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Items: 1 to 20 of 35

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
3.
The Deficiency of SCARB2/LIMP-2 Impairs Metabolism via Disrupted mTORC1-Dependent Mitochondrial OXPHOS
Yujie Zou, Jingwen Pei, Yushu Wang, Qin Chen, Minli Sun, Lulu Kang, Xuyuan Zhang, Liguo Zhang, Xiang Gao, Zhaoyu Lin
Int J Mol Sci. 2022 Aug; 23(15): 8634. Published online 2022 Aug 3. doi: 10.3390/ijms23158634
PMCID:
PMC9368982
AbstractArticlePDF–5.5M
4.
Mouse Scarb2 Modulates EV-A71 Pathogenicity in Neonatal Mice
Wakako Miwatashi, Minori Ishida, Ayako Takashino, Kyousuke Kobayashi, Midori Yamaguchi, Hiroshi Shitara, Satoshi Koike
J Virol. 2022 Aug; 96(15): e00561-22. Published online 2022 Jul 14. doi: 10.1128/jvi.00561-22
PMCID:
PMC9364792
AbstractArticlePDF–4.4M
5.
Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking
Iva Stojkovska, Willayat Y. Wani, Friederike Zunke, Nandkishore R. Belur, Egor A. Pavlenko, Nkatha Mwenda, Karan Sharma, Laetitia Francelle, Joseph R. Mazzulli
Neuron. Author manuscript; available in PMC 2023 Feb 2.
Published in final edited form as: Neuron. 2022 Feb 2; 110(3): 436–451.e11. Published online 2021 Nov 17. doi: 10.1016/j.neuron.2021.10.032
PMCID:
PMC8815333
AbstractArticlePDF–2.8M
6.
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export
Saskia Heybrock, Kristiina Kanerva, Ying Meng, Chris Ing, Anna Liang, Zi-Jian Xiong, Xialian Weng, Young Ah Kim, Richard Collins, William Trimble, Régis Pomès, Gilbert G. Privé, Wim Annaert, Michael Schwake, Joerg Heeren, Renate Lüllmann-Rauch, Sergio Grinstein, Elina Ikonen, Paul Saftig, Dante Neculai
Nat Commun. 2019; 10: 3521. Published online 2019 Aug 6. doi: 10.1038/s41467-019-11425-0
PMCID:
PMC6684646
AbstractArticlePDF–3.3M
7.
Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies
Karen S. Conrad, Ting-Wen Cheng, Daniel Ysselstein, Saskia Heybrock, Lise R. Hoth, Boris A. Chrunyk, Christopher W. am Ende, Dimitri Krainc, Michael Schwake, Paul Saftig, Shenping Liu, Xiayang Qiu, Michael D. Ehlers
Nat Commun. 2017; 8: 1908. Published online 2017 Dec 4. doi: 10.1038/s41467-017-02044-8
PMCID:
PMC5712522
AbstractArticlePDF–3.8M
8.
Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo
Irina N. Baranova, Ana C. P. Souza, Alexander V. Bocharov, Tatyana G. Vishnyakova, Xuzhen Hu, Boris L. Vaisman, Marcelo J. Amar, Zhigang Chen, Alan T. Remaley, Amy P. Patterson, Peter S. T. Yuen, Robert A. Star, Thomas L. Eggerman
PLoS One. 2017; 12(4): e0175824. Published online 2017 Apr 19. doi: 10.1371/journal.pone.0175824
PMCID:
PMC5396919
AbstractArticlePDF–3.6M
9.
Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease
Jinlong Jian, Qing-Yun Tian, Aubryanna Hettinghouse, Shuai Zhao, Helen Liu, Jianlu Wei, Gabriele Grunig, Wujuan Zhang, Kenneth D.R. Setchell, Ying Sun, Herman S. Overkleeft, Gerald L. Chan, Chuan-ju Liu
EBioMedicine. 2016 Nov; 13: 212–224. Published online 2016 Oct 24. doi: 10.1016/j.ebiom.2016.10.010
PMCID:
PMC5264254
AbstractArticlePDF–2.2M
10.
Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice
Seunghyi Kook, Ping Wang, Lisa R. Young, Michael Schwake, Paul Saftig, Xialian Weng, Ying Meng, Dante Neculai, Michael S. Marks, Linda Gonzales, Michael F. Beers, Susan Guttentag
J Biol Chem. 2016 Apr 15; 291(16): 8414–8427. Published online 2016 Feb 23. doi: 10.1074/jbc.M116.720201
PMCID:
PMC4861416
AbstractArticlePDF–2.1M
11.
Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases
André R. A. Marques, Mina Mirzaian, Hisako Akiyama, Patrick Wisse, Maria J. Ferraz, Paulo Gaspar, Karen Ghauharali-van der Vlugt, Rianne Meijer, Pilar Giraldo, Pilar Alfonso, Pilar Irún, Maria Dahl, Stefan Karlsson, Elena V. Pavlova, Timothy M. Cox, Saskia Scheij, Marri Verhoek, Roelof Ottenhoff, Cindy P. A. A. van Roomen, Navraj S. Pannu, Marco van Eijk, Nick Dekker, Rolf G. Boot, Herman S. Overkleeft, Edward Blommaart, Yoshio Hirabayashi, Johannes M. Aerts
J Lipid Res. 2016 Mar; 57(3): 451–463. doi: 10.1194/jlr.M064923
PMCID:
PMC4766994
AbstractArticlePDF–1.2M
12.
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance
Michelle Rothaug, Friederike Zunke, Joseph R. Mazzulli, Michaela Schweizer, Hermann Altmeppen, Renate Lüllmann-Rauch, Wouter W. Kallemeijn, Paulo Gaspar, Johannes M. Aerts, Markus Glatzel, Paul Saftig, Dimitri Krainc, Michael Schwake, Judith Blanz
Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43): 15573–15578. Published online 2014 Oct 14. doi: 10.1073/pnas.1405700111
PMCID:
PMC4217458
AbstractArticlePDF–1.4M
13.
Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor
Yuguang Zhao, Jingshan Ren, Sergi Padilla-Parra, Elizabeth E. Fry, David I. Stuart
Nat Commun. 2014 Jul 14; 5: 4321. Published online 2014 Jul 14. doi: 10.1038/ncomms5321
PMCID:
PMC4104448
AbstractArticlePDF–2.3M
14.
Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis
Paulo Gaspar, Wouter W. Kallemeijn, Anneke Strijland, Saskia Scheij, Marco Van Eijk, Jan Aten, Herman S. Overkleeft, Andrea Balreira, Friederike Zunke, Michael Schwake, Clara Sá Miranda, Johannes M. F. G. Aerts
J Lipid Res. 2014 Jan; 55(1): 138–145. doi: 10.1194/jlr.M043802
PMCID:
PMC3927471
AbstractArticlePDF–819K
15.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
16.
HSL-knockout mouse testis exhibits class B scavenger receptor upregulation and disrupted lipid raft microdomains
María Emilia Casado, Lydia Huerta, Ana Isabel Ortiz, Mirian Pérez-Crespo, Alfonso Gutiérrez-Adán, Fredric B. Kraemer, Miguel Ángel Lasunción, Rebeca Busto, Antonia Martín-Hidalgo
J Lipid Res. 2012 Dec; 53(12): 2586–2597. doi: 10.1194/jlr.M028076
PMCID:
PMC3494238
AbstractArticlePDF–1.4M
17.
Sex Reversal in C57BL/6J XY Mice Caused by Increased Expression of Ovarian Genes and Insufficient Activation of the Testis Determining Pathway
Stephanie M. Correa, Linda L. Washburn, Ravi S. Kahlon, Michelle C. Musson, Gerrit J. Bouma, Eva M. Eicher, Kenneth H. Albrecht
PLoS Genet. 2012 Apr; 8(4): e1002569. Published online 2012 Apr 5. doi: 10.1371/journal.pgen.1002569
PMCID:
PMC3320579
AbstractArticlePDF–7.1M
18.
Molecular Determinants of Enterovirus 71 Viral Entry: CLEFT AROUND GLN-172 ON VP1 PROTEIN INTERACTS WITH VARIABLE REGION ON SCAVENGE RECEPTOR B 2
Pan Chen, Zilin Song, Yonghe Qi, Xiaofeng Feng, Naiqing Xu, Yinyan Sun, Xing Wu, Xin Yao, Qunyin Mao, Xiuling Li, Wenjuan Dong, Xiaobo Wan, Niu Huang, Xinliang Shen, Zhenglun Liang, Wenhui Li
J Biol Chem. 2012 Feb 24; 287(9): 6406–6420. Published online 2012 Jan 4. doi: 10.1074/jbc.M111.301622
PMCID:
PMC3307280
AbstractArticlePDF–2.9M
19.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
20.
LIMP-2 Links Late Phagosomal Trafficking with the Onset of the Innate Immune Response to Listeria monocytogenes: A ROLE IN MACROPHAGE ACTIVATION
Eugenio Carrasco-Marín, Lorena Fernández-Prieto, Estela Rodriguez-Del Rio, Fidel Madrazo-Toca, Thomas Reinheckel, Paul Saftig, Carmen Alvarez-Dominguez
J Biol Chem. 2011 Feb 4; 286(5): 3332–3341. Published online 2010 Dec 1. doi: 10.1074/jbc.M110.146761
PMCID:
PMC3030339
AbstractArticlePDF–1.2M

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