

Version 4. bioRxiv. Preprint. NaN NaN [revised 2024 Nov 4]. doi: 10.1101/2023.06.16.545386

PMCID:: PMC10312804

Abstract Article PDF–8.8M

Select item 102794727.

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

Julie K. Monda, Xuezhen Ge, Moritz Hunkeler, Katherine A. Donovan, Michelle W. Ma, Cyrus Y. Jin, Marilyn Leonard, Eric S. Fischer, Eric J. Bennett

Cell Rep. Author manuscript; available in PMC 2023 Jun 19.

Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112496. Published online 2023 May 9. doi: 10.1016/j.celrep.2023.112496

PMCID:: PMC10279472

Abstract Article PDF–2.9M

Select item 102374228.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101224059.

A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer

Li Xiong, Hua-shan Liu, Chi Zhou, Xin Yang, Liang Huang, Hai-qing Jie, Zi-wei Zeng, Xiao-bin Zheng, Wen-xin Li, Zhan-zhen Liu, Liang Kang, Zhen-xing Liang

Mol Cancer. 2023; 22: 72. Published online 2023 Apr 22. doi: 10.1186/s12943-023-01773-3

PMCID:: PMC10122405

Abstract Article PDF–12M

Select item 987586110.

The human protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1) associates with Cullin-RING ligase proteins

Rebeccah A. Warmack, Eric Z. Pang, Esther Peluso, Jonathan D. Lowenson, Joseph Y. Ong, Jorge Z. Torres, Steven G. Clarke

Biochemistry. Author manuscript; available in PMC 2023 May 17.

Published in final edited form as: Biochemistry. 2022 May 17; 61(10): 879–894. Published online 2022 Apr 29. doi: 10.1021/acs.biochem.2c00130

PMCID:: PMC9875861

Abstract Article PDF–2.1M

Select item 985851211.

Cullin-5 deficiency orchestrates the tumor microenvironment to promote mammary tumor development through CREB1-CCL2 signaling

Si Chen, Fangyuan Shao, Jianming Zeng, Sen Guo, Lijian Wang, Heng Sun, Josh Haipeng Lei, Xueying Lyu, Shuai Gao, Qiang Chen, Kai Miao, Xiaoling Xu, Chu-Xia Deng

Sci Adv. 2023 Jan; 9(3): eabq1395. Published online 2023 Jan 20. doi: 10.1126/sciadv.abq1395

PMCID:: PMC9858512

Abstract Article PDF–2.9M

Select item 976969812.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 957675713.

A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer

Tiantian Xu, Qisheng Ma, Yanan Li, Qing Yu, Peichen Pan, Yawen Zheng, Zhijian Li, Xiufang Xiong, Tingjun Hou, Bin Yu, Hongmin Liu, Yi Sun

Signal Transduct Target Ther. 2022; 7: 354. Published online 2022 Oct 17. doi: 10.1038/s41392-022-01182-w

PMCID:: PMC9576757

Abstract Article PDF–6.0M

Select item 952399714.

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer

Natsumi Tsuboyama, Aileen Patricia Szczepanski, Zibo Zhao, Lu Wang

Genome Biol. 2022; 23: 206. Published online 2022 Sep 30. doi: 10.1186/s13059-022-02776-x

PMCID:: PMC9523997

Abstract Article PDF–6.9M

Select item 950796415.

Structure of CRL7^FBXW8 reveals coupling with CUL1–RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation

Linus V. M. Hopf, Kheewoong Baek, Maren Klügel, Susanne von Gronau, Yue Xiong, Brenda A. Schulman

Nat Struct Mol Biol. 2022; 29(9): 854–862. Published online 2022 Aug 18. doi: 10.1038/s41594-022-00815-6

PMCID:: PMC9507964

Abstract Article PDF–15M

Select item 948193316.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 947546217.

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold

Wenjing Yang, Beili Wang, Qian Yu, Te Liu, Tong Li, Tongtong Tian, Anli Jin, Lin Ding, Wei Chen, Hao Wang, Jingrong Xian, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo

Theranostics. 2022; 12(14): 6189–6206. Published online 2022 Aug 21. doi: 10.7150/thno.72134

PMCID:: PMC9475462

Abstract Article PDF–4.6M

Select item 927928518.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 910523519.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 909888220.

Biophysical and functional study of CRL5^Ozz, a muscle specific ubiquitin ligase complex

Yvan Campos, Amanda Nourse, Ajay Tanwar, Ravi Kalathur, Erik Bonten, Alessandra d’Azzo

Sci Rep. 2022; 12: 7820. Published online 2022 May 12. doi: 10.1038/s41598-022-10955-w

PMCID:: PMC9098882

Abstract Article PDF–4.6M

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