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Select item 115144641.

LAP2alpha facilitates myogenic gene expression by preventing nucleoplasmic lamin A/C from spreading to active chromatin regions

Simona Ferraioli, Fatih Sarigol, Celine Prakash, Daria Filipczak, Roland Foisner, Nana Naetar

Nucleic Acids Res. 2024 Oct 28; 52(19): 11500–11518. Published online 2024 Sep 4. doi: 10.1093/nar/gkae752

PMCID:: PMC11514464

Abstract Article PDF–3.5M

Select item 113932822.

Role of lamin A/C on dendritic cell function in antiviral immunity

Beatriz Herrero-Fernández, Marina Ortega-Zapero, Raquel Gómez-Bris, Angela Sáez, Salvador Iborra, Virginia Zorita, Ana Quintas, Enrique Vázquez, Ana Dopazo, Francisco Sánchez-Madrid, Silvia Magdalena Arribas, Jose Maria González-Granado

Cell Mol Life Sci. 2024 Dec; 81(1): 400. Published online 2024 Sep 12. doi: 10.1007/s00018-024-05423-9

PMCID:: PMC11393282

Abstract Article PDF–7.1M

Select item 113499833.

miR-29 is an important driver of aging-related phenotypes

Vijay Swahari, Ayumi Nakamura, Emilie Hollville, Yu-Han Hung, Matt Kanke, C. Lisa Kurtz, Xurde M. Caravia, David Roiz-Valle, Shenghui He, Janakiraman Krishnamurthy, Sahil Kapoor, Varun Prasad, Cornelius Flowers, Matt Beck, Jeanette Baran-Gale, Norman Sharpless, Carlos López-Otín, Praveen Sethupathy, Mohanish Deshmukh

Commun Biol. 2024; 7: 1055. Published online 2024 Aug 27. doi: 10.1038/s42003-024-06735-z

PMCID:: PMC11349983

Abstract Article PDF–1.7M

Select item 112905914.

Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice

Atsuki En, Hanumakumar Bogireddi, Briana Thomas, Alexis V. Stutzman, Sachie Ikegami, Brigitte LaForest, Omar Almakki, Peter Pytel, Ivan P. Moskowitz, Kohta Ikegami

Cell Rep. Author manuscript; available in PMC 2024 Jul 31.

Published in final edited form as: Cell Rep. 2024 Jun 25; 43(6): 114284. Published online 2024 May 29. doi: 10.1016/j.celrep.2024.114284

PMCID:: PMC11290591

Abstract Article PDF–2.2M

Select item 112285175.

An aggregated mitochondrial distribution in preimplantation embryos disrupts nuclear morphology, function, and developmental potential

In-Won Lee, Abbas Pirpour Tazehkand, Zi-Yi Sha, Deepak Adhikari, John Carroll

Proc Natl Acad Sci U S A. 2024 Jul 2; 121(27): e2317316121. Published online 2024 Jun 25. doi: 10.1073/pnas.2317316121

PMCID:: PMC11228517

Abstract Article PDF–8.9M

Select item 111788426.

Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics

Ken Hashimoto, Momoko Ohira, Aya Kodama, Misaki Kimoto, Mariko Inoue, Shigenobu Toné, Yuu Usui, Akira Hanashima, Takato Goto, Yuhei Ogura, Yoshihiro Ujihara, Satoshi Mohri

Sci Rep. 2024; 14: 13727. Published online 2024 Jun 14. doi: 10.1038/s41598-024-64608-1

PMCID:: PMC11178842

Abstract Article PDF–5.4M

Select item 110669787.

Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells

Ignacio Benedicto, Rosa M. Carmona, Ana Barettino, Carla Espinós-Estévez, Pilar Gonzalo, Rosa M. Nevado, Miguel de la Fuente-Pérez, María J. Andrés-Manzano, Cristina González-Gómez, Loïc Rolas, Beatriz Dorado, Sussan Nourshargh, Magda R. Hamczyk, Vicente Andrés

Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18): e2400752121. Published online 2024 Apr 22. doi: 10.1073/pnas.2400752121

PMCID:: PMC11066978

Abstract Article PDF–3.9M

Select item 109176608.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108535879.

Adenine base editor‐based correction of the cardiac pathogenic Lmna c.1621C > T mutation in murine hearts

Luzi Yang, Zhanzhao Liu, Jinhuan Sun, Zhan Chen, Fei Gao, Yuxuan Guo

J Cell Mol Med. 2024 Feb; 28(4): e18145. Published online 2024 Feb 8. doi: 10.1111/jcmm.18145

PMCID:: PMC10853587

Abstract Article PDF–900K

Select item 1084650210.

Intracardiac electrophysiology to characterize susceptibility to ventricular arrhythmias in murine models

Marine C. Ferrand, Gauthier Giordano, Nathalie Mougenot, Pierre-Léo Laporte, Nicolas Vignier, Arnaud Leclerc, Vincent Algalarrondo, Fabrice Extramiana, Flavien Charpentier, Nathalie Neyroud

Front Physiol. 2024; 15: 1326663. Published online 2024 Jan 23. doi: 10.3389/fphys.2024.1326663

PMCID:: PMC10846502

Abstract Article PDF–3.0M

Select item 1076935011.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders

Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz

Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700

PMCID:: PMC10769350

Abstract Article PDF–11M

Select item 1071724012.

Emerin deficiency does not exacerbate cardiomyopathy in a murine model of Emery–Dreifuss muscular dystrophy caused by an LMNA gene mutation

Eiji Wada, Kohei Matsumoto, Nao Susumu, Megumi Kato, Yukiko K. Hayashi

J Physiol Sci. 2023; 73: 27. Published online 2023 Nov 8. doi: 10.1186/s12576-023-00886-0

PMCID:: PMC10717240

Abstract Article PDF–1.5M

Select item 1071156613.

The translational oscillation in oocyte and early embryo development

Rajan Iyyappan, Daria Aleshkina, Hao Ming, Michal Dvoran, Kianoush Kakavand, Denisa Jansova, Edgar del Llano, Lenka Gahurova, Alexander W Bruce, Tomas Masek, Martin Pospisek, Filip Horvat, Michal Kubelka, Zongliang Jiang, Andrej Susor

Nucleic Acids Res. 2023 Dec 11; 51(22): 12076–12091. Published online 2023 Nov 10. doi: 10.1093/nar/gkad996

PMCID:: PMC10711566

Abstract Article PDF–2.3M

Select item 1066612814.

Impaired end joining induces cardiac atrophy in a Hutchinson–Gilford progeria mouse model

Yu Chen, Shiqi Huang, Zhen Cui, Xiaoxiang Sun, Yansong Tang, Hongjie Zhang, Zhixi Chen, Rui Jiang, Weina Zhang, Xue Li, Jiayu Chen, Baohua Liu, Ying Jiang, Ke Wei, Zhiyong Mao

Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47): e2309200120. Published online 2023 Nov 15. doi: 10.1073/pnas.2309200120

PMCID:: PMC10666128

Abstract Article PDF–9.7M

Select item 1064407315.

The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment

Ming-Yue Fei, Yong Wang, Bin-He Chang, Kai Xue, Fangyi Dong, Dan Huang, Xi-Ya Li, Zi-Juan Li, Cheng-Long Hu, Ping Liu, Ji-Chuan Wu, Peng-Cheng Yu, Ming-Hua Hong, Shu-Bei Chen, Chun-Hui Xu, Bing-Yi Chen, Yi-Lun Jiang, Na Liu, Chong Zhao, Jia-Cheng Jin, Dan Hou, Xin-Chi Chen, Yi-Yi Ren, Chu-Han Deng, Jia-Ying Zhang, Li-juan Zong, Rou-Jia Wang, Fei-Fei Gao, Hui Liu, Qun-Ling Zhang, Ling-Yun Wu, Jinsong Yan, Shuhong Shen, Chun-Kang Chang, Xiao-Jian Sun, Lan Wang

Blood. 2023 Sep 7; 142(10): 903–917. Published online 2023 Jun 18. doi: 10.1182/blood.2022019537

PMCID:: PMC10644073

Abstract Article

Select item 1060094816.

The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina

Mathilde Pruvost, Julia Patzig, Camila Yattah, Ipek Selcen, Marylens Hernandez, Hye-Jin Park, Sarah Moyon, Shibo Liu, Malia S. Morioka, Lindsay Shopland, Osama Al-Dalahmah, Jaroslav Bendl, John F. Fullard, Panos Roussos, James Goldman, Ye He, Jeffrey L. Dupree, Patrizia Casaccia

Cell Rep. Author manuscript; available in PMC 2023 Oct 26.

Published in final edited form as: Cell Rep. 2023 Aug 29; 42(8): 112848. Published online 2023 Jul 28. doi: 10.1016/j.celrep.2023.112848

PMCID:: PMC10600948

Abstract Article PDF–3.6M

Select item 1060022017.

Lamin A upregulation reorganizes the genome during rod photoreceptor degeneration

Ivana Herrera, José Alex Lourenço Fernandes, Khatereh Shir-Mohammadi, Jasmine Levesque, Pierre Mattar

Cell Death Dis. 2023 Oct; 14(10): 701. Published online 2023 Oct 25. doi: 10.1038/s41419-023-06224-x

PMCID:: PMC10600220

Abstract Article PDF–5.1M

Select item 1054460718.

An alpha-helix variant p.Arg156Pro in LMNA as a cause of hereditary dilated cardiomyopathy: genetics and bioinfomatics exploration

Lei Chang, Rong Huang, Jianzhou Chen, Guannan Li, Guangfei Shi, Biao Xu, Lian Wang

BMC Med Genomics. 2023; 16: 229. Published online 2023 Oct 2. doi: 10.1186/s12920-023-01661-1

PMCID:: PMC10544607

Abstract Article PDF–2.0M

Select item 1053845719.

Revisiting the truncated lamin A produced by a commonly used strain of Lmna knockout mice

Joonyoung R. Kim, Paul H. Kim, Ashley Presnell, Yiping Tu, Stephen G. Young

Nucleus. 2023; 14(1): 2262308. Published online 2023 Sep 27. doi: 10.1080/19491034.2023.2262308

PMCID:: PMC10538457

Abstract Article PDF–2.3M

Select item 1047875320.

Lem2 is essential for cardiac development by maintaining nuclear integrity

Jacob A Ross, Nathaly Arcos-Villacis, Edmund Battey, Cornelis Boogerd, Constanza Avalos Orellana, Emilie Marhuenda, Pamela Swiatlowska, Didier Hodzic, Fabrice Prin, Tim Mohun, Norman Catibog, Olga Tapia, Larry Gerace, Thomas Iskratsch, Ajay M Shah, Matthew J Stroud

Cardiovasc Res. 2023 Aug; 119(11): 2074–2088. Published online 2023 Apr 17. doi: 10.1093/cvr/cvad061

PMCID:: PMC10478753

Abstract Article PDF–33M

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