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Items: 1 to 20 of 99

1.
SPAST Intragenic CNVs Lead to Hereditary Spastic Paraplegia via a Haploinsufficiency Mechanism
Ewelina Elert-Dobkowska, Iwona Stepniak, Wiktoria Radziwonik-Fraczyk, Amir Jahic, Christian Beetz, Anna Sulek
Int J Mol Sci. 2024 May; 25(9): 5008. Published online 2024 May 3. doi: 10.3390/ijms25095008
PMCID:
PMC11084448
AbstractArticlePDF–1.2M
2.
A novel truncated variant in SPAST results in spastin accumulation and defects in microtubule dynamics
Jie Wang, Yihan Wu, Hong Dong, Yunpeng Ji, Lichun Zhang, Yaxian Liu, Yueshi Liu, Xin Gao, Yueqi Jia, Xiaohua Wang
BMC Med Genomics. 2023; 16: 321. Published online 2023 Dec 8. doi: 10.1186/s12920-023-01759-6
PMCID:
PMC10704811
AbstractArticlePDF–2.6M
3.
Amplifying the spectrum of SPAST gene mutations
Lorenzo Verriello, Incoronata Renata Lonigro, Maria Elena Pessa, Elena Betto, Giada Pauletto, Federico Fogolari, Gian Luigi Gigli, Francesco Curcio
Acta Biomed. 2021; 92(Suppl 1): e2021220. Published online 2021 Nov 4. doi: 10.23750/abm.v92iS1.11608
PMCID:
PMC10523053
AbstractArticlePDF–1.7M
4.
Spastin is required for human immunodeficiency virus-1 efficient replication through cooperation with the endosomal sorting complex required for transport (ESCRT) protein
Wenyuan Shen, Chang Liu, Yue Hu, Qian Ding, Jiabin Feng, Zhou Liu, Xiaohong Kong
Virol Sin. 2023 Jun; 38(3): 448–458. Published online 2023 May 11. doi: 10.1016/j.virs.2023.05.006
PMCID:
PMC10311276
AbstractArticlePDF–1.7M
5.
Phosphorylation mutation impairs the promoting effect of spastin on neurite outgrowth without affecting its microtubule severing ability
Yunlong Zhang, Xin He, Jianyu Zou, Jie Yang, Ao Ma, Minghui Tan
Eur J Histochem. 2023 Jan 2; 67(1): 3594. Published online 2023 Jan 12. doi: 10.4081/ejh.2023.3594
PMCID:
PMC10300427
AbstractArticlePDF–670K
6.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
7.
Early-Onset and Severe Complex Hereditary Spastic Paraplegia Caused by De Novo Variants in SPAST
Alisa Mo, Afshin Saffari, Melanie Kellner, Marion Döbler-Neumann, Catherine Jordan, Siddharth Srivastava, Bo Zhang, Mustafa Sahin, John K. Fink, Linsley Smith, Jennifer E. Posey, Katharine E. Alter, Camilo Toro, Craig Blackstone, Ariane G. Soldatos, Michelle Christie, Rebecca Schüle, Darius Ebrahimi-Fakhari
Mov Disord. Author manuscript; available in PMC 2023 Mar 30.
Published in final edited form as: Mov Disord. 2022 Dec; 37(12): 2440–2446. Published online 2022 Sep 14. doi: 10.1002/mds.29225
PMCID:
PMC10062395
AbstractArticlePDF–558K
8.
A novel missense mutation in SPAST causes hereditary spastic paraplegia in male members of a family: A case report
Xing-Chen Wang, Rui-Han Liu, Ting Wang, Yanling Wang, Yan Jiang, Dan-Dan Chen, Xin-Yu Wang, Tong-Shu Hou, Qing-Xia Kong
Mol Med Rep. 2023 Apr; 27(4): 79. Published online 2023 Feb 21. doi: 10.3892/mmr.2023.12966
PMCID:
PMC10018243
AbstractArticlePDF–2.2M
9.
Fibril treatment changes protein interactions of tau and α-synuclein in human neurons
Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson
J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888
PMCID:
PMC9978635
AbstractArticlePDF–10M
10.
Spastin Promotes the Migration and Invasion Capability of T98G Glioblastoma Cells by Interacting with Pin1 through Its Microtubule-Binding Domain
Benan Temizci, Seren Kucukvardar, Arzu Karabay
Cells. 2023 Feb; 12(3): 427. Published online 2023 Jan 27. doi: 10.3390/cells12030427
PMCID:
PMC9913556
AbstractArticlePDF–6.1M
11.
The enhanced association between mutant CHMP2B and spastin is a novel pathological link between frontotemporal dementia and hereditary spastic paraplegias
Yongping Chen, Gopinath Krishnan, Sepideh Parsi, Marine Pons, Veroniki Nikolaki, Lu Cao, Zuoshang Xu, Fen-Biao Gao
Acta Neuropathol Commun. 2022; 10: 169. Published online 2022 Nov 22. doi: 10.1186/s40478-022-01476-8
PMCID:
PMC9682730
AbstractArticlePDF–2.0M
12.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
13.
FBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia
Hyun Mi Kang, Dae Hun Kim, Mijin Kim, Yoohong Min, Bohyeon Jeong, Kyung Hee Noh, Da Yong Lee, Hyun-Soo Cho, Nam-Soon Kim, Cho-Rok Jung, Jung Hwa Lim
Cell Biosci. 2022; 12: 110. Published online 2022 Jul 22. doi: 10.1186/s13578-022-00851-1
PMCID:
PMC9308218
AbstractArticlePDF–2.8M
14.
A Novel SPAST Mutation Results in Spastin Accumulation and Defects in Microtubule Dynamics
Rui Chen, Shiyue Du, Yanyi Yao, Lu Zhang, Junyu Luo, Yinhua Shen, Zhenping Xu, Xiaomei Zeng, Luoying Zhang, Mugen Liu, Chuang Yin, Beisha Tang, Jun Tan, Xuan Xu, Jing Yu Liu
Mov Disord. 2022 Mar; 37(3): 598–607. Published online 2021 Dec 20. doi: 10.1002/mds.28885
PMCID:
PMC9300132
AbstractArticlePDF–6.2M
15.
Modeling gain-of-function and loss-of-function components of SPAST-based hereditary spastic paraplegia using transgenic mice
Emanuela Piermarini, Seyma Akarsu, Theresa Connors, Matthias Kneussel, Michael A Lane, Gerardo Morfini, Arzu Karabay, Peter W Baas, Liang Qiang
Hum Mol Genet. 2022 Jun 1; 31(11): 1844–1859. Published online 2021 Dec 22. doi: 10.1093/hmg/ddab367
PMCID:
PMC9169457
AbstractArticlePDF–2.0M
16.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
17.
SSNA1 stabilizes dynamic microtubules and detects microtubule damage
Elizabeth J Lawrence, Goker Arpag, Cayetana Arnaiz, Marija Zanic
eLife. 2021; 10: e67282. Published online 2021 Dec 31. doi: 10.7554/eLife.67282
PMCID:
PMC8798045
AbstractArticlePDF–8.4M
18.
Different fusion tags affect the activity of ubiquitin overexpression on spastin protein stability
Jianyu Zou, Zhenbin Cai, Zhi Liang, Yaozhong Liang, Guowei Zhang, Jie Yang, Yunlong Zhang, Hongsheng Lin, Minghui Tan
Eur J Histochem. 2021 Nov 2; 65(4): 3352. Published online 2021 Dec 7. doi: 10.4081/ejh.2021.3352
PMCID:
PMC8678624
AbstractArticlePDF–977K
19.
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity
Fabien Thery, Lia Martina, Caroline Asselman, Yifeng Zhang, Madeleine Vessely, Heidi Repo, Koen Sedeyn, George D. Moschonas, Clara Bredow, Qi Wen Teo, Jingshu Zhang, Kevin Leandro, Denzel Eggermont, Delphine De Sutter, Katie Boucher, Tino Hochepied, Nele Festjens, Nico Callewaert, Xavier Saelens, Bart Dermaut, Klaus-Peter Knobeloch, Antje Beling, Sumana Sanyal, Lilliana Radoshevich, Sven Eyckerman, Francis Impens
Nat Commun. 2021; 12: 5772. Published online 2021 Oct 1. doi: 10.1038/s41467-021-26061-w
PMCID:
PMC8486878
AbstractArticlePDF–7.6M
20.
Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry
Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang
Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118
PMCID:
PMC8364181
AbstractArticlePDF–3.0M

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